Incidental Mutation 'R5468:Adrb2'
ID 433383
Institutional Source Beutler Lab
Gene Symbol Adrb2
Ensembl Gene ENSMUSG00000045730
Gene Name adrenergic receptor, beta 2
Synonyms Adrb-2, Gpcr7, Badm, beta 2-AR, beta 2-adrenoceptor
MMRRC Submission 043029-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5468 (G1)
Quality Score 225
Status Not validated
Chromosome 18
Chromosomal Location 62310887-62313030 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 62312696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 43 (I43N)
Ref Sequence ENSEMBL: ENSMUSP00000062256 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053640] [ENSMUST00000067743]
AlphaFold P18762
Predicted Effect probably damaging
Transcript: ENSMUST00000053640
AA Change: I43N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062256
Gene: ENSMUSG00000045730
AA Change: I43N

DomainStartEndE-ValueType
Pfam:7tm_4 40 246 4.7e-10 PFAM
Pfam:7TM_GPCR_Srx 41 250 2.2e-8 PFAM
Pfam:7TM_GPCR_Srsx 43 340 1.4e-15 PFAM
Pfam:7tm_1 50 326 9.8e-74 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000067743
SMART Domains Protein: ENSMUSP00000065944
Gene: ENSMUSG00000054589

DomainStartEndE-ValueType
low complexity region 53 69 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.2%
  • 3x: 97.3%
  • 10x: 95.2%
  • 20x: 91.0%
Validation Efficiency
MGI Phenotype FUNCTION: This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]
PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene exhibit increased bone mass. The primary physiological consequences are seen during exercise stress and result from alterations in vascular tone and energy metabolism. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700008O03Rik C T 7: 44,009,659 (GRCm39) R181Q probably damaging Het
Abca13 T A 11: 9,244,062 (GRCm39) L1975Q probably damaging Het
Acp2 T A 2: 91,036,443 (GRCm39) I180N probably benign Het
Adam12 T C 7: 133,577,202 (GRCm39) D221G probably damaging Het
Adamts4 A G 1: 171,080,178 (GRCm39) T244A probably benign Het
Anxa1 A T 19: 20,355,847 (GRCm39) Y207N probably damaging Het
Apba2 T C 7: 64,395,510 (GRCm39) L662P probably damaging Het
Arhgap18 T A 10: 26,788,667 (GRCm39) I593K probably damaging Het
Arsj T C 3: 126,232,037 (GRCm39) V261A possibly damaging Het
Atp7b A T 8: 22,549,986 (GRCm39) probably null Het
C2cd2 C T 16: 97,669,791 (GRCm39) probably null Het
Cenpf A T 1: 189,384,568 (GRCm39) S2571T probably damaging Het
Cep162 A C 9: 87,109,290 (GRCm39) L438V probably benign Het
Cfap74 A T 4: 155,510,498 (GRCm39) N361I probably benign Het
Cntn5 A G 9: 9,743,633 (GRCm39) I548T probably damaging Het
Cracd A T 5: 76,988,610 (GRCm39) probably benign Het
Dglucy A G 12: 100,816,594 (GRCm39) N382S probably benign Het
Dnah10 C A 5: 124,907,557 (GRCm39) N4306K probably damaging Het
Fam181a A T 12: 103,282,937 (GRCm39) M281L probably benign Het
Fam186b A G 15: 99,176,751 (GRCm39) I713T possibly damaging Het
Fetub C T 16: 22,751,081 (GRCm39) R143C probably damaging Het
Fry A T 5: 150,323,053 (GRCm39) Y1068F probably benign Het
Fubp3 A G 2: 31,493,247 (GRCm39) I231V probably benign Het
Gbf1 A G 19: 46,272,735 (GRCm39) D1681G possibly damaging Het
Gm10999 G A 8: 129,858,130 (GRCm39) P5S probably damaging Het
Gm12689 T C 4: 99,184,402 (GRCm39) I85T unknown Het
Impg1 T C 9: 80,347,318 (GRCm39) I9V probably benign Het
Lama4 A G 10: 38,948,678 (GRCm39) probably null Het
Lamc1 A G 1: 153,109,310 (GRCm39) S1161P probably damaging Het
Lipm T A 19: 34,086,954 (GRCm39) probably null Het
Lrrc7 G T 3: 158,024,073 (GRCm39) N107K probably damaging Het
Lypd8 T C 11: 58,277,586 (GRCm39) S123P probably damaging Het
Man2a2 T C 7: 80,002,729 (GRCm39) D1084G probably damaging Het
Man2b2 A G 5: 36,964,519 (GRCm39) S1000P probably benign Het
Ms4a7 C T 19: 11,299,778 (GRCm39) C71Y probably benign Het
Mtus1 A G 8: 41,537,615 (GRCm39) S34P probably benign Het
Myo3b A G 2: 70,064,785 (GRCm39) N406S probably benign Het
Nbr1 A T 11: 101,463,290 (GRCm39) M586L probably benign Het
Nfatc1 C T 18: 80,693,070 (GRCm39) R677H probably benign Het
Nlrc3 A C 16: 3,781,899 (GRCm39) S503R probably damaging Het
Nlrp9c A T 7: 26,064,425 (GRCm39) F968I probably benign Het
Onecut1 A T 9: 74,770,614 (GRCm39) T346S probably damaging Het
Or1j12 A T 2: 36,343,455 (GRCm39) N286I probably damaging Het
Or8b35 G A 9: 37,904,307 (GRCm39) C168Y probably damaging Het
Or8g32 A G 9: 39,305,257 (GRCm39) N57D probably benign Het
Pclo A T 5: 14,730,966 (GRCm39) K3156M unknown Het
Pigo C T 4: 43,024,562 (GRCm39) probably null Het
Plcb4 T C 2: 135,809,072 (GRCm39) F580S probably damaging Het
Plekhm2 G T 4: 141,355,411 (GRCm39) P879H probably damaging Het
Ppm1e T A 11: 87,121,716 (GRCm39) Y747F probably benign Het
Ppwd1 A G 13: 104,361,952 (GRCm39) F69L possibly damaging Het
Prss27 C A 17: 24,257,287 (GRCm39) Q3K possibly damaging Het
Prss29 T A 17: 25,540,020 (GRCm39) N139K possibly damaging Het
Qrich2 T A 11: 116,339,191 (GRCm39) T1777S probably damaging Het
Rbp3 A T 14: 33,678,584 (GRCm39) H844L possibly damaging Het
Rubcnl G A 14: 75,269,471 (GRCm39) C43Y possibly damaging Het
Sec14l5 A G 16: 4,985,004 (GRCm39) probably null Het
Sepsecs A T 5: 52,801,356 (GRCm39) N435K probably damaging Het
Sfrp1 A G 8: 23,936,226 (GRCm39) K223E probably benign Het
Sh3tc2 G A 18: 62,106,502 (GRCm39) probably null Het
Slc35e2 C T 4: 155,694,483 (GRCm39) P10L probably benign Het
Tmprss7 A G 16: 45,476,811 (GRCm39) F817S probably damaging Het
Tril T C 6: 53,796,632 (GRCm39) N197D probably damaging Het
Tspan18 T C 2: 93,040,207 (GRCm39) T183A probably benign Het
Uroc1 A T 6: 90,315,586 (GRCm39) M156L probably benign Het
Wnt16 T C 6: 22,291,160 (GRCm39) V196A probably benign Het
Xpnpep1 A G 19: 52,983,950 (GRCm39) Y592H probably benign Het
Zfp553 T C 7: 126,836,202 (GRCm39) S586P probably benign Het
Zfp619 C T 7: 39,185,152 (GRCm39) A394V unknown Het
Zfp985 A G 4: 147,667,702 (GRCm39) Y190C probably benign Het
Zmynd10 T A 9: 107,427,536 (GRCm39) D309E probably benign Het
Zmynd15 T C 11: 70,352,646 (GRCm39) L73P probably damaging Het
Other mutations in Adrb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02336:Adrb2 APN 18 62,312,078 (GRCm39) missense probably benign 0.00
getup UTSW 18 62,312,142 (GRCm39) missense probably benign 0.03
go UTSW 18 62,312,004 (GRCm39) missense probably damaging 1.00
PIT4514001:Adrb2 UTSW 18 62,312,798 (GRCm39) missense probably benign 0.00
R0091:Adrb2 UTSW 18 62,312,090 (GRCm39) missense probably benign
R0420:Adrb2 UTSW 18 62,312,610 (GRCm39) missense possibly damaging 0.76
R0436:Adrb2 UTSW 18 62,312,624 (GRCm39) missense possibly damaging 0.93
R0604:Adrb2 UTSW 18 62,311,586 (GRCm39) missense possibly damaging 0.49
R0626:Adrb2 UTSW 18 62,312,441 (GRCm39) missense probably damaging 1.00
R0843:Adrb2 UTSW 18 62,312,142 (GRCm39) missense probably benign 0.03
R0940:Adrb2 UTSW 18 62,312,762 (GRCm39) missense probably benign 0.00
R1498:Adrb2 UTSW 18 62,312,004 (GRCm39) missense probably damaging 1.00
R1517:Adrb2 UTSW 18 62,311,871 (GRCm39) missense probably damaging 1.00
R1603:Adrb2 UTSW 18 62,312,579 (GRCm39) missense probably damaging 1.00
R1944:Adrb2 UTSW 18 62,312,484 (GRCm39) missense probably damaging 1.00
R4367:Adrb2 UTSW 18 62,312,127 (GRCm39) missense probably damaging 1.00
R5143:Adrb2 UTSW 18 62,311,847 (GRCm39) missense probably damaging 1.00
R5644:Adrb2 UTSW 18 62,311,753 (GRCm39) missense probably benign 0.01
R6073:Adrb2 UTSW 18 62,312,537 (GRCm39) missense probably benign 0.01
R6753:Adrb2 UTSW 18 62,312,624 (GRCm39) missense possibly damaging 0.93
R7883:Adrb2 UTSW 18 62,312,447 (GRCm39) missense probably damaging 0.98
R8298:Adrb2 UTSW 18 62,311,753 (GRCm39) missense probably benign 0.01
R8366:Adrb2 UTSW 18 62,311,775 (GRCm39) missense probably benign 0.00
R8420:Adrb2 UTSW 18 62,312,004 (GRCm39) missense probably damaging 1.00
R8427:Adrb2 UTSW 18 62,312,345 (GRCm39) missense possibly damaging 0.88
R9246:Adrb2 UTSW 18 62,312,226 (GRCm39) missense probably damaging 1.00
R9398:Adrb2 UTSW 18 62,312,276 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCACCAGAAGTTGCCAAAATTC -3'
(R):5'- GAATGAAGCTTCCAGGAGTCCG -3'

Sequencing Primer
(F):5'- CCACATTTTCATAAGGATGTGACTGG -3'
(R):5'- AGGTGCACCCGCTGAGAG -3'
Posted On 2016-10-06