Incidental Mutation 'R5472:Zfp109'
ID 433868
Institutional Source Beutler Lab
Gene Symbol Zfp109
Ensembl Gene ENSMUSG00000074283
Gene Name zinc finger protein 109
Synonyms
MMRRC Submission 043033-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R5472 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 23926997-23936985 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 23928046 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 462 (C462*)
Ref Sequence ENSEMBL: ENSMUSP00000145925 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037448] [ENSMUST00000206362] [ENSMUST00000206960]
AlphaFold A0A0U1RPC5
Predicted Effect probably null
Transcript: ENSMUST00000037448
AA Change: C454*
SMART Domains Protein: ENSMUSP00000045498
Gene: ENSMUSG00000074283
AA Change: C454*

DomainStartEndE-ValueType
KRAB 8 74 8.77e-20 SMART
ZnF_C2H2 283 305 2.91e-2 SMART
ZnF_C2H2 311 333 4.47e-3 SMART
ZnF_C2H2 339 361 4.11e-2 SMART
ZnF_C2H2 367 387 5.54e1 SMART
ZnF_C2H2 393 415 1.98e-4 SMART
ZnF_C2H2 421 443 8.67e-1 SMART
ZnF_C2H2 449 471 4.87e-4 SMART
ZnF_C2H2 477 499 7.49e-5 SMART
ZnF_C2H2 505 527 1.47e-3 SMART
ZnF_C2H2 533 555 3.21e-4 SMART
ZnF_C2H2 561 583 8.47e-4 SMART
ZnF_C2H2 589 611 2.57e-3 SMART
ZnF_C2H2 617 639 4.4e-2 SMART
Predicted Effect probably null
Transcript: ENSMUST00000206362
AA Change: C454*
Predicted Effect probably null
Transcript: ENSMUST00000206960
AA Change: C462*
Coding Region Coverage
  • 1x: 98.3%
  • 3x: 97.3%
  • 10x: 95.3%
  • 20x: 91.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ajm1 T C 2: 25,469,714 (GRCm39) T66A probably benign Het
Akap11 T C 14: 78,750,869 (GRCm39) N506S probably benign Het
Brinp3 A T 1: 146,777,197 (GRCm39) H548L possibly damaging Het
Cacna1c A G 6: 118,615,407 (GRCm39) V1328A possibly damaging Het
Carmil1 C T 13: 24,339,454 (GRCm39) V47I probably damaging Het
Cdk2ap2 C A 19: 4,148,048 (GRCm39) T76K probably benign Het
Col16a1 T C 4: 129,986,564 (GRCm39) probably benign Het
Cspg4b A G 13: 113,455,703 (GRCm39) D583G probably benign Het
Cxcr4 C A 1: 128,517,362 (GRCm39) A100S probably damaging Het
Fancl G T 11: 26,419,677 (GRCm39) C305F probably damaging Het
Gcnt2 T C 13: 41,107,055 (GRCm39) V308A probably benign Het
Gm11733 A T 11: 117,375,322 (GRCm39) I24L unknown Het
Gm973 A G 1: 59,667,446 (GRCm39) probably null Het
Heatr5b A T 17: 79,109,089 (GRCm39) F1057I probably damaging Het
Ifi213 A T 1: 173,394,838 (GRCm39) probably null Het
Ighv1-20 A T 12: 114,687,471 (GRCm39) V91E probably damaging Het
Inhba A G 13: 16,201,371 (GRCm39) E311G probably damaging Het
Irx3 G T 8: 92,526,108 (GRCm39) probably null Het
Jag1 C A 2: 136,926,915 (GRCm39) C948F probably damaging Het
Kcna2 T C 3: 107,012,625 (GRCm39) I402T possibly damaging Het
Kcnh8 A T 17: 53,284,844 (GRCm39) Q938L possibly damaging Het
Lrsam1 ACC AC 2: 32,835,870 (GRCm39) probably null Het
Macf1 T C 4: 123,343,854 (GRCm39) T2123A probably benign Het
Mdfic2 A T 6: 98,215,237 (GRCm39) C129S probably damaging Het
Mdh1 A T 11: 21,509,786 (GRCm39) N196K probably benign Het
Msh6 G A 17: 88,291,989 (GRCm39) R248Q possibly damaging Het
Odf2l G T 3: 144,852,627 (GRCm39) R457L probably benign Het
Or6c69c A T 10: 129,910,898 (GRCm39) L206F probably damaging Het
Pphln1 T C 15: 93,386,856 (GRCm39) V318A possibly damaging Het
Ppp1r12a C T 10: 108,075,973 (GRCm39) T267I probably damaging Het
Pramel15 T C 4: 144,103,727 (GRCm39) D133G probably benign Het
Prpf8 A C 11: 75,394,469 (GRCm39) K1801N possibly damaging Het
Raf1 A G 6: 115,603,667 (GRCm39) probably null Het
Rasal3 C A 17: 32,615,643 (GRCm39) L374F probably damaging Het
S1pr3 T A 13: 51,573,683 (GRCm39) V288D probably damaging Het
Setd7 G A 3: 51,428,886 (GRCm39) P315S probably benign Het
Slx4 C T 16: 3,809,404 (GRCm39) A364T probably benign Het
Sp7 G A 15: 102,267,749 (GRCm39) T19I probably benign Het
Tlr9 T A 9: 106,101,512 (GRCm39) C268S probably damaging Het
Tmem117 T A 15: 94,992,394 (GRCm39) D351E possibly damaging Het
Tmem45b T A 9: 31,339,340 (GRCm39) D211V possibly damaging Het
Tns3 A G 11: 8,401,092 (GRCm39) S1069P probably benign Het
Tsnax A G 8: 125,742,501 (GRCm39) I77V probably benign Het
Txndc5 G A 13: 38,697,101 (GRCm39) L79F possibly damaging Het
Ube2q1 A G 3: 89,684,548 (GRCm39) E14G probably benign Het
Vmn2r28 C T 7: 5,490,943 (GRCm39) probably null Het
Vwde A T 6: 13,193,117 (GRCm39) D407E probably benign Het
Wdr35 T A 12: 9,066,619 (GRCm39) M749K probably benign Het
Other mutations in Zfp109
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00646:Zfp109 APN 7 23,928,237 (GRCm39) nonsense probably null
IGL01082:Zfp109 APN 7 23,933,784 (GRCm39) missense probably damaging 1.00
IGL02129:Zfp109 APN 7 23,936,054 (GRCm39) missense possibly damaging 0.76
PIT4585001:Zfp109 UTSW 7 23,928,779 (GRCm39) missense probably benign 0.35
R0319:Zfp109 UTSW 7 23,933,895 (GRCm39) missense probably damaging 1.00
R1502:Zfp109 UTSW 7 23,927,588 (GRCm39) missense probably damaging 1.00
R1912:Zfp109 UTSW 7 23,927,676 (GRCm39) missense probably damaging 0.97
R1930:Zfp109 UTSW 7 23,928,161 (GRCm39) missense probably damaging 1.00
R1931:Zfp109 UTSW 7 23,928,161 (GRCm39) missense probably damaging 1.00
R1994:Zfp109 UTSW 7 23,928,743 (GRCm39) missense probably benign 0.04
R2105:Zfp109 UTSW 7 23,936,041 (GRCm39) critical splice donor site probably null
R2219:Zfp109 UTSW 7 23,927,886 (GRCm39) missense probably damaging 1.00
R2353:Zfp109 UTSW 7 23,928,806 (GRCm39) missense probably benign 0.06
R3754:Zfp109 UTSW 7 23,929,181 (GRCm39) missense probably benign 0.34
R4434:Zfp109 UTSW 7 23,928,771 (GRCm39) missense probably benign 0.02
R4884:Zfp109 UTSW 7 23,928,570 (GRCm39) missense probably benign 0.06
R5056:Zfp109 UTSW 7 23,928,162 (GRCm39) missense possibly damaging 0.75
R5220:Zfp109 UTSW 7 23,928,179 (GRCm39) missense probably benign 0.03
R5715:Zfp109 UTSW 7 23,928,995 (GRCm39) missense possibly damaging 0.92
R5801:Zfp109 UTSW 7 23,928,126 (GRCm39) missense probably damaging 0.99
R6092:Zfp109 UTSW 7 23,928,978 (GRCm39) missense possibly damaging 0.57
R6093:Zfp109 UTSW 7 23,928,558 (GRCm39) missense probably benign 0.03
R6334:Zfp109 UTSW 7 23,928,308 (GRCm39) missense probably damaging 0.96
R6458:Zfp109 UTSW 7 23,927,870 (GRCm39) missense probably benign 0.01
R6856:Zfp109 UTSW 7 23,928,823 (GRCm39) missense probably benign 0.03
R6879:Zfp109 UTSW 7 23,928,615 (GRCm39) missense probably benign 0.02
R7069:Zfp109 UTSW 7 23,928,785 (GRCm39) missense probably benign 0.01
R7151:Zfp109 UTSW 7 23,929,231 (GRCm39) missense probably benign 0.01
R7822:Zfp109 UTSW 7 23,928,570 (GRCm39) missense probably benign 0.06
R8205:Zfp109 UTSW 7 23,928,635 (GRCm39) missense probably damaging 0.99
R8492:Zfp109 UTSW 7 23,927,499 (GRCm39) missense possibly damaging 0.79
Z1088:Zfp109 UTSW 7 23,928,360 (GRCm39) missense probably benign 0.08
Z1177:Zfp109 UTSW 7 23,928,212 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGGACTATCTGGTGAGAACTCAG -3'
(R):5'- GGAAGGGTTTCACTTCAGCC -3'

Sequencing Primer
(F):5'- TCTGAAGATATGAGCTCCGGC -3'
(R):5'- GAAGGGTTTCACTTCAGCCTCAAAC -3'
Posted On 2016-10-06