Mutagenetix > Incidental Mutation

Incidental Mutation 'R5476:Vmn1r175'

434079

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r175

Ensembl Gene

ENSMUSG00000095632

Gene Name

vomeronasal 1 receptor 175

Synonyms

Gm6299

MMRRC Submission

043037-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R5476 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

23507711-23508625 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 23508556 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 24 (V24I)

Ref Sequence

ENSEMBL: ENSMUSP00000154170 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166141] [ENSMUST00000228383]

AlphaFold

K7N6T9

Predicted Effect

possibly damaging
Transcript: ENSMUST00000166141
AA Change: V24I

PolyPhen 2 Score 0.824 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000126357
Gene: ENSMUSG00000095632
AA Change: V24I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	8.8e-15	PFAM
Pfam:7tm_1	13	285	2.5e-6	PFAM
Pfam:V1R	41	295	4.4e-22	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000228383
AA Change: V24I

PolyPhen 2 Score 0.824 (Sensitivity: 0.84; Specificity: 0.93)

Coding Region Coverage

1x: 98.4%
3x: 97.4%
10x: 95.5%
20x: 91.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh16a1	T	G	7: 44,791,493 (GRCm39)	N71H	possibly damaging	Het
Alg5	T	A	3: 54,654,019 (GRCm39)	S252T	probably benign	Het
Arhgap21	T	C	2: 20,885,497 (GRCm39)	N560S	probably benign	Het
Ccdc96	A	G	5: 36,642,981 (GRCm39)	D329G	possibly damaging	Het
Cep128	T	C	12: 91,180,392 (GRCm39)	E917G	probably damaging	Het
Cpox	G	C	16: 58,499,088 (GRCm39)	V434L	probably damaging	Het
D5Ertd579e	G	T	5: 36,772,601 (GRCm39)	S598Y	probably damaging	Het
Ddx6	A	G	9: 44,518,753 (GRCm39)	R22G	possibly damaging	Het
Dgcr8	A	T	16: 18,077,843 (GRCm39)	Y597N	probably damaging	Het
Dnah2	C	T	11: 69,349,746 (GRCm39)	R2399Q	probably benign	Het
Dock5	T	C	14: 68,051,456 (GRCm39)	D671G	possibly damaging	Het
Dock6	A	G	9: 21,720,885 (GRCm39)	S1707P	probably damaging	Het
Dop1b	A	G	16: 93,570,801 (GRCm39)		probably null	Het
Faim	A	G	9: 98,874,782 (GRCm39)	R110G	probably damaging	Het
Grm4	A	G	17: 27,653,772 (GRCm39)	V726A	probably benign	Het
Hps1	T	C	19: 42,758,041 (GRCm39)		probably null	Het
Lefty1	T	C	1: 180,765,263 (GRCm39)	M277T	probably benign	Het
Mmp9	A	G	2: 164,794,414 (GRCm39)	M469V	probably benign	Het
Mroh4	A	T	15: 74,483,510 (GRCm39)	I609N	probably benign	Het
Myl6b	C	T	10: 128,333,216 (GRCm39)		probably benign	Het
Nt5m	A	G	11: 59,766,733 (GRCm39)	D208G	probably damaging	Het
Pard3b	G	T	1: 62,049,565 (GRCm39)	V108L	probably benign	Het
Pbp2	A	G	6: 135,286,922 (GRCm39)	S142P	probably benign	Het
Pbrm1	T	A	14: 30,754,476 (GRCm39)	D165E	probably benign	Het
Pde4b	A	G	4: 102,459,896 (GRCm39)	K577R	probably benign	Het
Phf21b	A	G	15: 84,671,466 (GRCm39)	M476T	probably benign	Het
Prr14l	T	C	5: 33,001,482 (GRCm39)		probably benign	Het
Ralgapa2	A	G	2: 146,289,356 (GRCm39)	V282A	probably benign	Het
Rif1	A	G	2: 51,979,607 (GRCm39)	I430V	probably damaging	Het
Slc25a12	A	G	2: 71,105,666 (GRCm39)	S623P	probably benign	Het
Smc1b	A	T	15: 84,970,352 (GRCm39)	I967N	probably damaging	Het
Snx13	A	G	12: 35,156,819 (GRCm39)		probably null	Het
Spata2	A	T	2: 167,326,079 (GRCm39)	S247T	probably damaging	Het
Stpg2	T	A	3: 138,948,899 (GRCm39)	Y232N	probably benign	Het
Tor3a	G	T	1: 156,501,137 (GRCm39)	S100R	possibly damaging	Het
Trappc8	A	G	18: 20,998,165 (GRCm39)	F385S	probably damaging	Het
Uggt2	T	A	14: 119,328,121 (GRCm39)	T134S	probably benign	Het
Wdr1	C	T	5: 38,686,931 (GRCm39)	G278S	probably damaging	Het
Zfp157	T	G	5: 138,455,443 (GRCm39)	V547G	possibly damaging	Het
Zfp442	A	T	2: 150,250,079 (GRCm39)	C551S	probably damaging	Het

Other mutations in Vmn1r175

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02944:Vmn1r175	APN	7	23,508,591 (GRCm39)	missense	probably damaging	0.97
PIT4531001:Vmn1r175	UTSW	7	23,508,603 (GRCm39)	missense	possibly damaging	0.62
R1163:Vmn1r175	UTSW	7	23,507,937 (GRCm39)	missense	probably benign	0.30
R1901:Vmn1r175	UTSW	7	23,508,218 (GRCm39)	missense	probably benign	0.00
R1926:Vmn1r175	UTSW	7	23,508,466 (GRCm39)	missense	possibly damaging	0.81
R1957:Vmn1r175	UTSW	7	23,507,808 (GRCm39)	missense	probably benign	0.21
R2163:Vmn1r175	UTSW	7	23,508,352 (GRCm39)	missense	probably benign	0.29
R2381:Vmn1r175	UTSW	7	23,508,093 (GRCm39)	missense	probably benign	0.31
R3109:Vmn1r175	UTSW	7	23,508,393 (GRCm39)	missense	probably benign	0.00
R3419:Vmn1r175	UTSW	7	23,508,075 (GRCm39)	missense	probably damaging	0.96
R3941:Vmn1r175	UTSW	7	23,508,393 (GRCm39)	missense	probably benign	0.00
R4982:Vmn1r175	UTSW	7	23,508,494 (GRCm39)	missense	possibly damaging	0.61
R5191:Vmn1r175	UTSW	7	23,508,447 (GRCm39)	missense	possibly damaging	0.91
R5326:Vmn1r175	UTSW	7	23,508,531 (GRCm39)	missense	possibly damaging	0.88
R5333:Vmn1r175	UTSW	7	23,508,004 (GRCm39)	missense	possibly damaging	0.69
R5542:Vmn1r175	UTSW	7	23,508,531 (GRCm39)	missense	possibly damaging	0.88
R5761:Vmn1r175	UTSW	7	23,507,905 (GRCm39)	missense	probably benign	0.01
R5918:Vmn1r175	UTSW	7	23,508,372 (GRCm39)	missense	probably damaging	1.00
R6163:Vmn1r175	UTSW	7	23,508,591 (GRCm39)	missense	possibly damaging	0.71
R6563:Vmn1r175	UTSW	7	23,508,030 (GRCm39)	missense	possibly damaging	0.61
R7476:Vmn1r175	UTSW	7	23,507,847 (GRCm39)	missense	probably benign	0.01
R7616:Vmn1r175	UTSW	7	23,508,031 (GRCm39)	missense	possibly damaging	0.79
R8100:Vmn1r175	UTSW	7	23,508,012 (GRCm39)	missense	probably damaging	1.00
R8157:Vmn1r175	UTSW	7	23,508,523 (GRCm39)	missense	probably benign	0.00
R8699:Vmn1r175	UTSW	7	23,508,234 (GRCm39)	missense	probably benign	0.01
R8744:Vmn1r175	UTSW	7	23,508,403 (GRCm39)	missense	probably benign	0.00
R9595:Vmn1r175	UTSW	7	23,508,508 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- TTTGTACTTCGAGCCACCAG -3'
(R):5'- AAGTAGAGCTGCCCTTCGTG -3'

Sequencing Primer
(F):5'- CCAAGTTTACATTTTAGGTCAGTTGG -3'
(R):5'- CCTTCGTGGGGGAAAATGTC -3'

Posted On

2016-10-06