Incidental Mutation 'R5483:Klf11'
ID 434440
Institutional Source Beutler Lab
Gene Symbol Klf11
Ensembl Gene ENSMUSG00000020653
Gene Name Kruppel-like transcription factor 11
Synonyms D12Ertd427e, Tieg3, Tieg2, Tieg2b
MMRRC Submission 043044-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5483 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 24701370-24712781 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 24705410 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 288 (L288*)
Ref Sequence ENSEMBL: ENSMUSP00000020982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020982] [ENSMUST00000139940] [ENSMUST00000144046] [ENSMUST00000146894]
AlphaFold Q8K1S5
Predicted Effect probably null
Transcript: ENSMUST00000020982
AA Change: L288*
SMART Domains Protein: ENSMUSP00000020982
Gene: ENSMUSG00000020653
AA Change: L288*

DomainStartEndE-ValueType
low complexity region 267 275 N/A INTRINSIC
low complexity region 356 367 N/A INTRINSIC
ZnF_C2H2 384 408 5.9e-3 SMART
ZnF_C2H2 414 438 9.22e-5 SMART
ZnF_C2H2 444 466 1.38e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000139940
Predicted Effect probably benign
Transcript: ENSMUST00000144046
Predicted Effect probably benign
Transcript: ENSMUST00000146894
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 97.5%
  • 10x: 94.8%
  • 20x: 89.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile, show normal hematopoiesis, growth and development, and display no evidence of increased tumor formation following gamma-irradiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cfap206 G T 4: 34,711,404 (GRCm39) Q498K probably benign Het
Dnmt3a A G 12: 3,949,615 (GRCm39) Y524C probably damaging Het
Dnttip2 A T 3: 122,070,446 (GRCm39) T554S probably damaging Het
Emc1 A G 4: 139,102,687 (GRCm39) T949A probably damaging Het
Enkur A T 2: 21,199,109 (GRCm39) F142I probably benign Het
Fbxo24 C T 5: 137,617,002 (GRCm39) A362T probably damaging Het
Heatr1 A G 13: 12,413,795 (GRCm39) H124R probably damaging Het
Hira T A 16: 18,788,290 (GRCm39) I1011N possibly damaging Het
Ipo5 T A 14: 121,157,450 (GRCm39) I96N probably benign Het
Kctd16 A G 18: 40,663,929 (GRCm39) I353V probably benign Het
Kmt2a A T 9: 44,735,921 (GRCm39) probably benign Het
Lmbrd1 T C 1: 24,783,989 (GRCm39) Y373H probably damaging Het
Mlh1 G A 9: 111,060,126 (GRCm39) A584V possibly damaging Het
Ociad1 T C 5: 73,452,314 (GRCm39) F35S probably damaging Het
Or11l3 T A 11: 58,516,783 (GRCm39) I30F possibly damaging Het
Or6c208 T C 10: 129,223,526 (GRCm39) I8T probably benign Het
Or8u3-ps C T 2: 85,952,962 (GRCm39) Q232* probably null Het
Pkd1l1 C T 11: 8,851,141 (GRCm39) probably null Het
Pole T A 5: 110,442,434 (GRCm39) D287E probably damaging Het
Polh G T 17: 46,483,671 (GRCm39) S531R probably benign Het
Prss29 A G 17: 25,541,177 (GRCm39) K207R probably benign Het
Rasgrp3 T G 17: 75,832,013 (GRCm39) S611R probably damaging Het
Rffl G T 11: 82,703,549 (GRCm39) probably null Het
Scrib A G 15: 75,939,508 (GRCm39) probably null Het
Serpinb3a T A 1: 106,974,899 (GRCm39) K211N probably benign Het
Slc22a3 C T 17: 12,683,354 (GRCm39) A170T probably damaging Het
Socs5 T G 17: 87,442,402 (GRCm39) F447L probably damaging Het
Srrm2 T A 17: 24,040,246 (GRCm39) S2393T probably damaging Het
Usp7 T A 16: 8,516,404 (GRCm39) Y585F probably benign Het
Vps39 A T 2: 120,153,564 (GRCm39) I670N probably benign Het
Other mutations in Klf11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01630:Klf11 APN 12 24,710,368 (GRCm39) missense probably benign 0.01
IGL02202:Klf11 APN 12 24,703,631 (GRCm39) missense probably benign 0.37
IGL02527:Klf11 APN 12 24,705,322 (GRCm39) missense probably benign 0.31
IGL02964:Klf11 APN 12 24,705,626 (GRCm39) missense probably damaging 1.00
R0254:Klf11 UTSW 12 24,703,582 (GRCm39) missense probably damaging 1.00
R0553:Klf11 UTSW 12 24,705,089 (GRCm39) missense probably benign 0.12
R0739:Klf11 UTSW 12 24,710,247 (GRCm39) missense probably damaging 1.00
R1584:Klf11 UTSW 12 24,705,304 (GRCm39) missense probably damaging 1.00
R1592:Klf11 UTSW 12 24,703,737 (GRCm39) missense probably damaging 1.00
R2356:Klf11 UTSW 12 24,703,582 (GRCm39) missense probably damaging 1.00
R3085:Klf11 UTSW 12 24,705,490 (GRCm39) missense probably benign
R4690:Klf11 UTSW 12 24,705,071 (GRCm39) missense probably damaging 0.97
R5023:Klf11 UTSW 12 24,705,358 (GRCm39) missense probably benign 0.00
R5528:Klf11 UTSW 12 24,704,929 (GRCm39) missense probably benign 0.00
R6148:Klf11 UTSW 12 24,701,567 (GRCm39) critical splice donor site probably null
R6698:Klf11 UTSW 12 24,703,618 (GRCm39) missense probably damaging 1.00
R6799:Klf11 UTSW 12 24,705,638 (GRCm39) missense possibly damaging 0.59
R7317:Klf11 UTSW 12 24,705,518 (GRCm39) missense possibly damaging 0.59
R7384:Klf11 UTSW 12 24,703,742 (GRCm39) missense probably damaging 0.97
R7440:Klf11 UTSW 12 24,705,490 (GRCm39) missense probably benign
R7473:Klf11 UTSW 12 24,705,141 (GRCm39) splice site probably null
R7477:Klf11 UTSW 12 24,703,562 (GRCm39) missense probably benign 0.01
R7658:Klf11 UTSW 12 24,703,670 (GRCm39) missense probably damaging 1.00
R9378:Klf11 UTSW 12 24,705,043 (GRCm39) missense probably benign 0.01
R9479:Klf11 UTSW 12 24,705,029 (GRCm39) missense probably benign 0.10
R9663:Klf11 UTSW 12 24,705,731 (GRCm39) missense probably damaging 1.00
R9721:Klf11 UTSW 12 24,710,240 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGCACAAGTCCGGTGGTTC -3'
(R):5'- GGGGCAACAGCTTGGTATTTC -3'

Sequencing Primer
(F):5'- GTTCGTTCCCCACTGACAAAGG -3'
(R):5'- GGTATTTCCAATGGCCATGACACTG -3'
Posted On 2016-10-06