Incidental Mutation 'R5534:Pramel26'
ID 434694
Institutional Source Beutler Lab
Gene Symbol Pramel26
Ensembl Gene ENSMUSG00000059218
Gene Name PRAME like 26
Synonyms Gm13084
MMRRC Submission 043092-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R5534 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 143535817-143542663 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 143539169 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Stop codon at position 108 (S108*)
Ref Sequence ENSEMBL: ENSMUSP00000101395 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075045] [ENSMUST00000105769]
AlphaFold A2A8N0
Predicted Effect probably null
Transcript: ENSMUST00000075045
AA Change: S108*
SMART Domains Protein: ENSMUSP00000074557
Gene: ENSMUSG00000059218
AA Change: S108*

DomainStartEndE-ValueType
SCOP:d1a4ya_ 222 409 9e-8 SMART
Predicted Effect probably null
Transcript: ENSMUST00000105769
AA Change: S108*
SMART Domains Protein: ENSMUSP00000101395
Gene: ENSMUSG00000059218
AA Change: S108*

DomainStartEndE-ValueType
low complexity region 223 238 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137635
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 T A 8: 25,155,530 (GRCm39) D163V probably benign Het
Ank2 A T 3: 126,740,947 (GRCm39) probably benign Het
Ankmy1 T C 1: 92,814,442 (GRCm39) E355G probably damaging Het
Ankmy2 A G 12: 36,232,491 (GRCm39) N172S probably damaging Het
Ankrd50 A G 3: 38,510,231 (GRCm39) M712T probably damaging Het
Apcdd1 T C 18: 63,070,105 (GRCm39) I124T probably benign Het
Carmil3 A G 14: 55,732,347 (GRCm39) K256R probably damaging Het
Cass4 G T 2: 172,268,688 (GRCm39) V259L probably benign Het
Ccdc141 A G 2: 76,888,241 (GRCm39) V508A probably benign Het
Ccdc33 A G 9: 58,024,450 (GRCm39) S226P possibly damaging Het
Cep72 T C 13: 74,210,335 (GRCm39) E9G probably benign Het
Clca4b A T 3: 144,621,227 (GRCm39) Y616N probably damaging Het
Cnot4 A G 6: 35,054,939 (GRCm39) S117P possibly damaging Het
Col11a2 C T 17: 34,269,998 (GRCm39) A429V probably damaging Het
Col4a4 T C 1: 82,465,238 (GRCm39) E979G unknown Het
Coq10b T C 1: 55,103,359 (GRCm39) Y46H possibly damaging Het
Cplane1 C A 15: 8,258,319 (GRCm39) F2188L probably benign Het
Dnah17 T C 11: 117,943,596 (GRCm39) T3169A possibly damaging Het
Dock6 G A 9: 21,714,372 (GRCm39) R1824* probably null Het
Dsp A C 13: 38,379,818 (GRCm39) I1589L probably benign Het
Edil3 A G 13: 89,347,593 (GRCm39) T383A probably benign Het
Efemp1 T C 11: 28,817,758 (GRCm39) V79A probably damaging Het
Esyt1 C T 10: 128,355,329 (GRCm39) V471I probably benign Het
Fbxo30 T C 10: 11,165,409 (GRCm39) S44P possibly damaging Het
Fdx2 G T 9: 20,984,562 (GRCm39) D57E probably benign Het
Gbp11 A T 5: 105,478,904 (GRCm39) V178D probably damaging Het
Gna11 A T 10: 81,366,967 (GRCm39) I283N probably damaging Het
Grid2 A T 6: 63,480,345 (GRCm39) Q53L probably benign Het
Jmjd6 A G 11: 116,731,252 (GRCm39) S266P probably damaging Het
Kirrel1 G A 3: 86,997,825 (GRCm39) R233C probably damaging Het
Kmt2d A G 15: 98,735,238 (GRCm39) probably benign Het
Lama3 A T 18: 12,686,267 (GRCm39) T1171S probably benign Het
Ltbr G A 6: 125,289,757 (GRCm39) R146W probably damaging Het
Med13 A T 11: 86,210,191 (GRCm39) S650R probably benign Het
Meltf T A 16: 31,709,632 (GRCm39) probably null Het
Mgat1 T C 11: 49,151,976 (GRCm39) V153A probably benign Het
Mmp16 A T 4: 18,110,452 (GRCm39) D416V probably damaging Het
Myh3 A T 11: 66,987,870 (GRCm39) R1448W probably damaging Het
Nedd1 A T 10: 92,530,894 (GRCm39) F398L probably benign Het
Or2a14 A G 6: 43,130,567 (GRCm39) I109M probably benign Het
Or4k45 T C 2: 111,395,349 (GRCm39) T147A probably benign Het
Or5ac17 T C 16: 59,036,403 (GRCm39) D191G probably benign Het
Or5g9 T C 2: 85,552,331 (GRCm39) I194T probably benign Het
Otud3 A G 4: 138,624,894 (GRCm39) L269P probably damaging Het
Otx1 A G 11: 21,946,296 (GRCm39) probably benign Het
Pcdhga7 A C 18: 37,849,331 (GRCm39) D446A probably damaging Het
Pcnx2 T G 8: 126,564,754 (GRCm39) K1046N possibly damaging Het
Pfkp C A 13: 6,698,619 (GRCm39) G33W probably damaging Het
Poglut2 C T 1: 44,151,837 (GRCm39) V351M probably damaging Het
Pold1 A G 7: 44,188,043 (GRCm39) I585T probably damaging Het
Pole4 A G 6: 82,629,115 (GRCm39) Y84H possibly damaging Het
Ptpn23 A G 9: 110,221,809 (GRCm39) S126P possibly damaging Het
R3hdm4 C T 10: 79,748,292 (GRCm39) E162K possibly damaging Het
Rin3 T C 12: 102,353,891 (GRCm39) L766P probably damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rras2 G A 7: 113,649,650 (GRCm39) T138I possibly damaging Het
Scrn2 A G 11: 96,921,751 (GRCm39) I74V probably benign Het
Sema6d T C 2: 124,501,735 (GRCm39) I526T possibly damaging Het
Shd G T 17: 56,278,577 (GRCm39) E47* probably null Het
Slc22a27 T C 19: 7,903,996 (GRCm39) H47R probably damaging Het
Slc36a3 C G 11: 55,033,595 (GRCm39) W141S possibly damaging Het
Slc9c1 T A 16: 45,376,977 (GRCm39) V429E probably benign Het
Smg8 A T 11: 86,976,296 (GRCm39) D428E probably benign Het
Snrpe A T 1: 133,534,211 (GRCm39) F84Y probably benign Het
Tbc1d2b C T 9: 90,109,559 (GRCm39) D306N possibly damaging Het
Trav9n-4 A G 14: 53,532,356 (GRCm39) Y70C probably damaging Het
Tut7 A G 13: 59,936,367 (GRCm39) F843L probably damaging Het
Ush1c A G 7: 45,870,847 (GRCm39) I330T probably damaging Het
Wnt11 T C 7: 98,488,349 (GRCm39) L12P probably damaging Het
Zan A G 5: 137,436,713 (GRCm39) S2047P unknown Het
Zfp763 A C 17: 33,240,768 (GRCm39) S20R probably damaging Het
Other mutations in Pramel26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00839:Pramel26 APN 4 143,539,293 (GRCm39) missense probably benign 0.32
IGL01075:Pramel26 APN 4 143,538,216 (GRCm39) missense possibly damaging 0.47
IGL02705:Pramel26 APN 4 143,537,372 (GRCm39) missense probably damaging 1.00
IGL03011:Pramel26 APN 4 143,538,330 (GRCm39) missense possibly damaging 0.95
PIT4498001:Pramel26 UTSW 4 143,539,406 (GRCm39) missense possibly damaging 0.63
R0268:Pramel26 UTSW 4 143,537,338 (GRCm39) missense probably damaging 1.00
R0344:Pramel26 UTSW 4 143,537,338 (GRCm39) missense probably damaging 1.00
R0390:Pramel26 UTSW 4 143,538,269 (GRCm39) missense probably benign 0.09
R0597:Pramel26 UTSW 4 143,539,222 (GRCm39) missense probably damaging 0.98
R0646:Pramel26 UTSW 4 143,539,155 (GRCm39) missense possibly damaging 0.83
R0927:Pramel26 UTSW 4 143,539,378 (GRCm39) missense probably benign 0.05
R0973:Pramel26 UTSW 4 143,538,428 (GRCm39) missense probably damaging 1.00
R1851:Pramel26 UTSW 4 143,539,396 (GRCm39) missense probably benign 0.33
R1852:Pramel26 UTSW 4 143,539,396 (GRCm39) missense probably benign 0.33
R3699:Pramel26 UTSW 4 143,536,922 (GRCm39) missense probably benign 0.05
R3705:Pramel26 UTSW 4 143,538,345 (GRCm39) missense probably benign 0.06
R3845:Pramel26 UTSW 4 143,538,545 (GRCm39) missense probably damaging 0.96
R4035:Pramel26 UTSW 4 143,537,026 (GRCm39) missense probably benign 0.08
R4044:Pramel26 UTSW 4 143,538,170 (GRCm39) missense probably benign 0.34
R4439:Pramel26 UTSW 4 143,538,143 (GRCm39) missense possibly damaging 0.49
R4660:Pramel26 UTSW 4 143,538,435 (GRCm39) missense probably benign 0.19
R4770:Pramel26 UTSW 4 143,538,519 (GRCm39) missense probably damaging 0.96
R4838:Pramel26 UTSW 4 143,537,375 (GRCm39) nonsense probably null
R5691:Pramel26 UTSW 4 143,538,579 (GRCm39) missense probably benign 0.44
R5893:Pramel26 UTSW 4 143,537,038 (GRCm39) missense probably damaging 1.00
R6123:Pramel26 UTSW 4 143,539,334 (GRCm39) missense possibly damaging 0.89
R6285:Pramel26 UTSW 4 143,542,609 (GRCm39) missense probably damaging 1.00
R6886:Pramel26 UTSW 4 143,539,332 (GRCm39) missense probably benign 0.29
R7105:Pramel26 UTSW 4 143,537,341 (GRCm39) missense probably benign 0.04
R7135:Pramel26 UTSW 4 143,537,233 (GRCm39) missense probably damaging 1.00
R7474:Pramel26 UTSW 4 143,538,269 (GRCm39) missense probably benign 0.03
R7594:Pramel26 UTSW 4 143,539,286 (GRCm39) missense probably damaging 0.99
R7610:Pramel26 UTSW 4 143,539,436 (GRCm39) missense probably damaging 1.00
R7635:Pramel26 UTSW 4 143,536,987 (GRCm39) missense probably damaging 1.00
R7682:Pramel26 UTSW 4 143,537,290 (GRCm39) missense probably benign 0.38
R7986:Pramel26 UTSW 4 143,538,590 (GRCm39) nonsense probably null
R8222:Pramel26 UTSW 4 143,536,893 (GRCm39) missense possibly damaging 0.61
R8328:Pramel26 UTSW 4 143,537,380 (GRCm39) missense probably damaging 1.00
R8678:Pramel26 UTSW 4 143,538,576 (GRCm39) missense probably benign 0.21
R8887:Pramel26 UTSW 4 143,539,257 (GRCm39) missense probably damaging 0.99
R8942:Pramel26 UTSW 4 143,536,861 (GRCm39) missense probably benign 0.00
R9219:Pramel26 UTSW 4 143,537,303 (GRCm39) missense probably benign 0.02
R9291:Pramel26 UTSW 4 143,539,251 (GRCm39) missense probably benign 0.13
R9649:Pramel26 UTSW 4 143,542,609 (GRCm39) missense probably damaging 1.00
R9746:Pramel26 UTSW 4 143,536,886 (GRCm39) missense probably benign 0.24
Z1177:Pramel26 UTSW 4 143,538,588 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- TGCCCAGATAGCCAAGACTG -3'
(R):5'- ACCTGCCCAATATGATGTTCC -3'

Sequencing Primer
(F):5'- AGATAGCCAAGACTGTTCTCAAG -3'
(R):5'- GCCCAATATGATGTTCCCAGTGATG -3'
Posted On 2016-10-24