Mutagenetix > Incidental Mutation

Incidental Mutation 'R0190:Taar2'

43515

Institutional Source

Beutler Lab

Gene Symbol

Taar2

Ensembl Gene

ENSMUSG00000059763

Gene Name

trace amine-associated receptor 2

Synonyms

Gpr58

MMRRC Submission

038451-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0190 (G1)

Quality Score

178

Status

Not validated

Chromosome

Chromosomal Location

23814470-23817481 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 23817393 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Histidine at position 311 (R311H)

Ref Sequence

ENSEMBL: ENSMUSP00000078137 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079134]

AlphaFold

Q5QD17

Predicted Effect

probably benign
Transcript: ENSMUST00000079134
AA Change: R311H

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000078137
Gene: ENSMUSG00000059763
AA Change: R311H

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	42	318	2.4e-10	PFAM
Pfam:7tm_1	48	303	2.9e-54	PFAM

Meta Mutation Damage Score

0.4819

Coding Region Coverage

1x: 98.8%
3x: 97.6%
10x: 91.6%
20x: 72.5%

Validation Efficiency

75% (45/60)

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acsl1	T	C	8: 46,966,429 (GRCm39)		probably null	Het
Aff2	CA	CAAA	X: 68,892,711 (GRCm39)		probably null	Het
Ankrd34a	A	G	3: 96,505,105 (GRCm39)	D103G	probably damaging	Het
Atp1b2	T	C	11: 69,492,388 (GRCm39)	D224G	probably damaging	Het
Atxn10	A	G	15: 85,220,730 (GRCm39)	D22G	possibly damaging	Het
Btbd9	C	T	17: 30,493,916 (GRCm39)	D492N	possibly damaging	Het
Caskin1	C	T	17: 24,723,596 (GRCm39)	L795F	possibly damaging	Het
Cdk12	T	C	11: 98,132,657 (GRCm39)		probably null	Het
Crtc2	A	G	3: 90,166,716 (GRCm39)	H91R	probably damaging	Het
Dbt	A	G	3: 116,332,736 (GRCm39)		probably null	Het
Dda1	C	A	8: 71,924,877 (GRCm39)	Y41*	probably null	Het
Dnah2	T	A	11: 69,326,075 (GRCm39)	D3692V	probably damaging	Het
Dpep1	A	G	8: 123,927,447 (GRCm39)	T334A	probably benign	Het
Enthd1	C	T	15: 80,418,695 (GRCm39)		probably null	Het
Fpr-rs6	T	A	17: 20,402,741 (GRCm39)	I207F	probably benign	Het
Fsip2	T	A	2: 82,815,521 (GRCm39)	S3751R	possibly damaging	Het
Gigyf2	A	T	1: 87,356,410 (GRCm39)		probably benign	Het
Gtf3c4	C	A	2: 28,730,140 (GRCm39)	D34Y	probably benign	Het
Iftap	G	A	2: 101,416,775 (GRCm39)	S58L	probably benign	Het
Igfn1	A	T	1: 135,889,790 (GRCm39)	V2419E	probably damaging	Het
Kank1	A	T	19: 25,386,647 (GRCm39)	I79L	probably benign	Het
Kif21b	A	G	1: 136,098,957 (GRCm39)	H1415R	probably benign	Het
Mad2l1	T	C	6: 66,516,862 (GRCm39)	S185P	possibly damaging	Het
Mettl18	A	G	1: 163,823,991 (GRCm39)	E104G	probably damaging	Het
Mrgprb2	G	A	7: 48,202,525 (GRCm39)	H67Y	possibly damaging	Het
Mrgprd	G	A	7: 144,875,439 (GRCm39)	M103I	probably benign	Het
Nanos3	C	T	8: 84,902,763 (GRCm39)	R133Q	probably damaging	Het
Npc1	G	A	18: 12,324,887 (GRCm39)	T1202I	probably damaging	Het
Nucks1	A	G	1: 131,852,329 (GRCm39)	D60G	probably damaging	Het
Or10g7	A	G	9: 39,905,840 (GRCm39)	I245V	probably benign	Het
Or13f5	G	C	4: 52,825,613 (GRCm39)	W72S	probably damaging	Het
Or4a72	T	A	2: 89,405,302 (GRCm39)	Y256F	probably damaging	Het
Paqr8	A	G	1: 21,005,271 (GRCm39)	T142A	probably benign	Het
Pdss1	T	C	2: 22,796,843 (GRCm39)	S119P	probably damaging	Het
Plcl2	A	G	17: 50,914,671 (GRCm39)	D560G	probably benign	Het
Ppm1b	T	A	17: 85,301,531 (GRCm39)	V137E	probably damaging	Het
Ppp1r16b	A	C	2: 158,537,983 (GRCm39)	K35Q	probably damaging	Het
Prkd2	A	T	7: 16,603,815 (GRCm39)	E832V	probably damaging	Het
Rab34	G	T	11: 78,082,232 (GRCm39)	K191N	possibly damaging	Het
Rad51ap2	A	C	12: 11,508,540 (GRCm39)	T821P	probably benign	Het
Rbm19	A	G	5: 120,282,111 (GRCm39)	T823A	probably benign	Het
Rpf2	T	G	10: 40,103,597 (GRCm39)	H106P	probably damaging	Het
Schip1	A	G	3: 68,533,177 (GRCm39)	M453V	probably benign	Het
Sema5a	T	A	15: 32,562,920 (GRCm39)	N310K	possibly damaging	Het
Sf3b1	T	C	1: 55,029,465 (GRCm39)	D1179G	probably damaging	Het
Skint2	A	T	4: 112,473,729 (GRCm39)	T4S	possibly damaging	Het
Slc22a5	A	T	11: 53,760,241 (GRCm39)	Y358*	probably null	Het
Slc34a1	T	C	13: 55,556,914 (GRCm39)	M251T	probably benign	Het
Slc44a5	A	G	3: 153,944,755 (GRCm39)	D124G	probably null	Het
Slc9b1	G	A	3: 135,063,434 (GRCm39)	E73K	unknown	Het
Ssbp2	T	C	13: 91,817,829 (GRCm39)	L156P	probably damaging	Het
Trim47	A	G	11: 115,997,053 (GRCm39)	V568A	probably damaging	Het
Ttn	A	T	2: 76,718,324 (GRCm39)		probably benign	Het
Ttpa	A	T	4: 20,021,260 (GRCm39)	I74F	probably damaging	Het
Vmn2r52	T	C	7: 9,905,315 (GRCm39)	I175V	probably benign	Het
Wrn	C	T	8: 33,731,011 (GRCm39)	C1350Y	probably benign	Het
Zfp11	C	T	5: 129,735,302 (GRCm39)	G53E	possibly damaging	Het
Zfp422	A	T	6: 116,603,572 (GRCm39)	D142E	probably damaging	Het
Zfp473	A	T	7: 44,382,612 (GRCm39)	C574S	probably damaging	Het
Zfp638	T	A	6: 83,905,946 (GRCm39)	M37K	probably damaging	Het
Zfp976	C	A	7: 42,291,948 (GRCm39)		probably benign	Het

Other mutations in Taar2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Taar2	APN	10	23,817,266 (GRCm39)	missense	possibly damaging	0.50
IGL00807:Taar2	APN	10	23,816,573 (GRCm39)	missense	probably benign	0.00
IGL01346:Taar2	APN	10	23,816,997 (GRCm39)	missense	probably damaging	1.00
IGL01433:Taar2	APN	10	23,816,657 (GRCm39)	missense	probably benign	0.02
IGL01782:Taar2	APN	10	23,817,042 (GRCm39)	missense	probably damaging	1.00
IGL03106:Taar2	APN	10	23,817,195 (GRCm39)	missense	probably damaging	0.99
IGL03372:Taar2	APN	10	23,817,069 (GRCm39)	missense	probably benign	0.03
R0046:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0046:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0090:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0101:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0101:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0103:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0157:Taar2	UTSW	10	23,817,389 (GRCm39)	missense	probably damaging	1.00
R0189:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0226:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0226:Taar2	UTSW	10	23,816,961 (GRCm39)	missense	probably damaging	1.00
R0265:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0267:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0349:Taar2	UTSW	10	23,817,407 (GRCm39)	missense	probably benign	0.01
R0349:Taar2	UTSW	10	23,817,327 (GRCm39)	missense	possibly damaging	0.79
R0426:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R0556:Taar2	UTSW	10	23,816,793 (GRCm39)	missense	probably damaging	1.00
R0698:Taar2	UTSW	10	23,817,393 (GRCm39)	missense	probably benign	0.00
R1191:Taar2	UTSW	10	23,816,927 (GRCm39)	missense	probably damaging	1.00
R2919:Taar2	UTSW	10	23,817,454 (GRCm39)	missense	probably benign	0.00
R4615:Taar2	UTSW	10	23,817,263 (GRCm39)	missense	probably benign	0.43
R4658:Taar2	UTSW	10	23,817,401 (GRCm39)	missense	probably benign	0.04
R4766:Taar2	UTSW	10	23,816,669 (GRCm39)	missense	probably damaging	0.98
R4872:Taar2	UTSW	10	23,816,591 (GRCm39)	missense	probably benign	0.02
R5205:Taar2	UTSW	10	23,816,874 (GRCm39)	missense	probably benign	0.42
R5271:Taar2	UTSW	10	23,816,930 (GRCm39)	missense	probably damaging	0.97
R5517:Taar2	UTSW	10	23,816,627 (GRCm39)	missense	possibly damaging	0.92
R6033:Taar2	UTSW	10	23,816,874 (GRCm39)	missense	probably benign
R6033:Taar2	UTSW	10	23,816,874 (GRCm39)	missense	probably benign
R6325:Taar2	UTSW	10	23,816,615 (GRCm39)	missense	probably benign	0.05
R6398:Taar2	UTSW	10	23,817,177 (GRCm39)	missense	probably benign	0.00
R6762:Taar2	UTSW	10	23,817,300 (GRCm39)	missense	probably damaging	0.98
R7121:Taar2	UTSW	10	23,816,725 (GRCm39)	missense	probably damaging	1.00
R7209:Taar2	UTSW	10	23,816,597 (GRCm39)	missense	possibly damaging	0.57
R7709:Taar2	UTSW	10	23,816,621 (GRCm39)	missense	probably benign	0.00
R8045:Taar2	UTSW	10	23,817,386 (GRCm39)	missense	probably damaging	1.00
R8223:Taar2	UTSW	10	23,817,248 (GRCm39)	missense	probably damaging	1.00
R8743:Taar2	UTSW	10	23,817,369 (GRCm39)	missense	probably damaging	1.00
R9307:Taar2	UTSW	10	23,817,237 (GRCm39)	missense	probably damaging	1.00
R9350:Taar2	UTSW	10	23,817,345 (GRCm39)	missense	probably damaging	1.00
R9351:Taar2	UTSW	10	23,816,900 (GRCm39)	missense	probably benign	0.14
R9755:Taar2	UTSW	10	23,817,038 (GRCm39)	missense	probably damaging	1.00
Z1176:Taar2	UTSW	10	23,817,084 (GRCm39)	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- GCTCGCGTAATTGACAACTTGCC -3'
(R):5'- TCAGTCTCCTAAGCCCCTTGAAGC -3'

Sequencing Primer
(F):5'- CAGCCAAAACTTTAGGGATAGTG -3'
(R):5'- GCAAATTCATTCTTTGAGTGCCAG -3'

Posted On

2013-05-24