Incidental Mutation 'R5553:Olfr485'
ID435223
Institutional Source Beutler Lab
Gene Symbol Olfr485
Ensembl Gene ENSMUSG00000108995
Gene Nameolfactory receptor 485
SynonymsGA_x6K02T2PBJ9-10489044-10488091, MOR204-30P, MOR204-40_p
MMRRC Submission 043110-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.131) question?
Stock #R5553 (G1)
Quality Score225
Status Not validated
Chromosome7
Chromosomal Location108158918-108159871 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 108159271 bp
ZygosityHeterozygous
Amino Acid Change Serine to Threonine at position 201 (S201T)
Ref Sequence ENSEMBL: ENSMUSP00000147194 (fasta)
Gene Model
Predicted Effect noncoding transcript
Transcript: ENSMUST00000094105
AA Change: S197T
Predicted Effect probably benign
Transcript: ENSMUST00000208296
AA Change: S201T

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg T A 15: 60,920,841 I86F probably damaging Het
Abca13 C T 11: 9,328,158 L3113F probably damaging Het
Ankrd39 C T 1: 36,541,981 G96R probably damaging Het
Ano8 T A 8: 71,484,997 probably null Het
Arid1b A T 17: 5,313,877 S1041C probably damaging Het
Bsn T A 9: 108,110,421 probably benign Het
Cbr3 A G 16: 93,683,563 E80G possibly damaging Het
Chd1 A G 17: 17,385,613 E271G probably benign Het
Dock3 T A 9: 106,991,110 K658N possibly damaging Het
Dot1l CCAGCCCCACCCTCAGCC CCAGCC 10: 80,783,628 probably benign Het
Dppa1 T A 11: 46,613,034 probably null Het
Fam129a C T 1: 151,717,235 T557M probably damaging Het
Fen1 T C 19: 10,200,423 N219S probably benign Het
Fsip2 A G 2: 82,962,746 T416A probably benign Het
Gm14393 A T 2: 175,061,846 C89* probably null Het
Grin2c C T 11: 115,252,725 M736I probably null Het
Heatr5b A T 17: 78,753,351 probably null Het
Hspbap1 G T 16: 35,801,597 W104L probably damaging Het
Igfn1 C T 1: 135,967,884 G1648E probably damaging Het
Irf4 A G 13: 30,751,828 Y122C probably damaging Het
Kremen2 A G 17: 23,741,802 probably benign Het
Nubpl T A 12: 52,181,299 L169M possibly damaging Het
Nwd1 T C 8: 72,704,976 S1200P possibly damaging Het
Olfr352 A G 2: 36,870,465 I300V probably benign Het
Parp14 G T 16: 35,856,936 H887Q probably benign Het
Paxip1 G A 5: 27,775,639 probably benign Het
Piwil1 T C 5: 128,745,501 M392T probably benign Het
Plekhm3 T C 1: 64,921,886 S404G possibly damaging Het
Prelid3a T C 18: 67,477,023 L141P probably damaging Het
Ptprb T A 10: 116,350,185 V1715E probably damaging Het
Rc3h2 G A 2: 37,398,311 R420* probably null Het
Selenon C A 4: 134,540,917 R435L probably damaging Het
Slc29a4 T C 5: 142,720,036 L425P probably damaging Het
Slc30a9 T A 5: 67,345,604 probably null Het
Slc9a5 T C 8: 105,357,040 V404A probably damaging Het
Ssc5d A T 7: 4,936,290 D575V probably damaging Het
Ttn A C 2: 76,891,596 probably null Het
Vmn2r100 A G 17: 19,504,848 Q13R possibly damaging Het
Wfikkn1 T A 17: 25,878,494 L285F possibly damaging Het
Zcchc17 A G 4: 130,354,134 probably null Het
Other mutations in Olfr485
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3115:Olfr485 UTSW 7 108159822 missense probably benign 0.00
R3116:Olfr485 UTSW 7 108159822 missense probably benign 0.00
R3978:Olfr485 UTSW 7 108159612 missense possibly damaging 0.52
R4722:Olfr485 UTSW 7 108159238 missense probably benign 0.04
R5337:Olfr485 UTSW 7 108159273 missense probably benign 0.01
R6258:Olfr485 UTSW 7 108158974 missense probably damaging 1.00
R6386:Olfr485 UTSW 7 108159202 missense probably damaging 1.00
R6498:Olfr485 UTSW 7 108159432 missense probably benign 0.20
Predicted Primers PCR Primer
(F):5'- AGACACCACCTTGTTCTGGTC -3'
(R):5'- CACAAGTGTGTATCCAGTTGGTTG -3'

Sequencing Primer
(F):5'- GGTGGATTTTGGCATCACATAAATG -3'
(R):5'- ATCCAGTTGGTTGTAGGATCTTATG -3'
Posted On2016-10-24