Incidental Mutation 'R5554:Vmn1r184'
ID 435285
Institutional Source Beutler Lab
Gene Symbol Vmn1r184
Ensembl Gene ENSMUSG00000046130
Gene Name vomeronasal 1 receptor, 184
Synonyms
MMRRC Submission 043111-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R5554 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 25966256-25967200 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 25966413 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 53 (H53L)
Ref Sequence ENSEMBL: ENSMUSP00000154576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057123] [ENSMUST00000227230] [ENSMUST00000227232] [ENSMUST00000227534] [ENSMUST00000227790] [ENSMUST00000228145] [ENSMUST00000228369]
AlphaFold E9Q2N4
Predicted Effect probably damaging
Transcript: ENSMUST00000057123
AA Change: H53L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000061885
Gene: ENSMUSG00000046130
AA Change: H53L

DomainStartEndE-ValueType
Pfam:TAS2R 8 308 1.7e-7 PFAM
Pfam:V1R 35 297 7.5e-31 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000227230
AA Change: H53L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227232
AA Change: H53L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227534
AA Change: H53L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000227790
AA Change: H53L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228145
AA Change: H53L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228369
AA Change: H53L

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.1%
Validation Efficiency 97% (73/75)
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aarsd1 C A 11: 101,304,807 (GRCm39) R227L probably benign Het
Adamtsl1 A G 4: 86,195,182 (GRCm39) Q533R possibly damaging Het
Adgb C T 10: 10,216,217 (GRCm39) R1524H probably damaging Het
Ank2 A T 3: 126,792,622 (GRCm39) N739K possibly damaging Het
Ankrd39 C T 1: 36,581,062 (GRCm39) G96R probably damaging Het
Anxa10 G A 8: 62,514,080 (GRCm39) P249L possibly damaging Het
Banp G A 8: 122,718,334 (GRCm39) E183K probably damaging Het
BC051665 C G 13: 60,932,435 (GRCm39) L83F probably damaging Het
Btn1a1 A T 13: 23,643,295 (GRCm39) F385I possibly damaging Het
Chchd4 A T 6: 91,441,999 (GRCm39) *140R probably null Het
Dcpp2 T C 17: 24,119,545 (GRCm39) Y120H probably damaging Het
Dlx2 G A 2: 71,375,805 (GRCm39) R173C possibly damaging Het
Dmbt1 C A 7: 130,701,030 (GRCm39) Y1069* probably null Het
Dop1a T A 9: 86,403,710 (GRCm39) F1637I probably damaging Het
Dusp18 T C 11: 3,847,202 (GRCm39) I64T probably damaging Het
Evi5l A G 8: 4,256,491 (GRCm39) probably benign Het
Fiz1 T C 7: 5,015,849 (GRCm39) H47R probably damaging Het
Fndc3b G T 3: 27,697,162 (GRCm39) P17T possibly damaging Het
Foxa1 T A 12: 57,589,077 (GRCm39) Q381L probably benign Het
Gda A G 19: 21,405,837 (GRCm39) probably null Het
Gm10044 T C 14: 7,771,181 (GRCm38) noncoding transcript Het
Gm12258 T A 11: 58,749,294 (GRCm39) S156R possibly damaging Het
Gm973 A G 1: 59,566,131 (GRCm39) R117G probably benign Het
Grwd1 C T 7: 45,480,064 (GRCm39) V48I probably damaging Het
Ifi209 T A 1: 173,468,763 (GRCm39) S198T probably benign Het
Inka2 T A 3: 105,623,930 (GRCm39) S82R possibly damaging Het
Itga1 A T 13: 115,129,010 (GRCm39) C549* probably null Het
Kmt2c C A 5: 25,499,608 (GRCm39) G511C probably damaging Het
Knstrn T C 2: 118,664,444 (GRCm39) probably benign Het
Lrp2 T C 2: 69,382,768 (GRCm39) Y39C possibly damaging Het
Maco1 T C 4: 134,555,445 (GRCm39) I343V probably benign Het
Micos10 T C 4: 138,833,218 (GRCm39) probably benign Het
N4bp2 T C 5: 65,965,457 (GRCm39) Y1169H probably benign Het
Nbr1 C T 11: 101,455,633 (GRCm39) T129I probably benign Het
Or52e8 A C 7: 104,625,189 (GRCm39) M1R probably null Het
Or5k15 A T 16: 58,710,169 (GRCm39) M138K possibly damaging Het
Or7g25 T C 9: 19,160,039 (GRCm39) I219V probably benign Het
Oxct1 T A 15: 4,120,677 (GRCm39) F254I probably benign Het
Patj T A 4: 98,342,633 (GRCm39) S576T possibly damaging Het
Pdxdc1 A T 16: 13,690,363 (GRCm39) C202S probably benign Het
Pet100 A T 8: 3,672,381 (GRCm39) I19F probably damaging Het
Pik3r5 T C 11: 68,385,059 (GRCm39) Y655H probably damaging Het
Pkhd1 A G 1: 20,151,476 (GRCm39) S3807P probably damaging Het
Ptma A G 1: 86,454,649 (GRCm39) T8A probably damaging Het
Ptpn3 G T 4: 57,240,843 (GRCm39) N257K probably damaging Het
R3hdm1 C A 1: 128,164,409 (GRCm39) Q1108K probably benign Het
Rimbp2 T C 5: 128,857,406 (GRCm39) D815G probably damaging Het
Scn10a A G 9: 119,523,196 (GRCm39) F66L probably benign Het
Selenot T C 3: 58,484,296 (GRCm39) probably null Het
Serpinb8 A G 1: 107,526,705 (GRCm39) T82A probably benign Het
Serpini2 G A 3: 75,175,295 (GRCm39) probably benign Het
Slc1a6 G T 10: 78,631,816 (GRCm39) G214V probably benign Het
Slc5a6 C A 5: 31,195,444 (GRCm39) A425S probably damaging Het
Smo C A 6: 29,736,123 (GRCm39) N38K possibly damaging Het
Smtn A T 11: 3,470,811 (GRCm39) C909* probably null Het
Sntg2 C T 12: 30,308,040 (GRCm39) R215H probably benign Het
Stk4 T A 2: 163,941,645 (GRCm39) V287E probably benign Het
Tdrd7 A G 4: 46,005,358 (GRCm39) D388G possibly damaging Het
Ttn A T 2: 76,642,652 (GRCm39) F13294L probably damaging Het
Ube2j1 T G 4: 33,040,745 (GRCm39) F84V probably damaging Het
Ugt3a1 A G 15: 9,370,287 (GRCm39) Q477R probably damaging Het
Utf1 T C 7: 139,523,859 (GRCm39) S25P probably benign Het
Vmn2r13 A T 5: 109,339,860 (GRCm39) N38K possibly damaging Het
Vps13a C T 19: 16,699,775 (GRCm39) D756N probably damaging Het
Vwa1 G T 4: 155,857,695 (GRCm39) D34E probably damaging Het
Zfhx2 A C 14: 55,301,774 (GRCm39) L2070R probably damaging Het
Zfp984 A G 4: 147,840,362 (GRCm39) V163A probably benign Het
Zp3r A T 1: 130,511,208 (GRCm39) M325K probably benign Het
Other mutations in Vmn1r184
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01396:Vmn1r184 APN 7 25,966,862 (GRCm39) missense probably damaging 1.00
IGL01411:Vmn1r184 APN 7 25,966,320 (GRCm39) missense probably benign 0.06
IGL02961:Vmn1r184 APN 7 25,967,075 (GRCm39) missense probably benign 0.27
IGL03271:Vmn1r184 APN 7 25,967,034 (GRCm39) missense probably benign
R0302:Vmn1r184 UTSW 7 25,966,968 (GRCm39) missense probably damaging 1.00
R0384:Vmn1r184 UTSW 7 25,967,076 (GRCm39) missense probably benign 0.41
R0591:Vmn1r184 UTSW 7 25,966,500 (GRCm39) missense probably damaging 0.98
R0620:Vmn1r184 UTSW 7 25,966,602 (GRCm39) missense possibly damaging 0.46
R1644:Vmn1r184 UTSW 7 25,966,670 (GRCm39) missense probably benign 0.00
R2304:Vmn1r184 UTSW 7 25,966,550 (GRCm39) missense probably damaging 1.00
R2329:Vmn1r184 UTSW 7 25,966,387 (GRCm39) missense probably damaging 1.00
R3522:Vmn1r184 UTSW 7 25,967,008 (GRCm39) nonsense probably null
R5020:Vmn1r184 UTSW 7 25,966,955 (GRCm39) missense possibly damaging 0.87
R5030:Vmn1r184 UTSW 7 25,966,881 (GRCm39) missense probably benign 0.25
R5049:Vmn1r184 UTSW 7 25,966,793 (GRCm39) missense possibly damaging 0.49
R5076:Vmn1r184 UTSW 7 25,966,346 (GRCm39) missense probably benign 0.00
R5213:Vmn1r184 UTSW 7 25,967,136 (GRCm39) missense probably damaging 0.99
R6146:Vmn1r184 UTSW 7 25,966,817 (GRCm39) missense probably benign 0.08
R6868:Vmn1r184 UTSW 7 25,966,727 (GRCm39) missense probably benign 0.00
R6937:Vmn1r184 UTSW 7 25,966,750 (GRCm39) missense probably benign 0.08
R6943:Vmn1r184 UTSW 7 25,966,563 (GRCm39) missense possibly damaging 0.77
R7190:Vmn1r184 UTSW 7 25,967,105 (GRCm39) missense probably damaging 1.00
R7239:Vmn1r184 UTSW 7 25,966,602 (GRCm39) missense possibly damaging 0.79
R7472:Vmn1r184 UTSW 7 25,966,824 (GRCm39) missense possibly damaging 0.82
R8258:Vmn1r184 UTSW 7 25,966,686 (GRCm39) missense probably benign 0.44
R8259:Vmn1r184 UTSW 7 25,966,686 (GRCm39) missense probably benign 0.44
R8911:Vmn1r184 UTSW 7 25,966,310 (GRCm39) missense possibly damaging 0.89
R9008:Vmn1r184 UTSW 7 25,967,177 (GRCm39) missense probably benign
R9159:Vmn1r184 UTSW 7 25,966,545 (GRCm39) missense possibly damaging 0.65
R9216:Vmn1r184 UTSW 7 25,966,703 (GRCm39) missense probably benign 0.00
R9548:Vmn1r184 UTSW 7 25,966,734 (GRCm39) missense probably benign 0.29
R9588:Vmn1r184 UTSW 7 25,966,347 (GRCm39) missense probably null 0.78
Z1177:Vmn1r184 UTSW 7 25,966,415 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- TCTAACTCGAGAAATGGTGGGG -3'
(R):5'- AACAGGATTTTCTGGGGCTG -3'

Sequencing Primer
(F):5'- CTCGAGAAATGGTGGGGATATATTC -3'
(R):5'- GATGGTCATGGCCTGAAAAACACTC -3'
Posted On 2016-10-24