|Institutional Source||Beutler Lab|
|Gene Name||F-box and leucine-rich repeat protein 18|
|Is this an essential gene?||Probably non essential (E-score: 0.083)|
|Stock #||R5570 (G1)|
|Chromosomal Location||142866946-142895421 bp(-) (GRCm38)|
|Type of Mutation||unclassified|
|DNA Base Change (assembly)||A to G at 142895267 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000041700 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000035985] [ENSMUST00000110766]|
|Predicted Effect||probably benign
AA Change: V11A
AA Change: V11A
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fbxl18||
(F):5'- ATGGGCCTTGGAATAAAGCCAG -3'
(R):5'- TGTAGCGCGAATGGCAAATG -3'
(F):5'- CCTTGGAATAAAGCCAGGGTCG -3'
(R):5'- TGGCAAATGCAAAGGCCTG -3'