Incidental Mutation 'R5570:Dock2'
ID 435622
Institutional Source Beutler Lab
Gene Symbol Dock2
Ensembl Gene ENSMUSG00000020143
Gene Name dedicator of cyto-kinesis 2
Synonyms CED-5, Hch, MBC
MMRRC Submission 043127-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5570 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 34176815-34674719 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 34618233 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 128 (R128S)
Ref Sequence ENSEMBL: ENSMUSP00000116893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093193] [ENSMUST00000101365] [ENSMUST00000143540]
AlphaFold Q8C3J5
Predicted Effect probably damaging
Transcript: ENSMUST00000093193
AA Change: R128S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143
AA Change: R128S

DomainStartEndE-ValueType
SH3 11 68 1.22e-11 SMART
Pfam:DOCK_N 71 414 2e-113 PFAM
Pfam:DOCK-C2 419 616 1e-60 PFAM
Pfam:DHR-2 1114 1614 6.3e-96 PFAM
low complexity region 1691 1706 N/A INTRINSIC
low complexity region 1793 1800 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000101365
AA Change: R128S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143
AA Change: R128S

DomainStartEndE-ValueType
SH3 11 68 1.22e-11 SMART
Pfam:DOCK_N 71 414 1.4e-113 PFAM
Pfam:DOCK-C2 419 616 5.5e-61 PFAM
low complexity region 1163 1171 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000143540
AA Change: R128S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000116893
Gene: ENSMUSG00000020143
AA Change: R128S

DomainStartEndE-ValueType
SH3 11 68 1.22e-11 SMART
Pfam:DOCK-C2 418 617 1.8e-55 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154178
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acrv1 C A 9: 36,605,577 (GRCm39) S41R probably damaging Het
Aqr G A 2: 113,979,451 (GRCm39) T328M probably damaging Het
Arhgap26 C A 18: 39,232,671 (GRCm39) D99E probably damaging Het
Boc G A 16: 44,313,187 (GRCm39) T559I probably damaging Het
Cadps A T 14: 12,473,497 (GRCm38) I876N possibly damaging Het
Cep72 T C 13: 74,188,260 (GRCm39) Q211R probably benign Het
Clmp T C 9: 40,683,826 (GRCm39) probably null Het
Coq6 T A 12: 84,415,413 (GRCm39) D145E probably benign Het
Crym T C 7: 119,801,116 (GRCm39) E11G probably benign Het
Defb36 T A 2: 152,454,503 (GRCm39) V54E probably damaging Het
Dlg5 C A 14: 24,242,981 (GRCm39) E55* probably null Het
E330034G19Rik A G 14: 24,346,892 (GRCm39) K60E possibly damaging Het
Eps8l2 G A 7: 140,934,920 (GRCm39) R76Q possibly damaging Het
Espn T C 4: 152,208,237 (GRCm39) E460G probably damaging Het
Fbxl18 A G 5: 142,881,022 (GRCm39) probably benign Het
Fgd5 T C 6: 91,965,668 (GRCm39) S476P probably damaging Het
Gsto1 T C 19: 47,846,338 (GRCm39) W62R probably damaging Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Gxylt1 A G 15: 93,152,180 (GRCm39) probably null Het
Hs6st1 C T 1: 36,142,719 (GRCm39) P218L probably benign Het
Kif5c A G 2: 49,620,211 (GRCm39) D226G possibly damaging Het
Krt1 A G 15: 101,755,340 (GRCm39) F473S probably benign Het
Lpxn T A 19: 12,810,023 (GRCm39) M265K possibly damaging Het
Map3k9 A G 12: 81,778,798 (GRCm39) L505P possibly damaging Het
Mcm3ap C T 10: 76,316,930 (GRCm39) R645W possibly damaging Het
Msr1 T C 8: 40,064,760 (GRCm39) I305V probably benign Het
Muc4 A G 16: 32,598,066 (GRCm39) E3237G possibly damaging Het
Necap1 T C 6: 122,858,471 (GRCm39) F105L probably damaging Het
Nploc4 C T 11: 120,275,440 (GRCm39) V499M probably benign Het
Nup93 T C 8: 95,041,298 (GRCm39) V812A probably damaging Het
Or10ak7 T A 4: 118,791,263 (GRCm39) I259F possibly damaging Het
Or6e1 A G 14: 54,519,825 (GRCm39) F176L probably damaging Het
Or9g3 G A 2: 85,589,994 (GRCm39) S242F probably damaging Het
Parn G A 16: 13,483,794 (GRCm39) P50L probably damaging Het
Pcdhb7 T C 18: 37,477,224 (GRCm39) C787R probably benign Het
Pdk2 A T 11: 94,920,826 (GRCm39) I175N probably damaging Het
Pelo T C 13: 115,226,152 (GRCm39) I102V probably benign Het
Phf12 A G 11: 77,908,937 (GRCm39) D339G possibly damaging Het
Phlpp1 A T 1: 106,101,162 (GRCm39) I477F probably benign Het
Pigt T A 2: 164,343,482 (GRCm39) Y319* probably null Het
Pmpca A G 2: 26,280,553 (GRCm39) E133G probably damaging Het
Ptgs2 A G 1: 149,979,859 (GRCm39) I321M Het
Pus7l G A 15: 94,425,746 (GRCm39) P552S probably benign Het
Qsox2 A G 2: 26,115,230 (GRCm39) M1T probably null Het
Rara C G 11: 98,863,478 (GRCm39) R382G probably damaging Het
Rbbp6 A G 7: 122,601,057 (GRCm39) probably benign Het
Rev3l T C 10: 39,728,071 (GRCm39) probably null Het
Robo3 T A 9: 37,336,571 (GRCm39) Y399F possibly damaging Het
Rpl31 C T 1: 39,409,108 (GRCm39) R41C probably benign Het
Skint3 A G 4: 112,092,995 (GRCm39) M20V probably benign Het
Slc17a6 A G 7: 51,308,504 (GRCm39) D276G probably benign Het
Sult3a2 A T 10: 33,654,268 (GRCm39) V128D probably damaging Het
Syt3 T A 7: 44,040,043 (GRCm39) V92E possibly damaging Het
Them7 A G 2: 105,209,153 (GRCm39) T158A probably benign Het
Utp14b G A 1: 78,643,118 (GRCm39) D339N probably damaging Het
Vars1 T C 17: 35,235,214 (GRCm39) F1259L probably benign Het
Vmn1r115 A C 7: 20,578,555 (GRCm39) V119G possibly damaging Het
Zc3h12a C T 4: 125,014,166 (GRCm39) R293H probably damaging Het
Zfp638 A T 6: 83,956,170 (GRCm39) E1592D probably damaging Het
Other mutations in Dock2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:Dock2 APN 11 34,595,488 (GRCm39) missense probably damaging 1.00
IGL00469:Dock2 APN 11 34,179,603 (GRCm39) splice site probably benign
IGL01061:Dock2 APN 11 34,596,653 (GRCm39) missense probably damaging 1.00
IGL01319:Dock2 APN 11 34,589,617 (GRCm39) missense possibly damaging 0.61
IGL01451:Dock2 APN 11 34,260,390 (GRCm39) missense probably damaging 1.00
IGL01490:Dock2 APN 11 34,596,608 (GRCm39) missense probably damaging 0.97
IGL01601:Dock2 APN 11 34,189,528 (GRCm39) critical splice donor site probably null
IGL01800:Dock2 APN 11 34,647,100 (GRCm39) missense probably damaging 1.00
IGL01804:Dock2 APN 11 34,212,433 (GRCm39) missense probably benign 0.01
IGL01823:Dock2 APN 11 34,212,391 (GRCm39) missense probably damaging 1.00
IGL01829:Dock2 APN 11 34,596,668 (GRCm39) missense probably damaging 0.98
IGL01830:Dock2 APN 11 34,582,744 (GRCm39) nonsense probably null
IGL01835:Dock2 APN 11 34,260,435 (GRCm39) missense possibly damaging 0.51
IGL01845:Dock2 APN 11 34,599,692 (GRCm39) missense probably benign 0.02
IGL01953:Dock2 APN 11 34,623,183 (GRCm39) missense probably benign 0.28
IGL01989:Dock2 APN 11 34,218,053 (GRCm39) missense probably benign
IGL02081:Dock2 APN 11 34,204,355 (GRCm39) missense probably benign
IGL02105:Dock2 APN 11 34,605,352 (GRCm39) missense probably damaging 1.00
IGL02153:Dock2 APN 11 34,180,670 (GRCm39) missense probably benign 0.01
IGL02170:Dock2 APN 11 34,217,949 (GRCm39) missense probably damaging 1.00
IGL02344:Dock2 APN 11 34,622,337 (GRCm39) missense probably damaging 0.98
IGL02389:Dock2 APN 11 34,589,567 (GRCm39) splice site probably benign
IGL02409:Dock2 APN 11 34,451,204 (GRCm39) missense probably benign 0.00
IGL02472:Dock2 APN 11 34,199,801 (GRCm39) missense probably benign 0.00
IGL02625:Dock2 APN 11 34,451,168 (GRCm39) critical splice donor site probably null
IGL02929:Dock2 APN 11 34,218,048 (GRCm39) missense probably damaging 1.00
IGL02951:Dock2 APN 11 34,260,448 (GRCm39) unclassified probably benign
IGL02999:Dock2 APN 11 34,583,086 (GRCm39) missense probably damaging 0.99
IGL03165:Dock2 APN 11 34,578,360 (GRCm39) missense probably damaging 0.99
Arches UTSW 11 34,580,587 (GRCm39) missense probably damaging 1.00
capitol_reef UTSW 11 34,244,170 (GRCm39) critical splice acceptor site probably null
Croesus UTSW 11 34,611,854 (GRCm39) missense probably damaging 1.00
denali UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
dew UTSW 11 34,198,636 (GRCm39) nonsense probably null
Dinghy UTSW 11 34,212,460 (GRCm39) missense possibly damaging 0.70
Dry UTSW 11 34,181,652 (GRCm39) missense possibly damaging 0.79
frazz UTSW 11 34,198,572 (GRCm39) critical splice donor site probably benign
frizz UTSW 11 34,208,184 (GRCm39) splice site probably benign
gildenstern UTSW 11 34,623,166 (GRCm39) critical splice donor site probably null
godsgrace UTSW 11 34,586,280 (GRCm39) missense probably damaging 1.00
Harborside UTSW 11 34,212,445 (GRCm39) missense probably benign
Landing UTSW 11 34,605,328 (GRCm39) missense possibly damaging 0.83
latest UTSW 11 34,647,049 (GRCm39) missense probably damaging 1.00
Launch UTSW 11 34,206,562 (GRCm39) missense probably damaging 1.00
liaoning UTSW 11 34,599,620 (GRCm39) missense probably damaging 1.00
lucre UTSW 11 34,595,436 (GRCm39) frame shift probably null
midas UTSW 11 34,244,323 (GRCm39) missense probably damaging 0.99
muelle UTSW 11 34,578,365 (GRCm39) missense probably damaging 1.00
narrowest UTSW 11 34,232,652 (GRCm39) missense probably damaging 0.98
pier UTSW 11 34,580,593 (GRCm39) missense probably damaging 1.00
Plank UTSW 11 34,674,622 (GRCm39) missense possibly damaging 0.51
resplendent UTSW 11 34,618,287 (GRCm39) nonsense probably null
riches UTSW 11 34,579,279 (GRCm39) critical splice donor site probably null
skiff UTSW 11 34,212,388 (GRCm39) missense probably null 0.80
Slip UTSW 11 34,244,286 (GRCm39) missense probably benign 0.25
toothskin UTSW 11 34,414,922 (GRCm39) missense probably damaging 1.00
Touch UTSW 11 34,223,750 (GRCm39) missense possibly damaging 0.95
wassup UTSW 11 34,453,413 (GRCm39) missense probably damaging 1.00
Wharf UTSW 11 34,623,198 (GRCm39) missense possibly damaging 0.81
BB009:Dock2 UTSW 11 34,217,998 (GRCm39) missense probably benign 0.00
BB019:Dock2 UTSW 11 34,217,998 (GRCm39) missense probably benign 0.00
IGL03052:Dock2 UTSW 11 34,182,853 (GRCm39) missense probably benign 0.01
PIT4377001:Dock2 UTSW 11 34,611,835 (GRCm39) missense probably benign 0.02
R0006:Dock2 UTSW 11 34,262,453 (GRCm39) unclassified probably benign
R0012:Dock2 UTSW 11 34,674,622 (GRCm39) missense possibly damaging 0.51
R0063:Dock2 UTSW 11 34,647,111 (GRCm39) critical splice acceptor site probably null
R0063:Dock2 UTSW 11 34,647,111 (GRCm39) critical splice acceptor site probably null
R0116:Dock2 UTSW 11 34,579,392 (GRCm39) intron probably benign
R0149:Dock2 UTSW 11 34,388,327 (GRCm39) missense probably damaging 1.00
R0361:Dock2 UTSW 11 34,388,327 (GRCm39) missense probably damaging 1.00
R0462:Dock2 UTSW 11 34,218,052 (GRCm39) missense possibly damaging 0.74
R0471:Dock2 UTSW 11 34,579,380 (GRCm39) missense probably benign 0.30
R0538:Dock2 UTSW 11 34,595,545 (GRCm39) splice site probably benign
R0543:Dock2 UTSW 11 34,244,325 (GRCm39) missense probably damaging 1.00
R0660:Dock2 UTSW 11 34,198,621 (GRCm39) missense probably damaging 1.00
R0676:Dock2 UTSW 11 34,586,063 (GRCm39) missense probably damaging 0.99
R0722:Dock2 UTSW 11 34,414,970 (GRCm39) splice site probably benign
R0801:Dock2 UTSW 11 34,599,620 (GRCm39) missense probably damaging 1.00
R1110:Dock2 UTSW 11 34,206,535 (GRCm39) missense possibly damaging 0.78
R1171:Dock2 UTSW 11 34,586,068 (GRCm39) missense probably damaging 1.00
R1387:Dock2 UTSW 11 34,223,309 (GRCm39) splice site probably benign
R1445:Dock2 UTSW 11 34,189,705 (GRCm39) missense probably benign
R1494:Dock2 UTSW 11 34,232,761 (GRCm39) nonsense probably null
R1589:Dock2 UTSW 11 34,597,288 (GRCm39) missense probably damaging 0.99
R1597:Dock2 UTSW 11 34,595,474 (GRCm39) missense probably benign 0.00
R1629:Dock2 UTSW 11 34,212,480 (GRCm39) splice site probably null
R1749:Dock2 UTSW 11 34,182,767 (GRCm39) critical splice donor site probably null
R1888:Dock2 UTSW 11 34,598,169 (GRCm39) missense probably damaging 1.00
R1888:Dock2 UTSW 11 34,598,169 (GRCm39) missense probably damaging 1.00
R1899:Dock2 UTSW 11 34,244,286 (GRCm39) missense probably benign 0.25
R1924:Dock2 UTSW 11 34,414,934 (GRCm39) missense possibly damaging 0.69
R2031:Dock2 UTSW 11 34,618,297 (GRCm39) splice site probably benign
R2045:Dock2 UTSW 11 34,244,106 (GRCm39) splice site probably null
R2098:Dock2 UTSW 11 34,609,832 (GRCm39) missense probably damaging 0.99
R2098:Dock2 UTSW 11 34,216,279 (GRCm39) missense probably benign 0.16
R2129:Dock2 UTSW 11 34,618,242 (GRCm39) missense probably damaging 1.00
R2147:Dock2 UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
R2149:Dock2 UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
R2150:Dock2 UTSW 11 34,179,472 (GRCm39) critical splice donor site probably null
R2176:Dock2 UTSW 11 34,586,044 (GRCm39) missense probably benign 0.00
R2230:Dock2 UTSW 11 34,244,323 (GRCm39) missense probably damaging 0.99
R2508:Dock2 UTSW 11 34,262,485 (GRCm39) missense probably benign 0.04
R2875:Dock2 UTSW 11 34,609,712 (GRCm39) missense probably damaging 1.00
R2885:Dock2 UTSW 11 34,580,593 (GRCm39) missense probably damaging 1.00
R2910:Dock2 UTSW 11 34,182,910 (GRCm39) splice site probably benign
R3081:Dock2 UTSW 11 34,181,610 (GRCm39) missense probably benign
R3418:Dock2 UTSW 11 34,580,587 (GRCm39) missense probably damaging 1.00
R3552:Dock2 UTSW 11 34,611,787 (GRCm39) missense probably benign 0.22
R3731:Dock2 UTSW 11 34,599,722 (GRCm39) missense probably damaging 1.00
R3846:Dock2 UTSW 11 34,623,198 (GRCm39) missense possibly damaging 0.81
R4135:Dock2 UTSW 11 34,605,328 (GRCm39) missense possibly damaging 0.83
R4598:Dock2 UTSW 11 34,189,536 (GRCm39) missense probably damaging 1.00
R4599:Dock2 UTSW 11 34,189,536 (GRCm39) missense probably damaging 1.00
R4715:Dock2 UTSW 11 34,244,118 (GRCm39) missense probably damaging 1.00
R4722:Dock2 UTSW 11 34,586,298 (GRCm39) missense probably damaging 1.00
R4742:Dock2 UTSW 11 34,244,170 (GRCm39) critical splice acceptor site probably null
R4830:Dock2 UTSW 11 34,223,767 (GRCm39) splice site probably null
R4884:Dock2 UTSW 11 34,216,248 (GRCm39) missense probably damaging 1.00
R4990:Dock2 UTSW 11 34,586,078 (GRCm39) missense probably damaging 1.00
R5334:Dock2 UTSW 11 34,178,643 (GRCm39) missense probably benign 0.00
R5602:Dock2 UTSW 11 34,204,391 (GRCm39) missense probably benign 0.16
R5681:Dock2 UTSW 11 34,199,836 (GRCm39) missense probably benign 0.06
R5809:Dock2 UTSW 11 34,212,445 (GRCm39) missense probably benign
R5860:Dock2 UTSW 11 34,206,562 (GRCm39) missense probably damaging 1.00
R6111:Dock2 UTSW 11 34,599,614 (GRCm39) missense probably damaging 0.99
R6155:Dock2 UTSW 11 34,244,123 (GRCm39) missense probably benign 0.06
R6156:Dock2 UTSW 11 34,197,789 (GRCm39) missense possibly damaging 0.51
R6173:Dock2 UTSW 11 34,212,388 (GRCm39) missense probably null 0.80
R6182:Dock2 UTSW 11 34,179,476 (GRCm39) missense probably damaging 0.97
R6188:Dock2 UTSW 11 34,453,396 (GRCm39) missense probably damaging 0.98
R6191:Dock2 UTSW 11 34,181,652 (GRCm39) missense possibly damaging 0.79
R6283:Dock2 UTSW 11 34,598,152 (GRCm39) missense probably damaging 0.99
R6395:Dock2 UTSW 11 34,182,874 (GRCm39) missense probably damaging 1.00
R6465:Dock2 UTSW 11 34,453,413 (GRCm39) missense probably damaging 1.00
R6500:Dock2 UTSW 11 34,312,822 (GRCm39) missense possibly damaging 0.76
R6561:Dock2 UTSW 11 34,578,365 (GRCm39) missense probably damaging 1.00
R6745:Dock2 UTSW 11 34,596,670 (GRCm39) missense probably damaging 1.00
R6745:Dock2 UTSW 11 34,596,669 (GRCm39) missense probably damaging 1.00
R6880:Dock2 UTSW 11 34,579,279 (GRCm39) critical splice donor site probably null
R6913:Dock2 UTSW 11 34,647,049 (GRCm39) missense probably damaging 1.00
R6997:Dock2 UTSW 11 34,414,922 (GRCm39) missense probably damaging 1.00
R7057:Dock2 UTSW 11 34,586,044 (GRCm39) missense probably benign 0.00
R7057:Dock2 UTSW 11 34,177,684 (GRCm39) missense probably benign 0.10
R7134:Dock2 UTSW 11 34,260,363 (GRCm39) missense probably benign 0.03
R7188:Dock2 UTSW 11 34,189,675 (GRCm39) missense possibly damaging 0.87
R7239:Dock2 UTSW 11 34,181,677 (GRCm39) missense probably benign 0.00
R7247:Dock2 UTSW 11 34,605,340 (GRCm39) nonsense probably null
R7250:Dock2 UTSW 11 34,586,120 (GRCm39) missense probably damaging 1.00
R7250:Dock2 UTSW 11 34,586,032 (GRCm39) missense probably benign 0.01
R7271:Dock2 UTSW 11 34,223,750 (GRCm39) missense possibly damaging 0.95
R7284:Dock2 UTSW 11 34,180,672 (GRCm39) missense probably benign 0.01
R7397:Dock2 UTSW 11 34,609,816 (GRCm39) missense probably benign 0.00
R7464:Dock2 UTSW 11 34,586,105 (GRCm39) missense probably damaging 0.99
R7512:Dock2 UTSW 11 34,262,542 (GRCm39) missense possibly damaging 0.95
R7556:Dock2 UTSW 11 34,611,778 (GRCm39) missense probably benign 0.43
R7663:Dock2 UTSW 11 34,611,854 (GRCm39) missense probably damaging 1.00
R7779:Dock2 UTSW 11 34,605,282 (GRCm39) missense probably benign 0.38
R7797:Dock2 UTSW 11 34,232,652 (GRCm39) missense probably damaging 0.98
R7855:Dock2 UTSW 11 34,223,698 (GRCm39) missense probably damaging 1.00
R7922:Dock2 UTSW 11 34,598,154 (GRCm39) missense probably benign 0.29
R7932:Dock2 UTSW 11 34,217,998 (GRCm39) missense probably benign 0.00
R8013:Dock2 UTSW 11 34,596,677 (GRCm39) missense probably damaging 0.96
R8192:Dock2 UTSW 11 34,623,166 (GRCm39) critical splice donor site probably null
R8244:Dock2 UTSW 11 34,586,280 (GRCm39) missense probably damaging 1.00
R8307:Dock2 UTSW 11 34,260,362 (GRCm39) missense possibly damaging 0.95
R8418:Dock2 UTSW 11 34,609,795 (GRCm39) missense probably benign 0.01
R8460:Dock2 UTSW 11 34,180,825 (GRCm39) critical splice acceptor site probably null
R8495:Dock2 UTSW 11 34,181,622 (GRCm39) missense probably benign 0.14
R8556:Dock2 UTSW 11 34,212,457 (GRCm39) missense possibly damaging 0.84
R8690:Dock2 UTSW 11 34,618,287 (GRCm39) nonsense probably null
R8743:Dock2 UTSW 11 34,223,252 (GRCm39) nonsense probably null
R8757:Dock2 UTSW 11 34,586,067 (GRCm39) missense probably benign 0.13
R8759:Dock2 UTSW 11 34,586,067 (GRCm39) missense probably benign 0.13
R8793:Dock2 UTSW 11 34,451,215 (GRCm39) missense probably benign 0.00
R8882:Dock2 UTSW 11 34,595,436 (GRCm39) frame shift probably null
R8885:Dock2 UTSW 11 34,260,396 (GRCm39) missense probably benign 0.01
R8943:Dock2 UTSW 11 34,599,646 (GRCm39) missense possibly damaging 0.63
R9171:Dock2 UTSW 11 34,589,670 (GRCm39) missense probably benign 0.12
R9182:Dock2 UTSW 11 34,260,398 (GRCm39) missense possibly damaging 0.51
R9203:Dock2 UTSW 11 34,622,366 (GRCm39) missense possibly damaging 0.92
R9310:Dock2 UTSW 11 34,244,139 (GRCm39) missense possibly damaging 0.71
R9388:Dock2 UTSW 11 34,212,460 (GRCm39) missense possibly damaging 0.70
R9490:Dock2 UTSW 11 34,589,582 (GRCm39) missense possibly damaging 0.90
R9568:Dock2 UTSW 11 34,599,638 (GRCm39) missense possibly damaging 0.83
R9593:Dock2 UTSW 11 34,178,607 (GRCm39) missense probably benign 0.34
R9694:Dock2 UTSW 11 34,218,054 (GRCm39) missense probably benign
R9697:Dock2 UTSW 11 34,204,417 (GRCm39) missense probably benign
R9753:Dock2 UTSW 11 34,223,673 (GRCm39) missense possibly damaging 0.68
R9783:Dock2 UTSW 11 34,208,128 (GRCm39) missense possibly damaging 0.83
X0017:Dock2 UTSW 11 34,216,271 (GRCm39) missense probably benign 0.08
X0018:Dock2 UTSW 11 34,182,833 (GRCm39) missense possibly damaging 0.65
X0058:Dock2 UTSW 11 34,206,564 (GRCm39) missense probably damaging 1.00
X0066:Dock2 UTSW 11 34,260,357 (GRCm39) missense possibly damaging 0.95
Z1088:Dock2 UTSW 11 34,583,209 (GRCm39) missense probably damaging 1.00
Z1088:Dock2 UTSW 11 34,388,300 (GRCm39) missense probably benign 0.14
Z1088:Dock2 UTSW 11 34,586,039 (GRCm39) nonsense probably null
Z1176:Dock2 UTSW 11 34,609,751 (GRCm39) missense probably benign 0.04
Z1177:Dock2 UTSW 11 34,262,553 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- CAGCCTTCTCCCAAATAGAGAGTG -3'
(R):5'- AGCCGAGCACCAATTCTGTC -3'

Sequencing Primer
(F):5'- TTCTCCCAAATAGAGAGTGGCAGAC -3'
(R):5'- CCCTTTGCAGCTGGGTAAG -3'
Posted On 2016-10-24