Incidental Mutation 'R5539:Or1m1'
ID 435827
Institutional Source Beutler Lab
Gene Symbol Or1m1
Ensembl Gene ENSMUSG00000054141
Gene Name olfactory receptor family 1 subfamily M member 1
Synonyms GA_x6K02T2PVTD-12498544-12497603, MTPCR51, Olfr24, MOR132-1
MMRRC Submission 043097-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R5539 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 18665988-18666929 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 18666134 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Cysteine at position 266 (R266C)
Ref Sequence ENSEMBL: ENSMUSP00000149702 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066997] [ENSMUST00000216754]
AlphaFold Q8VFM9
Predicted Effect probably damaging
Transcript: ENSMUST00000066997
AA Change: R266C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000064189
Gene: ENSMUSG00000054141
AA Change: R266C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.6e-64 PFAM
Pfam:7TM_GPCR_Srsx 35 304 9.2e-9 PFAM
Pfam:7tm_1 41 290 3.2e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212239
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214366
Predicted Effect probably damaging
Transcript: ENSMUST00000216754
AA Change: R266C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310034C09Rik A T 16: 88,555,917 (GRCm39) S44C probably damaging Het
Abca4 A G 3: 121,963,557 (GRCm39) I846V probably damaging Het
Aldh4a1 T C 4: 139,365,833 (GRCm39) S275P probably benign Het
Arhgap12 A T 18: 6,111,932 (GRCm39) L144H probably benign Het
Ccdc141 A T 2: 76,845,437 (GRCm39) I1210N probably damaging Het
Ccdc175 T C 12: 72,191,587 (GRCm39) T330A probably benign Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Dnah17 T C 11: 117,964,486 (GRCm39) K2444E probably benign Het
Dnajc3 G A 14: 119,208,159 (GRCm39) V265M probably damaging Het
Flg2 T A 3: 93,127,753 (GRCm39) Y2222N unknown Het
Flnc G T 6: 29,446,229 (GRCm39) G882V probably damaging Het
Fndc5 T A 4: 129,032,514 (GRCm39) V39D probably damaging Het
Gabrr3 A T 16: 59,281,758 (GRCm39) H371L probably benign Het
Gm10717 A T 9: 3,030,438 (GRCm39) H33L probably damaging Het
Gm5422 A G 10: 31,124,646 (GRCm39) noncoding transcript Het
Kri1 G A 9: 21,190,668 (GRCm39) Q280* probably null Het
Lcp1 T C 14: 75,466,738 (GRCm39) V615A probably benign Het
Ltbp4 T C 7: 27,027,149 (GRCm39) Y407C probably damaging Het
Med30 G T 15: 52,584,462 (GRCm39) D127Y probably damaging Het
Mybpc2 A G 7: 44,164,317 (GRCm39) V416A probably benign Het
Notch2 C T 3: 98,044,898 (GRCm39) R1607C probably damaging Het
Nr4a3 T A 4: 48,056,525 (GRCm39) probably null Het
Ntf5 G T 7: 45,065,354 (GRCm39) R162L probably benign Het
Nxpe3 A G 16: 55,711,034 (GRCm39) W2R possibly damaging Het
Or10d1c T C 9: 38,893,573 (GRCm39) I256V possibly damaging Het
Or14j4 T A 17: 37,921,646 (GRCm39) M1L probably benign Het
Or5p58 A T 7: 107,694,433 (GRCm39) C115S probably benign Het
Pan2 C A 10: 128,144,002 (GRCm39) D99E probably benign Het
Pcdh12 T C 18: 38,414,797 (GRCm39) H776R possibly damaging Het
Prdm2 T C 4: 142,859,264 (GRCm39) H1342R possibly damaging Het
Prpf8 A G 11: 75,394,464 (GRCm39) T1800A probably benign Het
Prss40 T C 1: 34,591,760 (GRCm39) *148W probably null Het
Pygo1 C T 9: 72,852,061 (GRCm39) P83S probably damaging Het
Raf1 G T 6: 115,596,317 (GRCm39) S619R probably damaging Het
Rtf1 A G 2: 119,560,405 (GRCm39) M596V possibly damaging Het
Slc12a5 T A 2: 164,829,126 (GRCm39) D578E possibly damaging Het
Slc35b4 A G 6: 34,153,737 (GRCm39) V18A probably damaging Het
Spata31 T A 13: 65,070,783 (GRCm39) I977K probably benign Het
Tor2a T C 2: 32,650,672 (GRCm39) I222T probably damaging Het
Trim23 T C 13: 104,334,541 (GRCm39) V347A probably damaging Het
Trip11 A G 12: 101,851,386 (GRCm39) S893P probably damaging Het
Trmt10c G A 16: 55,855,324 (GRCm39) P104S probably damaging Het
Ubr3 A T 2: 69,850,877 (GRCm39) Y1765F probably damaging Het
Zfp951 C T 5: 104,962,712 (GRCm39) E285K probably damaging Het
Other mutations in Or1m1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02346:Or1m1 APN 9 18,666,065 (GRCm39) missense probably damaging 0.97
IGL02371:Or1m1 APN 9 18,666,000 (GRCm39) missense probably benign 0.07
IGL02555:Or1m1 APN 9 18,666,769 (GRCm39) missense probably benign 0.40
IGL03025:Or1m1 APN 9 18,666,665 (GRCm39) missense probably benign 0.00
IGL03259:Or1m1 APN 9 18,666,811 (GRCm39) missense probably benign
IGL03050:Or1m1 UTSW 9 18,666,750 (GRCm39) nonsense probably null
R0310:Or1m1 UTSW 9 18,666,629 (GRCm39) missense possibly damaging 0.91
R0410:Or1m1 UTSW 9 18,666,137 (GRCm39) missense probably damaging 0.96
R2152:Or1m1 UTSW 9 18,666,391 (GRCm39) missense probably damaging 1.00
R2153:Or1m1 UTSW 9 18,666,391 (GRCm39) missense probably damaging 1.00
R2918:Or1m1 UTSW 9 18,666,775 (GRCm39) missense probably damaging 1.00
R4552:Or1m1 UTSW 9 18,666,430 (GRCm39) missense possibly damaging 0.60
R5073:Or1m1 UTSW 9 18,666,118 (GRCm39) missense possibly damaging 0.89
R5662:Or1m1 UTSW 9 18,666,896 (GRCm39) missense probably damaging 0.99
R6145:Or1m1 UTSW 9 18,666,865 (GRCm39) missense probably benign 0.06
R7125:Or1m1 UTSW 9 18,666,174 (GRCm39) nonsense probably null
R7196:Or1m1 UTSW 9 18,666,886 (GRCm39) nonsense probably null
R7607:Or1m1 UTSW 9 18,666,178 (GRCm39) missense possibly damaging 0.93
R9136:Or1m1 UTSW 9 18,666,175 (GRCm39) missense probably damaging 1.00
Z1177:Or1m1 UTSW 9 18,666,815 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- ACTCGGGTCTTTACGTTCTG -3'
(R):5'- TGCTCATTGTGGCAGGAATG -3'

Sequencing Primer
(F):5'- TGCTGCCTTGAAATTCCACAAC -3'
(R):5'- CATTGTGGCAGGAATGGTGATAGC -3'
Posted On 2016-10-24