Incidental Mutation 'R5543:Ifitm3'
ID 436103
Institutional Source Beutler Lab
Gene Symbol Ifitm3
Ensembl Gene ENSMUSG00000025492
Gene Name interferon induced transmembrane protein 3
Synonyms Fgls, 1110004C05Rik, IP15, mil-1, fragilis
MMRRC Submission 043101-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5543 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 140589503-140590657 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 140589730 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 108 (I108F)
Ref Sequence ENSEMBL: ENSMUSP00000026565 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026565]
AlphaFold Q9CQW9
Predicted Effect unknown
Transcript: ENSMUST00000026565
AA Change: I108F
SMART Domains Protein: ENSMUSP00000026565
Gene: ENSMUSG00000025492
AA Change: I108F

DomainStartEndE-ValueType
Pfam:CD225 47 130 7.6e-33 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]
PHENOTYPE: Mice homozygous for a reporter allele are viable and fertile with no detectable defects in embryogenesis or germ cell development but show increased susceptibility to respiratory syncytial virus and influenza A virus infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130023H24Rik C A 7: 127,836,353 (GRCm39) S80I probably benign Het
Aak1 T C 6: 86,959,627 (GRCm39) probably null Het
Abcc6 A G 7: 45,638,960 (GRCm39) probably null Het
Acvr1 A G 2: 58,353,157 (GRCm39) S268P probably damaging Het
Apod T C 16: 31,122,351 (GRCm39) probably null Het
Atp5po T C 16: 91,723,418 (GRCm39) I58V probably benign Het
AU040320 C T 4: 126,735,017 (GRCm39) T777M probably damaging Het
Ccne2 A T 4: 11,194,026 (GRCm39) N89I probably benign Het
Cspg4b C A 13: 113,457,407 (GRCm39) T1151K probably damaging Het
Dnah7a A G 1: 53,543,228 (GRCm39) V2314A probably damaging Het
Dop1b T C 16: 93,595,808 (GRCm39) S1881P probably damaging Het
E4f1 A G 17: 24,666,336 (GRCm39) V24A possibly damaging Het
Esrrg A T 1: 187,882,451 (GRCm39) D236V probably damaging Het
Fam240b T A 13: 64,633,736 (GRCm39) I27F possibly damaging Het
Fat1 T A 8: 45,476,516 (GRCm39) I1854N probably damaging Het
Fchsd2 T C 7: 100,920,906 (GRCm39) Y480H probably damaging Het
Fras1 A G 5: 96,676,394 (GRCm39) N47S probably benign Het
Gabrr3 T C 16: 59,253,870 (GRCm39) S196P probably damaging Het
Gbp8 T A 5: 105,165,696 (GRCm39) D319V possibly damaging Het
Hrh3 G T 2: 179,745,763 (GRCm39) A61E probably damaging Het
Idua T C 5: 108,818,095 (GRCm39) I89T probably benign Het
Izumo4 T C 10: 80,538,668 (GRCm39) F40S probably damaging Het
Kifc2 A G 15: 76,551,242 (GRCm39) R679G probably damaging Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Ldha A T 7: 46,500,314 (GRCm39) I171F possibly damaging Het
Lrfn4 T C 19: 4,662,191 (GRCm39) S609G probably benign Het
Mmp15 T C 8: 96,094,729 (GRCm39) F201S possibly damaging Het
Myof C T 19: 37,969,778 (GRCm39) V295I probably benign Het
Or1n2 C T 2: 36,797,369 (GRCm39) T137I possibly damaging Het
Or2z2 T A 11: 58,345,993 (GRCm39) M261L probably damaging Het
Or5m12 G T 2: 85,734,672 (GRCm39) A242D probably damaging Het
Parp14 T C 16: 35,655,137 (GRCm39) D1778G probably benign Het
Pcnt A T 10: 76,247,886 (GRCm39) D969E probably benign Het
Pibf1 A T 14: 99,350,428 (GRCm39) N192I probably benign Het
Pitpnm3 A G 11: 71,947,023 (GRCm39) F792S probably damaging Het
Pkd2 T A 5: 104,637,199 (GRCm39) I604N probably damaging Het
Pla2g15 T C 8: 106,887,775 (GRCm39) Y188H probably damaging Het
Plxnc1 G T 10: 94,700,636 (GRCm39) D643E probably benign Het
Prrc2c G A 1: 162,501,080 (GRCm39) P1241L probably damaging Het
Ptprd T C 4: 75,977,990 (GRCm39) E173G probably damaging Het
Shank3 T C 15: 89,416,557 (GRCm39) V232A probably damaging Het
Shbg A G 11: 69,507,564 (GRCm39) I171T probably damaging Het
Slc22a14 A T 9: 119,002,674 (GRCm39) F404L probably benign Het
Slc37a3 C A 6: 39,331,960 (GRCm39) G158C probably damaging Het
Slfn9 C A 11: 82,873,207 (GRCm39) L565F probably damaging Het
Spmip10 G A 18: 56,727,760 (GRCm39) probably benign Het
Trank1 T A 9: 111,195,180 (GRCm39) M1068K probably damaging Het
Trbv15 A T 6: 41,118,187 (GRCm39) I15L probably benign Het
Ttn C T 2: 76,569,918 (GRCm39) V26992M probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ugt2b34 T A 5: 87,054,560 (GRCm39) I74F probably damaging Het
Vamp3 A G 4: 151,135,477 (GRCm39) L47P probably damaging Het
Zfp143 T A 7: 109,682,522 (GRCm39) C363* probably null Het
Zfp438 T C 18: 5,213,761 (GRCm39) E399G probably damaging Het
Other mutations in Ifitm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02039:Ifitm3 APN 7 140,590,563 (GRCm39) utr 5 prime probably benign
IGL02478:Ifitm3 APN 7 140,589,787 (GRCm39) missense possibly damaging 0.68
IGL02889:Ifitm3 APN 7 140,589,792 (GRCm39) missense probably damaging 1.00
I0000:Ifitm3 UTSW 7 140,590,441 (GRCm39) missense possibly damaging 0.85
R1069:Ifitm3 UTSW 7 140,589,813 (GRCm39) splice site probably benign
R4019:Ifitm3 UTSW 7 140,589,772 (GRCm39) missense possibly damaging 0.71
R4991:Ifitm3 UTSW 7 140,590,372 (GRCm39) missense probably damaging 1.00
R5288:Ifitm3 UTSW 7 140,590,554 (GRCm39) missense probably benign 0.00
R5385:Ifitm3 UTSW 7 140,590,554 (GRCm39) missense probably benign 0.00
R5386:Ifitm3 UTSW 7 140,590,554 (GRCm39) missense probably benign 0.00
R7071:Ifitm3 UTSW 7 140,590,437 (GRCm39) missense probably benign 0.03
R7602:Ifitm3 UTSW 7 140,590,372 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCACTTTATTGAATCCACTGTGG -3'
(R):5'- TGTTCCTGACCTAAGATGGGG -3'

Sequencing Primer
(F):5'- AAATGAGTGTTACACCTGCGTG -3'
(R):5'- TTCCTGACCTAAGATGGGGAGATG -3'
Posted On 2016-10-24