Incidental Mutation 'R5544:Vmn1r231'
| ID |
436165 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r231
|
| Ensembl Gene |
ENSMUSG00000050933 |
| Gene Name |
vomeronasal 1 receptor 231 |
| Synonyms |
V1re7 |
| MMRRC Submission |
043102-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.052)
|
| Stock # |
R5544 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
21109978-21110913 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 21110840 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 25
(I25T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000056228
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061278]
|
| AlphaFold |
Q8R2A3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000061278
AA Change: I25T
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000056228
Gene: ENSMUSG00000050933
AA Change: I25T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
6 |
294 |
1.6e-13 |
PFAM |
|
Pfam:V1R
|
36 |
297 |
1.6e-27 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232004
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 36 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts8 |
G |
A |
9: 30,863,999 (GRCm39) |
A372T |
probably damaging |
Het |
| Ap4m1 |
A |
G |
5: 138,176,632 (GRCm39) |
T411A |
probably benign |
Het |
| Arid3b |
T |
A |
9: 57,705,380 (GRCm39) |
K274* |
probably null |
Het |
| Bcan |
A |
G |
3: 87,900,360 (GRCm39) |
|
probably null |
Het |
| Birc6 |
A |
C |
17: 74,977,369 (GRCm39) |
N4388T |
probably damaging |
Het |
| C9 |
T |
A |
15: 6,526,508 (GRCm39) |
V514D |
probably damaging |
Het |
| Cdk2 |
A |
C |
10: 128,535,008 (GRCm39) |
D336E |
probably benign |
Het |
| Corin |
A |
T |
5: 72,462,357 (GRCm39) |
Y825* |
probably null |
Het |
| Cyp17a1 |
A |
G |
19: 46,661,093 (GRCm39) |
Y64H |
probably damaging |
Het |
| Dock4 |
T |
G |
12: 40,884,701 (GRCm39) |
I1735S |
possibly damaging |
Het |
| Dock7 |
T |
C |
4: 98,855,494 (GRCm39) |
H1486R |
probably damaging |
Het |
| Fam171b |
C |
A |
2: 83,685,871 (GRCm39) |
A185D |
possibly damaging |
Het |
| Fbxl13 |
A |
G |
5: 21,729,489 (GRCm39) |
I441T |
probably damaging |
Het |
| Gm7347 |
T |
A |
5: 26,260,016 (GRCm39) |
D178V |
possibly damaging |
Het |
| Greb1 |
C |
A |
12: 16,723,797 (GRCm39) |
C1884F |
probably damaging |
Het |
| Kdr |
G |
A |
5: 76,121,403 (GRCm39) |
R536* |
probably null |
Het |
| Lamc2 |
T |
C |
1: 152,999,799 (GRCm39) |
T1187A |
possibly damaging |
Het |
| Mal |
T |
A |
2: 127,476,937 (GRCm39) |
H142L |
probably damaging |
Het |
| Map4k2 |
A |
C |
19: 6,395,944 (GRCm39) |
|
probably null |
Het |
| Morn4 |
T |
C |
19: 42,064,686 (GRCm39) |
T101A |
possibly damaging |
Het |
| Neto2 |
A |
G |
8: 86,374,506 (GRCm39) |
V241A |
possibly damaging |
Het |
| Nprl2 |
T |
C |
9: 107,421,808 (GRCm39) |
V232A |
probably benign |
Het |
| Pcdhb13 |
T |
C |
18: 37,576,573 (GRCm39) |
V317A |
possibly damaging |
Het |
| Pcdhb17 |
T |
A |
18: 37,620,474 (GRCm39) |
C755S |
possibly damaging |
Het |
| Pgc |
A |
G |
17: 48,043,429 (GRCm39) |
D259G |
probably benign |
Het |
| Ptprh |
C |
A |
7: 4,583,909 (GRCm39) |
E228* |
probably null |
Het |
| R3hdml |
A |
G |
2: 163,340,342 (GRCm39) |
T170A |
probably damaging |
Het |
| Retreg2 |
T |
G |
1: 75,121,333 (GRCm39) |
*174G |
probably null |
Het |
| Rps6ka1 |
A |
G |
4: 133,599,326 (GRCm39) |
S34P |
probably benign |
Het |
| Rptn |
A |
G |
3: 93,305,780 (GRCm39) |
T1038A |
possibly damaging |
Het |
| Sel1l3 |
A |
T |
5: 53,357,644 (GRCm39) |
V116D |
probably damaging |
Het |
| Sidt2 |
A |
T |
9: 45,855,753 (GRCm39) |
Y509N |
probably damaging |
Het |
| Slc16a11 |
T |
A |
11: 70,105,826 (GRCm39) |
|
probably null |
Het |
| Thsd7a |
G |
T |
6: 12,379,470 (GRCm39) |
Q985K |
possibly damaging |
Het |
| Ttn |
T |
C |
2: 76,556,882 (GRCm39) |
N30041S |
probably benign |
Het |
| Wdr81 |
T |
C |
11: 75,332,623 (GRCm39) |
D1926G |
probably damaging |
Het |
|
| Other mutations in Vmn1r231 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00233:Vmn1r231
|
APN |
17 |
21,110,828 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02124:Vmn1r231
|
APN |
17 |
21,110,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02151:Vmn1r231
|
APN |
17 |
21,109,997 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0066:Vmn1r231
|
UTSW |
17 |
21,109,998 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0066:Vmn1r231
|
UTSW |
17 |
21,109,998 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0396:Vmn1r231
|
UTSW |
17 |
21,110,661 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0427:Vmn1r231
|
UTSW |
17 |
21,110,490 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0470:Vmn1r231
|
UTSW |
17 |
21,110,265 (GRCm39) |
nonsense |
probably null |
|
|
R0848:Vmn1r231
|
UTSW |
17 |
21,110,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1692:Vmn1r231
|
UTSW |
17 |
21,110,871 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1987:Vmn1r231
|
UTSW |
17 |
21,110,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1988:Vmn1r231
|
UTSW |
17 |
21,110,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2105:Vmn1r231
|
UTSW |
17 |
21,110,380 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4440:Vmn1r231
|
UTSW |
17 |
21,110,718 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R4634:Vmn1r231
|
UTSW |
17 |
21,110,660 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4646:Vmn1r231
|
UTSW |
17 |
21,110,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4678:Vmn1r231
|
UTSW |
17 |
21,110,489 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4696:Vmn1r231
|
UTSW |
17 |
21,110,901 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R4938:Vmn1r231
|
UTSW |
17 |
21,110,613 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5942:Vmn1r231
|
UTSW |
17 |
21,110,417 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6053:Vmn1r231
|
UTSW |
17 |
21,110,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6692:Vmn1r231
|
UTSW |
17 |
21,110,745 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6712:Vmn1r231
|
UTSW |
17 |
21,109,992 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7131:Vmn1r231
|
UTSW |
17 |
21,110,140 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7854:Vmn1r231
|
UTSW |
17 |
21,110,894 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7918:Vmn1r231
|
UTSW |
17 |
21,110,236 (GRCm39) |
nonsense |
probably null |
|
|
R8187:Vmn1r231
|
UTSW |
17 |
21,110,893 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8238:Vmn1r231
|
UTSW |
17 |
21,110,640 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8313:Vmn1r231
|
UTSW |
17 |
21,110,289 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8525:Vmn1r231
|
UTSW |
17 |
21,110,001 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9276:Vmn1r231
|
UTSW |
17 |
21,110,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
RF010:Vmn1r231
|
UTSW |
17 |
21,110,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCAACTCTTTCAGTATACATAGGG -3'
(R):5'- CCACTGGTTTCATAAGCTGC -3'
Sequencing Primer
(F):5'- TCAGTATACATAGGGAATTTGCAAAC -3'
(R):5'- TCATCCACTGCCTAATGG -3'
|
| Posted On |
2016-10-24 |
Incidental Mutation