Incidental Mutation 'R5532:Cenpv'
ID 436235
Institutional Source Beutler Lab
Gene Symbol Cenpv
Ensembl Gene ENSMUSG00000018509
Gene Name centromere protein V
Synonyms Prr6, 3110013H01Rik
MMRRC Submission 043090-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R5532 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 62415772-62430087 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 62418398 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 185 (T185M)
Ref Sequence ENSEMBL: ENSMUSP00000018653 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018653]
AlphaFold Q9CXS4
Predicted Effect probably damaging
Transcript: ENSMUST00000018653
AA Change: T185M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000018653
Gene: ENSMUSG00000018509
AA Change: T185M

DomainStartEndE-ValueType
low complexity region 29 85 N/A INTRINSIC
Pfam:GFA 147 234 3.2e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123542
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135497
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143382
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156349
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T A 6: 128,530,293 (GRCm39) probably null Het
Adsl C G 15: 80,848,110 (GRCm39) P118A probably damaging Het
Ano6 C T 15: 95,860,122 (GRCm39) P748L probably damaging Het
Arhgap10 A T 8: 78,146,701 (GRCm39) N234K probably benign Het
Arhgap18 T A 10: 26,722,104 (GRCm39) I25K possibly damaging Het
AW551984 T C 9: 39,508,481 (GRCm39) Y345C probably damaging Het
Ccdc146 A G 5: 21,510,329 (GRCm39) V561A probably benign Het
Fat2 T A 11: 55,153,163 (GRCm39) D3683V probably damaging Het
Galns T C 8: 123,311,765 (GRCm39) D415G possibly damaging Het
Gatad2a G A 8: 70,369,070 (GRCm39) T259M probably damaging Het
Gja8 T C 3: 96,827,648 (GRCm39) S5G probably benign Het
Ifi209 T C 1: 173,466,542 (GRCm39) S125P probably damaging Het
Iigp1c A G 18: 60,379,142 (GRCm39) I226V probably benign Het
Il12rb2 G A 6: 67,269,246 (GRCm39) R856W probably damaging Het
Kcnq3 A T 15: 65,869,622 (GRCm39) Y605* probably null Het
Klk1b16 T C 7: 43,790,950 (GRCm39) S251P probably benign Het
Map2 A G 1: 66,453,779 (GRCm39) N890D probably damaging Het
Map4 T A 9: 109,863,746 (GRCm39) S324T probably benign Het
Mmp28 T C 11: 83,333,684 (GRCm39) D419G probably damaging Het
Mtnr1b A G 9: 15,774,210 (GRCm39) L283P probably benign Het
Ndufb7 T A 8: 84,298,063 (GRCm39) Y95N probably damaging Het
Nfrkb C T 9: 31,309,075 (GRCm39) R280W probably damaging Het
Npc1l1 A G 11: 6,174,245 (GRCm39) Y687H probably damaging Het
Or6f1 A C 7: 85,970,879 (GRCm39) F94V possibly damaging Het
Or8b40 C T 9: 38,027,923 (GRCm39) T277I probably benign Het
Or8g51 T C 9: 38,608,943 (GRCm39) T240A probably damaging Het
Or8h9 T A 2: 86,788,924 (GRCm39) R293* probably null Het
Pabpc4l T C 3: 46,401,044 (GRCm39) D200G probably benign Het
Plekhg6 T C 6: 125,349,514 (GRCm39) E361G possibly damaging Het
Pramel31 A T 4: 144,090,061 (GRCm39) D367V probably damaging Het
Rictor A G 15: 6,819,046 (GRCm39) Y1423C probably damaging Het
Rsf1 G A 7: 97,329,902 (GRCm39) D1143N probably damaging Het
Spsb4 C T 9: 96,877,627 (GRCm39) probably null Het
Strada G T 11: 106,061,843 (GRCm39) A136E probably damaging Het
Syce2 A T 8: 85,610,131 (GRCm39) Q73L probably damaging Het
Teddm2 A T 1: 153,726,130 (GRCm39) V195D probably benign Het
Tex36 A T 7: 133,203,712 (GRCm39) N12K probably benign Het
Ubtf A G 11: 102,199,785 (GRCm39) S484P probably benign Het
Ufd1 T G 16: 18,636,680 (GRCm39) L66R probably damaging Het
Vmn2r74 C T 7: 85,601,197 (GRCm39) A814T probably benign Het
Vmn2r98 T C 17: 19,287,645 (GRCm39) S493P possibly damaging Het
Xrcc1 T A 7: 24,267,353 (GRCm39) probably null Het
Zfp277 A C 12: 40,385,308 (GRCm39) C305G probably damaging Het
Zfp998 A T 13: 66,579,740 (GRCm39) C248S probably damaging Het
Other mutations in Cenpv
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1472:Cenpv UTSW 11 62,427,121 (GRCm39) missense probably benign 0.00
R1607:Cenpv UTSW 11 62,416,002 (GRCm39) missense probably benign 0.01
R1929:Cenpv UTSW 11 62,416,059 (GRCm39) missense probably benign 0.19
R4895:Cenpv UTSW 11 62,418,346 (GRCm39) nonsense probably null
R6419:Cenpv UTSW 11 62,416,008 (GRCm39) missense probably benign 0.01
R7394:Cenpv UTSW 11 62,427,114 (GRCm39) missense probably damaging 0.96
R9275:Cenpv UTSW 11 62,415,989 (GRCm39) makesense probably null
R9291:Cenpv UTSW 11 62,429,688 (GRCm39) missense probably benign 0.05
Z1176:Cenpv UTSW 11 62,418,351 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTTACCATAGGCCCAGACG -3'
(R):5'- TGACTTCAAGAGGCTTTCGGTC -3'

Sequencing Primer
(F):5'- ACCAGAGGAGGCTTATTCTTCTGAC -3'
(R):5'- TCTTTTCTCGGAATCAGGAGC -3'
Posted On 2016-10-24