Incidental Mutation 'R5546:Zfp619'
ID 436282
Institutional Source Beutler Lab
Gene Symbol Zfp619
Ensembl Gene ENSMUSG00000068959
Gene Name zinc finger protein 619
Synonyms 3000002G13Rik
MMRRC Submission 043104-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R5546 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 39167190-39189844 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 39184577 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 202 (H202Q)
Ref Sequence ENSEMBL: ENSMUSP00000103650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108015]
AlphaFold G3X9T2
Predicted Effect probably benign
Transcript: ENSMUST00000108015
AA Change: H202Q

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000103650
Gene: ENSMUSG00000068959
AA Change: H202Q

DomainStartEndE-ValueType
KRAB 4 61 2.19e-20 SMART
ZnF_C2H2 218 240 2.91e-2 SMART
ZnF_C2H2 246 268 5.81e-2 SMART
ZnF_C2H2 274 296 3.16e-3 SMART
ZnF_C2H2 302 324 2.4e-3 SMART
ZnF_C2H2 330 352 2.95e-3 SMART
ZnF_C2H2 358 380 6.32e-3 SMART
ZnF_C2H2 386 408 8.47e-4 SMART
ZnF_C2H2 414 436 5.06e-2 SMART
ZnF_C2H2 442 464 1.58e-3 SMART
ZnF_C2H2 470 492 5.42e-2 SMART
ZnF_C2H2 526 548 2.09e-3 SMART
ZnF_C2H2 554 576 3.39e-3 SMART
ZnF_C2H2 582 604 1.56e-2 SMART
ZnF_C2H2 610 632 2.24e-3 SMART
ZnF_C2H2 638 660 4.72e-2 SMART
ZnF_C2H2 666 688 7.78e-3 SMART
ZnF_C2H2 694 716 5.9e-3 SMART
ZnF_C2H2 722 744 1.12e-3 SMART
ZnF_C2H2 748 770 6.42e-4 SMART
ZnF_C2H2 776 798 1.38e-3 SMART
ZnF_C2H2 804 826 9.44e-2 SMART
ZnF_C2H2 832 854 2.36e-2 SMART
ZnF_C2H2 860 882 8.94e-3 SMART
ZnF_C2H2 888 910 3.58e-2 SMART
ZnF_C2H2 916 938 6.42e-4 SMART
ZnF_C2H2 942 964 4.72e-2 SMART
ZnF_C2H2 970 992 2.3e-5 SMART
ZnF_C2H2 998 1020 8.34e-3 SMART
ZnF_C2H2 1026 1048 8.81e-2 SMART
ZnF_C2H2 1054 1076 1.69e-3 SMART
ZnF_C2H2 1082 1104 6.32e-3 SMART
ZnF_C2H2 1110 1132 1.47e-3 SMART
ZnF_C2H2 1138 1160 7.15e-2 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]
Allele List at MGI

All alleles(5) : Gene trapped(5)

Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl11 A G 9: 107,806,832 (GRCm39) N385S probably benign Het
Ahctf1 A T 1: 179,581,633 (GRCm39) I1523N probably benign Het
Akna C T 4: 63,313,196 (GRCm39) G309E probably benign Het
Akna T C 4: 63,313,803 (GRCm39) N107D probably benign Het
Arhgef15 G A 11: 68,844,877 (GRCm39) P240L probably benign Het
Brd1 T A 15: 88,585,325 (GRCm39) E836D probably benign Het
Brf2 A G 8: 27,614,311 (GRCm39) S292P possibly damaging Het
C3 A G 17: 57,529,976 (GRCm39) L500P probably damaging Het
Cblif T C 19: 11,725,859 (GRCm39) S50P possibly damaging Het
Ccdc107 T C 4: 43,495,685 (GRCm39) L196P probably damaging Het
Cdcp1 G T 9: 123,007,094 (GRCm39) P551Q probably damaging Het
Ckap5 T C 2: 91,425,161 (GRCm39) L1224P probably damaging Het
Csnk1g2 C A 10: 80,474,232 (GRCm39) T178K probably benign Het
Ctsq A T 13: 61,185,702 (GRCm39) C146* probably null Het
Cyp2ab1 T A 16: 20,132,507 (GRCm39) I264F probably damaging Het
Daxx TGATGATGACGATGATGACGATGATGA TGATGATGACGATGATGA 17: 34,131,615 (GRCm39) probably benign Het
Dnah11 G A 12: 117,939,583 (GRCm39) T3179M possibly damaging Het
Dnah7c A T 1: 46,705,477 (GRCm39) T2497S probably damaging Het
Eif4enif1 T C 11: 3,193,989 (GRCm39) V776A probably damaging Het
Erbb4 G T 1: 68,337,452 (GRCm39) T622N probably damaging Het
Erich6 A G 3: 58,526,218 (GRCm39) Y595H probably benign Het
Fam107a C T 14: 8,298,764 (GRCm38) A121T probably benign Het
Gpatch11 C T 17: 79,149,548 (GRCm39) Q183* probably null Het
Gpr161 C A 1: 165,133,982 (GRCm39) F81L possibly damaging Het
Hook1 G T 4: 95,890,765 (GRCm39) E291D probably benign Het
Hsf2bp T A 17: 32,165,669 (GRCm39) I309F probably damaging Het
Hspg2 T C 4: 137,275,485 (GRCm39) probably null Het
Ide T G 19: 37,249,623 (GRCm39) M910L unknown Het
Igdcc4 A G 9: 65,036,077 (GRCm39) Y712C probably damaging Het
Kmt2d T C 15: 98,750,949 (GRCm39) probably benign Het
Lats1 T C 10: 7,581,518 (GRCm39) Y768H probably damaging Het
Mageb3 A G 2: 121,784,868 (GRCm39) V278A probably damaging Het
Mapkbp1 G A 2: 119,849,724 (GRCm39) R732H probably damaging Het
Marveld2 T C 13: 100,737,446 (GRCm39) I148V probably benign Het
Mast1 G C 8: 85,642,889 (GRCm39) P969A probably damaging Het
Myh10 T G 11: 68,689,206 (GRCm39) V1261G possibly damaging Het
Nlrp1b A T 11: 71,108,102 (GRCm39) H466Q probably benign Het
Npr2 T G 4: 43,650,150 (GRCm39) V905G probably damaging Het
Oip5 T A 2: 119,440,808 (GRCm39) I240F unknown Het
Or4c12 A G 2: 89,773,929 (GRCm39) C177R probably damaging Het
Or5k8 G T 16: 58,644,516 (GRCm39) Y185* probably null Het
Or8b12 T A 9: 37,657,820 (GRCm39) M130K probably benign Het
Pcsk2 G A 2: 143,388,480 (GRCm39) A24T probably benign Het
Plxnb1 G T 9: 108,929,818 (GRCm39) G225W probably damaging Het
Polr1a T C 6: 71,906,350 (GRCm39) S389P possibly damaging Het
Prkca A G 11: 107,944,806 (GRCm39) V175A probably benign Het
Rassf7 C A 7: 140,796,973 (GRCm39) probably null Het
Rbl2 A G 8: 91,805,560 (GRCm39) I206V probably benign Het
Rnf111 A T 9: 70,366,378 (GRCm39) H353Q probably benign Het
Rpn1 T G 6: 88,070,841 (GRCm39) V237G probably damaging Het
Sec61a2 T A 2: 5,881,351 (GRCm39) I267F possibly damaging Het
Spop G T 11: 95,376,669 (GRCm39) V241F probably damaging Het
Sptbn2 C T 19: 4,775,978 (GRCm39) A178V probably damaging Het
Stard13 A G 5: 150,969,366 (GRCm39) Y791H probably benign Het
Susd2 T A 10: 75,478,052 (GRCm39) I113L probably benign Het
Tcof1 T C 18: 60,964,628 (GRCm39) E666G possibly damaging Het
Tekt5 G T 16: 10,179,254 (GRCm39) A371E possibly damaging Het
Thap11 G A 8: 106,582,548 (GRCm39) E186K probably damaging Het
Tk2 A T 8: 104,974,315 (GRCm39) D45E possibly damaging Het
Tuba8 C A 6: 121,199,872 (GRCm39) Y185* probably null Het
Usp24 T A 4: 106,273,244 (GRCm39) Y2210N probably damaging Het
Wfdc8 A T 2: 164,439,239 (GRCm39) probably benign Het
Zar1l T C 5: 150,436,365 (GRCm39) N237S probably damaging Het
Zfp607b A T 7: 27,402,032 (GRCm39) T163S probably benign Het
Other mutations in Zfp619
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02157:Zfp619 APN 7 39,184,288 (GRCm39) missense probably damaging 1.00
IGL02221:Zfp619 APN 7 39,186,334 (GRCm39) missense probably benign 0.00
IGL02625:Zfp619 APN 7 39,183,609 (GRCm39) splice site probably benign
3-1:Zfp619 UTSW 7 39,186,189 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0113:Zfp619 UTSW 7 39,187,183 (GRCm39) missense probably benign 0.01
R0377:Zfp619 UTSW 7 39,186,221 (GRCm39) nonsense probably null
R0614:Zfp619 UTSW 7 39,187,099 (GRCm39) missense possibly damaging 0.79
R0848:Zfp619 UTSW 7 39,185,983 (GRCm39) missense probably damaging 1.00
R1157:Zfp619 UTSW 7 39,186,282 (GRCm39) missense probably damaging 0.98
R2047:Zfp619 UTSW 7 39,187,062 (GRCm39) missense probably damaging 0.99
R2074:Zfp619 UTSW 7 39,184,185 (GRCm39) missense probably benign 0.00
R2419:Zfp619 UTSW 7 39,185,307 (GRCm39) missense possibly damaging 0.71
R2571:Zfp619 UTSW 7 39,186,595 (GRCm39) missense probably damaging 1.00
R2890:Zfp619 UTSW 7 39,184,393 (GRCm39) missense probably benign 0.00
R3814:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4003:Zfp619 UTSW 7 39,186,730 (GRCm39) missense possibly damaging 0.91
R4059:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4503:Zfp619 UTSW 7 39,186,280 (GRCm39) missense probably damaging 1.00
R4664:Zfp619 UTSW 7 39,183,559 (GRCm39) missense probably benign 0.00
R4696:Zfp619 UTSW 7 39,186,412 (GRCm39) missense probably benign 0.00
R4895:Zfp619 UTSW 7 39,187,396 (GRCm39) missense possibly damaging 0.68
R4975:Zfp619 UTSW 7 39,186,504 (GRCm39) missense possibly damaging 0.90
R4977:Zfp619 UTSW 7 39,186,811 (GRCm39) missense probably damaging 1.00
R5049:Zfp619 UTSW 7 39,184,938 (GRCm39) missense probably benign 0.02
R5240:Zfp619 UTSW 7 39,186,642 (GRCm39) missense possibly damaging 0.68
R5468:Zfp619 UTSW 7 39,185,152 (GRCm39) missense unknown
R5572:Zfp619 UTSW 7 39,184,663 (GRCm39) missense probably benign 0.01
R6106:Zfp619 UTSW 7 39,184,558 (GRCm39) missense probably benign 0.01
R6329:Zfp619 UTSW 7 39,186,969 (GRCm39) missense probably damaging 1.00
R6354:Zfp619 UTSW 7 39,184,243 (GRCm39) missense probably benign 0.02
R6395:Zfp619 UTSW 7 39,186,454 (GRCm39) missense possibly damaging 0.91
R6490:Zfp619 UTSW 7 39,183,586 (GRCm39) missense probably benign 0.00
R6560:Zfp619 UTSW 7 39,186,954 (GRCm39) missense probably damaging 1.00
R6713:Zfp619 UTSW 7 39,187,322 (GRCm39) missense probably damaging 0.99
R7011:Zfp619 UTSW 7 39,187,186 (GRCm39) missense probably damaging 1.00
R7022:Zfp619 UTSW 7 39,184,387 (GRCm39) missense probably benign 0.00
R7046:Zfp619 UTSW 7 39,186,787 (GRCm39) missense possibly damaging 0.95
R7206:Zfp619 UTSW 7 39,184,824 (GRCm39) missense probably benign 0.00
R7780:Zfp619 UTSW 7 39,184,432 (GRCm39) missense possibly damaging 0.68
R7787:Zfp619 UTSW 7 39,186,226 (GRCm39) missense possibly damaging 0.91
R8001:Zfp619 UTSW 7 39,184,645 (GRCm39) missense probably benign 0.29
R8559:Zfp619 UTSW 7 39,186,559 (GRCm39) missense probably benign 0.31
R8775:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R8775-TAIL:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R9014:Zfp619 UTSW 7 39,187,246 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AGTTCATGTGGCACTGGTGAG -3'
(R):5'- TTGAAGGGAACTGTGGCTTCT -3'

Sequencing Primer
(F):5'- TGGCACTGGTGAGCAAATTC -3'
(R):5'- CGTCTAAAGGGCTTAGCACACTG -3'
Posted On 2016-10-24