Incidental Mutation 'R5547:Zfp850'
ID 436347
Institutional Source Beutler Lab
Gene Symbol Zfp850
Ensembl Gene ENSMUSG00000096916
Gene Name zinc finger protein 850
Synonyms C130069I09Rik, Gm4636
MMRRC Submission 043105-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R5547 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 27684279-27713540 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 27688844 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 455 (C455R)
Ref Sequence ENSEMBL: ENSMUSP00000141063 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099111] [ENSMUST00000180024] [ENSMUST00000180502]
AlphaFold J3QPC5
Predicted Effect probably benign
Transcript: ENSMUST00000099111
Predicted Effect probably damaging
Transcript: ENSMUST00000180024
AA Change: C455R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000137192
Gene: ENSMUSG00000096916
AA Change: C455R

DomainStartEndE-ValueType
KRAB 14 75 1.56e-34 SMART
ZnF_C2H2 172 194 7.18e1 SMART
ZnF_C2H2 200 222 3.63e-3 SMART
ZnF_C2H2 228 250 8.94e-3 SMART
ZnF_C2H2 256 278 7.49e-5 SMART
ZnF_C2H2 313 335 1.01e-1 SMART
ZnF_C2H2 341 363 4.4e-2 SMART
ZnF_C2H2 369 391 7.37e-4 SMART
ZnF_C2H2 397 419 8.47e-4 SMART
ZnF_C2H2 425 447 1.92e-2 SMART
ZnF_C2H2 453 475 2.99e-4 SMART
ZnF_C2H2 481 503 7.78e-3 SMART
ZnF_C2H2 509 531 1.95e-3 SMART
ZnF_C2H2 537 559 1.92e-2 SMART
ZnF_C2H2 565 587 2.99e-4 SMART
ZnF_C2H2 593 615 1.79e-2 SMART
ZnF_C2H2 621 643 7.37e-4 SMART
ZnF_C2H2 649 671 4.4e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000180502
AA Change: C455R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141063
Gene: ENSMUSG00000096916
AA Change: C455R

DomainStartEndE-ValueType
KRAB 14 75 6.5e-37 SMART
ZnF_C2H2 172 194 3e-1 SMART
ZnF_C2H2 200 222 1.5e-5 SMART
ZnF_C2H2 228 250 3.8e-5 SMART
ZnF_C2H2 256 274 2.5e-1 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh7a1 A G 18: 56,661,356 (GRCm39) S492P probably damaging Het
Arfgef1 A T 1: 10,231,201 (GRCm39) D1133E probably damaging Het
Avpi1 T C 19: 42,113,382 (GRCm39) K25R probably damaging Het
Bank1 T C 3: 135,772,110 (GRCm39) S708G probably damaging Het
C1qtnf2 A G 11: 43,381,794 (GRCm39) E202G probably damaging Het
C6 T A 15: 4,837,970 (GRCm39) V860E probably benign Het
Cbr1 T A 16: 93,406,698 (GRCm39) V138E probably damaging Het
Cdip1 A G 16: 4,587,988 (GRCm39) S2P probably damaging Het
Cep126 T C 9: 8,100,428 (GRCm39) N702S probably damaging Het
Chek1 T C 9: 36,623,400 (GRCm39) I381V probably benign Het
Clock G A 5: 76,378,185 (GRCm39) P572S probably benign Het
Cryz C T 3: 154,317,194 (GRCm39) R138* probably null Het
Ctsll3 T A 13: 60,948,551 (GRCm39) M103L probably benign Het
Daxx TGATGATGACGATGATGACGATGATGA TGATGATGACGATGATGA 17: 34,131,615 (GRCm39) probably benign Het
Daxx CGATGATGATGA CGA 17: 34,131,633 (GRCm39) probably benign Het
Dsg1a T G 18: 20,469,097 (GRCm39) probably null Het
Eya4 T C 10: 22,985,753 (GRCm39) E583G possibly damaging Het
Flt1 T A 5: 147,591,948 (GRCm39) S505C probably damaging Het
Gpr161 C A 1: 165,133,982 (GRCm39) F81L possibly damaging Het
H2-T15 G A 17: 36,368,796 (GRCm39) H95Y possibly damaging Het
Hmcn1 A G 1: 150,613,257 (GRCm39) V1390A possibly damaging Het
Ifi44l C T 3: 151,467,142 (GRCm39) V63I unknown Het
Klhl3 C T 13: 58,250,243 (GRCm39) probably null Het
Lekr1 T A 3: 65,576,601 (GRCm39) probably null Het
Lhx5 A G 5: 120,572,675 (GRCm39) Q98R probably benign Het
Nuggc A G 14: 65,879,330 (GRCm39) K681E possibly damaging Het
Numa1 G T 7: 101,663,137 (GRCm39) A735S probably damaging Het
Oog3 A T 4: 143,884,598 (GRCm39) L446Q probably benign Het
Or5ac19 G A 16: 59,089,479 (GRCm39) L184F probably benign Het
Otogl C T 10: 107,617,909 (GRCm39) E1735K possibly damaging Het
Pcsk5 T C 19: 17,729,488 (GRCm39) D119G probably benign Het
Pgpep1 T C 8: 71,105,069 (GRCm39) K64E probably benign Het
Prr19 A C 7: 25,003,388 (GRCm39) D334A probably damaging Het
Ptprh G T 7: 4,557,221 (GRCm39) S691* probably null Het
Recql4 G A 15: 76,589,994 (GRCm39) R684* probably null Het
Rnf112 C T 11: 61,341,854 (GRCm39) V317I possibly damaging Het
Rnf40 T C 7: 127,188,302 (GRCm39) probably null Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Spag17 T C 3: 99,963,468 (GRCm39) V1062A probably benign Het
Tbc1d1 A G 5: 64,481,887 (GRCm39) D696G possibly damaging Het
Tdo2 T C 3: 81,866,247 (GRCm39) R339G probably damaging Het
Tmem245 C T 4: 56,910,156 (GRCm39) probably null Het
Trim24 A G 6: 37,942,485 (GRCm39) E965G probably damaging Het
Trmt112 T C 19: 6,888,156 (GRCm39) S103P probably damaging Het
Trpv6 A T 6: 41,613,088 (GRCm39) V26D possibly damaging Het
Zfp946 T C 17: 22,673,873 (GRCm39) I209T probably benign Het
Zfp957 T C 14: 79,451,406 (GRCm39) N131S probably benign Het
Other mutations in Zfp850
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02278:Zfp850 APN 7 27,707,822 (GRCm39) missense probably damaging 0.96
R0610:Zfp850 UTSW 7 27,688,819 (GRCm39) missense probably damaging 0.99
R0690:Zfp850 UTSW 7 27,684,642 (GRCm39) missense possibly damaging 0.67
R0711:Zfp850 UTSW 7 27,689,698 (GRCm39) missense probably benign 0.00
R1310:Zfp850 UTSW 7 27,688,884 (GRCm39) missense probably benign 0.40
R1594:Zfp850 UTSW 7 27,688,816 (GRCm39) missense probably benign 0.00
R1771:Zfp850 UTSW 7 27,684,700 (GRCm39) nonsense probably null
R2189:Zfp850 UTSW 7 27,688,480 (GRCm39) missense probably benign 0.02
R2192:Zfp850 UTSW 7 27,684,620 (GRCm39) missense probably damaging 1.00
R2417:Zfp850 UTSW 7 27,688,608 (GRCm39) missense possibly damaging 0.54
R4321:Zfp850 UTSW 7 27,688,825 (GRCm39) missense probably damaging 0.99
R4770:Zfp850 UTSW 7 27,684,411 (GRCm39) splice site probably null
R4970:Zfp850 UTSW 7 27,689,658 (GRCm39) nonsense probably null
R5112:Zfp850 UTSW 7 27,689,658 (GRCm39) nonsense probably null
R5166:Zfp850 UTSW 7 27,689,781 (GRCm39) nonsense probably null
R5303:Zfp850 UTSW 7 27,707,838 (GRCm39) missense probably damaging 1.00
R5315:Zfp850 UTSW 7 27,689,743 (GRCm39) missense probably benign 0.02
R5496:Zfp850 UTSW 7 27,706,771 (GRCm39) missense probably damaging 0.98
R5677:Zfp850 UTSW 7 27,688,513 (GRCm39) missense probably damaging 1.00
R5927:Zfp850 UTSW 7 27,689,620 (GRCm39) missense probably benign 0.17
R6654:Zfp850 UTSW 7 27,684,640 (GRCm39) nonsense probably null
R6950:Zfp850 UTSW 7 27,689,939 (GRCm39) missense possibly damaging 0.86
R6987:Zfp850 UTSW 7 27,689,426 (GRCm39) missense probably damaging 1.00
R6990:Zfp850 UTSW 7 27,689,801 (GRCm39) missense probably benign 0.09
R7640:Zfp850 UTSW 7 27,688,634 (GRCm39) missense probably benign 0.05
R7856:Zfp850 UTSW 7 27,689,899 (GRCm39) missense probably benign 0.02
R9498:Zfp850 UTSW 7 27,689,275 (GRCm39) missense possibly damaging 0.88
R9506:Zfp850 UTSW 7 27,688,987 (GRCm39) missense possibly damaging 0.82
Z1186:Zfp850 UTSW 7 27,689,704 (GRCm39) missense probably benign 0.00
Z1186:Zfp850 UTSW 7 27,688,549 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGAAGTCTGAAGGCTGACCC -3'
(R):5'- CTGATGTGAAACTATATCAGTGCAAGG -3'

Sequencing Primer
(F):5'- CAGCTCACACTTGAAAGGTTTC -3'
(R):5'- GAATGCGGGAAATTATTTCGTCGAC -3'
Posted On 2016-10-24