Incidental Mutation 'R5561:Mllt10'
ID 436575
Institutional Source Beutler Lab
Gene Symbol Mllt10
Ensembl Gene ENSMUSG00000026743
Gene Name myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms B130021D15Rik, D630001B22Rik, Af10
MMRRC Submission 043118-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.704) question?
Stock # R5561 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 18060048-18217199 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 18114656 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 120 (M120K)
Ref Sequence ENSEMBL: ENSMUSP00000110328 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028076] [ENSMUST00000114671] [ENSMUST00000114680]
AlphaFold O54826
Predicted Effect probably damaging
Transcript: ENSMUST00000028076
AA Change: M120K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000028076
Gene: ENSMUSG00000026743
AA Change: M120K

DomainStartEndE-ValueType
PHD 24 72 8.51e-8 SMART
PHD 136 195 2.92e-6 SMART
low complexity region 217 248 N/A INTRINSIC
low complexity region 258 274 N/A INTRINSIC
low complexity region 308 326 N/A INTRINSIC
low complexity region 352 372 N/A INTRINSIC
low complexity region 490 515 N/A INTRINSIC
low complexity region 581 594 N/A INTRINSIC
low complexity region 609 627 N/A INTRINSIC
low complexity region 674 692 N/A INTRINSIC
coiled coil region 741 782 N/A INTRINSIC
low complexity region 836 879 N/A INTRINSIC
low complexity region 941 952 N/A INTRINSIC
low complexity region 966 986 N/A INTRINSIC
low complexity region 997 1018 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000114671
AA Change: M42K

PolyPhen 2 Score 0.802 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000110319
Gene: ENSMUSG00000026743
AA Change: M42K

DomainStartEndE-ValueType
PHD 58 117 2.92e-6 SMART
low complexity region 139 170 N/A INTRINSIC
low complexity region 180 196 N/A INTRINSIC
low complexity region 230 248 N/A INTRINSIC
low complexity region 274 294 N/A INTRINSIC
low complexity region 412 437 N/A INTRINSIC
low complexity region 503 516 N/A INTRINSIC
low complexity region 531 549 N/A INTRINSIC
low complexity region 596 614 N/A INTRINSIC
coiled coil region 663 704 N/A INTRINSIC
low complexity region 758 801 N/A INTRINSIC
low complexity region 863 874 N/A INTRINSIC
low complexity region 888 908 N/A INTRINSIC
low complexity region 919 940 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000114680
AA Change: M120K

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000110328
Gene: ENSMUSG00000026743
AA Change: M120K

DomainStartEndE-ValueType
PHD 24 72 8.51e-8 SMART
PHD 136 195 2.92e-6 SMART
low complexity region 217 248 N/A INTRINSIC
low complexity region 258 274 N/A INTRINSIC
low complexity region 308 326 N/A INTRINSIC
low complexity region 352 372 N/A INTRINSIC
low complexity region 490 515 N/A INTRINSIC
low complexity region 581 594 N/A INTRINSIC
low complexity region 609 627 N/A INTRINSIC
low complexity region 674 692 N/A INTRINSIC
coiled coil region 741 782 N/A INTRINSIC
low complexity region 836 879 N/A INTRINSIC
low complexity region 941 952 N/A INTRINSIC
low complexity region 966 986 N/A INTRINSIC
low complexity region 997 1018 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133649
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150422
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153279
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154041
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630095N17Rik T C 1: 75,197,181 (GRCm39) probably benign Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Adgrv1 A G 13: 81,624,683 (GRCm39) L3762P probably damaging Het
Amn1 G A 6: 149,086,522 (GRCm39) R4W probably damaging Het
Atxn1 G T 13: 45,720,347 (GRCm39) T516N possibly damaging Het
Atxn7 A T 14: 14,089,260 (GRCm38) T259S probably benign Het
Bsn C G 9: 107,982,710 (GRCm39) R3681P unknown Het
C8b T C 4: 104,641,645 (GRCm39) Y194H possibly damaging Het
Ccdc110 T G 8: 46,393,646 (GRCm39) S119R probably benign Het
Ccdc202 C A 14: 96,119,807 (GRCm39) A188E probably benign Het
Ceacam20 A T 7: 19,704,318 (GRCm39) Q123L possibly damaging Het
Clip3 A G 7: 29,998,274 (GRCm39) D240G possibly damaging Het
Col24a1 T C 3: 145,004,588 (GRCm39) F22S probably benign Het
Dlg5 T A 14: 24,227,860 (GRCm39) M354L probably benign Het
Dnajb12 GC G 10: 59,728,574 (GRCm39) probably null Het
Dnase1l3 A G 14: 7,967,847 (GRCm38) V282A probably damaging Het
Dnhd1 G A 7: 105,364,028 (GRCm39) G4127S probably damaging Het
Eed G A 7: 89,617,001 (GRCm39) R165W probably damaging Het
Ephb2 C T 4: 136,388,717 (GRCm39) V627M probably damaging Het
Fancc T C 13: 63,465,201 (GRCm39) E502G possibly damaging Het
Fbf1 T C 11: 116,048,646 (GRCm39) D105G probably damaging Het
Fer T A 17: 64,344,580 (GRCm39) Y246* probably null Het
Fer1l6 A G 15: 58,532,674 (GRCm39) K1792E probably damaging Het
Foxi2 A G 7: 135,013,376 (GRCm39) D202G probably damaging Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
H2-DMb2 G T 17: 34,364,445 (GRCm39) probably null Het
Helq G T 5: 100,934,916 (GRCm39) D491E probably benign Het
Hgsnat A G 8: 26,436,362 (GRCm39) V564A possibly damaging Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hs3st5 T A 10: 36,709,425 (GRCm39) V320D probably damaging Het
Ifit1bl1 A T 19: 34,571,197 (GRCm39) L420* probably null Het
Ift80 T G 3: 68,875,196 (GRCm39) N178T probably benign Het
Ing4 C T 6: 125,024,023 (GRCm39) T89I possibly damaging Het
Lcp1 G A 14: 75,449,948 (GRCm39) D386N probably benign Het
Mdc1 T A 17: 36,159,438 (GRCm39) I606K probably benign Het
Morc1 G T 16: 48,269,711 (GRCm39) L89F probably benign Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Nav3 C A 10: 109,552,413 (GRCm39) D1810Y probably damaging Het
Obscn G A 11: 58,926,919 (GRCm39) T5532M probably damaging Het
Opn3 C T 1: 175,493,153 (GRCm39) R137H probably damaging Het
Or12j2 C T 7: 139,916,065 (GRCm39) Q97* probably null Het
Or2d36 A G 7: 106,747,297 (GRCm39) N258S probably benign Het
Palld G A 8: 61,969,619 (GRCm39) A993V probably damaging Het
Ppp1r12c A T 7: 4,489,355 (GRCm39) probably null Het
Prdm4 TCTCCTCCT TCTCCT 10: 85,728,987 (GRCm39) probably null Het
Rapgef2 A T 3: 78,995,950 (GRCm39) probably null Het
Ring1 T C 17: 34,240,432 (GRCm39) E382G possibly damaging Het
Rpl22l1 T A 3: 28,860,969 (GRCm39) N61K probably benign Het
Rpp14 A G 14: 8,090,558 (GRCm38) probably null Het
Rusc2 C T 4: 43,415,932 (GRCm39) Q413* probably null Het
Slco3a1 A G 7: 73,968,247 (GRCm39) I491T possibly damaging Het
Smtnl1 C T 2: 84,648,739 (GRCm39) V172I probably benign Het
Spats2l T A 1: 57,939,780 (GRCm39) probably null Het
Spire1 T A 18: 67,639,716 (GRCm39) N266Y probably damaging Het
Stox2 T C 8: 47,646,041 (GRCm39) H473R probably damaging Het
Syne2 C T 12: 76,141,232 (GRCm39) R121* probably null Het
Synrg G A 11: 83,893,066 (GRCm39) probably null Het
Tm9sf1 C T 14: 55,875,554 (GRCm39) V397M probably damaging Het
Trabd T C 15: 88,966,187 (GRCm39) M48T probably benign Het
Ttn T A 2: 76,537,577 (GRCm39) I26457F possibly damaging Het
Uggt2 C T 14: 119,278,939 (GRCm39) R856Q probably benign Het
Ugt1a5 T A 1: 88,094,039 (GRCm39) M89K probably benign Het
Vmn2r53 A T 7: 12,335,347 (GRCm39) S104R probably damaging Het
Zdhhc12 A T 2: 29,982,496 (GRCm39) L53Q probably null Het
Other mutations in Mllt10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01646:Mllt10 APN 2 18,127,128 (GRCm39) missense probably damaging 1.00
IGL02366:Mllt10 APN 2 18,069,898 (GRCm39) missense probably damaging 0.99
IGL02990:Mllt10 APN 2 18,128,522 (GRCm39) splice site probably benign
IGL03034:Mllt10 APN 2 18,069,847 (GRCm39) start codon destroyed probably null 0.55
R0348:Mllt10 UTSW 2 18,167,424 (GRCm39) missense probably damaging 1.00
R0487:Mllt10 UTSW 2 18,211,948 (GRCm39) missense probably damaging 0.98
R0492:Mllt10 UTSW 2 18,151,698 (GRCm39) splice site probably benign
R0518:Mllt10 UTSW 2 18,076,017 (GRCm39) critical splice donor site probably null
R0720:Mllt10 UTSW 2 18,201,406 (GRCm39) missense probably benign
R0733:Mllt10 UTSW 2 18,208,577 (GRCm39) intron probably benign
R1532:Mllt10 UTSW 2 18,097,646 (GRCm39) critical splice donor site probably null
R1665:Mllt10 UTSW 2 18,213,601 (GRCm39) missense possibly damaging 0.93
R1768:Mllt10 UTSW 2 18,167,657 (GRCm39) missense probably damaging 1.00
R2098:Mllt10 UTSW 2 18,167,464 (GRCm39) missense possibly damaging 0.50
R2114:Mllt10 UTSW 2 18,167,380 (GRCm39) missense probably benign
R2116:Mllt10 UTSW 2 18,167,380 (GRCm39) missense probably benign
R2117:Mllt10 UTSW 2 18,167,380 (GRCm39) missense probably benign
R2179:Mllt10 UTSW 2 18,215,604 (GRCm39) missense probably damaging 1.00
R2192:Mllt10 UTSW 2 18,211,871 (GRCm39) missense probably benign 0.11
R2510:Mllt10 UTSW 2 18,069,935 (GRCm39) missense possibly damaging 0.94
R2511:Mllt10 UTSW 2 18,069,935 (GRCm39) missense possibly damaging 0.94
R4669:Mllt10 UTSW 2 18,208,444 (GRCm39) missense probably damaging 1.00
R5004:Mllt10 UTSW 2 18,175,079 (GRCm39) missense probably damaging 1.00
R5072:Mllt10 UTSW 2 18,114,685 (GRCm39) missense possibly damaging 0.72
R5187:Mllt10 UTSW 2 18,213,585 (GRCm39) nonsense probably null
R6141:Mllt10 UTSW 2 18,215,604 (GRCm39) missense probably damaging 1.00
R6352:Mllt10 UTSW 2 18,128,604 (GRCm39) missense probably damaging 1.00
R6844:Mllt10 UTSW 2 18,164,294 (GRCm39) missense probably benign 0.02
R7060:Mllt10 UTSW 2 18,164,371 (GRCm39) missense possibly damaging 0.64
R7464:Mllt10 UTSW 2 18,175,090 (GRCm39) missense probably benign
R7691:Mllt10 UTSW 2 18,208,423 (GRCm39) missense probably null 0.94
R7691:Mllt10 UTSW 2 18,208,422 (GRCm39) missense possibly damaging 0.94
R7937:Mllt10 UTSW 2 18,210,895 (GRCm39) missense probably damaging 1.00
R7956:Mllt10 UTSW 2 18,175,068 (GRCm39) missense probably benign 0.01
R7976:Mllt10 UTSW 2 18,167,214 (GRCm39) missense possibly damaging 0.94
R8079:Mllt10 UTSW 2 18,128,567 (GRCm39) missense probably damaging 0.99
R8084:Mllt10 UTSW 2 18,114,637 (GRCm39) missense probably damaging 0.99
R8518:Mllt10 UTSW 2 18,151,670 (GRCm39) missense probably damaging 0.99
R8768:Mllt10 UTSW 2 18,167,583 (GRCm39) missense probably damaging 1.00
R8826:Mllt10 UTSW 2 18,167,353 (GRCm39) missense probably benign 0.10
R8850:Mllt10 UTSW 2 18,201,469 (GRCm39) missense probably benign 0.33
R8932:Mllt10 UTSW 2 18,128,617 (GRCm39) missense probably benign 0.31
R9009:Mllt10 UTSW 2 18,167,163 (GRCm39) missense probably damaging 0.96
R9129:Mllt10 UTSW 2 18,167,404 (GRCm39) missense probably benign 0.41
R9514:Mllt10 UTSW 2 18,164,322 (GRCm39) missense probably damaging 1.00
R9602:Mllt10 UTSW 2 18,211,850 (GRCm39) missense probably damaging 1.00
R9706:Mllt10 UTSW 2 18,151,655 (GRCm39) missense possibly damaging 0.50
Z1177:Mllt10 UTSW 2 18,175,887 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- CAGCAGCCAGAGTTTTATTACGG -3'
(R):5'- GCAAGAGGTCAGTAAATCTTCAAAG -3'

Sequencing Primer
(F):5'- CAGCCAGAGTTTTATTACGGTTTTG -3'
(R):5'- GGCTCAAGATGGTAACTATTTTTCTC -3'
Posted On 2016-10-24