Incidental Mutation 'R5562:Or5w1b'
ID 436649
Institutional Source Beutler Lab
Gene Symbol Or5w1b
Ensembl Gene ENSMUSG00000075155
Gene Name olfactory receptor family 5 subfamily W member 1B
Synonyms GA_x6K02T2Q125-49151278-49150337, Olfr1133, MOR176-2
MMRRC Submission 043119-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R5562 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 87475524-87476465 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87476063 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 135 (I135V)
Ref Sequence ENSEMBL: ENSMUSP00000149460 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099855] [ENSMUST00000217368]
AlphaFold Q7TR44
Predicted Effect probably benign
Transcript: ENSMUST00000099855
AA Change: I135V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000097441
Gene: ENSMUSG00000075155
AA Change: I135V

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
Pfam:7tm_4 32 308 7e-51 PFAM
Pfam:7tm_1 42 291 1.8e-15 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118805
Predicted Effect probably benign
Transcript: ENSMUST00000217368
AA Change: I135V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1a7 G A 19: 20,679,628 (GRCm39) Q383* probably null Het
Alkbh3 A T 2: 93,826,724 (GRCm39) probably null Het
Amotl1 G A 9: 14,486,593 (GRCm39) P434S possibly damaging Het
Arfgef1 T C 1: 10,214,971 (GRCm39) E1641G probably damaging Het
Arih2 T C 9: 108,484,546 (GRCm39) T422A probably damaging Het
C7 A T 15: 5,061,397 (GRCm39) Y317* probably null Het
Car4 A T 11: 84,854,924 (GRCm39) M91L probably benign Het
Ccdc7a T C 8: 129,785,266 (GRCm39) D98G possibly damaging Het
Cdc25b A G 2: 131,036,678 (GRCm39) M493V probably damaging Het
Cdhr3 C G 12: 33,101,054 (GRCm39) R452T probably benign Het
Col6a2 G A 10: 76,435,509 (GRCm39) Q909* probably null Het
Cyp2j8 A G 4: 96,358,890 (GRCm39) I343T probably damaging Het
Dcstamp G A 15: 39,617,798 (GRCm39) C69Y possibly damaging Het
Dnaaf8 C A 16: 4,791,940 (GRCm39) noncoding transcript Het
Efhc1 C T 1: 21,043,104 (GRCm39) T341I probably damaging Het
Elovl2 A G 13: 41,338,772 (GRCm39) *276Q probably null Het
Fnip1 T A 11: 54,380,168 (GRCm39) probably null Het
Foxc1 A G 13: 31,991,573 (GRCm39) H128R probably damaging Het
Gpr107 C T 2: 31,042,375 (GRCm39) A2V probably damaging Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Kif15 A T 9: 122,807,081 (GRCm39) Q44H probably damaging Het
Masp1 T C 16: 23,283,917 (GRCm39) probably null Het
Muc5b T C 7: 141,400,975 (GRCm39) I530T unknown Het
Ncoa4-ps T A 12: 119,225,957 (GRCm39) noncoding transcript Het
Nherf2 A G 17: 24,860,798 (GRCm39) V137A probably benign Het
Nudt7 C A 8: 114,874,723 (GRCm39) A93D probably damaging Het
Pcdha8 A G 18: 37,126,024 (GRCm39) T169A possibly damaging Het
Prnp A G 2: 131,778,951 (GRCm39) D201G probably damaging Het
Serinc1 G A 10: 57,400,147 (GRCm39) Q167* probably null Het
Slc13a5 A G 11: 72,152,865 (GRCm39) V35A probably damaging Het
Slc30a6 C T 17: 74,719,700 (GRCm39) T220I possibly damaging Het
Slc7a7 T A 14: 54,646,269 (GRCm39) M65L probably benign Het
Speg T A 1: 75,403,700 (GRCm39) L2627Q probably damaging Het
Tank A G 2: 61,480,552 (GRCm39) T363A possibly damaging Het
Taok3 T A 5: 117,389,029 (GRCm39) L478Q probably damaging Het
Trim55 A T 3: 19,713,317 (GRCm39) M123L probably benign Het
Trpm2 A G 10: 77,795,773 (GRCm39) V118A possibly damaging Het
Ttn A T 2: 76,600,803 (GRCm39) Y17114N probably damaging Het
Unc5c A G 3: 141,474,291 (GRCm39) T214A probably damaging Het
Ush2a T A 1: 188,308,414 (GRCm39) V2021E probably damaging Het
Utp4 G A 8: 107,649,557 (GRCm39) D669N probably benign Het
Zfp560 G T 9: 20,261,883 (GRCm39) Y89* probably null Het
Zfp64 A G 2: 168,767,642 (GRCm39) S657P probably benign Het
Other mutations in Or5w1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02377:Or5w1b APN 2 87,475,630 (GRCm39) missense probably damaging 1.00
IGL03354:Or5w1b APN 2 87,475,939 (GRCm39) missense probably damaging 0.99
PIT4366001:Or5w1b UTSW 2 87,475,534 (GRCm39) nonsense probably null
R1375:Or5w1b UTSW 2 87,476,081 (GRCm39) missense probably damaging 1.00
R1413:Or5w1b UTSW 2 87,476,182 (GRCm39) missense probably benign 0.02
R2011:Or5w1b UTSW 2 87,476,233 (GRCm39) missense probably damaging 0.97
R2016:Or5w1b UTSW 2 87,476,396 (GRCm39) missense probably benign 0.18
R2026:Or5w1b UTSW 2 87,475,753 (GRCm39) missense probably damaging 1.00
R2106:Or5w1b UTSW 2 87,475,895 (GRCm39) missense probably damaging 1.00
R4393:Or5w1b UTSW 2 87,476,256 (GRCm39) nonsense probably null
R5292:Or5w1b UTSW 2 87,476,339 (GRCm39) missense probably damaging 1.00
R5631:Or5w1b UTSW 2 87,475,952 (GRCm39) missense probably benign 0.16
R5632:Or5w1b UTSW 2 87,475,573 (GRCm39) missense probably damaging 1.00
R6801:Or5w1b UTSW 2 87,475,667 (GRCm39) missense probably benign 0.23
R7014:Or5w1b UTSW 2 87,476,320 (GRCm39) missense probably damaging 1.00
R7963:Or5w1b UTSW 2 87,475,769 (GRCm39) missense probably benign 0.16
R8769:Or5w1b UTSW 2 87,475,960 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGTGACAATGCTACACCCTACC -3'
(R):5'- TCTCCAAAGATGCTGGCTG -3'

Sequencing Primer
(F):5'- CATTGATGGATGTATCTGAGCAG -3'
(R):5'- CCAAAGATGCTGGCTGATTTC -3'
Posted On 2016-10-24