Incidental Mutation 'R5577:Lcn9'
ID 437245
Institutional Source Beutler Lab
Gene Symbol Lcn9
Ensembl Gene ENSMUSG00000023210
Gene Name lipocalin 9
Synonyms
MMRRC Submission 043132-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R5577 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 25713165-25715549 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 25713663 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 63 (I63N)
Ref Sequence ENSEMBL: ENSMUSP00000023978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023978]
AlphaFold Q9D267
Predicted Effect probably damaging
Transcript: ENSMUST00000023978
AA Change: I63N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000023978
Gene: ENSMUSG00000023210
AA Change: I63N

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Lipocalin 34 174 6e-37 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the lipocalin family, such as LCN9, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130023H24Rik A C 7: 127,835,826 (GRCm39) Y256D probably damaging Het
Acr C A 15: 89,458,441 (GRCm39) T374K probably benign Het
Akt2 G A 7: 27,335,731 (GRCm39) G335R probably damaging Het
Ccn3 T A 15: 54,615,897 (GRCm39) I354N possibly damaging Het
Cd177 A T 7: 24,444,562 (GRCm39) F673Y probably damaging Het
Clmn G T 12: 104,743,329 (GRCm39) S879R probably damaging Het
Csrp3 T C 7: 48,489,225 (GRCm39) H19R possibly damaging Het
Dmkn T C 7: 30,463,971 (GRCm39) S137P probably damaging Het
Eno1 C A 4: 150,331,067 (GRCm39) Y236* probably null Het
Enpp7 T A 11: 118,882,953 (GRCm39) N342K probably benign Het
Fancm T A 12: 65,177,185 (GRCm39) probably benign Het
Fshr A T 17: 89,293,351 (GRCm39) D442E probably benign Het
Gm3898 T A 9: 43,741,362 (GRCm39) noncoding transcript Het
Hdac7 A T 15: 97,709,336 (GRCm39) S43T probably benign Het
Herc1 T C 9: 66,389,263 (GRCm39) C3927R probably damaging Het
Klc4 G T 17: 46,946,355 (GRCm39) A490D probably damaging Het
Lgalsl G A 11: 20,779,316 (GRCm39) Q110* probably null Het
Lrp1b A T 2: 40,765,135 (GRCm39) M2783K possibly damaging Het
Lrrk2 A T 15: 91,649,948 (GRCm39) Y1695F probably damaging Het
Myo1e G A 9: 70,277,753 (GRCm39) E817K probably benign Het
Nav3 A T 10: 109,605,264 (GRCm39) D936E probably damaging Het
Necab3 T C 2: 154,387,076 (GRCm39) probably null Het
Nlrp1a T A 11: 70,990,400 (GRCm39) I951F probably damaging Het
Or5v1 T A 17: 37,810,493 (GRCm39) I317K probably benign Het
Or8b52 A G 9: 38,576,297 (GRCm39) I281T possibly damaging Het
Ppp2r5d T C 17: 46,998,901 (GRCm39) S54G probably benign Het
Prdx6 A G 1: 161,071,255 (GRCm39) S146P probably damaging Het
Sec24a A T 11: 51,625,448 (GRCm39) H258Q probably benign Het
Sec31a T C 5: 100,550,133 (GRCm39) T194A possibly damaging Het
Sqstm1 T C 11: 50,098,266 (GRCm39) I167V probably benign Het
Tas1r3 T C 4: 155,946,522 (GRCm39) E361G probably benign Het
Tlr1 T A 5: 65,083,428 (GRCm39) Q383L possibly damaging Het
Trappc8 G C 18: 20,969,836 (GRCm39) Y1051* probably null Het
Vmn2r2 T A 3: 64,024,416 (GRCm39) M722L probably benign Het
Vmn2r43 T C 7: 8,247,811 (GRCm39) H784R probably damaging Het
Zfp534 T G 4: 147,759,173 (GRCm39) K499Q probably damaging Het
Other mutations in Lcn9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01952:Lcn9 APN 2 25,714,550 (GRCm39) missense probably damaging 1.00
IGL02417:Lcn9 APN 2 25,713,692 (GRCm39) missense possibly damaging 0.91
PIT4418001:Lcn9 UTSW 2 25,714,553 (GRCm39) missense probably damaging 1.00
R1479:Lcn9 UTSW 2 25,713,715 (GRCm39) splice site probably benign
R1657:Lcn9 UTSW 2 25,714,722 (GRCm39) missense probably benign 0.17
R4199:Lcn9 UTSW 2 25,714,773 (GRCm39) missense probably benign 0.15
R4526:Lcn9 UTSW 2 25,714,520 (GRCm39) missense possibly damaging 0.85
R4570:Lcn9 UTSW 2 25,713,591 (GRCm39) missense probably benign 0.04
R5232:Lcn9 UTSW 2 25,714,067 (GRCm39) critical splice donor site probably null
R5849:Lcn9 UTSW 2 25,713,268 (GRCm39) critical splice donor site probably null
R6059:Lcn9 UTSW 2 25,714,737 (GRCm39) missense possibly damaging 0.62
R7748:Lcn9 UTSW 2 25,714,926 (GRCm39) makesense probably null
R9257:Lcn9 UTSW 2 25,714,784 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TCACCCAGGATTGAGACTGTG -3'
(R):5'- GGGCCTTTCAGCTTAACTCAC -3'

Sequencing Primer
(F):5'- ACTGTGAGGGCCAAGCAGTC -3'
(R):5'- CCATCATGCTGATCTGCAGG -3'
Posted On 2016-10-26