Incidental Mutation 'R5577:Tas1r3'
ID 437249
Institutional Source Beutler Lab
Gene Symbol Tas1r3
Ensembl Gene ENSMUSG00000029072
Gene Name taste receptor, type 1, member 3
Synonyms T1r3
MMRRC Submission 043132-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R5577 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 155943725-155947810 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 155946522 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 361 (E361G)
Ref Sequence ENSEMBL: ENSMUSP00000030949 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030948] [ENSMUST00000030949] [ENSMUST00000030950] [ENSMUST00000151961] [ENSMUST00000168552]
AlphaFold Q925D8
Predicted Effect probably benign
Transcript: ENSMUST00000030948
SMART Domains Protein: ENSMUSP00000030948
Gene: ENSMUSG00000029071

DomainStartEndE-ValueType
DAX 1 85 2.17e-52 SMART
Pfam:Dishevelled 144 215 1.1e-31 PFAM
low complexity region 217 233 N/A INTRINSIC
low complexity region 235 246 N/A INTRINSIC
PDZ 260 339 3.13e-16 SMART
low complexity region 380 397 N/A INTRINSIC
DEP 425 499 1.47e-26 SMART
Pfam:Dsh_C 503 685 4.2e-67 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000030949
AA Change: E361G

PolyPhen 2 Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000030949
Gene: ENSMUSG00000029072
AA Change: E361G

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:ANF_receptor 72 469 2e-79 PFAM
Pfam:NCD3G 500 552 1.9e-16 PFAM
Pfam:7tm_3 576 821 9.6e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000030950
SMART Domains Protein: ENSMUSP00000030950
Gene: ENSMUSG00000029073

DomainStartEndE-ValueType
Pfam:GLTP 27 179 1.4e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133184
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141539
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143457
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156997
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156266
Predicted Effect probably benign
Transcript: ENSMUST00000151961
SMART Domains Protein: ENSMUSP00000115935
Gene: ENSMUSG00000029073

DomainStartEndE-ValueType
Pfam:GLTP 25 181 1.9e-49 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000168552
SMART Domains Protein: ENSMUSP00000133137
Gene: ENSMUSG00000029071

DomainStartEndE-ValueType
DAX 1 85 2.17e-52 SMART
Pfam:Dishevelled 90 247 1.7e-60 PFAM
PDZ 260 339 3.13e-16 SMART
low complexity region 380 397 N/A INTRINSIC
DEP 425 499 1.47e-26 SMART
Pfam:Dsh_C 503 685 7.6e-59 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G-protein coupled receptor involved in taste responses. The encoded protein can form a heterodimeric receptor with TAS1R1 to elicit the umami taste response, or it can bind with TAS1R2 to form a receptor for the sweet taste response. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mutation of this locus affects taste perception. Complete inactivation results in diminished behavioral and nervous repsonses to both sweet and umami tastants. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130023H24Rik A C 7: 127,835,826 (GRCm39) Y256D probably damaging Het
Acr C A 15: 89,458,441 (GRCm39) T374K probably benign Het
Akt2 G A 7: 27,335,731 (GRCm39) G335R probably damaging Het
Ccn3 T A 15: 54,615,897 (GRCm39) I354N possibly damaging Het
Cd177 A T 7: 24,444,562 (GRCm39) F673Y probably damaging Het
Clmn G T 12: 104,743,329 (GRCm39) S879R probably damaging Het
Csrp3 T C 7: 48,489,225 (GRCm39) H19R possibly damaging Het
Dmkn T C 7: 30,463,971 (GRCm39) S137P probably damaging Het
Eno1 C A 4: 150,331,067 (GRCm39) Y236* probably null Het
Enpp7 T A 11: 118,882,953 (GRCm39) N342K probably benign Het
Fancm T A 12: 65,177,185 (GRCm39) probably benign Het
Fshr A T 17: 89,293,351 (GRCm39) D442E probably benign Het
Gm3898 T A 9: 43,741,362 (GRCm39) noncoding transcript Het
Hdac7 A T 15: 97,709,336 (GRCm39) S43T probably benign Het
Herc1 T C 9: 66,389,263 (GRCm39) C3927R probably damaging Het
Klc4 G T 17: 46,946,355 (GRCm39) A490D probably damaging Het
Lcn9 T A 2: 25,713,663 (GRCm39) I63N probably damaging Het
Lgalsl G A 11: 20,779,316 (GRCm39) Q110* probably null Het
Lrp1b A T 2: 40,765,135 (GRCm39) M2783K possibly damaging Het
Lrrk2 A T 15: 91,649,948 (GRCm39) Y1695F probably damaging Het
Myo1e G A 9: 70,277,753 (GRCm39) E817K probably benign Het
Nav3 A T 10: 109,605,264 (GRCm39) D936E probably damaging Het
Necab3 T C 2: 154,387,076 (GRCm39) probably null Het
Nlrp1a T A 11: 70,990,400 (GRCm39) I951F probably damaging Het
Or5v1 T A 17: 37,810,493 (GRCm39) I317K probably benign Het
Or8b52 A G 9: 38,576,297 (GRCm39) I281T possibly damaging Het
Ppp2r5d T C 17: 46,998,901 (GRCm39) S54G probably benign Het
Prdx6 A G 1: 161,071,255 (GRCm39) S146P probably damaging Het
Sec24a A T 11: 51,625,448 (GRCm39) H258Q probably benign Het
Sec31a T C 5: 100,550,133 (GRCm39) T194A possibly damaging Het
Sqstm1 T C 11: 50,098,266 (GRCm39) I167V probably benign Het
Tlr1 T A 5: 65,083,428 (GRCm39) Q383L possibly damaging Het
Trappc8 G C 18: 20,969,836 (GRCm39) Y1051* probably null Het
Vmn2r2 T A 3: 64,024,416 (GRCm39) M722L probably benign Het
Vmn2r43 T C 7: 8,247,811 (GRCm39) H784R probably damaging Het
Zfp534 T G 4: 147,759,173 (GRCm39) K499Q probably damaging Het
Other mutations in Tas1r3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01356:Tas1r3 APN 4 155,945,784 (GRCm39) missense probably benign 0.43
IGL01587:Tas1r3 APN 4 155,945,816 (GRCm39) missense probably damaging 0.99
IGL02314:Tas1r3 APN 4 155,945,119 (GRCm39) missense probably damaging 1.00
IGL02747:Tas1r3 APN 4 155,944,917 (GRCm39) missense possibly damaging 0.92
IGL02999:Tas1r3 APN 4 155,946,816 (GRCm39) missense probably damaging 0.97
IGL03026:Tas1r3 APN 4 155,946,300 (GRCm39) unclassified probably benign
IGL03407:Tas1r3 APN 4 155,946,439 (GRCm39) splice site probably null
R0122:Tas1r3 UTSW 4 155,945,290 (GRCm39) missense probably benign
R0827:Tas1r3 UTSW 4 155,945,326 (GRCm39) missense probably benign 0.02
R1700:Tas1r3 UTSW 4 155,946,027 (GRCm39) missense probably benign
R1803:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R1804:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R1883:Tas1r3 UTSW 4 155,946,610 (GRCm39) missense probably damaging 1.00
R1998:Tas1r3 UTSW 4 155,947,377 (GRCm39) missense probably damaging 1.00
R2061:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R2104:Tas1r3 UTSW 4 155,946,588 (GRCm39) missense probably benign 0.26
R2127:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R2129:Tas1r3 UTSW 4 155,944,927 (GRCm39) missense probably damaging 0.99
R2237:Tas1r3 UTSW 4 155,946,675 (GRCm39) missense possibly damaging 0.58
R2316:Tas1r3 UTSW 4 155,947,772 (GRCm39) missense probably benign
R2847:Tas1r3 UTSW 4 155,944,659 (GRCm39) missense probably benign 0.08
R3619:Tas1r3 UTSW 4 155,945,410 (GRCm39) missense probably damaging 0.99
R3870:Tas1r3 UTSW 4 155,945,810 (GRCm39) missense probably damaging 1.00
R4194:Tas1r3 UTSW 4 155,947,442 (GRCm39) missense probably damaging 1.00
R4195:Tas1r3 UTSW 4 155,947,442 (GRCm39) missense probably damaging 1.00
R4420:Tas1r3 UTSW 4 155,946,789 (GRCm39) missense probably damaging 0.99
R6734:Tas1r3 UTSW 4 155,945,257 (GRCm39) missense probably damaging 1.00
R7006:Tas1r3 UTSW 4 155,947,361 (GRCm39) missense possibly damaging 0.93
R7231:Tas1r3 UTSW 4 155,947,283 (GRCm39) missense probably damaging 1.00
R7490:Tas1r3 UTSW 4 155,946,480 (GRCm39) missense probably damaging 0.97
R7895:Tas1r3 UTSW 4 155,947,005 (GRCm39) missense probably damaging 1.00
R8701:Tas1r3 UTSW 4 155,945,503 (GRCm39) missense probably benign 0.00
R8796:Tas1r3 UTSW 4 155,945,848 (GRCm39) missense probably benign 0.15
R8941:Tas1r3 UTSW 4 155,947,600 (GRCm39) critical splice donor site probably null
R9371:Tas1r3 UTSW 4 155,945,059 (GRCm39) missense possibly damaging 0.75
R9576:Tas1r3 UTSW 4 155,946,822 (GRCm39) missense probably benign
R9743:Tas1r3 UTSW 4 155,945,256 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACCTGCCAGGGTAGAACATG -3'
(R):5'- TGAGTCTTGGCTGACATCTGAC -3'

Sequencing Primer
(F):5'- GAACATGTTCTGATACGTGGCAATG -3'
(R):5'- GACATCTGACCTGGTCATGAC -3'
Posted On 2016-10-26