Incidental Mutation 'R5592:Cysltr2'
ID 437591
Institutional Source Beutler Lab
Gene Symbol Cysltr2
Ensembl Gene ENSMUSG00000033470
Gene Name cysteinyl leukotriene receptor 2
Synonyms CysLT2, 2300001H05Rik, Cyslt2, CYSLT2R
MMRRC Submission 043144-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R5592 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 73263043-73286554 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73266931 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 260 (K260E)
Ref Sequence ENSEMBL: ENSMUSP00000125958 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044664] [ENSMUST00000169168]
AlphaFold Q920A1
Predicted Effect probably benign
Transcript: ENSMUST00000044664
AA Change: K260E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000040715
Gene: ENSMUSG00000033470
AA Change: K260E

DomainStartEndE-ValueType
Pfam:TAS2R 18 307 1.6e-8 PFAM
Pfam:7tm_1 39 289 2.5e-50 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000169168
AA Change: K260E

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000125958
Gene: ENSMUSG00000033470
AA Change: K260E

DomainStartEndE-ValueType
Pfam:TAS2R 18 307 1.4e-8 PFAM
Pfam:7tm_1 39 289 1.3e-43 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226727
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228154
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.8%
  • 20x: 96.7%
Validation Efficiency 100% (48/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display reduced bleomycin-induced pulmonary fibrosis and reduced IgE dependent passive cutaneous anaphylaxis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630001G21Rik A T 1: 85,654,332 (GRCm39) F2I probably damaging Het
Adam17 C T 12: 21,384,138 (GRCm39) S454N probably damaging Het
Adcy1 A T 11: 7,089,088 (GRCm39) K501* probably null Het
Arhgap28 A T 17: 68,165,267 (GRCm39) M543K probably damaging Het
Art3 T A 5: 92,540,679 (GRCm39) Y141N probably damaging Het
Ccdc38 C T 10: 93,386,064 (GRCm39) T60I possibly damaging Het
Crmp1 A C 5: 37,422,609 (GRCm39) I139L probably benign Het
Cul9 G A 17: 46,831,517 (GRCm39) L1566F probably benign Het
Drd1 A T 13: 54,208,190 (GRCm39) M1K probably null Het
Flii T G 11: 60,611,225 (GRCm39) M449L probably benign Het
Galnt16 T C 12: 80,635,293 (GRCm39) V343A probably damaging Het
Gimap4 A T 6: 48,668,092 (GRCm39) E154D probably damaging Het
Glmp T G 3: 88,233,333 (GRCm39) probably benign Het
Glt1d1 A T 5: 127,734,183 (GRCm39) D119V probably benign Het
Gm5930 C T 14: 44,568,886 (GRCm39) M245I probably benign Het
Golgb1 T A 16: 36,746,125 (GRCm39) H2901Q probably benign Het
Krt12 C T 11: 99,311,650 (GRCm39) V184I probably benign Het
Lyst T G 13: 13,917,918 (GRCm39) I3326S probably damaging Het
Mier3 T A 13: 111,843,195 (GRCm39) Y182* probably null Het
Mlip G A 9: 77,137,764 (GRCm39) S381L probably damaging Het
Mmp25 A G 17: 23,859,176 (GRCm39) V157A possibly damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Ms4a6c A G 19: 11,458,496 (GRCm39) probably benign Het
Ms4a6c A G 19: 11,457,641 (GRCm39) probably benign Het
Muc19 T C 15: 91,828,199 (GRCm39) noncoding transcript Het
Mucl3 T C 17: 35,954,535 (GRCm39) Y9C probably damaging Het
Mycbp2 C A 14: 103,432,113 (GRCm39) M2308I probably benign Het
Myo1a G T 10: 127,549,908 (GRCm39) V463F probably damaging Het
Ogdh A T 11: 6,266,763 (GRCm39) probably null Het
Or52h9 A T 7: 104,202,938 (GRCm39) N271Y probably benign Het
Or5l14 A G 2: 87,792,684 (GRCm39) L184P probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Paip1 C A 13: 119,587,334 (GRCm39) D124E probably damaging Het
Pdcd11 T A 19: 47,091,164 (GRCm39) N379K probably benign Het
Pitpnm2 T C 5: 124,280,212 (GRCm39) E112G probably damaging Het
Prrg4 T C 2: 104,663,123 (GRCm39) Y161C probably benign Het
Rb1 A G 14: 73,449,187 (GRCm39) Y648H probably damaging Het
Rpa3 A T 6: 8,257,694 (GRCm39) M56K probably benign Het
Scarf1 A T 11: 75,416,513 (GRCm39) T652S probably benign Het
Slc16a5 A G 11: 115,363,608 (GRCm39) K423R probably benign Het
Sptan1 C T 2: 29,876,731 (GRCm39) probably benign Het
Ssrp1 T C 2: 84,875,863 (GRCm39) I574T probably benign Het
Synm A G 7: 67,409,264 (GRCm39) L38P probably damaging Het
Ubqln4 T G 3: 88,464,171 (GRCm39) M224R probably damaging Het
Uroc1 A G 6: 90,332,326 (GRCm39) N561S probably damaging Het
Vav1 A G 17: 57,611,835 (GRCm39) Y483C probably benign Het
Vps13a G A 19: 16,702,935 (GRCm39) L673F probably damaging Het
Zfp418 G T 7: 7,184,314 (GRCm39) K92N possibly damaging Het
Other mutations in Cysltr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03211:Cysltr2 APN 14 73,267,155 (GRCm39) missense possibly damaging 0.90
R1223:Cysltr2 UTSW 14 73,267,539 (GRCm39) missense probably damaging 1.00
R1689:Cysltr2 UTSW 14 73,267,470 (GRCm39) missense possibly damaging 0.75
R1695:Cysltr2 UTSW 14 73,267,321 (GRCm39) missense probably benign 0.01
R1898:Cysltr2 UTSW 14 73,266,973 (GRCm39) missense probably damaging 1.00
R3968:Cysltr2 UTSW 14 73,267,614 (GRCm39) missense probably damaging 0.99
R4013:Cysltr2 UTSW 14 73,267,005 (GRCm39) missense probably damaging 1.00
R4357:Cysltr2 UTSW 14 73,267,084 (GRCm39) missense probably benign 0.15
R4444:Cysltr2 UTSW 14 73,267,333 (GRCm39) missense possibly damaging 0.74
R4445:Cysltr2 UTSW 14 73,267,333 (GRCm39) missense possibly damaging 0.74
R5207:Cysltr2 UTSW 14 73,266,951 (GRCm39) missense probably damaging 0.99
R5591:Cysltr2 UTSW 14 73,266,931 (GRCm39) missense probably benign 0.00
R5593:Cysltr2 UTSW 14 73,266,931 (GRCm39) missense probably benign 0.00
R5839:Cysltr2 UTSW 14 73,267,623 (GRCm39) missense probably damaging 1.00
R5885:Cysltr2 UTSW 14 73,266,931 (GRCm39) missense probably benign 0.00
R5886:Cysltr2 UTSW 14 73,266,931 (GRCm39) missense probably benign 0.00
R5934:Cysltr2 UTSW 14 73,266,931 (GRCm39) missense probably benign 0.00
R5940:Cysltr2 UTSW 14 73,267,389 (GRCm39) missense probably damaging 1.00
R5940:Cysltr2 UTSW 14 73,266,931 (GRCm39) missense probably benign 0.00
R7775:Cysltr2 UTSW 14 73,267,203 (GRCm39) missense probably benign 0.00
R7778:Cysltr2 UTSW 14 73,267,203 (GRCm39) missense probably benign 0.00
R7824:Cysltr2 UTSW 14 73,267,203 (GRCm39) missense probably benign 0.00
R7939:Cysltr2 UTSW 14 73,267,399 (GRCm39) missense possibly damaging 0.95
R8719:Cysltr2 UTSW 14 73,267,111 (GRCm39) missense possibly damaging 0.90
R8750:Cysltr2 UTSW 14 73,267,078 (GRCm39) missense probably benign
R9764:Cysltr2 UTSW 14 73,266,906 (GRCm39) missense probably damaging 1.00
X0009:Cysltr2 UTSW 14 73,267,419 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- GCCTGCAGAACAGCTCCTTATAC -3'
(R):5'- TGCTACCTGCTGATCATCCG -3'

Sequencing Primer
(F):5'- TGTTCTTCAGCTACTCACAAACAGG -3'
(R):5'- CATCCGGATCTTGTTAAAGGC -3'
Posted On 2016-10-26