Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00435:Gpr65'

4379

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr65

Ensembl Gene

ENSMUSG00000021886

Gene Name

G-protein coupled receptor 65

Synonyms

TDAG8, Dig1, Gpcr25

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL00435

Quality Score

Status

Chromosome

Chromosomal Location

98234894-98242903 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 98241815 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 156 (E156G)

Ref Sequence

ENSEMBL: ENSMUSP00000074581 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075072]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000075072
AA Change: E156G

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000074581
Gene: ENSMUSG00000021886
AA Change: E156G

Domain	Start	End	E-Value	Type
Pfam:7tm_1	33	290	1.9e-41	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000218404

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219320

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap28	A	T	17: 68,152,796 (GRCm39)	D657E	probably damaging	Het
Cd200l1	A	T	16: 45,264,483 (GRCm39)	L25Q	probably damaging	Het
Cd68	T	C	11: 69,556,676 (GRCm39)	T44A	probably damaging	Het
Cecr2	C	T	6: 120,733,678 (GRCm39)	T555M	probably damaging	Het
Cep170b	A	G	12: 112,701,628 (GRCm39)	Q169R	probably damaging	Het
Cs	T	C	10: 128,195,912 (GRCm39)	F374L	probably damaging	Het
Dpy19l1	T	C	9: 24,393,226 (GRCm39)	E181G	probably damaging	Het
Efcab12	T	C	6: 115,800,625 (GRCm39)	T133A	probably benign	Het
Esr2	G	A	12: 76,180,653 (GRCm39)	R423W	probably damaging	Het
Eya4	T	C	10: 23,034,995 (GRCm39)	Y120C	probably benign	Het
Fbxw8	A	G	5: 118,206,202 (GRCm39)	M582T	probably benign	Het
Fcgbpl1	A	T	7: 27,863,953 (GRCm39)	D2575V	probably damaging	Het
Ghsr	A	G	3: 27,426,532 (GRCm39)	E196G	possibly damaging	Het
Gm10024	G	A	10: 77,547,295 (GRCm39)		probably benign	Het
Gtf3c3	T	C	1: 54,466,694 (GRCm39)	Y249C	possibly damaging	Het
H2-T23	G	A	17: 36,342,673 (GRCm39)	A155V	probably damaging	Het
Hadha	A	G	5: 30,327,171 (GRCm39)	S556P	probably benign	Het
Hdac7	T	A	15: 97,707,376 (GRCm39)	K187N	probably damaging	Het
Inpp5j	T	C	11: 3,452,255 (GRCm39)	I332V	probably benign	Het
Kank1	A	G	19: 25,407,600 (GRCm39)	D1198G	probably benign	Het
Kdr	A	G	5: 76,129,410 (GRCm39)	L159P	probably damaging	Het
Me2	T	C	18: 73,903,713 (GRCm39)	E585G	probably benign	Het
Nfu1	A	T	6: 86,992,577 (GRCm39)	T64S	probably damaging	Het
Nsd3	A	G	8: 26,166,728 (GRCm39)	D632G	probably benign	Het
Pcna	T	C	2: 132,093,852 (GRCm39)	D97G	probably benign	Het
Pgm2	A	G	5: 64,265,612 (GRCm39)		probably benign	Het
Phactr1	C	A	13: 43,110,122 (GRCm39)	R2S	probably damaging	Het
Psmd11	T	A	11: 80,361,210 (GRCm39)	I347N	possibly damaging	Het
Rad21l	T	C	2: 151,495,436 (GRCm39)	T416A	probably benign	Het
Ruvbl2	A	T	7: 45,074,596 (GRCm39)	S181T	probably benign	Het
Rxrb	A	G	17: 34,253,049 (GRCm39)	T109A	probably damaging	Het
Ryr3	T	A	2: 112,490,494 (GRCm39)	Y3785F	probably damaging	Het
Sec16a	T	C	2: 26,320,113 (GRCm39)	T1442A	probably benign	Het
Slc6a14	T	A	X: 21,600,363 (GRCm39)		probably benign	Het
Slco2b1	G	A	7: 99,309,259 (GRCm39)	Q691*	probably null	Het
Tent5c	A	G	3: 100,380,672 (GRCm39)	V28A	probably damaging	Het
Them5	A	G	3: 94,253,496 (GRCm39)	T169A	possibly damaging	Het
Trav13-2	T	C	14: 53,872,688 (GRCm39)	F55L	possibly damaging	Het
Tst	A	T	15: 78,289,661 (GRCm39)	S125T	probably damaging	Het
Ttn	T	C	2: 76,630,868 (GRCm39)	T14179A	probably benign	Het
Vps37b	A	G	5: 124,148,850 (GRCm39)	Y62H	probably damaging	Het

Other mutations in Gpr65

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00717:Gpr65	APN	12	98,242,314 (GRCm39)	missense	probably benign	0.09
IGL01643:Gpr65	APN	12	98,242,013 (GRCm39)	missense	probably damaging	1.00
IGL01942:Gpr65	APN	12	98,241,974 (GRCm39)	missense	possibly damaging	0.93
IGL02023:Gpr65	APN	12	98,242,127 (GRCm39)	missense	probably benign	0.25
IGL02803:Gpr65	APN	12	98,241,469 (GRCm39)	missense	probably damaging	1.00
R1343:Gpr65	UTSW	12	98,241,888 (GRCm39)	missense	probably benign	0.00
R1520:Gpr65	UTSW	12	98,241,434 (GRCm39)	missense	probably benign	0.01
R1771:Gpr65	UTSW	12	98,242,259 (GRCm39)	missense	probably damaging	0.96
R1812:Gpr65	UTSW	12	98,242,001 (GRCm39)	missense	probably damaging	1.00
R2261:Gpr65	UTSW	12	98,241,494 (GRCm39)	missense	probably damaging	1.00
R2263:Gpr65	UTSW	12	98,241,494 (GRCm39)	missense	probably damaging	1.00
R5720:Gpr65	UTSW	12	98,241,361 (GRCm39)	missense	probably damaging	1.00
R7458:Gpr65	UTSW	12	98,242,324 (GRCm39)	missense	probably damaging	0.99
R8136:Gpr65	UTSW	12	98,241,415 (GRCm39)	missense	probably damaging	1.00
R9376:Gpr65	UTSW	12	98,241,523 (GRCm39)	missense	probably damaging	1.00

Posted On

2012-04-20