Mutagenetix > Incidental Mutation

Incidental Mutation 'R5609:Vmn1r73'

437964

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r73

Ensembl Gene

ENSMUSG00000051687

Gene Name

vomeronasal 1 receptor 73

Synonyms

V1rg2

MMRRC Submission

043158-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

R5609 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

11490184-11491095 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 11490591 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Stop codon at position 136 (W136*)

Ref Sequence

ENSEMBL: ENSMUSP00000153827 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055070] [ENSMUST00000226516]

AlphaFold

Q8R293

Predicted Effect

probably null
Transcript: ENSMUST00000055070
AA Change: W136*

SMART Domains

Protein: ENSMUSP00000055353
Gene: ENSMUSG00000051687
AA Change: W136*

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	301	7.5e-7	PFAM
Pfam:V1R	32	297	1.9e-27	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000226516
AA Change: W136*

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,353,874 (GRCm39)	I3732T	probably benign	Het
Ago1	C	A	4: 126,354,830 (GRCm39)	K127N	possibly damaging	Het
Akap8l	T	C	17: 32,557,374 (GRCm39)	N79S	probably damaging	Het
Ano5	T	C	7: 51,243,385 (GRCm39)	L836P	probably damaging	Het
AY358078	A	G	14: 52,042,065 (GRCm39)	T147A	unknown	Het
Cabp4	T	C	19: 4,189,251 (GRCm39)	D102G	probably benign	Het
Cdc34	C	T	10: 79,520,655 (GRCm39)	R61C	probably damaging	Het
Chac1	A	G	2: 119,181,887 (GRCm39)	K2E	unknown	Het
Cltc	C	T	11: 86,621,093 (GRCm39)	V305I	probably damaging	Het
Cog7	T	C	7: 121,524,683 (GRCm39)	T704A	probably benign	Het
Cux1	A	G	5: 136,421,174 (GRCm39)	V184A	probably damaging	Het
Daglb	A	T	5: 143,464,274 (GRCm39)	T262S	probably benign	Het
Dglucy	A	G	12: 100,753,905 (GRCm39)	I12V	probably null	Het
Dnah7a	A	G	1: 53,621,753 (GRCm39)	V1124A	probably benign	Het
Eef2	C	CN	10: 81,014,603 (GRCm39)		probably null	Het
Eif3k	C	A	7: 28,681,133 (GRCm39)	A9S	probably benign	Het
Elapor1	T	A	3: 108,378,731 (GRCm39)	I408F	probably damaging	Het
Gli3	A	T	13: 15,723,038 (GRCm39)	M60L	possibly damaging	Het
Hk1	C	T	10: 62,178,330 (GRCm39)	E4K	probably benign	Het
Kmt2b	C	A	7: 30,276,570 (GRCm39)	V1701L	probably damaging	Het
Lrp1b	T	C	2: 41,231,807 (GRCm39)	H1107R	probably damaging	Het
Lypd10	A	T	7: 24,413,711 (GRCm39)	R242S	possibly damaging	Het
Ncor1	A	G	11: 62,249,679 (GRCm39)		probably null	Het
Or5h23	T	A	16: 58,906,439 (GRCm39)	M136L	possibly damaging	Het
Or6c70	T	G	10: 129,710,607 (GRCm39)	R6S	probably benign	Het
Plekhg4	G	A	8: 106,106,134 (GRCm39)		probably null	Het
Pmfbp1	G	T	8: 110,251,739 (GRCm39)	E327D	probably damaging	Het
Slc22a17	G	A	14: 55,146,427 (GRCm39)	P63L	probably damaging	Het
Slc37a1	G	A	17: 31,556,982 (GRCm39)	V383M	possibly damaging	Het
Slc9a9	T	A	9: 94,691,990 (GRCm39)	Y182N	probably damaging	Het
Slx4ip	A	G	2: 136,842,162 (GRCm39)	D29G	probably damaging	Het
St3gal5	T	C	6: 72,130,446 (GRCm39)	V319A	possibly damaging	Het
Tbc1d10c	C	T	19: 4,239,881 (GRCm39)	M76I	possibly damaging	Het
Thrb	C	A	14: 18,033,526 (GRCm38)	H416N	probably benign	Het
Timp2	T	A	11: 118,210,987 (GRCm39)	D60V	probably damaging	Het
Ubxn6	C	T	17: 56,376,745 (GRCm39)	E216K	probably benign	Het
Unc79	T	C	12: 103,094,527 (GRCm39)	M1977T	probably benign	Het
Uri1	G	A	7: 37,662,954 (GRCm39)	R347*	probably null	Het
Vmn2r124	T	C	17: 18,294,102 (GRCm39)	Y730H	probably benign	Het
Wnk4	C	T	11: 101,166,462 (GRCm39)		probably benign	Het
Zfhx4	A	G	3: 5,468,679 (GRCm39)	N2971D	probably damaging	Het

Other mutations in Vmn1r73

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01782:Vmn1r73	APN	7	11,490,665 (GRCm39)	missense	probably benign	0.02
IGL02337:Vmn1r73	APN	7	11,490,640 (GRCm39)	missense	possibly damaging	0.69
IGL02666:Vmn1r73	APN	7	11,490,865 (GRCm39)	missense	probably damaging	1.00
IGL02741:Vmn1r73	APN	7	11,490,710 (GRCm39)	missense	probably benign	0.05
IGL02756:Vmn1r73	APN	7	11,490,574 (GRCm39)	missense	possibly damaging	0.95
IGL03113:Vmn1r73	APN	7	11,490,527 (GRCm39)	missense	probably benign
IGL03195:Vmn1r73	APN	7	11,491,007 (GRCm39)	missense	probably damaging	1.00
R0023:Vmn1r73	UTSW	7	11,490,997 (GRCm39)	missense	probably benign	0.43
R0379:Vmn1r73	UTSW	7	11,490,773 (GRCm39)	missense	probably benign	0.16
R3941:Vmn1r73	UTSW	7	11,490,682 (GRCm39)	missense	probably damaging	1.00
R4224:Vmn1r73	UTSW	7	11,490,506 (GRCm39)	missense	probably damaging	0.99
R4631:Vmn1r73	UTSW	7	11,490,758 (GRCm39)	missense	probably benign	0.22
R4912:Vmn1r73	UTSW	7	11,490,596 (GRCm39)	missense	probably damaging	0.99
R5060:Vmn1r73	UTSW	7	11,490,683 (GRCm39)	missense	probably damaging	1.00
R5450:Vmn1r73	UTSW	7	11,490,376 (GRCm39)	missense	possibly damaging	0.63
R6059:Vmn1r73	UTSW	7	11,490,538 (GRCm39)	missense	probably benign	0.40
R6508:Vmn1r73	UTSW	7	11,490,631 (GRCm39)	missense	possibly damaging	0.73
R6967:Vmn1r73	UTSW	7	11,490,544 (GRCm39)	nonsense	probably null
R7099:Vmn1r73	UTSW	7	11,490,320 (GRCm39)	missense	probably damaging	1.00
R7304:Vmn1r73	UTSW	7	11,490,824 (GRCm39)	missense	probably damaging	1.00
R7579:Vmn1r73	UTSW	7	11,491,082 (GRCm39)	missense	probably benign	0.08
R7891:Vmn1r73	UTSW	7	11,491,036 (GRCm39)	missense	possibly damaging	0.87
R8914:Vmn1r73	UTSW	7	11,490,328 (GRCm39)	missense	probably damaging	1.00
R9072:Vmn1r73	UTSW	7	11,490,203 (GRCm39)	missense	probably benign	0.00
R9073:Vmn1r73	UTSW	7	11,490,203 (GRCm39)	missense	probably benign	0.00
R9275:Vmn1r73	UTSW	7	11,490,479 (GRCm39)	missense	probably benign	0.04
R9632:Vmn1r73	UTSW	7	11,490,407 (GRCm39)	missense	possibly damaging	0.56
R9710:Vmn1r73	UTSW	7	11,490,407 (GRCm39)	missense	possibly damaging	0.56
Z1176:Vmn1r73	UTSW	7	11,490,883 (GRCm39)	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- GGCATTCCACAGACACTGTTG -3'
(R):5'- TGAGACCCAGACATAGTCCATCAG -3'

Sequencing Primer
(F):5'- CCACAGACACTGTTGAATTATGG -3'
(R):5'- TAGTCCATCAGAGAAACACAGTAAG -3'

Posted On

2016-10-26