Mutagenetix > Incidental Mutation

Incidental Mutation 'R5613:Or13c7'

438074

Institutional Source

Beutler Lab

Gene Symbol

Or13c7

Ensembl Gene

ENSMUSG00000071000

Gene Name

olfactory receptor family 13 subfamily C member 7

Synonyms

MOR262-14, mOR37a, OR37A, GA_x6K02T2N78B-16092200-16091241, Olfr37a, Olfr155

MMRRC Submission

043274-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.067) question?

Stock #

R5613 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

43854292-43855463 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 43854528 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Tyrosine at position 73 (C73Y)

Ref Sequence

ENSEMBL: ENSMUSP00000103492 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095108] [ENSMUST00000107860]

AlphaFold

Q9QZ22

Predicted Effect

probably damaging
Transcript: ENSMUST00000095108
AA Change: C73Y

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000092726
Gene: ENSMUSG00000071000
AA Change: C73Y

Domain	Start	End	E-Value	Type
Pfam:7tm_1	42	297	2.8e-35	PFAM
Pfam:7tm_4	140	290	1.4e-45	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000107860
AA Change: C73Y

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000103492
Gene: ENSMUSG00000071000
AA Change: C73Y

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	315	9.7e-59	PFAM
Pfam:7tm_1	42	297	3.5e-25	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.9%
20x: 97.0%

Validation Efficiency

98% (59/60)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9430097D07Rik	T	C	2: 32,465,346 (GRCm39)		probably benign	Het
Adamts16	A	C	13: 70,878,253 (GRCm39)	S1171A	probably benign	Het
Agtr1b	T	C	3: 20,370,424 (GRCm39)	T61A	probably damaging	Het
Ankrd35	A	G	3: 96,590,334 (GRCm39)	D257G	possibly damaging	Het
Arhgef5	A	G	6: 43,250,997 (GRCm39)	T583A	probably benign	Het
Camk2g	T	C	14: 20,787,559 (GRCm39)	N423S	probably damaging	Het
Cand1	A	T	10: 119,051,228 (GRCm39)	H293Q	possibly damaging	Het
Chd4	A	C	6: 125,097,509 (GRCm39)	E1359D	probably damaging	Het
Creb3	T	C	4: 43,566,196 (GRCm39)	C264R	probably benign	Het
Cul9	T	C	17: 46,814,770 (GRCm39)	D2171G	probably damaging	Het
Cyp7a1	A	T	4: 6,272,799 (GRCm39)	L138Q	probably damaging	Het
Dclk1	A	G	3: 55,424,360 (GRCm39)	T380A	probably benign	Het
Dnm2	T	A	9: 21,383,963 (GRCm39)	I248N	probably damaging	Het
Dtx4	A	T	19: 12,462,767 (GRCm39)	S337R	probably damaging	Het
Dus3l	T	C	17: 57,074,882 (GRCm39)	S335P	possibly damaging	Het
Dync1h1	T	C	12: 110,599,254 (GRCm39)	Y1870H	possibly damaging	Het
Eral1	G	A	11: 77,965,230 (GRCm39)		probably benign	Het
Eya1	G	T	1: 14,373,153 (GRCm39)		probably benign	Het
Fbxw28	T	A	9: 109,167,601 (GRCm39)	Y52F	probably benign	Het
Fcgbpl1	A	T	7: 27,842,303 (GRCm39)		probably benign	Het
Gm5600	A	G	7: 113,307,293 (GRCm39)		noncoding transcript	Het
Gm5901	A	G	7: 105,026,532 (GRCm39)	Y100C	probably damaging	Het
Haus3	A	G	5: 34,325,173 (GRCm39)	L162P	probably damaging	Het
Hivep2	T	C	10: 14,015,239 (GRCm39)	I1802T	probably damaging	Het
Klf7	G	A	1: 64,081,555 (GRCm39)	R258C	probably damaging	Het
Mapt	A	G	11: 104,193,216 (GRCm39)	N66D	possibly damaging	Het
Mypop	G	A	7: 18,725,901 (GRCm39)		probably benign	Het
Nefm	T	A	14: 68,358,583 (GRCm39)	K484*	probably null	Het
Nup153	A	C	13: 46,840,747 (GRCm39)	S954A	possibly damaging	Het
Or4a78	T	C	2: 89,497,388 (GRCm39)	N281D	probably damaging	Het
Pkn1	C	T	8: 84,404,390 (GRCm39)	A543T	probably benign	Het
Ppp1r11	C	A	17: 37,262,380 (GRCm39)	G7W	probably damaging	Het
Prss52	A	T	14: 64,346,951 (GRCm39)	N42Y	possibly damaging	Het
Ptger2	T	G	14: 45,226,960 (GRCm39)	V180G	possibly damaging	Het
Rep15	G	T	6: 146,934,352 (GRCm39)	V64F	possibly damaging	Het
Rfpl4b	T	A	10: 38,697,373 (GRCm39)	Q76L	probably benign	Het
Slc11a1	G	A	1: 74,420,065 (GRCm39)	G191D	probably damaging	Het
Slc16a12	T	C	19: 34,652,358 (GRCm39)	M263V	probably benign	Het
Spdye4c	A	T	2: 128,434,889 (GRCm39)	Q95L	possibly damaging	Het
Srfbp1	G	A	18: 52,616,717 (GRCm39)	D81N	probably damaging	Het
Sspo	G	A	6: 48,431,978 (GRCm39)	V731M	possibly damaging	Het
Susd6	G	T	12: 80,915,308 (GRCm39)	G98C	probably damaging	Het
Tlr4	T	A	4: 66,759,122 (GRCm39)	S638R	possibly damaging	Het
Tnfsf13	G	T	11: 69,574,821 (GRCm39)		probably null	Het
Tnfsf18	A	G	1: 161,331,297 (GRCm39)	N149S	possibly damaging	Het
Tor1aip1	T	C	1: 155,909,499 (GRCm39)	K176E	probably damaging	Het
Trav10	A	T	14: 53,743,483 (GRCm39)	H28L	probably benign	Het
Trim30a	T	A	7: 104,079,389 (GRCm39)	K155N	probably damaging	Het
Trpm1	A	G	7: 63,858,159 (GRCm39)	D333G	probably damaging	Het
Tssk1	T	C	16: 17,712,364 (GRCm39)	S50P	probably benign	Het
Ttll9	CAAA	CAA	2: 152,815,521 (GRCm39)		probably null	Het
Ttn	A	T	2: 76,739,996 (GRCm39)		probably benign	Het
Vmn2r115	A	T	17: 23,564,307 (GRCm39)	I160L	probably benign	Het
Wdr95	A	T	5: 149,507,935 (GRCm39)	D396V	probably damaging	Het
Zbtb47	T	A	9: 121,596,585 (GRCm39)	I647N	probably damaging	Het
Zfp799	T	C	17: 33,038,964 (GRCm39)	Y433C	probably damaging	Het

Other mutations in Or13c7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02729:Or13c7	APN	4	43,854,439 (GRCm39)	missense	probably damaging	1.00
R0240:Or13c7	UTSW	4	43,854,512 (GRCm39)	missense	probably damaging	1.00
R0240:Or13c7	UTSW	4	43,854,512 (GRCm39)	missense	probably damaging	1.00
R0285:Or13c7	UTSW	4	43,854,398 (GRCm39)	missense	possibly damaging	0.46
R0427:Or13c7	UTSW	4	43,854,417 (GRCm39)	missense	probably damaging	1.00
R4468:Or13c7	UTSW	4	43,854,737 (GRCm39)	missense	probably benign	0.08
R4548:Or13c7	UTSW	4	43,854,834 (GRCm39)	missense	probably damaging	1.00
R4583:Or13c7	UTSW	4	43,855,262 (GRCm39)	missense	probably benign
R4793:Or13c7	UTSW	4	43,854,323 (GRCm39)	missense	probably benign	0.37
R4884:Or13c7	UTSW	4	43,854,890 (GRCm39)	missense	probably damaging	1.00
R5016:Or13c7	UTSW	4	43,854,596 (GRCm39)	missense	probably benign	0.02
R5220:Or13c7	UTSW	4	43,854,624 (GRCm39)	missense	possibly damaging	0.89
R5805:Or13c7	UTSW	4	43,855,152 (GRCm39)	missense	probably benign	0.15
R5955:Or13c7	UTSW	4	43,854,898 (GRCm39)	missense	probably damaging	1.00
R6250:Or13c7	UTSW	4	43,854,363 (GRCm39)	missense	possibly damaging	0.58
R6768:Or13c7	UTSW	4	43,854,351 (GRCm39)	missense	probably benign	0.01
R6801:Or13c7	UTSW	4	43,855,206 (GRCm39)	nonsense	probably null
R6835:Or13c7	UTSW	4	43,854,912 (GRCm39)	missense	probably benign	0.00
R7510:Or13c7	UTSW	4	43,854,482 (GRCm39)	missense	probably benign	0.20
R8013:Or13c7	UTSW	4	43,854,958 (GRCm39)	missense	probably benign	0.00
R8014:Or13c7	UTSW	4	43,854,958 (GRCm39)	missense	probably benign	0.00
R8312:Or13c7	UTSW	4	43,854,461 (GRCm39)	missense	probably benign	0.04
R9116:Or13c7	UTSW	4	43,854,602 (GRCm39)	missense	probably damaging	1.00
R9636:Or13c7	UTSW	4	43,854,898 (GRCm39)	missense	probably damaging	1.00
R9643:Or13c7	UTSW	4	43,855,183 (GRCm39)	missense	probably benign	0.31
W0251:Or13c7	UTSW	4	43,855,058 (GRCm39)	missense	probably benign	0.42

Predicted Primers

PCR Primer
(F):5'- TCAAACCGAATGTACCATGGACAG -3'
(R):5'- GGTTGCAGATGGCCACATAAC -3'

Sequencing Primer
(F):5'- GGACAGATCCAATGAGACCGC -3'
(R):5'- GATGGCCACATAACGATCAAACG -3'

Posted On

2016-10-26