Incidental Mutation 'R5614:Fus'
ID 438140
Institutional Source Beutler Lab
Gene Symbol Fus
Ensembl Gene ENSMUSG00000030795
Gene Name fused in sarcoma
Synonyms D930039C12Rik, translocated in liposarcoma, pigpen, hnRNP P2, Tls, D430004D17Rik
MMRRC Submission 043275-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5614 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 127565276-127581204 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 127573543 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000077609] [ENSMUST00000106251] [ENSMUST00000121616]
AlphaFold P56959
Predicted Effect probably benign
Transcript: ENSMUST00000077609
SMART Domains Protein: ENSMUSP00000076801
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 48 67 N/A INTRINSIC
low complexity region 72 104 N/A INTRINSIC
low complexity region 110 179 N/A INTRINSIC
low complexity region 185 253 N/A INTRINSIC
RRM 278 359 3.85e-16 SMART
ZnF_RBZ 416 442 9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106251
SMART Domains Protein: ENSMUSP00000101858
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 47 63 N/A INTRINSIC
low complexity region 73 105 N/A INTRINSIC
low complexity region 111 180 N/A INTRINSIC
low complexity region 186 254 N/A INTRINSIC
RRM 279 360 3.85e-16 SMART
ZnF_RBZ 417 443 9e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000121616
SMART Domains Protein: ENSMUSP00000112721
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
low complexity region 20 44 N/A INTRINSIC
low complexity region 47 63 N/A INTRINSIC
low complexity region 73 105 N/A INTRINSIC
low complexity region 111 176 N/A INTRINSIC
ZnF_RBZ 179 205 9e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123151
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128851
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136289
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155941
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174196
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154843
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205261
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205351
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137464
Predicted Effect probably benign
Transcript: ENSMUST00000174632
SMART Domains Protein: ENSMUSP00000133820
Gene: ENSMUSG00000030795

DomainStartEndE-ValueType
Pfam:RRM_1 6 56 6.6e-9 PFAM
ZnF_RBZ 77 103 9e-4 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency 100% (62/62)
MGI Phenotype PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 A G 4: 53,046,132 (GRCm39) V1712A probably damaging Het
Ankmy2 T C 12: 36,243,783 (GRCm39) S333P probably damaging Het
Arfrp1 A G 2: 181,001,236 (GRCm39) probably benign Het
Atp13a2 A G 4: 140,719,493 (GRCm39) T21A probably benign Het
Bud23 C A 5: 135,087,966 (GRCm39) A152S probably benign Het
Cant1 T C 11: 118,299,569 (GRCm39) D260G probably benign Het
Ces1b T C 8: 93,794,836 (GRCm39) I254M probably benign Het
Ces1d T C 8: 93,902,832 (GRCm39) T375A probably benign Het
Cfap54 A G 10: 92,880,911 (GRCm39) L384P probably damaging Het
Chrne C T 11: 70,505,879 (GRCm39) V469I possibly damaging Het
Clspn A G 4: 126,474,755 (GRCm39) E968G probably damaging Het
Col5a3 A G 9: 20,694,772 (GRCm39) probably benign Het
Dtx4 T C 19: 12,459,547 (GRCm39) Y419C probably damaging Het
Fam171b T A 2: 83,643,217 (GRCm39) I42N probably damaging Het
Fam43a T C 16: 30,420,490 (GRCm39) I358T possibly damaging Het
Fasn T C 11: 120,704,154 (GRCm39) S1422G probably benign Het
Fig4 A T 10: 41,148,981 (GRCm39) V157E probably damaging Het
Hmcn2 G T 2: 31,318,315 (GRCm39) V3887F probably damaging Het
Hmgcll1 A G 9: 75,988,675 (GRCm39) Y182C probably damaging Het
Hook2 T A 8: 85,729,137 (GRCm39) I585N probably damaging Het
Iars2 T C 1: 185,021,705 (GRCm39) T866A probably benign Het
Iqca1l G A 5: 24,755,140 (GRCm39) A330V probably benign Het
Lrit1 T A 14: 36,783,911 (GRCm39) M413K probably benign Het
Myl9 G A 2: 156,623,083 (GRCm39) probably benign Het
Nelfa A T 5: 34,077,844 (GRCm39) L179Q probably damaging Het
Nod2 A T 8: 89,390,824 (GRCm39) D355V probably damaging Het
Npbwr1 A T 1: 5,987,030 (GRCm39) S161R probably damaging Het
Nxpe2 A T 9: 48,234,401 (GRCm39) F289I probably benign Het
Odf2 A G 2: 29,810,879 (GRCm39) I538M probably damaging Het
Osbpl6 T A 2: 76,398,453 (GRCm39) V379E probably damaging Het
Pkhd1 A G 1: 20,143,750 (GRCm39) C3859R possibly damaging Het
Rgs1 G T 1: 144,121,995 (GRCm39) T99N probably benign Het
Rnf6 T C 5: 146,154,910 (GRCm39) probably null Het
Rtp1 C A 16: 23,249,940 (GRCm39) Q102K possibly damaging Het
Sec24c T A 14: 20,732,806 (GRCm39) V123E possibly damaging Het
Serpini2 T C 3: 75,165,014 (GRCm39) probably benign Het
Stxbp5 A T 10: 9,636,638 (GRCm39) probably benign Het
Tecta A G 9: 42,250,351 (GRCm39) S1809P probably damaging Het
Tgfb2 T A 1: 186,357,710 (GRCm39) I394F probably benign Het
Thg1l T C 11: 45,841,054 (GRCm39) Y175C possibly damaging Het
Tmem67 C A 4: 12,061,755 (GRCm39) K572N possibly damaging Het
Tollip T C 7: 141,445,825 (GRCm39) T19A probably damaging Het
Ttn A G 2: 76,542,451 (GRCm39) Y25185H probably damaging Het
Vgll2 A T 10: 51,901,318 (GRCm39) R83* probably null Het
Wfdc8 G T 2: 164,445,123 (GRCm39) A164E probably damaging Het
Ylpm1 T C 12: 85,111,718 (GRCm39) probably benign Het
Zfp326 T A 5: 106,036,361 (GRCm39) S91T probably damaging Het
Zfp638 T C 6: 83,906,623 (GRCm39) F263L probably damaging Het
Zfp800 G A 6: 28,243,135 (GRCm39) T610I probably damaging Het
Zmym4 A G 4: 126,804,729 (GRCm39) F475L possibly damaging Het
Other mutations in Fus
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02505:Fus APN 7 127,580,679 (GRCm39) missense possibly damaging 0.53
IGL02622:Fus APN 7 127,584,794 (GRCm39) missense probably damaging 0.99
IGL02951:Fus APN 7 127,581,009 (GRCm39) unclassified probably benign
IGL03029:Fus APN 7 127,584,712 (GRCm39) unclassified probably benign
R0588:Fus UTSW 7 127,584,746 (GRCm39) missense probably damaging 0.99
R0674:Fus UTSW 7 127,571,948 (GRCm39) unclassified probably benign
R0686:Fus UTSW 7 127,571,935 (GRCm39) unclassified probably benign
R0746:Fus UTSW 7 127,584,596 (GRCm39) unclassified probably benign
R1562:Fus UTSW 7 127,579,094 (GRCm39) missense probably damaging 1.00
R1733:Fus UTSW 7 127,580,717 (GRCm39) missense probably benign 0.01
R2186:Fus UTSW 7 127,584,706 (GRCm39) unclassified probably benign
R2200:Fus UTSW 7 127,576,400 (GRCm39) missense probably damaging 0.99
R4537:Fus UTSW 7 127,575,087 (GRCm39) missense probably damaging 0.99
R4981:Fus UTSW 7 127,566,727 (GRCm39) start gained probably benign
R5206:Fus UTSW 7 127,568,969 (GRCm39) missense unknown
R5283:Fus UTSW 7 127,584,719 (GRCm39) unclassified probably benign
R6182:Fus UTSW 7 127,576,465 (GRCm39) missense probably damaging 0.97
R6239:Fus UTSW 7 127,580,606 (GRCm39) missense possibly damaging 0.91
R6939:Fus UTSW 7 127,571,741 (GRCm39) unclassified probably benign
R7130:Fus UTSW 7 127,573,585 (GRCm39) missense unknown
R7340:Fus UTSW 7 127,581,123 (GRCm39) splice site probably null
R8293:Fus UTSW 7 127,571,749 (GRCm39) missense unknown
R8440:Fus UTSW 7 127,568,998 (GRCm39) missense unknown
R9154:Fus UTSW 7 127,580,440 (GRCm39) missense unknown
X0061:Fus UTSW 7 127,584,605 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TGTGTGATAAGCTCAAAGGTCAG -3'
(R):5'- AGTTAGCACACATCTGGCAGC -3'

Sequencing Primer
(F):5'- TCAAAGGTCAGACAAGGGTGGTC -3'
(R):5'- CTTCTGGAGGTGGCTACAGAC -3'
Posted On 2016-10-26