Incidental Mutation 'R5580:Pik3c2g'
| ID |
438385 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pik3c2g
|
| Ensembl Gene |
ENSMUSG00000030228 |
| Gene Name |
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma |
| Synonyms |
|
| MMRRC Submission |
043134-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.118)
|
| Stock # |
R5580 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
139591070-139915010 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 139603531 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Leucine
at position 239
(Q239L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140368
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032353]
[ENSMUST00000185968]
[ENSMUST00000187618]
[ENSMUST00000188066]
[ENSMUST00000190962]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000032353
AA Change: Q239L
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000032353
Gene: ENSMUSG00000030228
AA Change: Q239L
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000185968
AA Change: Q239L
PolyPhen 2
Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000140368
Gene: ENSMUSG00000030228
AA Change: Q239L
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
371 |
2e-42 |
SMART |
|
Blast:PI3K_rbd
|
272 |
371 |
2e-64 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000186585
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000187618
AA Change: Q239L
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000141025
Gene: ENSMUSG00000030228
AA Change: Q239L
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188066
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000190962
AA Change: Q239L
PolyPhen 2
Score 0.816 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000141141
Gene: ENSMUSG00000030228
AA Change: Q239L
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1e8xa3
|
223 |
344 |
4e-33 |
SMART |
|
Blast:PI3K_rbd
|
272 |
345 |
7e-44 |
BLAST |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.6%
- 20x: 96.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
PHENOTYPE: Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2410002F23Rik |
A |
G |
7: 43,900,664 (GRCm39) |
T73A |
possibly damaging |
Het |
| A1bg |
A |
T |
15: 60,790,881 (GRCm39) |
V365E |
probably benign |
Het |
| Abcg5 |
A |
C |
17: 84,967,582 (GRCm39) |
V406G |
probably damaging |
Het |
| Adamts12 |
A |
G |
15: 11,152,086 (GRCm39) |
Y192C |
probably benign |
Het |
| Add3 |
C |
T |
19: 53,233,642 (GRCm39) |
S649L |
probably damaging |
Het |
| Adgrg6 |
A |
T |
10: 14,286,228 (GRCm39) |
C1129* |
probably null |
Het |
| Arsb |
T |
A |
13: 93,944,053 (GRCm39) |
V248D |
probably damaging |
Het |
| AW554918 |
A |
T |
18: 25,472,922 (GRCm39) |
N39I |
probably damaging |
Het |
| Cacna1b |
A |
T |
2: 24,540,566 (GRCm39) |
I1383N |
probably damaging |
Het |
| Caprin2 |
A |
T |
6: 148,760,232 (GRCm39) |
V625D |
possibly damaging |
Het |
| Cd9 |
A |
G |
6: 125,441,420 (GRCm39) |
L67P |
probably damaging |
Het |
| Cdh5 |
T |
A |
8: 104,852,126 (GRCm39) |
Y80* |
probably null |
Het |
| Csf2ra |
A |
G |
19: 61,214,655 (GRCm39) |
L223P |
probably damaging |
Het |
| Cyp2c67 |
T |
C |
19: 39,604,094 (GRCm39) |
K421E |
probably damaging |
Het |
| Dzank1 |
T |
C |
2: 144,348,098 (GRCm39) |
R223G |
probably damaging |
Het |
| Emilin2 |
A |
G |
17: 71,582,225 (GRCm39) |
V167A |
probably benign |
Het |
| Eps8l3 |
A |
G |
3: 107,788,919 (GRCm39) |
T81A |
probably damaging |
Het |
| Esrra |
T |
C |
19: 6,897,755 (GRCm39) |
M1V |
probably null |
Het |
| Evpl |
C |
A |
11: 116,125,058 (GRCm39) |
A135S |
probably benign |
Het |
| Fam193a |
A |
G |
5: 34,578,132 (GRCm39) |
I209V |
probably benign |
Het |
| Fbxl19 |
C |
A |
7: 127,350,168 (GRCm39) |
C253* |
probably null |
Het |
| Fer1l5 |
T |
A |
1: 36,424,539 (GRCm39) |
Y305* |
probably null |
Het |
| Fzd2 |
A |
C |
11: 102,496,665 (GRCm39) |
I370L |
probably damaging |
Het |
| Gnl3 |
T |
C |
14: 30,737,242 (GRCm39) |
K212R |
probably benign |
Het |
| Golm1 |
A |
G |
13: 59,790,179 (GRCm39) |
L207P |
probably benign |
Het |
| Gphn |
T |
A |
12: 78,538,818 (GRCm39) |
F155I |
probably damaging |
Het |
| Grhl1 |
G |
A |
12: 24,659,739 (GRCm39) |
G500S |
probably benign |
Het |
| Gucd1 |
C |
A |
10: 75,346,968 (GRCm39) |
G55V |
possibly damaging |
Het |
| Haus6 |
A |
T |
4: 86,517,503 (GRCm39) |
I287K |
possibly damaging |
Het |
| Hmcn1 |
G |
A |
1: 150,453,290 (GRCm39) |
P5342S |
probably benign |
Het |
| Hspa12a |
A |
G |
19: 58,788,092 (GRCm39) |
S577P |
probably benign |
Het |
| Ido2 |
T |
A |
8: 25,040,882 (GRCm39) |
I113F |
possibly damaging |
Het |
| Ifrd2 |
C |
T |
9: 107,469,511 (GRCm39) |
P396S |
probably damaging |
Het |
| Igkv4-86 |
T |
A |
6: 68,887,990 (GRCm39) |
|
probably benign |
Het |
| Ipo11 |
A |
G |
13: 107,037,255 (GRCm39) |
V196A |
probably benign |
Het |
| Itih2 |
T |
C |
2: 10,128,287 (GRCm39) |
E138G |
probably damaging |
Het |
| Kidins220 |
T |
G |
12: 25,097,896 (GRCm39) |
C1179G |
probably benign |
Het |
| Kif20b |
T |
A |
19: 34,927,128 (GRCm39) |
|
probably null |
Het |
| Klk1 |
T |
A |
7: 43,878,238 (GRCm39) |
Y63N |
probably benign |
Het |
| L3mbtl3 |
T |
G |
10: 26,179,604 (GRCm39) |
D517A |
unknown |
Het |
| Lars1 |
G |
T |
18: 42,347,916 (GRCm39) |
P969H |
probably damaging |
Het |
| Lrp1 |
C |
T |
10: 127,424,389 (GRCm39) |
V766I |
probably benign |
Het |
| Lrrc8c |
A |
G |
5: 105,755,553 (GRCm39) |
I443V |
probably benign |
Het |
| Lsg1 |
T |
C |
16: 30,387,985 (GRCm39) |
M439V |
probably null |
Het |
| Magi2 |
T |
A |
5: 20,420,422 (GRCm39) |
M286K |
probably benign |
Het |
| Med11 |
T |
C |
11: 70,342,891 (GRCm39) |
|
probably null |
Het |
| Med13l |
A |
G |
5: 118,889,695 (GRCm39) |
K1819E |
possibly damaging |
Het |
| Ms4a14 |
T |
A |
19: 11,280,590 (GRCm39) |
Q656L |
probably benign |
Het |
| Muc5b |
A |
G |
7: 141,415,084 (GRCm39) |
T2677A |
possibly damaging |
Het |
| Myo7a |
A |
T |
7: 97,722,367 (GRCm39) |
L1186H |
probably damaging |
Het |
| Naca |
C |
A |
10: 127,876,462 (GRCm39) |
|
probably benign |
Het |
| Nbeal1 |
T |
C |
1: 60,281,761 (GRCm39) |
I828T |
probably benign |
Het |
| Ncor1 |
A |
T |
11: 62,280,604 (GRCm39) |
C75* |
probably null |
Het |
| Nepn |
A |
C |
10: 52,280,398 (GRCm39) |
S497R |
probably damaging |
Het |
| Nf2 |
A |
G |
11: 4,753,689 (GRCm39) |
F222L |
probably damaging |
Het |
| Nlrp9b |
A |
C |
7: 19,757,089 (GRCm39) |
T109P |
probably damaging |
Het |
| Nr1h4 |
A |
T |
10: 89,352,302 (GRCm39) |
F22I |
probably benign |
Het |
| Ogg1 |
A |
G |
6: 113,306,337 (GRCm39) |
Y178C |
probably damaging |
Het |
| Or1e22 |
G |
T |
11: 73,377,036 (GRCm39) |
P205T |
probably benign |
Het |
| Or4b12 |
C |
A |
2: 90,096,694 (GRCm39) |
V27L |
probably benign |
Het |
| Or5b119 |
T |
A |
19: 13,456,791 (GRCm39) |
Y257F |
probably damaging |
Het |
| Or5b21 |
G |
A |
19: 12,839,168 (GRCm39) |
V10M |
possibly damaging |
Het |
| Or5d14 |
A |
T |
2: 87,880,668 (GRCm39) |
M100K |
possibly damaging |
Het |
| Osr1 |
G |
A |
12: 9,629,325 (GRCm39) |
R66Q |
probably damaging |
Het |
| Pi4ka |
A |
G |
16: 17,098,951 (GRCm39) |
S1978P |
probably damaging |
Het |
| Pin1rt1 |
A |
G |
2: 104,544,670 (GRCm39) |
I154T |
probably damaging |
Het |
| Pkdcc |
A |
G |
17: 83,527,511 (GRCm39) |
T230A |
probably damaging |
Het |
| Por |
A |
T |
5: 135,762,675 (GRCm39) |
I430F |
probably damaging |
Het |
| Prb1c |
T |
C |
6: 132,338,432 (GRCm39) |
N262S |
unknown |
Het |
| Prkcsh |
T |
A |
9: 21,922,551 (GRCm39) |
|
probably null |
Het |
| Pros1 |
A |
G |
16: 62,746,689 (GRCm39) |
|
probably null |
Het |
| Pus10 |
T |
A |
11: 23,622,556 (GRCm39) |
L59I |
probably benign |
Het |
| Pxmp2 |
A |
G |
5: 110,431,542 (GRCm39) |
V67A |
possibly damaging |
Het |
| Rab3gap1 |
C |
A |
1: 127,858,727 (GRCm39) |
A612E |
probably benign |
Het |
| Rpap2 |
A |
G |
5: 107,768,011 (GRCm39) |
E206G |
probably benign |
Het |
| Rpl31 |
C |
T |
1: 39,409,108 (GRCm39) |
R41C |
probably benign |
Het |
| Ryr3 |
C |
T |
2: 112,672,293 (GRCm39) |
G1393R |
probably damaging |
Het |
| Scara5 |
T |
C |
14: 65,968,528 (GRCm39) |
M267T |
probably benign |
Het |
| Sema5a |
A |
T |
15: 32,575,031 (GRCm39) |
I380F |
probably benign |
Het |
| Slc36a3 |
A |
G |
11: 55,026,279 (GRCm39) |
S180P |
probably benign |
Het |
| Slc44a5 |
A |
G |
3: 153,966,922 (GRCm39) |
K536R |
probably benign |
Het |
| Smg1 |
T |
C |
7: 117,748,125 (GRCm39) |
|
probably benign |
Het |
| Spata31d1e |
A |
T |
13: 59,890,070 (GRCm39) |
D583E |
probably benign |
Het |
| Strc |
T |
C |
2: 121,205,493 (GRCm39) |
K879R |
probably damaging |
Het |
| Swt1 |
T |
C |
1: 151,260,206 (GRCm39) |
E731G |
probably benign |
Het |
| Syngap1 |
G |
A |
17: 27,181,305 (GRCm39) |
A9T |
probably damaging |
Het |
| Tex15 |
C |
T |
8: 34,062,457 (GRCm39) |
T903I |
probably damaging |
Het |
| Tg |
A |
G |
15: 66,557,149 (GRCm39) |
I937V |
possibly damaging |
Het |
| Tm9sf4 |
T |
C |
2: 153,024,350 (GRCm39) |
Y58H |
probably damaging |
Het |
| Tsen2 |
A |
T |
6: 115,554,941 (GRCm39) |
D458V |
probably damaging |
Het |
| Ttn |
T |
A |
2: 76,748,146 (GRCm39) |
D4301V |
probably benign |
Het |
| Txk |
C |
A |
5: 72,864,932 (GRCm39) |
L314F |
probably damaging |
Het |
| Ube3b |
A |
G |
5: 114,553,384 (GRCm39) |
T919A |
probably benign |
Het |
| Ubn2 |
A |
G |
6: 38,460,187 (GRCm39) |
M641V |
probably damaging |
Het |
| Usp4 |
C |
T |
9: 108,243,058 (GRCm39) |
T242I |
probably benign |
Het |
| Usp53 |
A |
G |
3: 122,727,883 (GRCm39) |
S900P |
probably benign |
Het |
| Vmn1r225 |
T |
C |
17: 20,723,101 (GRCm39) |
Y181H |
probably damaging |
Het |
| Vmn1r83 |
T |
A |
7: 12,055,800 (GRCm39) |
I86L |
probably benign |
Het |
| Vmn2r65 |
T |
C |
7: 84,596,802 (GRCm39) |
I84M |
probably damaging |
Het |
| Vstm2b |
A |
G |
7: 40,552,050 (GRCm39) |
H126R |
probably damaging |
Het |
| Zfp524 |
A |
T |
7: 5,021,416 (GRCm39) |
I315F |
probably benign |
Het |
| Zfp975 |
A |
T |
7: 42,314,513 (GRCm39) |
L20* |
probably null |
Het |
|
| Other mutations in Pik3c2g |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Pik3c2g
|
APN |
6 |
139,841,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01355:Pik3c2g
|
APN |
6 |
139,798,583 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01579:Pik3c2g
|
APN |
6 |
139,700,467 (GRCm39) |
nonsense |
probably null |
|
|
IGL01580:Pik3c2g
|
APN |
6 |
139,599,514 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01587:Pik3c2g
|
APN |
6 |
139,700,467 (GRCm39) |
nonsense |
probably null |
|
|
IGL01813:Pik3c2g
|
APN |
6 |
139,599,407 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02218:Pik3c2g
|
APN |
6 |
139,806,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02479:Pik3c2g
|
APN |
6 |
139,863,730 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02480:Pik3c2g
|
APN |
6 |
139,798,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02721:Pik3c2g
|
APN |
6 |
139,682,699 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02967:Pik3c2g
|
APN |
6 |
139,913,554 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03221:Pik3c2g
|
APN |
6 |
139,718,133 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
FR4304:Pik3c2g
|
UTSW |
6 |
139,612,654 (GRCm39) |
frame shift |
probably null |
|
|
FR4340:Pik3c2g
|
UTSW |
6 |
139,612,654 (GRCm39) |
frame shift |
probably null |
|
|
FR4976:Pik3c2g
|
UTSW |
6 |
139,612,652 (GRCm39) |
frame shift |
probably null |
|
|
IGL02837:Pik3c2g
|
UTSW |
6 |
139,603,562 (GRCm39) |
nonsense |
probably null |
|
|
PIT4531001:Pik3c2g
|
UTSW |
6 |
139,805,096 (GRCm39) |
missense |
|
|
|
R0002:Pik3c2g
|
UTSW |
6 |
139,714,471 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0081:Pik3c2g
|
UTSW |
6 |
139,903,519 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0098:Pik3c2g
|
UTSW |
6 |
139,639,441 (GRCm39) |
missense |
unknown |
|
|
R0719:Pik3c2g
|
UTSW |
6 |
139,606,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0740:Pik3c2g
|
UTSW |
6 |
139,610,791 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0837:Pik3c2g
|
UTSW |
6 |
139,903,425 (GRCm39) |
splice site |
probably benign |
|
|
R0840:Pik3c2g
|
UTSW |
6 |
139,841,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1306:Pik3c2g
|
UTSW |
6 |
139,718,154 (GRCm39) |
missense |
probably benign |
|
|
R1501:Pik3c2g
|
UTSW |
6 |
139,789,796 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1591:Pik3c2g
|
UTSW |
6 |
139,693,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1666:Pik3c2g
|
UTSW |
6 |
139,612,634 (GRCm39) |
intron |
probably benign |
|
|
R1907:Pik3c2g
|
UTSW |
6 |
139,789,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1970:Pik3c2g
|
UTSW |
6 |
139,846,112 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1982:Pik3c2g
|
UTSW |
6 |
139,599,546 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2171:Pik3c2g
|
UTSW |
6 |
139,801,012 (GRCm39) |
nonsense |
probably null |
|
|
R2188:Pik3c2g
|
UTSW |
6 |
139,798,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3777:Pik3c2g
|
UTSW |
6 |
139,599,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3778:Pik3c2g
|
UTSW |
6 |
139,599,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3965:Pik3c2g
|
UTSW |
6 |
139,801,018 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4076:Pik3c2g
|
UTSW |
6 |
139,798,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4078:Pik3c2g
|
UTSW |
6 |
139,612,608 (GRCm39) |
intron |
probably benign |
|
|
R4108:Pik3c2g
|
UTSW |
6 |
139,676,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4461:Pik3c2g
|
UTSW |
6 |
139,787,407 (GRCm39) |
intron |
probably benign |
|
|
R4474:Pik3c2g
|
UTSW |
6 |
139,610,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4509:Pik3c2g
|
UTSW |
6 |
139,665,732 (GRCm39) |
missense |
probably benign |
0.25 |
|
R4646:Pik3c2g
|
UTSW |
6 |
139,665,744 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4732:Pik3c2g
|
UTSW |
6 |
139,881,711 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4733:Pik3c2g
|
UTSW |
6 |
139,881,711 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4854:Pik3c2g
|
UTSW |
6 |
139,714,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4928:Pik3c2g
|
UTSW |
6 |
139,913,528 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4959:Pik3c2g
|
UTSW |
6 |
139,789,657 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4973:Pik3c2g
|
UTSW |
6 |
139,789,657 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5032:Pik3c2g
|
UTSW |
6 |
139,841,928 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5071:Pik3c2g
|
UTSW |
6 |
139,665,873 (GRCm39) |
missense |
probably null |
0.00 |
|
R5072:Pik3c2g
|
UTSW |
6 |
139,665,873 (GRCm39) |
missense |
probably null |
0.00 |
|
R5073:Pik3c2g
|
UTSW |
6 |
139,665,873 (GRCm39) |
missense |
probably null |
0.00 |
|
R5074:Pik3c2g
|
UTSW |
6 |
139,665,873 (GRCm39) |
missense |
probably null |
0.00 |
|
R5107:Pik3c2g
|
UTSW |
6 |
139,612,623 (GRCm39) |
intron |
probably benign |
|
|
R5186:Pik3c2g
|
UTSW |
6 |
139,599,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5253:Pik3c2g
|
UTSW |
6 |
139,841,983 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5359:Pik3c2g
|
UTSW |
6 |
139,599,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Pik3c2g
|
UTSW |
6 |
139,665,808 (GRCm39) |
missense |
probably benign |
|
|
R5417:Pik3c2g
|
UTSW |
6 |
139,682,669 (GRCm39) |
missense |
probably benign |
|
|
R5435:Pik3c2g
|
UTSW |
6 |
139,661,581 (GRCm39) |
splice site |
probably null |
|
|
R5664:Pik3c2g
|
UTSW |
6 |
139,682,733 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5908:Pik3c2g
|
UTSW |
6 |
139,714,436 (GRCm39) |
missense |
|
|
|
R5914:Pik3c2g
|
UTSW |
6 |
139,599,477 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,842,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6046:Pik3c2g
|
UTSW |
6 |
139,599,137 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6298:Pik3c2g
|
UTSW |
6 |
139,603,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6382:Pik3c2g
|
UTSW |
6 |
139,665,724 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6480:Pik3c2g
|
UTSW |
6 |
139,676,195 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6917:Pik3c2g
|
UTSW |
6 |
139,841,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6929:Pik3c2g
|
UTSW |
6 |
139,903,502 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7022:Pik3c2g
|
UTSW |
6 |
139,599,061 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7144:Pik3c2g
|
UTSW |
6 |
139,606,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7213:Pik3c2g
|
UTSW |
6 |
139,805,990 (GRCm39) |
missense |
|
|
|
R7215:Pik3c2g
|
UTSW |
6 |
139,700,589 (GRCm39) |
missense |
|
|
|
R7332:Pik3c2g
|
UTSW |
6 |
139,841,981 (GRCm39) |
missense |
|
|
|
R7357:Pik3c2g
|
UTSW |
6 |
139,610,791 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7359:Pik3c2g
|
UTSW |
6 |
139,913,620 (GRCm39) |
missense |
unknown |
|
|
R7385:Pik3c2g
|
UTSW |
6 |
139,801,079 (GRCm39) |
missense |
|
|
|
R7455:Pik3c2g
|
UTSW |
6 |
139,913,643 (GRCm39) |
missense |
unknown |
|
|
R7651:Pik3c2g
|
UTSW |
6 |
139,599,070 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7888:Pik3c2g
|
UTSW |
6 |
139,842,470 (GRCm39) |
missense |
|
|
|
R7923:Pik3c2g
|
UTSW |
6 |
139,610,791 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7964:Pik3c2g
|
UTSW |
6 |
139,827,786 (GRCm39) |
missense |
|
|
|
R8005:Pik3c2g
|
UTSW |
6 |
139,599,067 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8371:Pik3c2g
|
UTSW |
6 |
139,881,782 (GRCm39) |
missense |
unknown |
|
|
R8724:Pik3c2g
|
UTSW |
6 |
139,913,619 (GRCm39) |
missense |
unknown |
|
|
R8733:Pik3c2g
|
UTSW |
6 |
139,714,426 (GRCm39) |
nonsense |
probably null |
|
|
R8809:Pik3c2g
|
UTSW |
6 |
139,714,436 (GRCm39) |
missense |
|
|
|
R8888:Pik3c2g
|
UTSW |
6 |
139,676,092 (GRCm39) |
nonsense |
probably null |
|
|
R8931:Pik3c2g
|
UTSW |
6 |
139,821,093 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9188:Pik3c2g
|
UTSW |
6 |
139,599,401 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9336:Pik3c2g
|
UTSW |
6 |
139,821,161 (GRCm39) |
missense |
|
|
|
R9383:Pik3c2g
|
UTSW |
6 |
139,827,742 (GRCm39) |
nonsense |
probably null |
|
|
R9524:Pik3c2g
|
UTSW |
6 |
139,606,768 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9531:Pik3c2g
|
UTSW |
6 |
139,841,926 (GRCm39) |
missense |
|
|
|
R9630:Pik3c2g
|
UTSW |
6 |
139,599,237 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9697:Pik3c2g
|
UTSW |
6 |
139,913,517 (GRCm39) |
missense |
unknown |
|
|
R9708:Pik3c2g
|
UTSW |
6 |
139,606,865 (GRCm39) |
missense |
probably benign |
|
|
R9717:Pik3c2g
|
UTSW |
6 |
139,841,910 (GRCm39) |
missense |
|
|
|
RF015:Pik3c2g
|
UTSW |
6 |
139,700,497 (GRCm39) |
missense |
|
|
|
RF032:Pik3c2g
|
UTSW |
6 |
139,612,656 (GRCm39) |
frame shift |
probably null |
|
|
X0024:Pik3c2g
|
UTSW |
6 |
139,805,984 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGATGCATACATTCCTGAAGAC -3'
(R):5'- AGCCAGCAAGGTGATCAATG -3'
Sequencing Primer
(F):5'- TGCATACATTCCTGAAGACTAAAATC -3'
(R):5'- CCAGCAAGGTGATCAATGATAGCTTG -3'
|
| Posted On |
2016-10-26 |
Incidental Mutation