Incidental Mutation 'R5586:Anks1b'
| ID |
438733 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Anks1b
|
| Ensembl Gene |
ENSMUSG00000058589 |
| Gene Name |
ankyrin repeat and sterile alpha motif domain containing 1B |
| Synonyms |
C030032C09Rik, Gm10937, AIDA-1b, LOC380650, E530015N03Rik |
| MMRRC Submission |
043140-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5586 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
89709371-90809162 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 89912926 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Glutamine
at position 316
(H316Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000138209
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099368]
[ENSMUST00000182907]
[ENSMUST00000182936]
[ENSMUST00000183156]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099368
AA Change: H350Q
PolyPhen 2
Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000096968
Gene: ENSMUSG00000058589
AA Change: H350Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
931 |
4.44e-1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182907
|
| SMART Domains |
Protein: ENSMUSP00000138614
Gene: ENSMUSG00000058589
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
45 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000182936
AA Change: H316Q
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000138209
Gene: ENSMUSG00000058589
AA Change: H316Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
5.03e2 |
SMART |
|
low complexity region
|
464 |
479 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
543 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000183109
AA Change: H87Q
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000183156
AA Change: H350Q
PolyPhen 2
Score 0.108 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000138539
Gene: ENSMUSG00000058589
AA Change: H350Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
46 |
N/A |
INTRINSIC |
|
ANK
|
58 |
87 |
1.88e-5 |
SMART |
|
ANK
|
91 |
123 |
3.13e-2 |
SMART |
|
ANK
|
127 |
156 |
6.92e-4 |
SMART |
|
ANK
|
160 |
189 |
3.08e-1 |
SMART |
|
ANK
|
193 |
222 |
1.43e-5 |
SMART |
|
ANK
|
225 |
254 |
4.75e-2 |
SMART |
|
low complexity region
|
498 |
513 |
N/A |
INTRINSIC |
|
low complexity region
|
551 |
577 |
N/A |
INTRINSIC |
|
low complexity region
|
659 |
670 |
N/A |
INTRINSIC |
|
SAM
|
806 |
875 |
2.06e-19 |
SMART |
|
SAM
|
880 |
948 |
5.66e-17 |
SMART |
|
low complexity region
|
968 |
983 |
N/A |
INTRINSIC |
|
PTB
|
1056 |
1194 |
2.94e-38 |
SMART |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.6%
- 20x: 96.0%
|
| Validation Efficiency |
98% (101/103) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a conditional allele activated in neurons alters hippocampal synaptic transmission. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432E11Rik |
A |
G |
7: 29,277,153 (GRCm39) |
|
noncoding transcript |
Het |
| Aaas |
A |
T |
15: 102,255,111 (GRCm39) |
|
probably null |
Het |
| Abcc3 |
G |
A |
11: 94,255,247 (GRCm39) |
R600W |
probably damaging |
Het |
| Abhd13 |
A |
T |
8: 10,038,318 (GRCm39) |
Q305L |
probably benign |
Het |
| Adcy5 |
A |
T |
16: 34,977,486 (GRCm39) |
I340F |
probably damaging |
Het |
| Adgrl3 |
T |
A |
5: 81,871,994 (GRCm39) |
I964N |
probably damaging |
Het |
| Ap3d1 |
A |
T |
10: 80,554,964 (GRCm39) |
F454I |
possibly damaging |
Het |
| Apol7c |
T |
C |
15: 77,410,599 (GRCm39) |
R116G |
possibly damaging |
Het |
| Arhgap5 |
A |
G |
12: 52,566,695 (GRCm39) |
E1222G |
possibly damaging |
Het |
| AW551984 |
A |
G |
9: 39,502,559 (GRCm39) |
V673A |
probably benign |
Het |
| Baiap2l1 |
A |
G |
5: 144,218,949 (GRCm39) |
S220P |
probably damaging |
Het |
| Bcl6 |
A |
G |
16: 23,791,926 (GRCm39) |
F143L |
probably benign |
Het |
| Calb1 |
A |
T |
4: 15,900,811 (GRCm39) |
T165S |
probably benign |
Het |
| Ccdc66 |
C |
A |
14: 27,228,668 (GRCm39) |
G6C |
probably damaging |
Het |
| Ccdc88a |
A |
G |
11: 29,453,484 (GRCm39) |
I344V |
probably benign |
Het |
| Cdh19 |
T |
A |
1: 110,857,587 (GRCm39) |
D249V |
probably damaging |
Het |
| Ces1c |
T |
A |
8: 93,854,227 (GRCm39) |
T103S |
probably benign |
Het |
| Cfap54 |
T |
A |
10: 92,808,473 (GRCm39) |
K1401* |
probably null |
Het |
| Copa |
T |
A |
1: 171,932,789 (GRCm39) |
N371K |
probably damaging |
Het |
| Cyp2b10 |
A |
T |
7: 25,616,437 (GRCm39) |
Y348F |
probably damaging |
Het |
| Dennd5a |
T |
C |
7: 109,504,928 (GRCm39) |
R861G |
possibly damaging |
Het |
| Dhx8 |
T |
C |
11: 101,623,862 (GRCm39) |
|
probably benign |
Het |
| Dido1 |
C |
T |
2: 180,301,445 (GRCm39) |
W2153* |
probably null |
Het |
| Dlgap1 |
T |
A |
17: 71,125,156 (GRCm39) |
V969D |
probably damaging |
Het |
| Dvl3 |
A |
G |
16: 20,336,039 (GRCm39) |
D32G |
probably damaging |
Het |
| Epdr1 |
T |
C |
13: 19,778,718 (GRCm39) |
D24G |
probably benign |
Het |
| Etnk2 |
T |
A |
1: 133,307,043 (GRCm39) |
|
probably null |
Het |
| Fhad1 |
C |
T |
4: 141,632,442 (GRCm39) |
M1232I |
probably benign |
Het |
| Gcnt2 |
A |
C |
13: 41,014,429 (GRCm39) |
E200A |
probably damaging |
Het |
| Gm5174 |
A |
G |
10: 86,492,409 (GRCm39) |
|
noncoding transcript |
Het |
| Gm6408 |
T |
A |
5: 146,421,267 (GRCm39) |
F299I |
possibly damaging |
Het |
| Gpr85 |
G |
T |
6: 13,836,000 (GRCm39) |
Y301* |
probably null |
Het |
| Gucy2e |
G |
T |
11: 69,117,082 (GRCm39) |
P780T |
probably damaging |
Het |
| Icam5 |
A |
T |
9: 20,946,116 (GRCm39) |
N316I |
probably damaging |
Het |
| Ifit1bl1 |
C |
T |
19: 34,571,677 (GRCm39) |
R260Q |
probably damaging |
Het |
| Il1r1 |
A |
C |
1: 40,264,411 (GRCm39) |
|
probably benign |
Het |
| Kif3c |
A |
T |
12: 3,439,656 (GRCm39) |
I86F |
probably benign |
Het |
| Klhdc2 |
A |
G |
12: 69,354,467 (GRCm39) |
|
probably null |
Het |
| Mast2 |
A |
G |
4: 116,292,760 (GRCm39) |
L9P |
probably damaging |
Het |
| Mcoln1 |
G |
T |
8: 3,560,389 (GRCm39) |
C316F |
probably damaging |
Het |
| Mon1a |
A |
T |
9: 107,775,894 (GRCm39) |
D4V |
probably damaging |
Het |
| Ms4a18 |
T |
A |
19: 10,991,038 (GRCm39) |
M19L |
probably benign |
Het |
| Nbea |
T |
C |
3: 55,539,392 (GRCm39) |
K2790E |
probably benign |
Het |
| Niban1 |
C |
T |
1: 151,593,307 (GRCm39) |
T664I |
probably benign |
Het |
| Noc3l |
C |
T |
19: 38,803,139 (GRCm39) |
E167K |
possibly damaging |
Het |
| Nol10 |
G |
A |
12: 17,466,829 (GRCm39) |
E570K |
possibly damaging |
Het |
| Nr2e3 |
T |
C |
9: 59,856,484 (GRCm39) |
R69G |
probably damaging |
Het |
| Obscn |
G |
A |
11: 58,892,294 (GRCm39) |
R1358* |
probably null |
Het |
| Or14j4 |
A |
T |
17: 37,921,145 (GRCm39) |
F166I |
probably damaging |
Het |
| Or2b7 |
C |
A |
13: 21,739,266 (GRCm39) |
V309F |
probably damaging |
Het |
| Or52e8b |
A |
G |
7: 104,673,428 (GRCm39) |
I253T |
probably damaging |
Het |
| Or5b117 |
A |
T |
19: 13,431,746 (GRCm39) |
M45K |
probably benign |
Het |
| Pak2 |
A |
T |
16: 31,860,337 (GRCm39) |
D175E |
probably benign |
Het |
| Pccb |
C |
T |
9: 100,867,856 (GRCm39) |
V357I |
possibly damaging |
Het |
| Pcdhb4 |
C |
T |
18: 37,442,034 (GRCm39) |
P448L |
probably damaging |
Het |
| Pcdhb9 |
A |
G |
18: 37,534,167 (GRCm39) |
M54V |
probably benign |
Het |
| Ppp3cb |
A |
G |
14: 20,570,758 (GRCm39) |
|
probably benign |
Het |
| Ppp4r1 |
A |
G |
17: 66,131,563 (GRCm39) |
D452G |
probably benign |
Het |
| Pramel18 |
T |
A |
4: 101,767,317 (GRCm39) |
F189I |
probably benign |
Het |
| Prmt3 |
T |
A |
7: 49,476,499 (GRCm39) |
D369E |
probably damaging |
Het |
| Psmd12 |
T |
A |
11: 107,377,301 (GRCm39) |
V120D |
probably benign |
Het |
| Ptprb |
T |
C |
10: 116,189,732 (GRCm39) |
L1797P |
probably damaging |
Het |
| Ptprm |
A |
G |
17: 67,227,191 (GRCm39) |
S653P |
probably damaging |
Het |
| Pxdn |
T |
A |
12: 30,053,141 (GRCm39) |
V926D |
probably damaging |
Het |
| Retreg3 |
T |
G |
11: 100,997,165 (GRCm39) |
Q105P |
probably damaging |
Het |
| Sacs |
A |
T |
14: 61,443,890 (GRCm39) |
R1979* |
probably null |
Het |
| Scn2a |
T |
A |
2: 65,537,639 (GRCm39) |
L696* |
probably null |
Het |
| Sema3c |
A |
T |
5: 17,916,422 (GRCm39) |
N465Y |
probably damaging |
Het |
| Slc25a32 |
A |
T |
15: 38,963,308 (GRCm39) |
V171E |
possibly damaging |
Het |
| Slc30a7 |
C |
T |
3: 115,783,700 (GRCm39) |
V158I |
probably benign |
Het |
| Slc44a5 |
G |
A |
3: 153,975,802 (GRCm39) |
|
probably benign |
Het |
| Slc4a8 |
A |
G |
15: 100,685,045 (GRCm39) |
D140G |
probably damaging |
Het |
| Slc7a11 |
G |
A |
3: 50,397,532 (GRCm39) |
S60L |
possibly damaging |
Het |
| Spryd3 |
A |
T |
15: 102,040,372 (GRCm39) |
H59Q |
probably benign |
Het |
| Sqstm1 |
T |
C |
11: 50,093,849 (GRCm39) |
D256G |
probably damaging |
Het |
| Sst |
A |
T |
16: 23,708,487 (GRCm39) |
S115T |
probably damaging |
Het |
| Stimate |
A |
G |
14: 30,592,776 (GRCm39) |
K166E |
probably damaging |
Het |
| Surf1 |
T |
C |
2: 26,805,963 (GRCm39) |
|
probably benign |
Het |
| Synj1 |
A |
T |
16: 90,806,865 (GRCm39) |
|
probably benign |
Het |
| Tet1 |
C |
A |
10: 62,714,073 (GRCm39) |
C574F |
probably damaging |
Het |
| Thnsl1 |
T |
A |
2: 21,217,201 (GRCm39) |
Y318* |
probably null |
Het |
| Tomm70a |
A |
G |
16: 56,942,493 (GRCm39) |
E90G |
probably damaging |
Het |
| Treml4 |
A |
G |
17: 48,571,927 (GRCm39) |
D110G |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Txnl1 |
C |
T |
18: 63,797,396 (GRCm39) |
G283D |
probably damaging |
Het |
| Uba6 |
T |
C |
5: 86,282,906 (GRCm39) |
D559G |
probably damaging |
Het |
| Usp4 |
T |
C |
9: 108,233,661 (GRCm39) |
V94A |
possibly damaging |
Het |
| Vmn2r25 |
A |
C |
6: 123,802,255 (GRCm39) |
C549W |
probably damaging |
Het |
| Vmn2r59 |
G |
T |
7: 41,695,105 (GRCm39) |
Q436K |
probably benign |
Het |
| Wdr70 |
A |
T |
15: 7,913,769 (GRCm39) |
Y627N |
possibly damaging |
Het |
| Xpr1 |
T |
C |
1: 155,188,609 (GRCm39) |
I344V |
probably benign |
Het |
| Zfp423 |
T |
A |
8: 88,585,968 (GRCm39) |
Q61L |
possibly damaging |
Het |
|
| Other mutations in Anks1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01669:Anks1b
|
APN |
10 |
90,733,100 (GRCm39) |
splice site |
probably benign |
|
|
IGL01890:Anks1b
|
APN |
10 |
90,480,389 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL01966:Anks1b
|
APN |
10 |
90,730,994 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02176:Anks1b
|
APN |
10 |
89,878,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02205:Anks1b
|
APN |
10 |
89,906,956 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02465:Anks1b
|
APN |
10 |
89,999,127 (GRCm39) |
nonsense |
probably null |
|
|
IGL02534:Anks1b
|
APN |
10 |
90,730,979 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02554:Anks1b
|
APN |
10 |
90,757,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02820:Anks1b
|
APN |
10 |
89,912,921 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03164:Anks1b
|
APN |
10 |
89,878,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0096:Anks1b
|
UTSW |
10 |
89,909,924 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0482:Anks1b
|
UTSW |
10 |
90,195,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0542:Anks1b
|
UTSW |
10 |
89,909,829 (GRCm39) |
splice site |
probably benign |
|
|
R0848:Anks1b
|
UTSW |
10 |
89,906,987 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1056:Anks1b
|
UTSW |
10 |
90,757,291 (GRCm39) |
splice site |
probably null |
|
|
R1398:Anks1b
|
UTSW |
10 |
89,885,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1446:Anks1b
|
UTSW |
10 |
90,346,935 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1548:Anks1b
|
UTSW |
10 |
89,885,847 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1551:Anks1b
|
UTSW |
10 |
89,912,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1607:Anks1b
|
UTSW |
10 |
89,878,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1667:Anks1b
|
UTSW |
10 |
90,347,046 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1701:Anks1b
|
UTSW |
10 |
89,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1843:Anks1b
|
UTSW |
10 |
90,348,751 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1899:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1957:Anks1b
|
UTSW |
10 |
89,885,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2036:Anks1b
|
UTSW |
10 |
90,805,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2279:Anks1b
|
UTSW |
10 |
89,885,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2280:Anks1b
|
UTSW |
10 |
90,802,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2937:Anks1b
|
UTSW |
10 |
89,912,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3739:Anks1b
|
UTSW |
10 |
89,869,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4061:Anks1b
|
UTSW |
10 |
90,143,484 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4459:Anks1b
|
UTSW |
10 |
90,346,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4479:Anks1b
|
UTSW |
10 |
89,885,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4511:Anks1b
|
UTSW |
10 |
90,346,652 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4780:Anks1b
|
UTSW |
10 |
89,709,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4785:Anks1b
|
UTSW |
10 |
90,750,612 (GRCm39) |
missense |
probably null |
0.88 |
|
R4790:Anks1b
|
UTSW |
10 |
89,999,137 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5012:Anks1b
|
UTSW |
10 |
90,194,999 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5400:Anks1b
|
UTSW |
10 |
90,348,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5687:Anks1b
|
UTSW |
10 |
90,750,573 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5899:Anks1b
|
UTSW |
10 |
90,759,379 (GRCm39) |
splice site |
probably null |
|
|
R5917:Anks1b
|
UTSW |
10 |
90,412,803 (GRCm39) |
intron |
probably benign |
|
|
R5999:Anks1b
|
UTSW |
10 |
90,194,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6080:Anks1b
|
UTSW |
10 |
90,802,211 (GRCm39) |
nonsense |
probably null |
|
|
R6216:Anks1b
|
UTSW |
10 |
90,096,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6265:Anks1b
|
UTSW |
10 |
90,777,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6298:Anks1b
|
UTSW |
10 |
90,516,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6337:Anks1b
|
UTSW |
10 |
90,757,158 (GRCm39) |
missense |
probably benign |
0.27 |
|
R6522:Anks1b
|
UTSW |
10 |
90,733,189 (GRCm39) |
intron |
probably benign |
|
|
R6843:Anks1b
|
UTSW |
10 |
90,784,460 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6852:Anks1b
|
UTSW |
10 |
90,096,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Anks1b
|
UTSW |
10 |
89,905,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7114:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7211:Anks1b
|
UTSW |
10 |
90,346,932 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7241:Anks1b
|
UTSW |
10 |
90,348,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7264:Anks1b
|
UTSW |
10 |
90,348,732 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7325:Anks1b
|
UTSW |
10 |
90,777,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7392:Anks1b
|
UTSW |
10 |
90,516,648 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7578:Anks1b
|
UTSW |
10 |
89,885,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7604:Anks1b
|
UTSW |
10 |
90,096,708 (GRCm39) |
splice site |
probably null |
|
|
R7633:Anks1b
|
UTSW |
10 |
90,784,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7881:Anks1b
|
UTSW |
10 |
90,802,880 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7910:Anks1b
|
UTSW |
10 |
90,516,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7941:Anks1b
|
UTSW |
10 |
90,413,017 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8045:Anks1b
|
UTSW |
10 |
90,516,722 (GRCm39) |
missense |
probably benign |
|
|
R8146:Anks1b
|
UTSW |
10 |
90,143,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Anks1b
|
UTSW |
10 |
89,905,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8535:Anks1b
|
UTSW |
10 |
90,784,493 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8681:Anks1b
|
UTSW |
10 |
89,885,868 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9300:Anks1b
|
UTSW |
10 |
90,412,966 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9469:Anks1b
|
UTSW |
10 |
90,733,205 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9541:Anks1b
|
UTSW |
10 |
90,412,947 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9550:Anks1b
|
UTSW |
10 |
90,412,360 (GRCm39) |
start codon destroyed |
probably null |
|
|
R9653:Anks1b
|
UTSW |
10 |
90,346,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF004:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF008:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF017:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF023:Anks1b
|
UTSW |
10 |
89,869,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0064:Anks1b
|
UTSW |
10 |
90,348,707 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTTTTGTCCTCTGTCAACACGG -3'
(R):5'- AGGGACATTGACATTTGATCAGC -3'
Sequencing Primer
(F):5'- ACGGCAGTCTCACTTACATG -3'
(R):5'- GACATTTGATCAGCGCTGAATCCG -3'
|
| Posted On |
2016-10-26 |
Incidental Mutation