Incidental Mutation 'R5602:Gpr3'
ID 439066
Institutional Source Beutler Lab
Gene Symbol Gpr3
Ensembl Gene ENSMUSG00000049649
Gene Name G-protein coupled receptor 3
Synonyms Gpcr3, Gpcr21
MMRRC Submission 043154-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.244) question?
Stock # R5602 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 132936651-132939847 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 132937805 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 289 (N289S)
Ref Sequence ENSEMBL: ENSMUSP00000101531 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052090] [ENSMUST00000105911] [ENSMUST00000151025]
AlphaFold P35413
Predicted Effect probably damaging
Transcript: ENSMUST00000052090
AA Change: N289S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000062083
Gene: ENSMUSG00000049649
AA Change: N289S

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:7tm_1 57 297 2.4e-40 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000105911
AA Change: N289S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101531
Gene: ENSMUSG00000049649
AA Change: N289S

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:7tm_1 57 297 2e-34 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150744
Predicted Effect probably benign
Transcript: ENSMUST00000151025
SMART Domains Protein: ENSMUSP00000116032
Gene: ENSMUSG00000049649

DomainStartEndE-ValueType
SCOP:d1l9ha_ 20 95 3e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218338
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218998
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mice homozygous for one allele display an increased thermal nociceptive threshold while females homozygous for another allele display age-related reproductive failure due to ovulation of a progressively increasing proportion of developmentally incompetent oocytes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik G A 2: 151,315,459 (GRCm39) S73F possibly damaging Het
4932414N04Rik A T 2: 68,578,712 (GRCm39) *753L probably null Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Adam19 T C 11: 46,027,142 (GRCm39) S592P probably benign Het
Adamtsl3 A G 7: 82,206,447 (GRCm39) K843R possibly damaging Het
Ap2a2 A T 7: 141,184,855 (GRCm39) T213S probably benign Het
Asb5 A G 8: 55,038,974 (GRCm39) E280G probably benign Het
Becn1 T C 11: 101,179,778 (GRCm39) D403G probably damaging Het
Ccr7 G T 11: 99,036,315 (GRCm39) N202K probably benign Het
Cd36 T C 5: 18,019,790 (GRCm39) T104A possibly damaging Het
Cnot4 C T 6: 35,028,464 (GRCm39) W384* probably null Het
Col15a1 G A 4: 47,312,087 (GRCm39) V1301M probably damaging Het
Dock2 C A 11: 34,204,391 (GRCm39) A1384S probably benign Het
Ehbp1l1 T C 19: 5,758,698 (GRCm39) E1648G possibly damaging Het
Fbn1 G T 2: 125,163,661 (GRCm39) A2065E possibly damaging Het
Fras1 A G 5: 96,884,880 (GRCm39) Y2586C probably damaging Het
Galm T A 17: 80,457,568 (GRCm39) Y28* probably null Het
Ggt7 A G 2: 155,332,919 (GRCm39) V648A possibly damaging Het
Gm17067 T A 7: 42,357,839 (GRCm39) D221V probably damaging Het
Ighv11-2 A G 12: 114,012,277 (GRCm39) probably benign Het
Ighv11-2 G A 12: 114,012,099 (GRCm39) L39F probably damaging Het
Ipo9 G A 1: 135,329,983 (GRCm39) L486F probably damaging Het
Jak2 T A 19: 29,275,739 (GRCm39) N726K probably benign Het
Map4 T C 9: 109,881,768 (GRCm39) S211P possibly damaging Het
Mlh1 A T 9: 111,081,946 (GRCm39) L259Q probably damaging Het
Naa25 A G 5: 121,558,558 (GRCm39) E300G probably benign Het
Or8g34 A T 9: 39,373,326 (GRCm39) M200L probably benign Het
Or8g54 T A 9: 39,707,490 (GRCm39) V273E possibly damaging Het
Parva G A 7: 112,166,972 (GRCm39) V182I probably benign Het
Pcdhgb4 T C 18: 37,854,697 (GRCm39) I364T probably damaging Het
Pdik1l A G 4: 134,011,580 (GRCm39) S164P probably damaging Het
Pfas A T 11: 68,881,871 (GRCm39) I938N probably benign Het
Plscr1l1 G A 9: 92,234,721 (GRCm39) C152Y possibly damaging Het
Prdm4 TCTCCTCCT TCTCCT 10: 85,728,987 (GRCm39) probably null Het
Prob1 C T 18: 35,787,079 (GRCm39) V392M possibly damaging Het
Rasgrf1 T C 9: 89,793,624 (GRCm39) S134P possibly damaging Het
Rorb T A 19: 18,955,301 (GRCm39) Y20F probably damaging Het
Rsph9 G T 17: 46,445,909 (GRCm39) D220E probably damaging Het
Safb2 C A 17: 56,882,630 (GRCm39) K334N possibly damaging Het
Sall3 T C 18: 81,016,027 (GRCm39) T634A probably benign Het
Scaf1 A G 7: 44,657,007 (GRCm39) probably benign Het
Slco1a5 T A 6: 142,221,255 (GRCm39) probably benign Het
Spata21 C T 4: 140,824,210 (GRCm39) R158C probably benign Het
Srrm2 G A 17: 24,038,311 (GRCm39) probably benign Het
Stk38l C A 6: 146,659,998 (GRCm39) T10N probably benign Het
Supv3l1 G A 10: 62,266,371 (GRCm39) P602S possibly damaging Het
Timm44 C T 8: 4,316,769 (GRCm39) probably null Het
Tll2 T A 19: 41,093,420 (GRCm39) R465S possibly damaging Het
Tmem104 G A 11: 115,095,950 (GRCm39) A164T probably damaging Het
Tmem151b A G 17: 45,856,526 (GRCm39) S305P probably damaging Het
Utrn T C 10: 12,625,839 (GRCm39) D114G probably damaging Het
Vmn2r109 A T 17: 20,760,933 (GRCm39) M808K possibly damaging Het
Washc2 T A 6: 116,225,056 (GRCm39) D801E possibly damaging Het
Xkr4 T C 1: 3,286,751 (GRCm39) I480V probably benign Het
Zfp507 G T 7: 35,475,663 (GRCm39) S58* probably null Het
Zfp768 T A 7: 126,943,804 (GRCm39) D108V possibly damaging Het
Other mutations in Gpr3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02424:Gpr3 APN 4 132,938,405 (GRCm39) missense probably damaging 1.00
IGL02974:Gpr3 APN 4 132,938,220 (GRCm39) missense possibly damaging 0.90
R0095:Gpr3 UTSW 4 132,938,597 (GRCm39) missense probably benign 0.01
R0532:Gpr3 UTSW 4 132,937,796 (GRCm39) missense probably damaging 1.00
R1831:Gpr3 UTSW 4 132,938,454 (GRCm39) missense possibly damaging 0.80
R2127:Gpr3 UTSW 4 132,937,932 (GRCm39) missense probably damaging 0.96
R4077:Gpr3 UTSW 4 132,938,226 (GRCm39) missense probably damaging 1.00
R4078:Gpr3 UTSW 4 132,938,226 (GRCm39) missense probably damaging 1.00
R5306:Gpr3 UTSW 4 132,938,490 (GRCm39) missense probably damaging 1.00
R5712:Gpr3 UTSW 4 132,937,719 (GRCm39) missense probably benign 0.01
R5913:Gpr3 UTSW 4 132,938,489 (GRCm39) missense probably damaging 1.00
R7434:Gpr3 UTSW 4 132,938,448 (GRCm39) missense probably benign 0.45
R7645:Gpr3 UTSW 4 132,938,640 (GRCm39) missense probably damaging 1.00
R7709:Gpr3 UTSW 4 132,937,748 (GRCm39) missense probably damaging 1.00
R8043:Gpr3 UTSW 4 132,938,271 (GRCm39) missense probably damaging 1.00
R8818:Gpr3 UTSW 4 132,938,538 (GRCm39) missense possibly damaging 0.95
R9015:Gpr3 UTSW 4 132,938,390 (GRCm39) missense possibly damaging 0.80
R9027:Gpr3 UTSW 4 132,938,209 (GRCm39) nonsense probably null
R9587:Gpr3 UTSW 4 132,937,988 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGGTGGACCTAACACTCTG -3'
(R):5'- AGCTCTATGCCCAGATCTGC -3'

Sequencing Primer
(F):5'- GTGGACCTAACACTCTGGAGTTC -3'
(R):5'- AGATCTGCCGCATCGTCTG -3'
Posted On 2016-10-26