Incidental Mutation 'R5604:Zfp87'
ID 439208
Institutional Source Beutler Lab
Gene Symbol Zfp87
Ensembl Gene ENSMUSG00000097333
Gene Name zinc finger protein 87
Synonyms Mzf22, 2210039O17Rik, 4631412O18Rik, Zfp72, KRAB4
MMRRC Submission 043156-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R5604 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 67663900-67674296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 67665945 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 172 (K172N)
Ref Sequence ENSEMBL: ENSMUSP00000138087 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167914] [ENSMUST00000180536] [ENSMUST00000181341] [ENSMUST00000181573] [ENSMUST00000181767]
AlphaFold Q8K2A4
Predicted Effect probably benign
Transcript: ENSMUST00000167914
SMART Domains Protein: ENSMUSP00000137830
Gene: ENSMUSG00000097565

DomainStartEndE-ValueType
KRAB 5 65 4.41e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000180536
SMART Domains Protein: ENSMUSP00000137812
Gene: ENSMUSG00000097333

DomainStartEndE-ValueType
KRAB 5 51 7.02e-19 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181341
SMART Domains Protein: ENSMUSP00000137689
Gene: ENSMUSG00000097333

DomainStartEndE-ValueType
KRAB 5 65 4.41e-34 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000181573
SMART Domains Protein: ENSMUSP00000138011
Gene: ENSMUSG00000097333

DomainStartEndE-ValueType
KRAB 5 51 7.02e-19 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000181767
AA Change: K172N

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000138087
Gene: ENSMUSG00000097333
AA Change: K172N

DomainStartEndE-ValueType
KRAB 5 65 4.41e-34 SMART
ZnF_C2H2 109 131 2.61e-4 SMART
ZnF_C2H2 137 159 9.22e-5 SMART
ZnF_C2H2 165 187 2.36e-2 SMART
ZnF_C2H2 193 215 7.15e-2 SMART
ZnF_C2H2 221 243 9.22e-5 SMART
ZnF_C2H2 249 271 3.63e-3 SMART
ZnF_C2H2 277 299 6.42e-4 SMART
ZnF_C2H2 305 327 2.99e-4 SMART
ZnF_C2H2 333 355 2.4e-3 SMART
ZnF_C2H2 361 383 5.59e-4 SMART
ZnF_C2H2 389 411 3.69e-4 SMART
ZnF_C2H2 417 439 5.9e-3 SMART
ZnF_C2H2 445 467 3.21e-4 SMART
ZnF_C2H2 472 494 9.08e-4 SMART
ZnF_C2H2 500 522 4.47e-3 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310034C09Rik A T 16: 88,556,278 (GRCm39) N164I possibly damaging Het
4933402J07Rik C A 8: 88,295,125 (GRCm39) R88S possibly damaging Het
Abca1 A T 4: 53,067,168 (GRCm39) probably null Het
Abca13 T A 11: 9,516,279 (GRCm39) I4406K probably damaging Het
Adam6b T A 12: 113,454,420 (GRCm39) Y412* probably null Het
Ahcyl2 C T 6: 29,908,366 (GRCm39) H370Y probably damaging Het
Ahi1 A G 10: 20,862,904 (GRCm39) Y693C probably damaging Het
Anapc4 T A 5: 52,999,076 (GRCm39) Y129* probably null Het
Ankrd35 A G 3: 96,592,215 (GRCm39) T834A probably benign Het
Antxr2 T C 5: 98,096,169 (GRCm39) K372E probably damaging Het
Arhgef1 C T 7: 24,612,210 (GRCm39) H198Y probably benign Het
Barhl2 T C 5: 106,603,412 (GRCm39) E249G probably benign Het
C2cd5 T C 6: 142,957,747 (GRCm39) E987G probably benign Het
C87436 T C 6: 86,424,337 (GRCm39) S290P probably benign Het
Ccser1 C T 6: 61,290,788 (GRCm39) T490M probably damaging Het
Cd8b1 T C 6: 71,303,159 (GRCm39) V78A probably benign Het
Cdc25c A G 18: 34,866,701 (GRCm39) Y374H probably damaging Het
Cmya5 C T 13: 93,229,271 (GRCm39) R1939H probably benign Het
Cyp2d40 A G 15: 82,648,256 (GRCm39) F19S probably damaging Het
Dll3 A G 7: 27,994,057 (GRCm39) V460A probably benign Het
Dnajb12 GC G 10: 59,728,574 (GRCm39) probably null Het
E4f1 A G 17: 24,663,118 (GRCm39) I729T probably damaging Het
Endou A C 15: 97,618,800 (GRCm39) S75A probably benign Het
Epas1 C T 17: 87,113,200 (GRCm39) H129Y probably damaging Het
Grm1 T A 10: 10,622,479 (GRCm39) N415Y probably damaging Het
Hdc A T 2: 126,436,583 (GRCm39) S429R probably benign Het
Hnf4g C T 3: 3,722,186 (GRCm39) Q447* probably null Het
Htr6 C T 4: 138,788,814 (GRCm39) A414T probably benign Het
Insig1 T C 5: 28,280,080 (GRCm39) L224P probably damaging Het
Ipo9 G A 1: 135,329,983 (GRCm39) L486F probably damaging Het
Irak2 T A 6: 113,667,792 (GRCm39) S458T possibly damaging Het
Irs2 A G 8: 11,055,007 (GRCm39) S1142P possibly damaging Het
Kirrel1 T A 3: 86,996,462 (GRCm39) N379I possibly damaging Het
L3mbtl4 T A 17: 69,084,917 (GRCm39) D609E probably benign Het
Lama3 A G 18: 12,572,405 (GRCm39) T537A probably benign Het
Lce1i A T 3: 92,685,056 (GRCm39) V40E unknown Het
Mprip T A 11: 59,649,293 (GRCm39) V999D probably benign Het
Myd88 G T 9: 119,168,829 (GRCm39) T85K possibly damaging Het
Or1e35 T A 11: 73,797,853 (GRCm39) H155L probably benign Het
Padi6 A T 4: 140,458,473 (GRCm39) M473K probably damaging Het
Pcdh12 T A 18: 38,401,935 (GRCm39) S97C probably damaging Het
Pkd1l1 T A 11: 8,783,877 (GRCm39) D2026V probably damaging Het
Plcxd1 T C 5: 110,250,451 (GRCm39) V264A probably benign Het
Plekha4 T C 7: 45,198,580 (GRCm39) S558P probably damaging Het
Ppm1a T A 12: 72,837,455 (GRCm39) M334K probably benign Het
Ppp1r13l T C 7: 19,109,524 (GRCm39) S684P possibly damaging Het
Prdm4 TCTCCTCCT TCTCCT 10: 85,728,987 (GRCm39) probably null Het
Prl2a1 T C 13: 27,990,369 (GRCm39) probably benign Het
Ptch1 T C 13: 63,672,936 (GRCm39) K753E probably benign Het
Qrich1 A G 9: 108,436,502 (GRCm39) probably benign Het
Ror2 G A 13: 53,271,201 (GRCm39) R373C probably benign Het
Rtn4 C A 11: 29,658,140 (GRCm39) L765I probably damaging Het
Sema3a T C 5: 13,523,487 (GRCm39) probably null Het
Setd2 T A 9: 110,433,284 (GRCm39) D62E probably damaging Het
Ss18 A T 18: 14,769,577 (GRCm39) Y327N unknown Het
Ticam1 G A 17: 56,578,756 (GRCm39) T113I probably benign Het
Tnrc6a A G 7: 122,773,459 (GRCm39) I1134V probably damaging Het
Top3b T G 16: 16,707,399 (GRCm39) Y526* probably null Het
Tph2 T C 10: 114,926,614 (GRCm39) E384G probably damaging Het
Ttll11 A T 2: 35,707,798 (GRCm39) I503N probably benign Het
Other mutations in Zfp87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02165:Zfp87 APN 13 67,665,989 (GRCm39) missense probably damaging 0.99
IGL02372:Zfp87 APN 13 67,668,739 (GRCm39) splice site probably benign
IGL03160:Zfp87 APN 13 67,669,392 (GRCm39) missense probably damaging 1.00
R0653:Zfp87 UTSW 13 74,520,190 (GRCm39) missense probably damaging 1.00
R0711:Zfp87 UTSW 13 74,524,544 (GRCm39) splice site probably benign
R1498:Zfp87 UTSW 13 74,520,736 (GRCm39) missense probably benign 0.01
R3801:Zfp87 UTSW 13 67,669,334 (GRCm39) missense probably damaging 1.00
R4032:Zfp87 UTSW 13 74,520,449 (GRCm39) missense possibly damaging 0.62
R4629:Zfp87 UTSW 13 74,520,512 (GRCm39) missense probably damaging 1.00
R4950:Zfp87 UTSW 13 67,666,018 (GRCm39) missense probably benign 0.20
R6111:Zfp87 UTSW 13 74,520,504 (GRCm39) missense probably benign 0.31
R6130:Zfp87 UTSW 13 74,520,460 (GRCm39) missense possibly damaging 0.75
R6277:Zfp87 UTSW 13 74,520,643 (GRCm39) nonsense probably null
R6392:Zfp87 UTSW 13 67,664,986 (GRCm39) missense probably benign 0.00
R6800:Zfp87 UTSW 13 74,520,080 (GRCm39) missense probably benign 0.00
R6909:Zfp87 UTSW 13 74,519,861 (GRCm39) missense possibly damaging 0.47
R7009:Zfp87 UTSW 13 67,665,173 (GRCm39) missense probably damaging 1.00
R7183:Zfp87 UTSW 13 67,665,593 (GRCm39) missense probably damaging 1.00
R7298:Zfp87 UTSW 13 74,520,513 (GRCm39) missense possibly damaging 0.93
R7330:Zfp87 UTSW 13 74,523,153 (GRCm39) missense probably damaging 0.99
R7341:Zfp87 UTSW 13 74,520,467 (GRCm39) missense possibly damaging 0.68
R7448:Zfp87 UTSW 13 67,665,163 (GRCm39) missense probably benign 0.01
R7597:Zfp87 UTSW 13 67,665,412 (GRCm39) missense probably benign 0.06
R8696:Zfp87 UTSW 13 74,520,599 (GRCm39) missense probably damaging 1.00
R9280:Zfp87 UTSW 13 74,520,803 (GRCm39) missense probably benign 0.16
R9429:Zfp87 UTSW 13 74,520,703 (GRCm39) missense probably damaging 1.00
R9780:Zfp87 UTSW 13 67,665,241 (GRCm39) missense probably damaging 1.00
R9782:Zfp87 UTSW 13 74,520,932 (GRCm39) missense probably benign 0.00
RF014:Zfp87 UTSW 13 74,523,173 (GRCm39) missense probably benign 0.17
Z1176:Zfp87 UTSW 13 67,674,275 (GRCm39) start gained probably benign
Z1177:Zfp87 UTSW 13 74,519,911 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTCTGAGCTAGTTCTAAACATGC -3'
(R):5'- GAATGTCGCTTGGAGCTCATTC -3'

Sequencing Primer
(F):5'- ACACTCTTCACACTGGTAGGG -3'
(R):5'- AGTTCATCCTGTGGAGAAGCC -3'
Posted On 2016-10-26