Incidental Mutation 'R5605:Lrrc10'
ID 439255
Institutional Source Beutler Lab
Gene Symbol Lrrc10
Ensembl Gene ENSMUSG00000060187
Gene Name leucine rich repeat containing 10
Synonyms D330003I11Rik, Hrlrrp, Serdin1
MMRRC Submission 043270-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5605 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 116881246-116882673 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 116881805 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 160 (P160T)
Ref Sequence ENSEMBL: ENSMUSP00000073502 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073834]
AlphaFold Q8K3W2
Predicted Effect probably damaging
Transcript: ENSMUST00000073834
AA Change: P160T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000073502
Gene: ENSMUSG00000060187
AA Change: P160T

DomainStartEndE-ValueType
LRR 51 73 3.75e0 SMART
LRR 74 95 2.2e1 SMART
LRR 97 119 2.76e1 SMART
LRR_TYP 120 143 1.92e-2 SMART
LRR 166 189 1.62e0 SMART
low complexity region 265 274 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217799
Meta Mutation Damage Score 0.3994 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.9%
Validation Efficiency 100% (55/55)
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation are viable and fertile. They show prenatal systolic dysfunction and development of dilated cardiomyopathy in postnatal life. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l2 C A 18: 67,575,425 (GRCm39) G83* probably null Het
Arap2 A T 5: 62,772,410 (GRCm39) M1476K possibly damaging Het
Catsper2 G A 2: 121,227,533 (GRCm39) R546C possibly damaging Het
Ceacam5 T C 7: 17,481,161 (GRCm39) F303L probably benign Het
Clvs1 A G 4: 9,281,751 (GRCm39) D65G probably damaging Het
Coq5 T C 5: 115,421,776 (GRCm39) probably null Het
D630045J12Rik A T 6: 38,168,699 (GRCm39) V950E probably damaging Het
Dennd4b G A 3: 90,175,675 (GRCm39) R148Q probably damaging Het
Dnah7c A G 1: 46,837,395 (GRCm39) D3936G possibly damaging Het
Doc2b T C 11: 75,662,786 (GRCm39) E404G probably damaging Het
Dsg1b C T 18: 20,532,596 (GRCm39) P547S probably benign Het
Eif1ad17 T A 12: 87,978,768 (GRCm39) C51S probably damaging Het
Erich6 A G 3: 58,532,540 (GRCm39) Y356H probably damaging Het
Galnt6 C T 15: 100,595,106 (GRCm39) R465Q probably damaging Het
Gbp5 T C 3: 142,207,037 (GRCm39) S69P probably damaging Het
Gdpd4 T C 7: 97,655,507 (GRCm39) V562A probably benign Het
Greb1 A T 12: 16,758,727 (GRCm39) V663D probably damaging Het
Gtf3c3 A T 1: 54,455,085 (GRCm39) S593T probably benign Het
H2-Eb1 T C 17: 34,528,807 (GRCm39) S113P probably benign Het
Herc3 C T 6: 58,834,712 (GRCm39) R240C probably damaging Het
Iqub T C 6: 24,505,620 (GRCm39) D96G probably benign Het
Irag1 C T 7: 110,545,209 (GRCm39) C29Y possibly damaging Het
Kcnt2 A T 1: 140,502,481 (GRCm39) E858D possibly damaging Het
Lcor T A 19: 41,571,302 (GRCm39) I165N probably damaging Het
Lrp2 C T 2: 69,353,643 (GRCm39) R539K probably damaging Het
Map3k12 G T 15: 102,412,300 (GRCm39) D280E probably benign Het
Mcub T C 3: 129,710,658 (GRCm39) E258G probably damaging Het
Mdn1 T C 4: 32,765,664 (GRCm39) S5208P probably benign Het
Med20 C A 17: 47,934,069 (GRCm39) probably benign Het
Mertk T C 2: 128,580,227 (GRCm39) V227A probably benign Het
Ncstn A G 1: 171,908,717 (GRCm39) probably benign Het
Nedd4l T C 18: 65,307,315 (GRCm39) probably null Het
Nfyc A G 4: 120,647,686 (GRCm39) probably benign Het
Npdc1 G A 2: 25,298,957 (GRCm39) D284N probably damaging Het
Nt5dc1 C T 10: 34,279,691 (GRCm39) C117Y probably benign Het
Nup88 A T 11: 70,834,896 (GRCm39) probably benign Het
Or6z7 C T 7: 6,483,325 (GRCm39) V277M probably benign Het
Pbrm1 T A 14: 30,757,949 (GRCm39) I193K probably benign Het
Pcsk2 T C 2: 143,591,165 (GRCm39) probably benign Het
Pdzd2 A T 15: 12,592,436 (GRCm39) C69* probably null Het
Polr1e A G 4: 45,018,723 (GRCm39) T18A probably benign Het
Prima1 T A 12: 103,166,163 (GRCm39) I124F probably benign Het
Rbm34 T C 8: 127,676,169 (GRCm39) K382R probably benign Het
Rftn1 T G 17: 50,354,435 (GRCm39) N309T probably damaging Het
Septin1 C T 7: 126,814,598 (GRCm39) D260N probably damaging Het
Serpina3g T C 12: 104,207,299 (GRCm39) V154A probably damaging Het
Spef2 A T 15: 9,609,606 (GRCm39) N1306K probably damaging Het
Stk4 T C 2: 163,921,486 (GRCm39) F29S probably damaging Het
Stxbp5 A G 10: 9,645,490 (GRCm39) probably benign Het
Tbl3 T C 17: 24,919,733 (GRCm39) T774A probably benign Het
Tinag A G 9: 76,952,694 (GRCm39) Y97H probably damaging Het
Tpm1 T C 9: 66,956,317 (GRCm39) E33G probably damaging Het
Usp17lb T C 7: 104,489,847 (GRCm39) E359G probably benign Het
Vmn2r91 A G 17: 18,356,763 (GRCm39) E810G probably damaging Het
Vwce A T 19: 10,635,402 (GRCm39) T633S possibly damaging Het
Ylpm1 G A 12: 85,075,627 (GRCm39) R326H probably damaging Het
Other mutations in Lrrc10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01985:Lrrc10 APN 10 116,881,921 (GRCm39) missense probably damaging 1.00
R0077:Lrrc10 UTSW 10 116,881,419 (GRCm39) missense probably damaging 1.00
R0110:Lrrc10 UTSW 10 116,881,695 (GRCm39) missense probably damaging 1.00
R0469:Lrrc10 UTSW 10 116,881,695 (GRCm39) missense probably damaging 1.00
R0510:Lrrc10 UTSW 10 116,881,695 (GRCm39) missense probably damaging 1.00
R1293:Lrrc10 UTSW 10 116,881,838 (GRCm39) missense probably benign 0.02
R1642:Lrrc10 UTSW 10 116,881,788 (GRCm39) missense probably damaging 1.00
R3835:Lrrc10 UTSW 10 116,881,691 (GRCm39) missense possibly damaging 0.75
R4413:Lrrc10 UTSW 10 116,881,719 (GRCm39) missense probably damaging 1.00
R5165:Lrrc10 UTSW 10 116,881,965 (GRCm39) missense probably benign 0.02
R5289:Lrrc10 UTSW 10 116,881,392 (GRCm39) missense probably benign 0.01
R6418:Lrrc10 UTSW 10 116,881,616 (GRCm39) missense probably damaging 1.00
R6827:Lrrc10 UTSW 10 116,881,545 (GRCm39) missense possibly damaging 0.79
R6916:Lrrc10 UTSW 10 116,881,454 (GRCm39) missense possibly damaging 0.80
R7678:Lrrc10 UTSW 10 116,881,662 (GRCm39) missense probably benign 0.00
R8866:Lrrc10 UTSW 10 116,881,858 (GRCm39) missense probably damaging 0.99
R9355:Lrrc10 UTSW 10 116,881,881 (GRCm39) missense probably damaging 1.00
X0020:Lrrc10 UTSW 10 116,881,335 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGCCTTGGATTTCAACAACTTC -3'
(R):5'- AGCTTCAGATTTGTCAAGTGGG -3'

Sequencing Primer
(F):5'- GTGTGTACCTTGAAACAGCTC -3'
(R):5'- CAGATTTGTCAAGTGGGCCAGG -3'
Posted On 2016-10-26