Mutagenetix > Incidental Mutation

Incidental Mutation 'R5618:Or8b44'

439645

Institutional Source

Beutler Lab

Gene Symbol

Or8b44

Ensembl Gene

ENSMUSG00000094810

Gene Name

olfactory receptor family 8 subfamily B member 44

Synonyms

MOR165-5, GA_x6K02T2PVTD-32204729-32205661, Olfr907

MMRRC Submission

043277-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R5618 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

38409967-38410899 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to T at 38410036 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 24 (Q24*)

Ref Sequence

ENSEMBL: ENSMUSP00000148894 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052901] [ENSMUST00000214003] [ENSMUST00000214264]

AlphaFold

Q7TRC7

Predicted Effect

probably null
Transcript: ENSMUST00000052901
AA Change: Q24*

SMART Domains

Protein: ENSMUSP00000051531
Gene: ENSMUSG00000094810
AA Change: Q24*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	3.4e-46	PFAM
Pfam:7tm_1	41	290	2.8e-21	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000214003
AA Change: Q24*

Predicted Effect

probably null
Transcript: ENSMUST00000214264
AA Change: Q24*

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.2%
20x: 95.2%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700028K03Rik	G	A	5: 107,696,065 (GRCm39)	W167*	probably null	Het
Acvr1	C	T	2: 58,352,955 (GRCm39)	R335Q	probably damaging	Het
Atg7	A	G	6: 114,650,660 (GRCm39)	D67G	probably damaging	Het
Avil	T	C	10: 126,846,446 (GRCm39)	F417S	possibly damaging	Het
AW551984	A	T	9: 39,502,000 (GRCm39)	L702Q	probably damaging	Het
Bcl7a	A	T	5: 123,499,265 (GRCm39)	N95Y	probably damaging	Het
Cblb	A	G	16: 51,973,031 (GRCm39)	D454G	possibly damaging	Het
Cc2d2a	A	T	5: 43,887,249 (GRCm39)	Q1226H	probably benign	Het
Cct5	A	G	15: 31,598,161 (GRCm39)	S13P	possibly damaging	Het
Clca3a1	C	T	3: 144,710,738 (GRCm39)	E822K	probably benign	Het
Csgalnact2	A	T	6: 118,103,277 (GRCm39)	D228E	probably damaging	Het
Defb12	A	T	8: 19,164,814 (GRCm39)	M8K	possibly damaging	Het
Dipk1b	T	C	2: 26,524,887 (GRCm39)	S96P	probably damaging	Het
Dysf	A	G	6: 84,083,806 (GRCm39)	D736G	probably benign	Het
Exog	G	T	9: 119,291,817 (GRCm39)	D365Y	probably damaging	Het
Fam222b	T	G	11: 78,045,066 (GRCm39)	V81G	probably benign	Het
Fbl	A	G	7: 27,878,411 (GRCm39)	E301G	probably damaging	Het
Fez1	A	T	9: 36,755,228 (GRCm39)	N76Y	probably damaging	Het
Gnb4	C	T	3: 32,645,356 (GRCm39)	V112I	probably benign	Het
H2-Q4	T	A	17: 35,598,901 (GRCm39)	F57Y	probably damaging	Het
Ift88	T	C	14: 57,718,965 (GRCm39)	I650T	possibly damaging	Het
Kif1b	A	T	4: 149,354,346 (GRCm39)	D231E	possibly damaging	Het
Lig4	A	T	8: 10,022,021 (GRCm39)	D586E	probably benign	Het
Mlc1	C	A	15: 88,858,769 (GRCm39)	L126F	probably damaging	Het
Muc4	A	G	16: 32,754,253 (GRCm38)	T1376A	probably benign	Het
Ncoa6	A	T	2: 155,279,817 (GRCm39)	D66E	possibly damaging	Het
Or6ae1	A	G	7: 139,742,185 (GRCm39)	V226A	probably damaging	Het
Pard6a	T	C	8: 106,429,546 (GRCm39)	V168A	probably damaging	Het
Pmpcb	A	G	5: 21,947,786 (GRCm39)	N163S	possibly damaging	Het
Pramel27	A	T	4: 143,577,263 (GRCm39)	E15V	possibly damaging	Het
Prdm2	C	T	4: 142,860,107 (GRCm39)	C1061Y	probably benign	Het
Prkdc	A	G	16: 15,627,476 (GRCm39)	Y3378C	probably damaging	Het
Sema6a	A	T	18: 47,415,015 (GRCm39)	V425E	probably damaging	Het
Sema7a	A	T	9: 57,867,566 (GRCm39)	E439D	possibly damaging	Het
Serpinf1	T	A	11: 75,301,010 (GRCm39)	T402S	possibly damaging	Het
Sf3a2	T	C	10: 80,640,410 (GRCm39)		probably benign	Het
Skic3	T	A	13: 76,321,545 (GRCm39)	S1346T	probably benign	Het
Smchd1	A	T	17: 71,762,722 (GRCm39)	D172E	probably damaging	Het
Spag5	T	G	11: 78,194,906 (GRCm39)	I71S	probably benign	Het
Spata31d1d	G	A	13: 59,874,214 (GRCm39)	A1107V	probably benign	Het
Svep1	A	C	4: 58,070,537 (GRCm39)	S2416R	probably benign	Het
Tbc1d9	A	G	8: 83,969,221 (GRCm39)	Y503C	probably damaging	Het
Tlr9	A	T	9: 106,101,938 (GRCm39)	I410F	possibly damaging	Het
Tmem87a	C	A	2: 120,199,787 (GRCm39)	L452F	probably benign	Het
Tmprss11d	A	T	5: 86,454,154 (GRCm39)	M217K	probably benign	Het
Uqcc4	G	A	17: 25,403,963 (GRCm39)	S101N	probably damaging	Het
Vmn2r80	T	C	10: 78,984,755 (GRCm39)	Y36H	probably benign	Het
Vmn2r87	A	T	10: 130,315,817 (GRCm39)	F83Y	probably damaging	Het
Vmp1	C	T	11: 86,554,388 (GRCm39)	R75H	probably benign	Het
Wapl	T	A	14: 34,413,863 (GRCm39)	Y242N	possibly damaging	Het
Zfp473	T	A	7: 44,391,156 (GRCm39)	D6V	probably benign	Het

Other mutations in Or8b44

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01506:Or8b44	APN	9	38,410,171 (GRCm39)	missense	probably benign	0.04
IGL01960:Or8b44	APN	9	38,410,003 (GRCm39)	missense	probably damaging	1.00
IGL02612:Or8b44	APN	9	38,410,769 (GRCm39)	missense	probably benign	0.01
R0366:Or8b44	UTSW	9	38,410,450 (GRCm39)	missense	possibly damaging	0.94
R0400:Or8b44	UTSW	9	38,410,207 (GRCm39)	missense	possibly damaging	0.63
R0726:Or8b44	UTSW	9	38,410,418 (GRCm39)	missense	possibly damaging	0.72
R1511:Or8b44	UTSW	9	38,410,114 (GRCm39)	missense	probably benign
R1663:Or8b44	UTSW	9	38,410,868 (GRCm39)	missense	unknown
R1763:Or8b44	UTSW	9	38,410,334 (GRCm39)	missense	probably damaging	1.00
R4810:Or8b44	UTSW	9	38,410,620 (GRCm39)	nonsense	probably null
R4851:Or8b44	UTSW	9	38,410,319 (GRCm39)	missense	probably damaging	1.00
R4945:Or8b44	UTSW	9	38,410,585 (GRCm39)	missense	probably damaging	1.00
R5535:Or8b44	UTSW	9	38,410,294 (GRCm39)	missense	probably benign	0.10
R5576:Or8b44	UTSW	9	38,410,204 (GRCm39)	missense	probably damaging	1.00
R5829:Or8b44	UTSW	9	38,410,545 (GRCm39)	nonsense	probably null
R6249:Or8b44	UTSW	9	38,410,880 (GRCm39)	missense	unknown
R6353:Or8b44	UTSW	9	38,410,112 (GRCm39)	missense	probably benign	0.30
R6580:Or8b44	UTSW	9	38,410,319 (GRCm39)	missense	probably damaging	1.00
R6611:Or8b44	UTSW	9	38,410,534 (GRCm39)	missense	probably damaging	1.00
R6997:Or8b44	UTSW	9	38,410,607 (GRCm39)	missense	possibly damaging	0.94
R7407:Or8b44	UTSW	9	38,410,800 (GRCm39)	nonsense	probably null
R7420:Or8b44	UTSW	9	38,410,359 (GRCm39)	missense	probably benign	0.11
R7567:Or8b44	UTSW	9	38,410,369 (GRCm39)	missense	probably benign	0.00
R8382:Or8b44	UTSW	9	38,410,588 (GRCm39)	missense	probably damaging	0.98
X0028:Or8b44	UTSW	9	38,410,386 (GRCm39)	missense	possibly damaging	0.53

Predicted Primers

Posted On

2016-11-08