Incidental Mutation 'IGL00472:Tex21'
ID 4397
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tex21
Ensembl Gene ENSMUSG00000021056
Gene Name testis expressed gene 21
Synonyms 4931406F04Rik, tsec-2, 4931412D23Rik, 4931421K24Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # IGL00472
Quality Score
Status
Chromosome 12
Chromosomal Location 76245460-76293520 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 76253571 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 447 (N447K)
Ref Sequence ENSEMBL: ENSMUSP00000021453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021453] [ENSMUST00000218426]
AlphaFold Q9R0U9
Predicted Effect probably damaging
Transcript: ENSMUST00000021453
AA Change: N447K

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000021453
Gene: ENSMUSG00000021056
AA Change: N447K

DomainStartEndE-ValueType
coiled coil region 83 190 N/A INTRINSIC
coiled coil region 308 356 N/A INTRINSIC
coiled coil region 409 447 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000218426
AA Change: N447K

PolyPhen 2 Score 0.959 (Sensitivity: 0.78; Specificity: 0.95)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 16 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg2a A G 3: 37,490,793 (GRCm39) H446R probably benign Het
Alpk3 C T 7: 80,745,401 (GRCm39) probably benign Het
Atp8b1 T A 18: 64,697,501 (GRCm39) I448F probably benign Het
C2cd2l A G 9: 44,228,400 (GRCm39) L156P probably damaging Het
Cbll1 G A 12: 31,537,832 (GRCm39) P308S probably damaging Het
Ccl3 C T 11: 83,539,467 (GRCm39) S39N possibly damaging Het
Cnih4 G T 1: 180,989,659 (GRCm39) G30C probably damaging Het
Endod1 A T 9: 14,268,049 (GRCm39) F479I possibly damaging Het
Gm572 T G 4: 148,751,849 (GRCm39) V238G possibly damaging Het
Grhl1 G T 12: 24,662,169 (GRCm39) R536L probably damaging Het
Itgae A G 11: 73,004,520 (GRCm39) K269R probably benign Het
Nin C A 12: 70,076,862 (GRCm39) M1064I probably damaging Het
Pnkd A G 1: 74,325,081 (GRCm39) K50E probably damaging Het
Rpl39l A G 16: 9,992,258 (GRCm39) M29V probably benign Het
Strip2 C T 6: 29,931,213 (GRCm39) A388V probably benign Het
Zfp760 A G 17: 21,942,457 (GRCm39) Y544C possibly damaging Het
Other mutations in Tex21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Tex21 APN 12 76,291,885 (GRCm39) missense probably damaging 1.00
IGL01062:Tex21 APN 12 76,245,718 (GRCm39) missense probably benign 0.03
IGL01063:Tex21 APN 12 76,245,592 (GRCm39) missense probably benign 0.34
IGL02624:Tex21 APN 12 76,261,398 (GRCm39) missense probably damaging 1.00
IGL03349:Tex21 APN 12 76,268,365 (GRCm39) missense probably benign 0.14
IGL03387:Tex21 APN 12 76,245,694 (GRCm39) missense probably damaging 1.00
IGL03412:Tex21 APN 12 76,291,780 (GRCm39) critical splice donor site probably null
ihop UTSW 12 76,286,229 (GRCm39) critical splice donor site probably null
R0189:Tex21 UTSW 12 76,286,307 (GRCm39) missense probably benign 0.13
R0730:Tex21 UTSW 12 76,250,940 (GRCm39) missense probably benign 0.25
R1521:Tex21 UTSW 12 76,251,044 (GRCm39) missense probably benign 0.38
R1572:Tex21 UTSW 12 76,253,665 (GRCm39) missense probably benign 0.03
R1700:Tex21 UTSW 12 76,268,446 (GRCm39) missense probably damaging 0.99
R1941:Tex21 UTSW 12 76,268,458 (GRCm39) missense possibly damaging 0.68
R4654:Tex21 UTSW 12 76,263,860 (GRCm39) missense probably benign 0.32
R4943:Tex21 UTSW 12 76,268,474 (GRCm39) missense probably damaging 1.00
R6175:Tex21 UTSW 12 76,245,707 (GRCm39) missense probably benign 0.00
R6262:Tex21 UTSW 12 76,259,306 (GRCm39) missense probably damaging 0.99
R6738:Tex21 UTSW 12 76,286,283 (GRCm39) missense probably benign 0.12
R6759:Tex21 UTSW 12 76,251,086 (GRCm39) critical splice acceptor site probably null
R6890:Tex21 UTSW 12 76,286,229 (GRCm39) critical splice donor site probably null
R8910:Tex21 UTSW 12 76,263,533 (GRCm39) unclassified probably benign
R9547:Tex21 UTSW 12 76,253,591 (GRCm39) missense probably damaging 0.99
Z1176:Tex21 UTSW 12 76,250,894 (GRCm39) missense probably damaging 1.00
Posted On 2012-04-20