Incidental Mutation 'R5619:Coro7'
ID 439739
Institutional Source Beutler Lab
Gene Symbol Coro7
Ensembl Gene ENSMUSG00000039637
Gene Name coronin 7
Synonyms 0610011B16Rik
MMRRC Submission 043278-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R5619 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 4444748-4497584 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to A at 4494799 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000087966 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038552] [ENSMUST00000090480] [ENSMUST00000090480] [ENSMUST00000135823]
AlphaFold Q9D2V7
Predicted Effect probably null
Transcript: ENSMUST00000038552
SMART Domains Protein: ENSMUSP00000048489
Gene: ENSMUSG00000039637

DomainStartEndE-ValueType
DUF1899 3 64 6.41e-15 SMART
WD40 66 106 1.83e-7 SMART
WD40 115 154 4.13e0 SMART
WD40 157 196 1.78e-5 SMART
DUF1900 251 385 4.49e-60 SMART
low complexity region 427 456 N/A INTRINSIC
DUF1899 463 528 1.2e-19 SMART
WD40 531 570 3.64e-2 SMART
WD40 580 620 8.55e-8 SMART
WD40 623 662 1.16e-9 SMART
low complexity region 667 679 N/A INTRINSIC
DUF1900 718 854 6.69e-68 SMART
Predicted Effect probably null
Transcript: ENSMUST00000090480
SMART Domains Protein: ENSMUSP00000087966
Gene: ENSMUSG00000039637

DomainStartEndE-ValueType
DUF1899 3 64 6.41e-15 SMART
WD40 66 106 1.83e-7 SMART
WD40 115 154 4.13e0 SMART
WD40 157 196 1.78e-5 SMART
Predicted Effect probably null
Transcript: ENSMUST00000090480
SMART Domains Protein: ENSMUSP00000087966
Gene: ENSMUSG00000039637

DomainStartEndE-ValueType
DUF1899 3 64 6.41e-15 SMART
WD40 66 106 1.83e-7 SMART
WD40 115 154 4.13e0 SMART
WD40 157 196 1.78e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123031
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127850
Predicted Effect probably benign
Transcript: ENSMUST00000135823
SMART Domains Protein: ENSMUSP00000118310
Gene: ENSMUSG00000039637

DomainStartEndE-ValueType
DUF1899 3 64 6.41e-15 SMART
WD40 66 106 1.83e-7 SMART
WD40 115 154 4.13e0 SMART
WD40 157 196 1.78e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144815
Meta Mutation Damage Score 0.9480 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 99% (80/81)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal but exhibit disruption of the Golgi apparatus. Mutant fibroblasts show increased cell spreading and cellular F-actin content, increased cell polarization and migration, and enhanced wound healing in a scratch-wound assay. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
Adgre1 T G 17: 57,727,437 (GRCm39) L456V probably benign Het
Adgrv1 C T 13: 81,620,619 (GRCm39) G3943R probably damaging Het
Akap9 A G 5: 4,004,760 (GRCm39) probably benign Het
Atp1a2 T A 1: 172,106,948 (GRCm39) I791F probably damaging Het
BC004004 C G 17: 29,501,703 (GRCm39) P81A probably damaging Het
Brca2 C A 5: 150,480,579 (GRCm39) T2755K probably damaging Het
Cacna1c T C 6: 118,719,322 (GRCm39) D215G probably damaging Het
Ccdc142 C T 6: 83,080,603 (GRCm39) S445F probably benign Het
Comt T C 16: 18,230,469 (GRCm39) E80G probably damaging Het
Coq7 T C 7: 118,126,709 (GRCm39) probably benign Het
Cyp2c40 A G 19: 39,792,228 (GRCm39) S239P probably damaging Het
Dnah5 T C 15: 28,302,581 (GRCm39) S1613P probably damaging Het
Dync2h1 T C 9: 7,118,885 (GRCm39) I2193M probably benign Het
Eipr1 A G 12: 28,917,078 (GRCm39) Y382C probably damaging Het
Fastkd2 T A 1: 63,778,469 (GRCm39) H447Q probably benign Het
Galk2 A T 2: 125,817,317 (GRCm39) R369* probably null Het
Gli2 G A 1: 118,764,485 (GRCm39) A1222V probably benign Het
Golim4 T A 3: 75,813,802 (GRCm39) K141* probably null Het
Gtpbp3 G T 8: 71,943,692 (GRCm39) probably benign Het
Gzmd C T 14: 56,367,224 (GRCm39) A223T probably benign Het
Igf2r T C 17: 12,958,221 (GRCm39) R151G probably damaging Het
Itga8 T A 2: 12,270,139 (GRCm39) R116W probably damaging Het
Klhdc1 T G 12: 69,304,919 (GRCm39) probably null Het
Klhl25 T C 7: 75,516,602 (GRCm39) Y198H probably benign Het
Klhl29 A T 12: 5,190,587 (GRCm39) M136K probably benign Het
Lipf A T 19: 33,944,292 (GRCm39) Y167F possibly damaging Het
Lpar1 T C 4: 58,487,155 (GRCm39) K39E possibly damaging Het
Mbtd1 T A 11: 93,820,705 (GRCm39) probably null Het
Myo1a T A 10: 127,554,413 (GRCm39) N794K probably benign Het
Nmrk1 T C 19: 18,622,452 (GRCm39) L177P possibly damaging Het
Noxa1 C T 2: 24,975,988 (GRCm39) E401K probably damaging Het
Or10g9b T A 9: 39,918,039 (GRCm39) M69L probably benign Het
Or4f53 A T 2: 111,087,856 (GRCm39) Y132F probably damaging Het
Ostm1 T A 10: 42,555,325 (GRCm39) C116S probably damaging Het
Pcdhga7 T C 18: 37,848,800 (GRCm39) I269T probably benign Het
Pfkfb3 T C 2: 11,489,470 (GRCm39) K276R probably benign Het
Pfkp A T 13: 6,648,765 (GRCm39) probably benign Het
Pitpnm1 A G 19: 4,153,270 (GRCm39) D142G probably damaging Het
Pkp3 T C 7: 140,668,419 (GRCm39) L556P probably damaging Het
Plb1 C A 5: 32,490,841 (GRCm39) T1046N probably damaging Het
Plxnb2 T C 15: 89,047,012 (GRCm39) S770G possibly damaging Het
Polk A T 13: 96,620,064 (GRCm39) I733N probably damaging Het
Potegl T C 2: 23,147,017 (GRCm39) probably null Het
Prkg2 C A 5: 99,136,156 (GRCm39) C301F probably damaging Het
Rabgap1l T C 1: 160,066,142 (GRCm39) T189A probably benign Het
Raph1 T C 1: 60,529,414 (GRCm39) probably benign Het
Rbm22 T A 18: 60,693,899 (GRCm39) M1K probably null Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rnf186 T A 4: 138,694,715 (GRCm39) I85N probably benign Het
Ryr2 C A 13: 11,723,088 (GRCm39) R2517L probably damaging Het
Sec63 T A 10: 42,665,378 (GRCm39) Y103N probably damaging Het
Serpinb3a G A 1: 106,974,838 (GRCm39) P232S probably damaging Het
Slco6d1 C A 1: 98,423,947 (GRCm39) T533K probably damaging Het
Smarcad1 T A 6: 65,088,865 (GRCm39) D1000E probably benign Het
Spata46 A T 1: 170,136,490 (GRCm39) I14F probably damaging Het
Speer4b T C 5: 27,703,815 (GRCm39) H106R possibly damaging Het
Spint4 T C 2: 164,542,761 (GRCm39) L118P probably benign Het
Sptbn5 A G 2: 119,880,613 (GRCm39) noncoding transcript Het
Tgfbr3 A T 5: 107,288,380 (GRCm39) I427N probably benign Het
Thbs2 C A 17: 14,901,506 (GRCm39) C491F probably damaging Het
Tmem232 T A 17: 65,793,506 (GRCm39) E64D probably benign Het
Tnpo3 A T 6: 29,565,197 (GRCm39) C585* probably null Het
Ttc13 A T 8: 125,406,683 (GRCm39) probably benign Het
Tuba8 C T 6: 121,202,854 (GRCm39) A389V probably damaging Het
Uqcc4 G A 17: 25,403,963 (GRCm39) S101N probably damaging Het
Usp25 A G 16: 76,830,833 (GRCm39) I30V probably benign Het
Vmn2r31 T A 7: 7,387,529 (GRCm39) K681* probably null Het
Vmn2r88 A G 14: 51,651,367 (GRCm39) E235G probably damaging Het
Vps29 T A 5: 122,492,511 (GRCm39) probably benign Het
Wdr1 A C 5: 38,686,879 (GRCm39) V568G possibly damaging Het
Zfp64 T G 2: 168,741,734 (GRCm39) Q398P probably damaging Het
Zfp64 G T 2: 168,741,735 (GRCm39) Q398K probably damaging Het
Zfp839 T C 12: 110,830,470 (GRCm39) Y398H probably damaging Het
Other mutations in Coro7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00428:Coro7 APN 16 4,452,500 (GRCm39) missense possibly damaging 0.83
IGL00885:Coro7 APN 16 4,452,890 (GRCm39) missense probably benign 0.00
IGL02944:Coro7 APN 16 4,453,276 (GRCm39) missense probably benign 0.14
IGL03104:Coro7 APN 16 4,446,990 (GRCm39) missense probably damaging 1.00
IGL03153:Coro7 APN 16 4,453,246 (GRCm39) critical splice donor site probably null
R0022:Coro7 UTSW 16 4,451,168 (GRCm39) missense probably benign 0.01
R0022:Coro7 UTSW 16 4,451,168 (GRCm39) missense probably benign 0.01
R0071:Coro7 UTSW 16 4,488,391 (GRCm39) missense probably damaging 1.00
R0071:Coro7 UTSW 16 4,488,391 (GRCm39) missense probably damaging 1.00
R0080:Coro7 UTSW 16 4,448,328 (GRCm39) missense probably damaging 1.00
R0193:Coro7 UTSW 16 4,445,368 (GRCm39) unclassified probably benign
R0242:Coro7 UTSW 16 4,448,042 (GRCm39) splice site probably benign
R0318:Coro7 UTSW 16 4,493,671 (GRCm39) missense probably benign 0.09
R0554:Coro7 UTSW 16 4,450,121 (GRCm39) missense possibly damaging 0.63
R0666:Coro7 UTSW 16 4,449,775 (GRCm39) missense possibly damaging 0.70
R0835:Coro7 UTSW 16 4,450,118 (GRCm39) missense probably benign 0.12
R0968:Coro7 UTSW 16 4,487,919 (GRCm39) splice site probably benign
R1670:Coro7 UTSW 16 4,446,097 (GRCm39) missense possibly damaging 0.76
R1709:Coro7 UTSW 16 4,452,305 (GRCm39) splice site probably null
R1848:Coro7 UTSW 16 4,448,298 (GRCm39) missense probably damaging 0.99
R1884:Coro7 UTSW 16 4,446,683 (GRCm39) unclassified probably benign
R1935:Coro7 UTSW 16 4,446,596 (GRCm39) missense probably benign
R1937:Coro7 UTSW 16 4,446,596 (GRCm39) missense probably benign
R1939:Coro7 UTSW 16 4,446,596 (GRCm39) missense probably benign
R1967:Coro7 UTSW 16 4,452,753 (GRCm39) missense probably damaging 1.00
R1969:Coro7 UTSW 16 4,451,620 (GRCm39) missense probably benign 0.19
R1970:Coro7 UTSW 16 4,451,620 (GRCm39) missense probably benign 0.19
R3034:Coro7 UTSW 16 4,450,155 (GRCm39) missense probably damaging 0.99
R4638:Coro7 UTSW 16 4,450,151 (GRCm39) missense probably damaging 0.96
R4710:Coro7 UTSW 16 4,452,797 (GRCm39) intron probably benign
R4723:Coro7 UTSW 16 4,449,858 (GRCm39) missense probably benign 0.00
R4789:Coro7 UTSW 16 4,446,085 (GRCm39) missense probably damaging 1.00
R5493:Coro7 UTSW 16 4,450,351 (GRCm39) missense probably damaging 0.99
R5756:Coro7 UTSW 16 4,450,148 (GRCm39) missense probably damaging 0.97
R5974:Coro7 UTSW 16 4,449,753 (GRCm39) missense possibly damaging 0.83
R6010:Coro7 UTSW 16 4,487,820 (GRCm39) missense possibly damaging 0.68
R6038:Coro7 UTSW 16 4,497,414 (GRCm39) critical splice donor site probably null
R6038:Coro7 UTSW 16 4,497,414 (GRCm39) critical splice donor site probably null
R6906:Coro7 UTSW 16 4,451,168 (GRCm39) missense probably benign 0.00
R6925:Coro7 UTSW 16 4,446,538 (GRCm39) critical splice donor site probably null
R7069:Coro7 UTSW 16 4,497,475 (GRCm39) start codon destroyed probably damaging 0.99
R7326:Coro7 UTSW 16 4,449,912 (GRCm39) missense probably damaging 0.96
R7421:Coro7 UTSW 16 4,486,615 (GRCm39) missense probably benign 0.19
R7521:Coro7 UTSW 16 4,449,346 (GRCm39) missense probably benign 0.00
R7773:Coro7 UTSW 16 4,449,870 (GRCm39) missense probably damaging 1.00
R7846:Coro7 UTSW 16 4,488,400 (GRCm39) missense probably damaging 1.00
R8240:Coro7 UTSW 16 4,486,660 (GRCm39) missense probably damaging 0.96
R8726:Coro7 UTSW 16 4,486,619 (GRCm39) missense possibly damaging 0.95
R8762:Coro7 UTSW 16 4,452,203 (GRCm39) missense probably benign
R9383:Coro7 UTSW 16 4,452,888 (GRCm39) missense probably damaging 1.00
R9451:Coro7 UTSW 16 4,488,402 (GRCm39) missense probably damaging 1.00
R9553:Coro7 UTSW 16 4,486,624 (GRCm39) missense possibly damaging 0.55
Predicted Primers PCR Primer
(F):5'- CTGTGGGGATGGCTGAAAAC -3'
(R):5'- GACATAAGTTTGATGTCCAGAACC -3'

Sequencing Primer
(F):5'- TGGCTAGAACCACCACCATAGTTTAC -3'
(R):5'- CCAGCCTAGCAGAATTTGTGAGTTC -3'
Posted On 2016-11-08