Incidental Mutation 'R5620:Grm2'
ID 439790
Institutional Source Beutler Lab
Gene Symbol Grm2
Ensembl Gene ENSMUSG00000023192
Gene Name glutamate receptor, metabotropic 2
Synonyms mGluR2, Gprc1b, 4930441L02Rik
MMRRC Submission 043160-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.466) question?
Stock # R5620 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 106521733-106533308 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 106527645 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 413 (V413D)
Ref Sequence ENSEMBL: ENSMUSP00000023959 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023959] [ENSMUST00000201681]
AlphaFold Q14BI2
Predicted Effect probably damaging
Transcript: ENSMUST00000023959
AA Change: V413D

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000023959
Gene: ENSMUSG00000023192
AA Change: V413D

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 60 460 1.3e-96 PFAM
Pfam:NCD3G 496 546 3.7e-13 PFAM
Pfam:7tm_3 579 816 4.3e-63 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000200826
Predicted Effect possibly damaging
Transcript: ENSMUST00000201681
AA Change: V413D

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000144631
Gene: ENSMUSG00000023192
AA Change: V413D

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 60 460 4.1e-95 PFAM
Pfam:7tm_3 458 538 4.6e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201955
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]
PHENOTYPE: Mice homozygous for disruptions in this gene display subtile behavioral modifications and moderate abnormalities in long term depression and EPSP in the hippocampus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aaas A C 15: 102,246,826 (GRCm39) S511A probably benign Het
Abca3 C T 17: 24,615,444 (GRCm39) T845I probably benign Het
Acaa2 G A 18: 74,938,945 (GRCm39) A377T possibly damaging Het
Adcy4 C A 14: 56,009,824 (GRCm39) E743* probably null Het
Ahnak T A 19: 8,990,458 (GRCm39) L3914* probably null Het
Akap1 G T 11: 88,736,343 (GRCm39) N106K possibly damaging Het
Arid2 C T 15: 96,270,387 (GRCm39) T1500I probably benign Het
Atp6v0a2 T A 5: 124,783,909 (GRCm39) Y252* probably null Het
C4bp A G 1: 130,581,090 (GRCm39) S140P probably damaging Het
Cald1 A G 6: 34,739,047 (GRCm39) I384M probably damaging Het
Cdk12 A G 11: 98,101,809 (GRCm39) I556V unknown Het
Chmp2a T C 7: 12,766,237 (GRCm39) S174G probably benign Het
Clybl T A 14: 122,548,755 (GRCm39) N52K probably damaging Het
Cyp4a29 C A 4: 115,108,088 (GRCm39) S303R probably benign Het
Dab2 T A 15: 6,447,796 (GRCm39) D59E probably damaging Het
Dag1 C A 9: 108,086,214 (GRCm39) R309L probably damaging Het
Dync1i2 T A 2: 71,088,483 (GRCm39) M505K probably benign Het
Eif2b1 A T 5: 124,717,075 (GRCm39) M1K probably null Het
Epc1 A G 18: 6,448,917 (GRCm39) S577P probably benign Het
Eps8l1 T A 7: 4,463,945 (GRCm39) I23N possibly damaging Het
Etl4 A G 2: 20,535,037 (GRCm39) E164G probably damaging Het
Firrm C A 1: 163,789,613 (GRCm39) G641* probably null Het
Gadl1 A T 9: 115,766,230 (GRCm39) M1L probably benign Het
Gda T C 19: 21,374,908 (GRCm39) D336G probably damaging Het
Hnrnpll G T 17: 80,346,051 (GRCm39) N403K probably damaging Het
Ifit1 T A 19: 34,625,238 (GRCm39) F125I probably damaging Het
Igkv5-43 C T 6: 69,800,892 (GRCm39) V2I probably benign Het
Kat5 A C 19: 5,659,507 (GRCm39) Y44* probably null Het
Klc2 A G 19: 5,162,884 (GRCm39) V205A probably damaging Het
Klrb1c T A 6: 128,761,706 (GRCm39) T133S possibly damaging Het
Krt20 A G 11: 99,326,283 (GRCm39) L157P probably damaging Het
Krt26 G T 11: 99,228,597 (GRCm39) T45N possibly damaging Het
Lama2 C T 10: 26,866,876 (GRCm39) D2873N probably damaging Het
Lig1 T A 7: 13,020,532 (GRCm39) C114S possibly damaging Het
Lonp1 G C 17: 56,927,263 (GRCm39) A330G probably benign Het
Maml2 A T 9: 13,608,616 (GRCm39) R21S probably damaging Het
Mrpl35 C T 6: 71,794,720 (GRCm39) V83I probably benign Het
Myo3b A G 2: 70,069,254 (GRCm39) R498G probably benign Het
Nup153 C A 13: 46,837,482 (GRCm39) E1247* probably null Het
Or2t48 A T 11: 58,420,557 (GRCm39) M85K probably damaging Het
Pcdhac2 A G 18: 37,277,257 (GRCm39) N79S probably benign Het
Pcgf6 C T 19: 47,036,406 (GRCm39) G221D probably damaging Het
Phf11b C T 14: 59,558,953 (GRCm39) D260N probably benign Het
Pla2g5 T C 4: 138,531,921 (GRCm39) M28V possibly damaging Het
Prpf8 T C 11: 75,395,927 (GRCm39) S1934P possibly damaging Het
Prr5 A G 15: 84,640,570 (GRCm39) S140G probably benign Het
Prrc2c T C 1: 162,501,098 (GRCm39) D1235G probably damaging Het
Rasgrp2 T C 19: 6,455,031 (GRCm39) S254P probably damaging Het
Rassf8 C T 6: 145,765,907 (GRCm39) probably benign Het
Rgs20 T A 1: 4,982,666 (GRCm39) E167D probably damaging Het
Rmnd1 G T 10: 4,372,159 (GRCm39) A180E probably damaging Het
Rnf103 A G 6: 71,486,992 (GRCm39) D541G probably benign Het
Rpl9 G T 5: 65,546,468 (GRCm39) Q140K probably benign Het
Sfmbt1 T G 14: 30,506,148 (GRCm39) probably null Het
Shank1 C A 7: 43,962,160 (GRCm39) D10E unknown Het
Srrm4 G T 5: 116,587,672 (GRCm39) probably benign Het
Sucla2 T A 14: 73,832,836 (GRCm39) V447E probably damaging Het
Tbc1d1 A G 5: 64,331,055 (GRCm39) D78G probably benign Het
Tcp1 T A 17: 13,138,224 (GRCm39) probably null Het
Tctn3 C A 19: 40,597,361 (GRCm39) E230* probably null Het
Thsd7b G A 1: 130,090,673 (GRCm39) probably null Het
Tmem63a A G 1: 180,797,811 (GRCm39) M621V probably benign Het
Tnxb A T 17: 34,936,504 (GRCm39) K2756* probably null Het
Trpm8 G A 1: 88,287,373 (GRCm39) probably null Het
Txndc16 C A 14: 45,373,335 (GRCm39) V764F possibly damaging Het
Ush2a A T 1: 188,492,020 (GRCm39) D3103V possibly damaging Het
Usp22 A T 11: 61,049,206 (GRCm39) I381N probably damaging Het
Zfp462 T A 4: 55,013,464 (GRCm39) M1810K probably benign Het
Zfp64 T A 2: 168,741,888 (GRCm39) M347L possibly damaging Het
Zfp69 T C 4: 120,787,719 (GRCm39) D532G probably damaging Het
Other mutations in Grm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1053:Grm2 UTSW 9 106,525,356 (GRCm39) missense probably damaging 0.98
R1116:Grm2 UTSW 9 106,525,126 (GRCm39) missense probably damaging 0.97
R1593:Grm2 UTSW 9 106,528,113 (GRCm39) missense probably damaging 1.00
R1619:Grm2 UTSW 9 106,524,670 (GRCm39) missense probably damaging 1.00
R2174:Grm2 UTSW 9 106,524,994 (GRCm39) missense probably benign 0.05
R2357:Grm2 UTSW 9 106,524,780 (GRCm39) missense probably damaging 0.99
R3115:Grm2 UTSW 9 106,524,822 (GRCm39) missense probably damaging 0.97
R4453:Grm2 UTSW 9 106,531,078 (GRCm39) missense probably damaging 0.97
R4700:Grm2 UTSW 9 106,531,130 (GRCm39) missense probably benign 0.18
R4854:Grm2 UTSW 9 106,531,331 (GRCm39) missense possibly damaging 0.80
R4871:Grm2 UTSW 9 106,524,844 (GRCm39) missense probably benign 0.00
R4888:Grm2 UTSW 9 106,527,865 (GRCm39) missense probably damaging 0.98
R4999:Grm2 UTSW 9 106,531,189 (GRCm39) missense probably damaging 1.00
R5617:Grm2 UTSW 9 106,528,275 (GRCm39) splice site probably null
R6021:Grm2 UTSW 9 106,527,999 (GRCm39) missense probably damaging 1.00
R6089:Grm2 UTSW 9 106,531,090 (GRCm39) missense probably damaging 1.00
R6662:Grm2 UTSW 9 106,525,252 (GRCm39) missense probably benign 0.01
R7061:Grm2 UTSW 9 106,528,424 (GRCm39) missense probably damaging 0.98
R7266:Grm2 UTSW 9 106,524,370 (GRCm39) missense
R7270:Grm2 UTSW 9 106,528,257 (GRCm39) missense probably damaging 0.98
R7479:Grm2 UTSW 9 106,531,050 (GRCm39) missense possibly damaging 0.84
R7542:Grm2 UTSW 9 106,528,368 (GRCm39) missense probably damaging 0.98
R8960:Grm2 UTSW 9 106,531,345 (GRCm39) missense probably benign 0.06
R9028:Grm2 UTSW 9 106,528,384 (GRCm39) missense possibly damaging 0.86
R9150:Grm2 UTSW 9 106,524,657 (GRCm39) missense
R9333:Grm2 UTSW 9 106,525,416 (GRCm39) missense possibly damaging 0.71
R9345:Grm2 UTSW 9 106,528,287 (GRCm39) missense probably damaging 0.98
R9520:Grm2 UTSW 9 106,525,230 (GRCm39) missense
R9594:Grm2 UTSW 9 106,524,408 (GRCm39) missense probably damaging 1.00
Z1177:Grm2 UTSW 9 106,522,264 (GRCm39) missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- TGGTCCCTGTGTCCTAAGTGAC -3'
(R):5'- ATCCCTGGAACAACAGCAGG -3'

Sequencing Primer
(F):5'- GTGTCCTAAGTGACACAGTCC -3'
(R):5'- AGAGGTTCCGTTGCAGCTTCC -3'
Posted On 2016-11-08