Incidental Mutation 'R5610:Cdh13'
ID 440311
Institutional Source Beutler Lab
Gene Symbol Cdh13
Ensembl Gene ENSMUSG00000031841
Gene Name cadherin 13
Synonyms T-cadherin, 4932416G01Rik, Tcad
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5610 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 119010472-120051660 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 119578462 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 163 (V163A)
Ref Sequence ENSEMBL: ENSMUSP00000113527 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117160]
AlphaFold Q9WTR5
PDB Structure Crystal Structure of mouse T-cadherin EC1 EC2 [X-RAY DIFFRACTION]
Crystal structure of mouse T-cadherin EC1 [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000117160
AA Change: V163A

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000113527
Gene: ENSMUSG00000031841
AA Change: V163A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Cadherin_pro 26 112 1.04e-17 SMART
CA 160 243 1.49e-18 SMART
CA 267 361 1.84e-23 SMART
CA 383 476 8.75e-16 SMART
CA 499 583 2.36e-21 SMART
CA 604 687 5.93e-2 SMART
low complexity region 695 714 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123567
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142551
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145849
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148836
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased retinal neovascularization and increased adiponectin levels. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700018F24Rik A G 5: 144,982,156 (GRCm39) D247G possibly damaging Het
1700123K08Rik A G 5: 138,562,403 (GRCm39) probably null Het
Abca8b C A 11: 109,868,639 (GRCm39) G175V probably damaging Het
Accsl C A 2: 93,692,118 (GRCm39) probably null Het
Adad2 C T 8: 120,341,500 (GRCm39) R171C probably benign Het
Adgrv1 A C 13: 81,669,236 (GRCm39) L2440R probably damaging Het
Antxr1 A G 6: 87,232,845 (GRCm39) V239A probably damaging Het
Aoc1l2 G A 6: 48,907,953 (GRCm39) V318I probably benign Het
Arhgap28 G A 17: 68,203,235 (GRCm39) Q73* probably null Het
Arrdc5 C T 17: 56,604,846 (GRCm39) R147H probably benign Het
Ash1l T C 3: 88,930,492 (GRCm39) Y1990H probably damaging Het
Bank1 T C 3: 135,772,148 (GRCm39) E494G probably damaging Het
Bicral A T 17: 47,119,418 (GRCm39) I701N probably damaging Het
Bod1l T C 5: 41,979,217 (GRCm39) Y699C probably damaging Het
C3ar1 T G 6: 122,827,537 (GRCm39) T227P probably benign Het
Ccr3 C A 9: 123,829,518 (GRCm39) D284E probably damaging Het
CK137956 C T 4: 127,840,440 (GRCm39) probably null Het
Cltc T C 11: 86,612,472 (GRCm39) S529G probably benign Het
Cplane2 C T 4: 140,947,177 (GRCm39) P186L probably benign Het
Ddx11 A G 17: 66,457,021 (GRCm39) K783E probably damaging Het
Dnah3 T A 7: 119,538,288 (GRCm39) probably null Het
Eef2k A G 7: 120,486,005 (GRCm39) H408R probably benign Het
Esr1 A G 10: 4,951,221 (GRCm39) K533R probably damaging Het
Fat1 T A 8: 45,406,109 (GRCm39) Y953* probably null Het
Fosl1 T A 19: 5,505,133 (GRCm39) probably null Het
Frmd4b A G 6: 97,283,752 (GRCm39) M373T probably benign Het
Gm1968 A G 16: 29,777,557 (GRCm39) noncoding transcript Het
Gpr26 T C 7: 131,568,694 (GRCm39) V13A possibly damaging Het
Gtf3c1 T C 7: 125,303,117 (GRCm39) N106S possibly damaging Het
Itgb8 T G 12: 119,134,429 (GRCm39) E546A probably damaging Het
Itpr3 C T 17: 27,337,540 (GRCm39) T2450M probably benign Het
Kif1a A T 1: 92,953,450 (GRCm39) Y1245N probably damaging Het
Klrb1f G A 6: 129,031,335 (GRCm39) probably null Het
Lars1 A G 18: 42,390,156 (GRCm39) L37P probably benign Het
Lnpk T C 2: 74,378,369 (GRCm39) T131A probably benign Het
Mob3c C T 4: 115,690,878 (GRCm39) T156I probably benign Het
Nadk T A 4: 155,668,628 (GRCm39) W100R probably damaging Het
Npy6r A T 18: 44,409,061 (GRCm39) I161F probably benign Het
Or4c107 A C 2: 88,789,170 (GRCm39) D120A probably damaging Het
Or6c204 G A 10: 129,022,426 (GRCm39) T288I probably damaging Het
Pcdhga3 A G 18: 37,808,276 (GRCm39) E243G possibly damaging Het
Pdss2 A G 10: 43,315,828 (GRCm39) T361A probably benign Het
Pkd1l2 G T 8: 117,769,059 (GRCm39) Q1198K probably benign Het
Prdx1 T A 4: 116,550,124 (GRCm39) I102N probably damaging Het
Prss1 G A 6: 41,438,147 (GRCm39) V25I probably benign Het
Pspc1 A G 14: 57,015,388 (GRCm39) Y77H probably damaging Het
Rnf5 T C 17: 34,820,712 (GRCm39) probably benign Het
Ryr1 C A 7: 28,811,399 (GRCm39) M235I probably benign Het
Sec24c A G 14: 20,741,893 (GRCm39) Y776C probably damaging Het
Sharpin A G 15: 76,234,253 (GRCm39) probably null Het
Slc12a4 C A 8: 106,676,845 (GRCm39) V482L possibly damaging Het
Slc38a1 C T 15: 96,514,022 (GRCm39) probably null Het
Smtn G T 11: 3,479,582 (GRCm39) T495N probably damaging Het
Sncaip A G 18: 53,001,991 (GRCm39) T171A probably benign Het
Sprr2e T C 3: 92,260,399 (GRCm39) *77R probably null Het
Syngap1 T A 17: 27,178,754 (GRCm39) D443E possibly damaging Het
Taldo1 T C 7: 140,972,205 (GRCm39) V24A probably damaging Het
Tfap2c T A 2: 172,391,778 (GRCm39) N8K probably benign Het
Tmem229a T C 6: 24,955,580 (GRCm39) Y58C probably damaging Het
Tubgcp3 T C 8: 12,689,577 (GRCm39) Y563C probably damaging Het
Ubr1 T A 2: 120,722,593 (GRCm39) D1342V probably benign Het
Usp7 C T 16: 8,534,374 (GRCm39) probably null Het
Wbp1 C T 6: 83,097,216 (GRCm39) G75D probably damaging Het
Zfp180 G T 7: 23,804,315 (GRCm39) V245F probably benign Het
Zfp414 C T 17: 33,849,012 (GRCm39) T33I probably damaging Het
Zfp646 T A 7: 127,478,530 (GRCm39) C236S probably damaging Het
Other mutations in Cdh13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00539:Cdh13 APN 8 120,039,245 (GRCm39) missense possibly damaging 0.87
IGL00659:Cdh13 APN 8 120,039,406 (GRCm39) missense probably damaging 1.00
IGL01662:Cdh13 APN 8 119,401,916 (GRCm39) missense probably damaging 0.99
IGL01719:Cdh13 APN 8 119,401,927 (GRCm39) missense probably benign 0.01
IGL02148:Cdh13 APN 8 119,925,697 (GRCm39) missense probably damaging 1.00
IGL02157:Cdh13 APN 8 119,232,410 (GRCm39) missense possibly damaging 0.68
IGL02188:Cdh13 APN 8 119,578,500 (GRCm39) missense probably benign 0.08
IGL02490:Cdh13 APN 8 119,822,062 (GRCm39) missense probably damaging 1.00
IGL02851:Cdh13 APN 8 119,401,897 (GRCm39) missense probably benign 0.32
IGL02958:Cdh13 APN 8 120,039,460 (GRCm39) missense possibly damaging 0.90
IGL03085:Cdh13 APN 8 120,015,463 (GRCm39) missense probably damaging 1.00
IGL03230:Cdh13 APN 8 119,969,056 (GRCm39) missense probably damaging 1.00
IGL03280:Cdh13 APN 8 120,040,873 (GRCm39) missense probably damaging 1.00
K3955:Cdh13 UTSW 8 119,401,843 (GRCm39) missense probably damaging 0.99
P0038:Cdh13 UTSW 8 119,401,843 (GRCm39) missense probably damaging 0.99
R0398:Cdh13 UTSW 8 120,040,786 (GRCm39) missense probably damaging 1.00
R2156:Cdh13 UTSW 8 119,963,703 (GRCm39) missense probably damaging 1.00
R3415:Cdh13 UTSW 8 119,401,946 (GRCm39) missense probably benign 0.35
R4243:Cdh13 UTSW 8 119,968,996 (GRCm39) missense probably damaging 1.00
R4839:Cdh13 UTSW 8 119,578,587 (GRCm39) nonsense probably null
R4851:Cdh13 UTSW 8 119,484,129 (GRCm39) missense possibly damaging 0.75
R5129:Cdh13 UTSW 8 119,821,954 (GRCm39) missense probably damaging 1.00
R5453:Cdh13 UTSW 8 119,925,706 (GRCm39) missense probably damaging 1.00
R5607:Cdh13 UTSW 8 119,484,213 (GRCm39) missense probably benign
R5608:Cdh13 UTSW 8 119,484,213 (GRCm39) missense probably benign
R6035:Cdh13 UTSW 8 119,232,437 (GRCm39) missense probably benign 0.03
R6035:Cdh13 UTSW 8 119,232,437 (GRCm39) missense probably benign 0.03
R6556:Cdh13 UTSW 8 119,694,926 (GRCm39) missense probably damaging 0.99
R7124:Cdh13 UTSW 8 119,694,912 (GRCm39) missense probably damaging 1.00
R7349:Cdh13 UTSW 8 119,969,097 (GRCm39) missense probably damaging 0.97
R7418:Cdh13 UTSW 8 120,039,264 (GRCm39) missense probably damaging 1.00
R7679:Cdh13 UTSW 8 119,963,658 (GRCm39) missense probably benign 0.29
R7807:Cdh13 UTSW 8 119,010,594 (GRCm39) start codon destroyed probably null 0.77
R8777:Cdh13 UTSW 8 119,963,706 (GRCm39) critical splice donor site probably null
R8777-TAIL:Cdh13 UTSW 8 119,963,706 (GRCm39) critical splice donor site probably null
R9175:Cdh13 UTSW 8 119,968,968 (GRCm39) missense probably damaging 1.00
R9481:Cdh13 UTSW 8 119,963,676 (GRCm39) missense
X0025:Cdh13 UTSW 8 119,232,418 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- CCAAGCTAAGCGATGATGATGC -3'
(R):5'- TCCATATCTCTATGCGCAGGG -3'

Sequencing Primer
(F):5'- AGCTAAGCGATGATGATGCTATTTTG -3'
(R):5'- ATATCTCTATGCGCAGGGTGAGC -3'
Posted On 2016-11-08