Incidental Mutation 'V3553:Zfp84'
ID 44052
Institutional Source Beutler Lab
Gene Symbol Zfp84
Ensembl Gene ENSMUSG00000046185
Gene Name zinc finger protein 84
Synonyms KRAB18, C86188, Zfp69, 2210410P13Rik, 4633401C23Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # V3553 () of strain feckless
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 29467977-29479246 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 29476672 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 455 (A455S)
Ref Sequence ENSEMBL: ENSMUSP00000032802 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032802]
AlphaFold Q9D654
Predicted Effect probably benign
Transcript: ENSMUST00000032802
AA Change: A455S

PolyPhen 2 Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000032802
Gene: ENSMUSG00000046185
AA Change: A455S

DomainStartEndE-ValueType
KRAB 14 74 9.09e-36 SMART
ZnF_C2H2 249 271 1.67e-2 SMART
ZnF_C2H2 277 299 1.43e-1 SMART
ZnF_C2H2 305 327 5.81e-2 SMART
ZnF_C2H2 333 355 1.95e-3 SMART
ZnF_C2H2 361 383 8.6e-5 SMART
ZnF_C2H2 389 411 2.32e-1 SMART
ZnF_C2H2 417 439 3.89e-3 SMART
ZnF_C2H2 445 467 1.69e-3 SMART
ZnF_C2H2 473 495 9.58e-3 SMART
ZnF_C2H2 501 523 1.38e-3 SMART
ZnF_C2H2 529 551 1.58e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158514
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 10 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bcas3 G A 11: 85,712,926 (GRCm39) probably benign Het
Bicral G T 17: 47,141,021 (GRCm39) N20K probably damaging Het
Dnah9 C A 11: 65,860,902 (GRCm39) G2823C probably damaging Het
Hcfc2 T C 10: 82,547,895 (GRCm39) W296R probably damaging Het
Lrp1 C T 10: 127,407,311 (GRCm39) G1877S probably damaging Het
Rhbdf1 G A 11: 32,161,583 (GRCm39) P575L probably damaging Het
Sh3pxd2a G A 19: 47,255,658 (GRCm39) P1048L probably benign Het
Tgm5 C T 2: 120,901,983 (GRCm39) V229I probably damaging Het
Tmem167 A C 13: 90,246,585 (GRCm39) K36N probably damaging Het
Tnfrsf21 G A 17: 43,348,822 (GRCm39) A145T probably benign Het
Other mutations in Zfp84
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01768:Zfp84 APN 7 29,476,091 (GRCm39) missense probably benign 0.16
IGL03022:Zfp84 APN 7 29,474,759 (GRCm39) splice site probably benign
R0666:Zfp84 UTSW 7 29,476,276 (GRCm39) missense probably damaging 1.00
R0781:Zfp84 UTSW 7 29,470,797 (GRCm39) start codon destroyed probably null 0.02
R1110:Zfp84 UTSW 7 29,470,797 (GRCm39) start codon destroyed probably null 0.02
R1353:Zfp84 UTSW 7 29,475,600 (GRCm39) missense probably benign 0.02
R1495:Zfp84 UTSW 7 29,476,728 (GRCm39) nonsense probably null
R1496:Zfp84 UTSW 7 29,476,039 (GRCm39) missense possibly damaging 0.53
R1681:Zfp84 UTSW 7 29,476,825 (GRCm39) missense probably damaging 1.00
R1827:Zfp84 UTSW 7 29,476,768 (GRCm39) missense possibly damaging 0.91
R1854:Zfp84 UTSW 7 29,474,796 (GRCm39) missense possibly damaging 0.84
R2209:Zfp84 UTSW 7 29,476,607 (GRCm39) missense probably damaging 0.99
R2843:Zfp84 UTSW 7 29,474,758 (GRCm39) splice site probably null
R2844:Zfp84 UTSW 7 29,474,758 (GRCm39) splice site probably null
R4691:Zfp84 UTSW 7 29,476,505 (GRCm39) missense probably damaging 1.00
R5453:Zfp84 UTSW 7 29,475,722 (GRCm39) missense possibly damaging 0.82
R5474:Zfp84 UTSW 7 29,476,514 (GRCm39) missense probably damaging 1.00
R5578:Zfp84 UTSW 7 29,474,856 (GRCm39) missense possibly damaging 0.93
R5646:Zfp84 UTSW 7 29,475,818 (GRCm39) missense probably benign 0.05
R5963:Zfp84 UTSW 7 29,476,378 (GRCm39) missense probably damaging 1.00
R6830:Zfp84 UTSW 7 29,475,911 (GRCm39) missense probably benign 0.00
R8129:Zfp84 UTSW 7 29,475,862 (GRCm39) missense probably benign 0.00
R8138:Zfp84 UTSW 7 29,474,797 (GRCm39) missense probably damaging 0.99
R9180:Zfp84 UTSW 7 29,474,873 (GRCm39) missense probably damaging 0.97
R9401:Zfp84 UTSW 7 29,476,297 (GRCm39) missense probably damaging 1.00
R9489:Zfp84 UTSW 7 29,476,264 (GRCm39) missense possibly damaging 0.89
R9555:Zfp84 UTSW 7 29,476,102 (GRCm39) missense probably damaging 0.99
R9605:Zfp84 UTSW 7 29,476,264 (GRCm39) missense possibly damaging 0.89
Z1186:Zfp84 UTSW 7 29,470,805 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GCCATACGAATGCCACAAATGTCAG -3'
(R):5'- TCACCTGTAAGAGCCGAGTGAAGG -3'

Sequencing Primer
(F):5'- ccacagcggcgagaaac -3'
(R):5'- ACACTCGTAGGGCTTCTCG -3'
Posted On 2013-05-31