Incidental Mutation 'V3553:Zfp84'
ID |
44052 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp84
|
Ensembl Gene |
ENSMUSG00000046185 |
Gene Name |
zinc finger protein 84 |
Synonyms |
KRAB18, C86188, Zfp69, 2210410P13Rik, 4633401C23Rik |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
V3553 ()
of strain
feckless
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
7 |
Chromosomal Location |
29467977-29479246 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to T
at 29476672 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Serine
at position 455
(A455S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000032802
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032802]
|
AlphaFold |
Q9D654 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000032802
AA Change: A455S
PolyPhen 2
Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
|
SMART Domains |
Protein: ENSMUSP00000032802 Gene: ENSMUSG00000046185 AA Change: A455S
Domain | Start | End | E-Value | Type |
KRAB
|
14 |
74 |
9.09e-36 |
SMART |
ZnF_C2H2
|
249 |
271 |
1.67e-2 |
SMART |
ZnF_C2H2
|
277 |
299 |
1.43e-1 |
SMART |
ZnF_C2H2
|
305 |
327 |
5.81e-2 |
SMART |
ZnF_C2H2
|
333 |
355 |
1.95e-3 |
SMART |
ZnF_C2H2
|
361 |
383 |
8.6e-5 |
SMART |
ZnF_C2H2
|
389 |
411 |
2.32e-1 |
SMART |
ZnF_C2H2
|
417 |
439 |
3.89e-3 |
SMART |
ZnF_C2H2
|
445 |
467 |
1.69e-3 |
SMART |
ZnF_C2H2
|
473 |
495 |
9.58e-3 |
SMART |
ZnF_C2H2
|
501 |
523 |
1.38e-3 |
SMART |
ZnF_C2H2
|
529 |
551 |
1.58e-3 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000158514
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 94.0%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 10 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Bcas3 |
G |
A |
11: 85,712,926 (GRCm39) |
|
probably benign |
Het |
Bicral |
G |
T |
17: 47,141,021 (GRCm39) |
N20K |
probably damaging |
Het |
Dnah9 |
C |
A |
11: 65,860,902 (GRCm39) |
G2823C |
probably damaging |
Het |
Hcfc2 |
T |
C |
10: 82,547,895 (GRCm39) |
W296R |
probably damaging |
Het |
Lrp1 |
C |
T |
10: 127,407,311 (GRCm39) |
G1877S |
probably damaging |
Het |
Rhbdf1 |
G |
A |
11: 32,161,583 (GRCm39) |
P575L |
probably damaging |
Het |
Sh3pxd2a |
G |
A |
19: 47,255,658 (GRCm39) |
P1048L |
probably benign |
Het |
Tgm5 |
C |
T |
2: 120,901,983 (GRCm39) |
V229I |
probably damaging |
Het |
Tmem167 |
A |
C |
13: 90,246,585 (GRCm39) |
K36N |
probably damaging |
Het |
Tnfrsf21 |
G |
A |
17: 43,348,822 (GRCm39) |
A145T |
probably benign |
Het |
|
Other mutations in Zfp84 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01768:Zfp84
|
APN |
7 |
29,476,091 (GRCm39) |
missense |
probably benign |
0.16 |
IGL03022:Zfp84
|
APN |
7 |
29,474,759 (GRCm39) |
splice site |
probably benign |
|
R0666:Zfp84
|
UTSW |
7 |
29,476,276 (GRCm39) |
missense |
probably damaging |
1.00 |
R0781:Zfp84
|
UTSW |
7 |
29,470,797 (GRCm39) |
start codon destroyed |
probably null |
0.02 |
R1110:Zfp84
|
UTSW |
7 |
29,470,797 (GRCm39) |
start codon destroyed |
probably null |
0.02 |
R1353:Zfp84
|
UTSW |
7 |
29,475,600 (GRCm39) |
missense |
probably benign |
0.02 |
R1495:Zfp84
|
UTSW |
7 |
29,476,728 (GRCm39) |
nonsense |
probably null |
|
R1496:Zfp84
|
UTSW |
7 |
29,476,039 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1681:Zfp84
|
UTSW |
7 |
29,476,825 (GRCm39) |
missense |
probably damaging |
1.00 |
R1827:Zfp84
|
UTSW |
7 |
29,476,768 (GRCm39) |
missense |
possibly damaging |
0.91 |
R1854:Zfp84
|
UTSW |
7 |
29,474,796 (GRCm39) |
missense |
possibly damaging |
0.84 |
R2209:Zfp84
|
UTSW |
7 |
29,476,607 (GRCm39) |
missense |
probably damaging |
0.99 |
R2843:Zfp84
|
UTSW |
7 |
29,474,758 (GRCm39) |
splice site |
probably null |
|
R2844:Zfp84
|
UTSW |
7 |
29,474,758 (GRCm39) |
splice site |
probably null |
|
R4691:Zfp84
|
UTSW |
7 |
29,476,505 (GRCm39) |
missense |
probably damaging |
1.00 |
R5453:Zfp84
|
UTSW |
7 |
29,475,722 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5474:Zfp84
|
UTSW |
7 |
29,476,514 (GRCm39) |
missense |
probably damaging |
1.00 |
R5578:Zfp84
|
UTSW |
7 |
29,474,856 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5646:Zfp84
|
UTSW |
7 |
29,475,818 (GRCm39) |
missense |
probably benign |
0.05 |
R5963:Zfp84
|
UTSW |
7 |
29,476,378 (GRCm39) |
missense |
probably damaging |
1.00 |
R6830:Zfp84
|
UTSW |
7 |
29,475,911 (GRCm39) |
missense |
probably benign |
0.00 |
R8129:Zfp84
|
UTSW |
7 |
29,475,862 (GRCm39) |
missense |
probably benign |
0.00 |
R8138:Zfp84
|
UTSW |
7 |
29,474,797 (GRCm39) |
missense |
probably damaging |
0.99 |
R9180:Zfp84
|
UTSW |
7 |
29,474,873 (GRCm39) |
missense |
probably damaging |
0.97 |
R9401:Zfp84
|
UTSW |
7 |
29,476,297 (GRCm39) |
missense |
probably damaging |
1.00 |
R9489:Zfp84
|
UTSW |
7 |
29,476,264 (GRCm39) |
missense |
possibly damaging |
0.89 |
R9555:Zfp84
|
UTSW |
7 |
29,476,102 (GRCm39) |
missense |
probably damaging |
0.99 |
R9605:Zfp84
|
UTSW |
7 |
29,476,264 (GRCm39) |
missense |
possibly damaging |
0.89 |
Z1186:Zfp84
|
UTSW |
7 |
29,470,805 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Predicted Primers |
PCR Primer
(F):5'- GCCATACGAATGCCACAAATGTCAG -3'
(R):5'- TCACCTGTAAGAGCCGAGTGAAGG -3'
Sequencing Primer
(F):5'- ccacagcggcgagaaac -3'
(R):5'- ACACTCGTAGGGCTTCTCG -3'
|
Posted On |
2013-05-31 |