Incidental Mutation 'V5088:Megf11'
ID 44064
Institutional Source Beutler Lab
Gene Symbol Megf11
Ensembl Gene ENSMUSG00000036466
Gene Name multiple EGF-like-domains 11
Synonyms 2410080H04Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.143) question?
Stock # V5088 () of strain 521
Quality Score 149
Status Not validated
Chromosome 9
Chromosomal Location 64292908-64616487 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 64597351 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 674 (C674*)
Ref Sequence ENSEMBL: ENSMUSP00000128672 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068967] [ENSMUST00000093829] [ENSMUST00000118485] [ENSMUST00000164113]
AlphaFold Q80T91
Predicted Effect probably null
Transcript: ENSMUST00000068967
AA Change: C674*
SMART Domains Protein: ENSMUSP00000065353
Gene: ENSMUSG00000036466
AA Change: C674*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 74 84 N/A INTRINSIC
EGF 101 129 1.85e0 SMART
EGF_Lam 145 184 9.55e-3 SMART
EGF_Lam 188 227 2e-5 SMART
EGF 226 258 5.57e-4 SMART
EGF_Lam 274 313 1.26e-2 SMART
EGF_Lam 317 357 2.52e-2 SMART
EGF_Lam 361 402 4.16e-3 SMART
EGF 401 433 6.21e-2 SMART
EGF 444 476 4.1e-2 SMART
EGF 487 519 7.02e-1 SMART
EGF_Lam 535 574 1.43e-1 SMART
EGF_Lam 578 617 5.04e-2 SMART
EGF 616 650 8.52e0 SMART
EGF 661 693 9.41e-2 SMART
EGF 704 736 8.52e0 SMART
EGF_Lam 752 791 2.99e-4 SMART
EGF 790 822 1.14e0 SMART
transmembrane domain 848 870 N/A INTRINSIC
low complexity region 895 909 N/A INTRINSIC
low complexity region 1022 1037 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000093829
AA Change: C643*
SMART Domains Protein: ENSMUSP00000091349
Gene: ENSMUSG00000036466
AA Change: C643*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 74 84 N/A INTRINSIC
EGF_Lam 114 153 9.55e-3 SMART
EGF_Lam 157 196 2e-5 SMART
EGF 195 227 5.57e-4 SMART
EGF_Lam 243 282 1.26e-2 SMART
EGF_Lam 286 326 2.52e-2 SMART
EGF_Lam 330 371 4.16e-3 SMART
EGF 370 402 6.21e-2 SMART
EGF 413 445 4.1e-2 SMART
EGF 456 488 7.02e-1 SMART
EGF_Lam 504 543 1.43e-1 SMART
EGF_Lam 547 586 5.04e-2 SMART
EGF 585 619 8.52e0 SMART
EGF 630 662 9.41e-2 SMART
EGF_Lam 678 717 2.99e-4 SMART
EGF 716 748 1.14e0 SMART
transmembrane domain 774 796 N/A INTRINSIC
low complexity region 821 835 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000118485
AA Change: C674*
SMART Domains Protein: ENSMUSP00000114035
Gene: ENSMUSG00000036466
AA Change: C674*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 74 84 N/A INTRINSIC
EGF 101 129 1.85e0 SMART
EGF_Lam 145 184 9.55e-3 SMART
EGF_Lam 188 227 2e-5 SMART
EGF 226 258 5.57e-4 SMART
EGF_Lam 274 313 1.26e-2 SMART
EGF_Lam 317 357 2.52e-2 SMART
EGF_Lam 361 402 4.16e-3 SMART
EGF 401 433 6.21e-2 SMART
EGF 444 476 4.1e-2 SMART
EGF 487 519 7.02e-1 SMART
EGF_Lam 535 574 1.43e-1 SMART
EGF_Lam 578 617 5.04e-2 SMART
EGF 616 650 8.52e0 SMART
EGF 661 693 9.41e-2 SMART
EGF 704 736 8.52e0 SMART
EGF_Lam 752 791 2.99e-4 SMART
EGF 790 822 1.14e0 SMART
transmembrane domain 848 870 N/A INTRINSIC
low complexity region 926 941 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124881
SMART Domains Protein: ENSMUSP00000120514
Gene: ENSMUSG00000036466

DomainStartEndE-ValueType
EGF_like 3 36 2.79e0 SMART
EGF 35 67 4.1e-2 SMART
EGF 78 110 7.02e-1 SMART
EGF_Lam 126 165 1.43e-1 SMART
EGF 164 196 1.64e-1 SMART
EGF_Lam 212 251 2.99e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144383
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153934
Predicted Effect probably null
Transcript: ENSMUST00000164113
AA Change: C674*
SMART Domains Protein: ENSMUSP00000128672
Gene: ENSMUSG00000036466
AA Change: C674*

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
low complexity region 74 84 N/A INTRINSIC
EGF 101 129 1.85e0 SMART
EGF_Lam 145 184 9.55e-3 SMART
EGF_Lam 188 227 2e-5 SMART
EGF 226 258 5.57e-4 SMART
EGF_Lam 274 313 1.26e-2 SMART
EGF_Lam 317 357 2.52e-2 SMART
EGF_Lam 361 402 4.16e-3 SMART
EGF 401 433 6.21e-2 SMART
EGF 444 476 4.1e-2 SMART
EGF 487 519 7.02e-1 SMART
EGF_Lam 535 574 1.43e-1 SMART
EGF_Lam 578 617 5.04e-2 SMART
EGF 616 650 8.52e0 SMART
EGF 661 693 9.41e-2 SMART
EGF_Lam 709 748 2.99e-4 SMART
EGF 747 779 1.14e0 SMART
transmembrane domain 805 827 N/A INTRINSIC
low complexity region 852 866 N/A INTRINSIC
low complexity region 979 994 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted allele exhibit abnormal spacing of horizontal cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 7 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik C T 4: 148,026,233 (GRCm39) S251F probably benign Het
Akap8l C G 17: 32,555,713 (GRCm39) probably null Het
Ccar2 G T 14: 70,388,738 (GRCm39) L158I probably damaging Het
Or2n1d A G 17: 38,646,050 (GRCm39) M1V probably null Het
Psme4 A G 11: 30,801,210 (GRCm39) E1455G probably benign Het
Wdr17 C T 8: 55,146,131 (GRCm39) A90T possibly damaging Het
Zbtb12 C A 17: 35,115,277 (GRCm39) A354E possibly damaging Het
Other mutations in Megf11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00979:Megf11 APN 9 64,416,009 (GRCm39) missense probably damaging 1.00
IGL01285:Megf11 APN 9 64,567,728 (GRCm39) missense probably damaging 1.00
IGL01309:Megf11 APN 9 64,588,698 (GRCm39) missense probably benign 0.01
IGL01953:Megf11 APN 9 64,597,370 (GRCm39) missense probably damaging 1.00
IGL02341:Megf11 APN 9 64,451,902 (GRCm39) missense probably damaging 1.00
IGL02407:Megf11 APN 9 64,587,531 (GRCm39) missense probably damaging 1.00
IGL02621:Megf11 APN 9 64,601,214 (GRCm39) missense probably benign 0.07
R0277:Megf11 UTSW 9 64,598,632 (GRCm39) critical splice donor site probably null
R0386:Megf11 UTSW 9 64,547,360 (GRCm39) missense probably damaging 1.00
R1354:Megf11 UTSW 9 64,560,459 (GRCm39) missense probably benign 0.00
R1709:Megf11 UTSW 9 64,602,694 (GRCm39) missense probably damaging 1.00
R1865:Megf11 UTSW 9 64,587,581 (GRCm39) missense probably benign 0.39
R1895:Megf11 UTSW 9 64,586,558 (GRCm39) missense probably damaging 1.00
R1946:Megf11 UTSW 9 64,586,558 (GRCm39) missense probably damaging 1.00
R2221:Megf11 UTSW 9 64,567,713 (GRCm39) missense possibly damaging 0.63
R2223:Megf11 UTSW 9 64,567,713 (GRCm39) missense possibly damaging 0.63
R3552:Megf11 UTSW 9 64,602,745 (GRCm39) missense possibly damaging 0.75
R4641:Megf11 UTSW 9 64,597,407 (GRCm39) missense possibly damaging 0.93
R4746:Megf11 UTSW 9 64,416,027 (GRCm39) missense probably damaging 1.00
R5594:Megf11 UTSW 9 64,593,755 (GRCm39) missense probably damaging 1.00
R5716:Megf11 UTSW 9 64,413,392 (GRCm39) missense possibly damaging 0.72
R5898:Megf11 UTSW 9 64,593,246 (GRCm39) missense probably damaging 1.00
R5960:Megf11 UTSW 9 64,567,731 (GRCm39) missense probably benign 0.00
R6372:Megf11 UTSW 9 64,613,907 (GRCm39) missense probably damaging 1.00
R6811:Megf11 UTSW 9 64,451,923 (GRCm39) missense probably damaging 0.99
R6868:Megf11 UTSW 9 64,587,591 (GRCm39) missense probably damaging 1.00
R6980:Megf11 UTSW 9 64,613,132 (GRCm39) missense probably damaging 1.00
R6984:Megf11 UTSW 9 64,593,734 (GRCm39) missense probably benign
R7155:Megf11 UTSW 9 64,555,233 (GRCm39) missense probably null 1.00
R7638:Megf11 UTSW 9 64,586,535 (GRCm39) missense probably damaging 0.96
R7643:Megf11 UTSW 9 64,613,914 (GRCm39) missense probably damaging 1.00
R7688:Megf11 UTSW 9 64,599,146 (GRCm39) missense possibly damaging 0.92
R7840:Megf11 UTSW 9 64,602,709 (GRCm39) missense possibly damaging 0.94
R8744:Megf11 UTSW 9 64,451,970 (GRCm39) critical splice donor site probably null
R8799:Megf11 UTSW 9 64,588,673 (GRCm39) missense probably benign 0.05
R9383:Megf11 UTSW 9 64,545,732 (GRCm39) missense probably damaging 1.00
R9493:Megf11 UTSW 9 64,547,376 (GRCm39) missense probably damaging 1.00
R9797:Megf11 UTSW 9 64,545,591 (GRCm39) missense possibly damaging 0.83
V5622:Megf11 UTSW 9 64,597,351 (GRCm39) nonsense probably null
V5622:Megf11 UTSW 9 64,597,351 (GRCm39) nonsense probably null
Z1088:Megf11 UTSW 9 64,567,758 (GRCm39) missense probably damaging 1.00
Z1177:Megf11 UTSW 9 64,587,608 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAAGGTTCCCATCCAGATCACACC -3'
(R):5'- TCAGGATTCACAGCACTAATGGCAG -3'

Sequencing Primer
(F):5'- TCACACCTAGAGTAGTCAGGGC -3'
(R):5'- gcacttgccacccaaac -3'
Posted On 2013-05-31