Incidental Mutation 'V5088:Akap8l'
ID 44067
Institutional Source Beutler Lab
Gene Symbol Akap8l
Ensembl Gene ENSMUSG00000002625
Gene Name A kinase anchor protein 8-like
Synonyms Nakap95
Accession Numbers
Essential gene? Possibly essential (E-score: 0.567) question?
Stock # V5088 () of strain 521
Quality Score 163
Status Not validated
Chromosome 17
Chromosomal Location 32540398-32569581 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) C to G at 32555713 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000051389 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050214]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000050214
SMART Domains Protein: ENSMUSP00000051389
Gene: ENSMUSG00000002625

DomainStartEndE-ValueType
low complexity region 37 62 N/A INTRINSIC
low complexity region 78 93 N/A INTRINSIC
low complexity region 112 120 N/A INTRINSIC
low complexity region 236 257 N/A INTRINSIC
low complexity region 296 306 N/A INTRINSIC
low complexity region 307 324 N/A INTRINSIC
low complexity region 330 350 N/A INTRINSIC
coiled coil region 356 383 N/A INTRINSIC
ZnF_C2H2 389 413 1.05e1 SMART
SCOP:d1jvr__ 538 613 7e-5 SMART
low complexity region 628 640 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.3%
  • 20x: 92.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 7 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2510039O18Rik C T 4: 148,026,233 (GRCm39) S251F probably benign Het
Ccar2 G T 14: 70,388,738 (GRCm39) L158I probably damaging Het
Megf11 C A 9: 64,597,351 (GRCm39) C674* probably null Het
Or2n1d A G 17: 38,646,050 (GRCm39) M1V probably null Het
Psme4 A G 11: 30,801,210 (GRCm39) E1455G probably benign Het
Wdr17 C T 8: 55,146,131 (GRCm39) A90T possibly damaging Het
Zbtb12 C A 17: 35,115,277 (GRCm39) A354E possibly damaging Het
Other mutations in Akap8l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00590:Akap8l APN 17 32,552,071 (GRCm39) missense possibly damaging 0.82
IGL01603:Akap8l APN 17 32,564,327 (GRCm39) missense probably damaging 1.00
IGL02028:Akap8l APN 17 32,557,495 (GRCm39) splice site probably null
IGL02033:Akap8l APN 17 32,557,246 (GRCm39) missense probably damaging 1.00
IGL02301:Akap8l APN 17 32,551,900 (GRCm39) splice site probably benign
R1136:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1137:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1192:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1277:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1279:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1703:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1705:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1706:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1727:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1763:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1774:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1796:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R1954:Akap8l UTSW 17 32,555,710 (GRCm39) missense possibly damaging 0.74
R2072:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R2073:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R2074:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R2107:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R2108:Akap8l UTSW 17 32,551,457 (GRCm39) missense probably damaging 1.00
R2214:Akap8l UTSW 17 32,557,799 (GRCm39) critical splice acceptor site probably null
R2215:Akap8l UTSW 17 32,540,569 (GRCm39) missense possibly damaging 0.72
R2219:Akap8l UTSW 17 32,553,605 (GRCm39) missense probably benign 0.23
R2234:Akap8l UTSW 17 32,557,777 (GRCm39) missense probably damaging 1.00
R2871:Akap8l UTSW 17 32,557,416 (GRCm39) missense possibly damaging 0.84
R2871:Akap8l UTSW 17 32,557,416 (GRCm39) missense possibly damaging 0.84
R4273:Akap8l UTSW 17 32,540,905 (GRCm39) nonsense probably null
R4379:Akap8l UTSW 17 32,540,488 (GRCm39) unclassified probably benign
R5061:Akap8l UTSW 17 32,551,868 (GRCm39) missense probably damaging 1.00
R5337:Akap8l UTSW 17 32,555,368 (GRCm39) missense possibly damaging 0.71
R5377:Akap8l UTSW 17 32,540,485 (GRCm39) unclassified probably benign
R5579:Akap8l UTSW 17 32,540,916 (GRCm39) missense probably damaging 1.00
R5609:Akap8l UTSW 17 32,557,374 (GRCm39) missense probably damaging 1.00
R5667:Akap8l UTSW 17 32,557,266 (GRCm39) missense probably damaging 1.00
R5671:Akap8l UTSW 17 32,557,266 (GRCm39) missense probably damaging 1.00
R5747:Akap8l UTSW 17 32,564,352 (GRCm39) missense probably damaging 0.97
R6186:Akap8l UTSW 17 32,552,018 (GRCm39) missense probably benign 0.02
R6400:Akap8l UTSW 17 32,555,294 (GRCm39) missense probably damaging 0.99
R6482:Akap8l UTSW 17 32,564,370 (GRCm39) missense possibly damaging 0.94
R6712:Akap8l UTSW 17 32,551,862 (GRCm39) missense probably damaging 1.00
R7165:Akap8l UTSW 17 32,557,386 (GRCm39) missense probably damaging 0.99
R7485:Akap8l UTSW 17 32,554,545 (GRCm39) missense probably benign 0.03
R7729:Akap8l UTSW 17 32,552,068 (GRCm39) missense probably damaging 1.00
R9437:Akap8l UTSW 17 32,553,608 (GRCm39) missense probably benign 0.24
R9651:Akap8l UTSW 17 32,557,783 (GRCm39) missense probably damaging 1.00
R9652:Akap8l UTSW 17 32,557,783 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGCATTCGAAACTGGTCACGGTAG -3'
(R):5'- GCAATGCTTGGGGTGAACGAAC -3'

Sequencing Primer
(F):5'- GTAGGCATCATATTGGCCCTCATAG -3'
(R):5'- CAGAGAGAGCCCTGTACTTGTG -3'
Posted On 2013-05-31