Incidental Mutation 'R5642:Trp53bp1'
| ID |
440718 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trp53bp1
|
| Ensembl Gene |
ENSMUSG00000043909 |
| Gene Name |
transformation related protein 53 binding protein 1 |
| Synonyms |
53BP1, p53BP1 |
| MMRRC Submission |
043290-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5642 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
121023762-121101888 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 121067143 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Valine
at position 528
(M528V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000114457
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110647]
[ENSMUST00000110648]
[ENSMUST00000129752]
[ENSMUST00000131245]
|
| AlphaFold |
P70399 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110647
AA Change: M528V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000106277
Gene: ENSMUSG00000043909
AA Change: M528V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1042 |
N/A |
INTRINSIC |
|
low complexity region
|
1099 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1332 |
N/A |
INTRINSIC |
|
Pfam:53-BP1_Tudor
|
1430 |
1551 |
2.5e-80 |
PFAM |
|
low complexity region
|
1581 |
1601 |
N/A |
INTRINSIC |
|
BRCT
|
1673 |
1785 |
7.13e-1 |
SMART |
|
BRCT
|
1813 |
1901 |
1.03e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110648
AA Change: M528V
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000106278
Gene: ENSMUSG00000043909
AA Change: M528V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1042 |
N/A |
INTRINSIC |
|
low complexity region
|
1099 |
1112 |
N/A |
INTRINSIC |
|
low complexity region
|
1260 |
1272 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1332 |
N/A |
INTRINSIC |
|
low complexity region
|
1389 |
1409 |
N/A |
INTRINSIC |
|
Pfam:53-BP1_Tudor
|
1480 |
1601 |
1.5e-80 |
PFAM |
|
low complexity region
|
1631 |
1651 |
N/A |
INTRINSIC |
|
BRCT
|
1723 |
1835 |
7.13e-1 |
SMART |
|
BRCT
|
1863 |
1951 |
1.03e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124031
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129752
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131245
AA Change: M528V
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000114457
Gene: ENSMUSG00000043909
AA Change: M528V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
136 |
149 |
N/A |
INTRINSIC |
|
low complexity region
|
158 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
647 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
991 |
1002 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000142400
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147540
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous mutations in this gene result in growth retardation, immunodeficiency, thymic hypoplasia, and increased incidence of thymic lymphomas. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc1 |
A |
G |
16: 14,261,319 (GRCm39) |
E699G |
probably damaging |
Het |
| Ap4e1 |
T |
A |
2: 126,906,899 (GRCm39) |
V1053D |
possibly damaging |
Het |
| Apobec1 |
T |
A |
6: 122,558,456 (GRCm39) |
I100F |
probably damaging |
Het |
| Atp6v1g3 |
G |
T |
1: 138,211,480 (GRCm39) |
K53N |
probably damaging |
Het |
| Bag3 |
C |
T |
7: 128,147,830 (GRCm39) |
R482W |
probably damaging |
Het |
| Brme1 |
C |
T |
8: 84,894,114 (GRCm39) |
T427I |
probably damaging |
Het |
| Cacna1i |
A |
G |
15: 80,279,279 (GRCm39) |
T2007A |
possibly damaging |
Het |
| Cd44 |
T |
C |
2: 102,731,687 (GRCm39) |
D2G |
probably damaging |
Het |
| Cdadc1 |
T |
A |
14: 59,827,372 (GRCm39) |
I100F |
possibly damaging |
Het |
| Cdh16 |
A |
G |
8: 105,344,677 (GRCm39) |
F485L |
probably damaging |
Het |
| Cdhr5 |
T |
A |
7: 140,849,110 (GRCm39) |
K817* |
probably null |
Het |
| Cfap46 |
G |
T |
7: 139,258,493 (GRCm39) |
P260Q |
probably damaging |
Het |
| Clec11a |
C |
T |
7: 43,955,832 (GRCm39) |
E72K |
possibly damaging |
Het |
| Cnr2 |
C |
A |
4: 135,644,076 (GRCm39) |
N51K |
probably damaging |
Het |
| Col3a1 |
T |
A |
1: 45,370,872 (GRCm39) |
|
probably benign |
Het |
| Cxcr1 |
G |
A |
1: 74,230,987 (GRCm39) |
T345M |
probably damaging |
Het |
| Cyp2s1 |
T |
C |
7: 25,515,744 (GRCm39) |
|
probably null |
Het |
| Dalrd3 |
C |
T |
9: 108,449,489 (GRCm39) |
T474M |
probably damaging |
Het |
| Ddit4 |
C |
T |
10: 59,787,327 (GRCm39) |
S3N |
probably benign |
Het |
| Ddx41 |
T |
C |
13: 55,683,708 (GRCm39) |
K108E |
possibly damaging |
Het |
| Dnaaf10 |
A |
G |
11: 17,177,263 (GRCm39) |
N207S |
possibly damaging |
Het |
| Ece2 |
A |
T |
16: 20,462,477 (GRCm39) |
H732L |
probably benign |
Het |
| Etv3 |
T |
G |
3: 87,443,322 (GRCm39) |
L302R |
possibly damaging |
Het |
| Fam135b |
A |
G |
15: 71,333,985 (GRCm39) |
S1070P |
probably damaging |
Het |
| Fhip1b |
A |
T |
7: 105,039,089 (GRCm39) |
I50N |
probably damaging |
Het |
| Gm11567 |
T |
A |
11: 99,770,437 (GRCm39) |
I125N |
unknown |
Het |
| Grm3 |
A |
G |
5: 9,620,536 (GRCm39) |
L236P |
probably benign |
Het |
| Hip1 |
T |
A |
5: 135,461,939 (GRCm39) |
R97* |
probably null |
Het |
| Hoxa5 |
T |
C |
6: 52,181,197 (GRCm39) |
Y45C |
probably damaging |
Het |
| Ighg1 |
T |
A |
12: 113,292,654 (GRCm39) |
H305L |
probably damaging |
Het |
| Inpp5b |
T |
A |
4: 124,676,229 (GRCm39) |
C362S |
probably benign |
Het |
| Kif1c |
A |
G |
11: 70,599,273 (GRCm39) |
K391E |
probably benign |
Het |
| Klf9 |
T |
C |
19: 23,119,246 (GRCm39) |
V43A |
probably benign |
Het |
| Krt28 |
T |
A |
11: 99,265,320 (GRCm39) |
I116F |
probably damaging |
Het |
| Lct |
A |
T |
1: 128,222,969 (GRCm39) |
D1439E |
probably damaging |
Het |
| Liph |
G |
A |
16: 21,784,745 (GRCm39) |
T284M |
possibly damaging |
Het |
| Lrrc75b |
T |
C |
10: 75,393,055 (GRCm39) |
K98R |
possibly damaging |
Het |
| Lypd4 |
T |
C |
7: 24,564,604 (GRCm39) |
Q178R |
probably benign |
Het |
| Map1a |
T |
A |
2: 121,136,524 (GRCm39) |
S2209T |
probably damaging |
Het |
| Map3k21 |
C |
T |
8: 126,665,563 (GRCm39) |
T584I |
probably benign |
Het |
| Map3k6 |
T |
C |
4: 132,972,855 (GRCm39) |
V338A |
probably damaging |
Het |
| Mapk8ip3 |
A |
T |
17: 25,122,285 (GRCm39) |
V699E |
possibly damaging |
Het |
| Mtarc1 |
A |
C |
1: 184,543,116 (GRCm39) |
S71A |
probably damaging |
Het |
| Nckap1l |
T |
C |
15: 103,363,452 (GRCm39) |
S53P |
probably benign |
Het |
| Nt5e |
T |
C |
9: 88,209,740 (GRCm39) |
M1T |
probably null |
Het |
| Nudt22 |
T |
C |
19: 6,972,896 (GRCm39) |
H64R |
probably damaging |
Het |
| Or1o11 |
A |
T |
17: 37,756,663 (GRCm39) |
T84S |
probably damaging |
Het |
| Or2t44 |
A |
T |
11: 58,677,654 (GRCm39) |
Y198F |
probably damaging |
Het |
| Or2w3 |
T |
C |
11: 58,557,225 (GRCm39) |
I280T |
possibly damaging |
Het |
| Or52b1 |
A |
T |
7: 104,978,772 (GRCm39) |
V209D |
probably damaging |
Het |
| Or5ac16 |
A |
G |
16: 59,022,369 (GRCm39) |
L140P |
probably damaging |
Het |
| Or8k17 |
T |
C |
2: 86,066,276 (GRCm39) |
N294S |
probably damaging |
Het |
| Otogl |
T |
C |
10: 107,722,413 (GRCm39) |
I314V |
probably benign |
Het |
| Pan2 |
G |
T |
10: 128,143,969 (GRCm39) |
E106D |
probably benign |
Het |
| Papss1 |
T |
A |
3: 131,337,565 (GRCm39) |
Y554* |
probably null |
Het |
| Pcnx1 |
T |
C |
12: 81,941,803 (GRCm39) |
V67A |
possibly damaging |
Het |
| Pdpk1 |
A |
C |
17: 24,325,829 (GRCm39) |
Y122* |
probably null |
Het |
| Pkd1l1 |
A |
T |
11: 8,829,202 (GRCm39) |
N1463K |
probably damaging |
Het |
| Ptgfrn |
C |
A |
3: 100,950,678 (GRCm39) |
M878I |
probably damaging |
Het |
| Ranbp3 |
G |
A |
17: 57,017,703 (GRCm39) |
G453E |
probably benign |
Het |
| Rapgef2 |
T |
C |
3: 79,002,157 (GRCm39) |
D261G |
probably damaging |
Het |
| Reep2 |
A |
G |
18: 34,979,271 (GRCm39) |
S199G |
probably benign |
Het |
| Rnpep |
G |
A |
1: 135,205,259 (GRCm39) |
T202I |
probably damaging |
Het |
| Sass6 |
T |
A |
3: 116,401,145 (GRCm39) |
|
probably null |
Het |
| Sema3e |
A |
G |
5: 14,212,257 (GRCm39) |
D111G |
probably damaging |
Het |
| Slc29a4 |
A |
G |
5: 142,697,727 (GRCm39) |
E60G |
probably damaging |
Het |
| Spata31g1 |
T |
C |
4: 42,971,831 (GRCm39) |
L388P |
possibly damaging |
Het |
| Spata31h1 |
T |
A |
10: 82,120,317 (GRCm39) |
Q4231L |
probably damaging |
Het |
| Sptlc3 |
T |
C |
2: 139,388,328 (GRCm39) |
Y107H |
probably damaging |
Het |
| Stx6 |
T |
C |
1: 155,073,925 (GRCm39) |
I245T |
probably benign |
Het |
| Syne2 |
T |
C |
12: 75,965,306 (GRCm39) |
S774P |
probably damaging |
Het |
| Tbc1d16 |
T |
A |
11: 119,049,617 (GRCm39) |
Q293L |
probably damaging |
Het |
| Tbc1d30 |
T |
C |
10: 121,132,692 (GRCm39) |
D224G |
probably damaging |
Het |
| Tbc1d32 |
T |
A |
10: 56,026,973 (GRCm39) |
N759Y |
possibly damaging |
Het |
| Tdrd12 |
G |
T |
7: 35,210,725 (GRCm39) |
A166E |
probably damaging |
Het |
| Tex14 |
A |
G |
11: 87,405,046 (GRCm39) |
R653G |
probably benign |
Het |
| Them6 |
A |
T |
15: 74,593,654 (GRCm39) |
R171W |
probably null |
Het |
| Tln2 |
T |
C |
9: 67,203,640 (GRCm39) |
T489A |
probably benign |
Het |
| Tmem87a |
A |
G |
2: 120,234,427 (GRCm39) |
F39L |
probably benign |
Het |
| Toporsl |
T |
A |
4: 52,611,515 (GRCm39) |
C469* |
probably null |
Het |
| Tpr |
T |
C |
1: 150,299,569 (GRCm39) |
S1147P |
probably damaging |
Het |
| Trpm6 |
T |
A |
19: 18,807,571 (GRCm39) |
C1039S |
probably damaging |
Het |
| Ttc16 |
T |
A |
2: 32,665,348 (GRCm39) |
S5C |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,617,412 (GRCm39) |
Y14607C |
probably damaging |
Het |
| Usp6nl |
T |
C |
2: 6,435,275 (GRCm39) |
F345L |
probably damaging |
Het |
| Vmn1r205 |
C |
T |
13: 22,776,206 (GRCm39) |
G299R |
probably benign |
Het |
| Vmn2r74 |
G |
A |
7: 85,606,588 (GRCm39) |
H253Y |
probably benign |
Het |
| Vps13d |
A |
T |
4: 144,896,872 (GRCm39) |
D343E |
possibly damaging |
Het |
| Vwf |
A |
G |
6: 125,580,381 (GRCm39) |
E543G |
|
Het |
| Zfat |
A |
T |
15: 68,052,765 (GRCm39) |
V343E |
probably damaging |
Het |
| Zfp316 |
T |
C |
5: 143,249,846 (GRCm39) |
E139G |
unknown |
Het |
| Zfp943 |
T |
A |
17: 22,211,813 (GRCm39) |
C300S |
probably damaging |
Het |
| Zkscan16 |
A |
G |
4: 58,957,748 (GRCm39) |
K677E |
probably benign |
Het |
|
| Other mutations in Trp53bp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00336:Trp53bp1
|
APN |
2 |
121,087,060 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL00690:Trp53bp1
|
APN |
2 |
121,066,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00922:Trp53bp1
|
APN |
2 |
121,038,963 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01475:Trp53bp1
|
APN |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
IGL01639:Trp53bp1
|
APN |
2 |
121,033,173 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01662:Trp53bp1
|
APN |
2 |
121,066,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01757:Trp53bp1
|
APN |
2 |
121,041,785 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01829:Trp53bp1
|
APN |
2 |
121,046,377 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02247:Trp53bp1
|
APN |
2 |
121,067,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02349:Trp53bp1
|
APN |
2 |
121,029,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02391:Trp53bp1
|
APN |
2 |
121,033,191 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
chives
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
concur
|
UTSW |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
confirmation
|
UTSW |
2 |
121,035,594 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Infra
|
UTSW |
2 |
121,077,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
Legume
|
UTSW |
2 |
121,029,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
lentil
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
lentil2
|
UTSW |
2 |
121,038,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Profundus
|
UTSW |
2 |
121,038,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
split_pea
|
UTSW |
2 |
121,059,087 (GRCm39) |
nonsense |
probably null |
|
|
verily
|
UTSW |
2 |
121,041,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT1430001:Trp53bp1
|
UTSW |
2 |
121,101,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0045:Trp53bp1
|
UTSW |
2 |
121,034,978 (GRCm39) |
missense |
probably benign |
|
|
R0060:Trp53bp1
|
UTSW |
2 |
121,035,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0060:Trp53bp1
|
UTSW |
2 |
121,035,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0103:Trp53bp1
|
UTSW |
2 |
121,067,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0103:Trp53bp1
|
UTSW |
2 |
121,067,240 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0281:Trp53bp1
|
UTSW |
2 |
121,100,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0386:Trp53bp1
|
UTSW |
2 |
121,035,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Trp53bp1
|
UTSW |
2 |
121,066,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Trp53bp1
|
UTSW |
2 |
121,100,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0522:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0523:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0525:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0543:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0559:Trp53bp1
|
UTSW |
2 |
121,058,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0573:Trp53bp1
|
UTSW |
2 |
121,058,653 (GRCm39) |
splice site |
probably benign |
|
|
R0593:Trp53bp1
|
UTSW |
2 |
121,101,009 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0648:Trp53bp1
|
UTSW |
2 |
121,066,188 (GRCm39) |
missense |
probably benign |
0.20 |
|
R0680:Trp53bp1
|
UTSW |
2 |
121,082,349 (GRCm39) |
missense |
probably null |
0.13 |
|
R0732:Trp53bp1
|
UTSW |
2 |
121,078,745 (GRCm39) |
missense |
probably null |
0.96 |
|
R0905:Trp53bp1
|
UTSW |
2 |
121,034,799 (GRCm39) |
splice site |
probably benign |
|
|
R1377:Trp53bp1
|
UTSW |
2 |
121,101,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1415:Trp53bp1
|
UTSW |
2 |
121,066,665 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1725:Trp53bp1
|
UTSW |
2 |
121,082,481 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1971:Trp53bp1
|
UTSW |
2 |
121,035,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Trp53bp1
|
UTSW |
2 |
121,034,964 (GRCm39) |
missense |
probably benign |
|
|
R2143:Trp53bp1
|
UTSW |
2 |
121,046,545 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2282:Trp53bp1
|
UTSW |
2 |
121,100,754 (GRCm39) |
nonsense |
probably null |
|
|
R2296:Trp53bp1
|
UTSW |
2 |
121,039,728 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3106:Trp53bp1
|
UTSW |
2 |
121,067,133 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3792:Trp53bp1
|
UTSW |
2 |
121,030,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3793:Trp53bp1
|
UTSW |
2 |
121,030,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3946:Trp53bp1
|
UTSW |
2 |
121,059,107 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4001:Trp53bp1
|
UTSW |
2 |
121,035,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4327:Trp53bp1
|
UTSW |
2 |
121,087,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Trp53bp1
|
UTSW |
2 |
121,038,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4630:Trp53bp1
|
UTSW |
2 |
121,038,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4744:Trp53bp1
|
UTSW |
2 |
121,041,794 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4751:Trp53bp1
|
UTSW |
2 |
121,058,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4754:Trp53bp1
|
UTSW |
2 |
121,038,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4755:Trp53bp1
|
UTSW |
2 |
121,059,087 (GRCm39) |
nonsense |
probably null |
|
|
R4850:Trp53bp1
|
UTSW |
2 |
121,035,594 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4870:Trp53bp1
|
UTSW |
2 |
121,087,122 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4879:Trp53bp1
|
UTSW |
2 |
121,033,084 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4924:Trp53bp1
|
UTSW |
2 |
121,051,701 (GRCm39) |
nonsense |
probably null |
|
|
R4962:Trp53bp1
|
UTSW |
2 |
121,101,027 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5019:Trp53bp1
|
UTSW |
2 |
121,100,800 (GRCm39) |
splice site |
probably null |
|
|
R5111:Trp53bp1
|
UTSW |
2 |
121,041,868 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5149:Trp53bp1
|
UTSW |
2 |
121,046,598 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5252:Trp53bp1
|
UTSW |
2 |
121,074,464 (GRCm39) |
missense |
probably benign |
0.40 |
|
R5533:Trp53bp1
|
UTSW |
2 |
121,038,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5773:Trp53bp1
|
UTSW |
2 |
121,074,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5819:Trp53bp1
|
UTSW |
2 |
121,038,873 (GRCm39) |
nonsense |
probably null |
|
|
R5886:Trp53bp1
|
UTSW |
2 |
121,035,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5908:Trp53bp1
|
UTSW |
2 |
121,067,304 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6012:Trp53bp1
|
UTSW |
2 |
121,087,083 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6351:Trp53bp1
|
UTSW |
2 |
121,100,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6406:Trp53bp1
|
UTSW |
2 |
121,101,093 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6575:Trp53bp1
|
UTSW |
2 |
121,059,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6619:Trp53bp1
|
UTSW |
2 |
121,077,980 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6626:Trp53bp1
|
UTSW |
2 |
121,038,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6754:Trp53bp1
|
UTSW |
2 |
121,101,057 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6765:Trp53bp1
|
UTSW |
2 |
121,039,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6806:Trp53bp1
|
UTSW |
2 |
121,059,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6860:Trp53bp1
|
UTSW |
2 |
121,029,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6991:Trp53bp1
|
UTSW |
2 |
121,038,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7278:Trp53bp1
|
UTSW |
2 |
121,029,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Trp53bp1
|
UTSW |
2 |
121,066,950 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7357:Trp53bp1
|
UTSW |
2 |
121,041,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7477:Trp53bp1
|
UTSW |
2 |
121,066,827 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7577:Trp53bp1
|
UTSW |
2 |
121,067,119 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7643:Trp53bp1
|
UTSW |
2 |
121,078,295 (GRCm39) |
splice site |
probably null |
|
|
R7728:Trp53bp1
|
UTSW |
2 |
121,038,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Trp53bp1
|
UTSW |
2 |
121,035,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7955:Trp53bp1
|
UTSW |
2 |
121,066,225 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8099:Trp53bp1
|
UTSW |
2 |
121,030,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8200:Trp53bp1
|
UTSW |
2 |
121,066,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8282:Trp53bp1
|
UTSW |
2 |
121,029,523 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9136:Trp53bp1
|
UTSW |
2 |
121,067,092 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9152:Trp53bp1
|
UTSW |
2 |
121,029,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9292:Trp53bp1
|
UTSW |
2 |
121,046,177 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9340:Trp53bp1
|
UTSW |
2 |
121,100,460 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9475:Trp53bp1
|
UTSW |
2 |
121,039,761 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9616:Trp53bp1
|
UTSW |
2 |
121,066,657 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9675:Trp53bp1
|
UTSW |
2 |
121,087,089 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9779:Trp53bp1
|
UTSW |
2 |
121,066,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF046:Trp53bp1
|
UTSW |
2 |
121,046,482 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Trp53bp1
|
UTSW |
2 |
121,084,126 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1177:Trp53bp1
|
UTSW |
2 |
121,074,541 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACATCTTCAGCAACCGCGTC -3'
(R):5'- TTCCATCACCAAGTCTGGAAGAAC -3'
Sequencing Primer
(F):5'- AGCAACCGCGTCTTCTCTG -3'
(R):5'- CCAAGACTTCAGAGAGTGA -3'
|
| Posted On |
2016-11-08 |
Incidental Mutation