Incidental Mutation 'R5644:Dpp8'
ID 440979
Institutional Source Beutler Lab
Gene Symbol Dpp8
Ensembl Gene ENSMUSG00000032393
Gene Name dipeptidylpeptidase 8
Synonyms 2310004I03Rik, 4932434F09Rik
MMRRC Submission 043292-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.167) question?
Stock # R5644 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 64939696-64989933 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 64953017 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Stop codon at position 231 (W231*)
Ref Sequence ENSEMBL: ENSMUSP00000150334 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034960] [ENSMUST00000167773] [ENSMUST00000217434]
AlphaFold Q80YA7
Predicted Effect probably null
Transcript: ENSMUST00000034960
AA Change: W231*
SMART Domains Protein: ENSMUSP00000034960
Gene: ENSMUSG00000032393
AA Change: W231*

DomainStartEndE-ValueType
low complexity region 144 154 N/A INTRINSIC
Pfam:DPPIV_N 168 589 1e-100 PFAM
Pfam:Peptidase_S15 636 830 7.3e-11 PFAM
Pfam:Abhydrolase_5 671 860 4.8e-9 PFAM
Pfam:Peptidase_S9 676 885 6.5e-62 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000167773
AA Change: W231*
SMART Domains Protein: ENSMUSP00000126065
Gene: ENSMUSG00000032393
AA Change: W231*

DomainStartEndE-ValueType
low complexity region 144 154 N/A INTRINSIC
Pfam:DPPIV_N 168 589 3.3e-102 PFAM
Pfam:Peptidase_S15 636 830 7.3e-11 PFAM
Pfam:Abhydrolase_5 670 860 6.5e-9 PFAM
Pfam:Peptidase_S9 677 885 8.6e-63 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000217434
AA Change: W231*
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 105 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg6 A T 10: 14,308,678 (GRCm39) D805E probably damaging Het
Adrb2 A T 18: 62,311,753 (GRCm39) N357K probably benign Het
Ahnak A G 19: 8,988,021 (GRCm39) K3102E possibly damaging Het
Alkal2 T A 12: 30,934,889 (GRCm39) L36Q probably damaging Het
Alkbh8 G T 9: 3,385,384 (GRCm39) V559F probably damaging Het
Apba2 A G 7: 64,365,259 (GRCm39) T346A probably benign Het
Arhgap10 C T 8: 78,137,684 (GRCm39) M302I probably benign Het
Asah1 G T 8: 41,813,332 (GRCm39) T27K possibly damaging Het
Bag2 A G 1: 33,786,034 (GRCm39) V96A probably damaging Het
Bicd1 C T 6: 149,421,901 (GRCm39) A874V probably damaging Het
C4b T C 17: 34,961,391 (GRCm39) I189M probably benign Het
Cacna1a A G 8: 85,189,406 (GRCm39) Y119C probably damaging Het
Calcr A G 6: 3,708,538 (GRCm39) I216T probably damaging Het
Ccar1 T C 10: 62,607,757 (GRCm39) N302S probably benign Het
Ccdc93 A G 1: 121,411,065 (GRCm39) H446R probably benign Het
Cct6b A T 11: 82,613,281 (GRCm39) L420Q probably benign Het
Cemip T C 7: 83,638,392 (GRCm39) T273A probably benign Het
Cep128 A T 12: 91,315,625 (GRCm39) I87K probably damaging Het
Cfap221 A G 1: 119,860,532 (GRCm39) L698P probably damaging Het
Cfap43 T A 19: 47,784,114 (GRCm39) N473I possibly damaging Het
Clec12b T A 6: 129,356,923 (GRCm39) I172L probably benign Het
Cntnap5b A C 1: 100,311,326 (GRCm39) E606D probably benign Het
Cyp2c67 A C 19: 39,604,138 (GRCm39) V406G possibly damaging Het
Dhx57 T C 17: 80,546,302 (GRCm39) I1308V possibly damaging Het
Dnah7a A T 1: 53,580,138 (GRCm39) M1599K probably benign Het
Dnajc21 A T 15: 10,462,001 (GRCm39) D133E probably benign Het
Dvl3 T A 16: 20,345,026 (GRCm39) I353N probably damaging Het
Fgd6 T A 10: 93,969,912 (GRCm39) I1187N possibly damaging Het
Fn1 A T 1: 71,666,409 (GRCm39) Y875N probably damaging Het
Gaa T A 11: 119,171,361 (GRCm39) M671K possibly damaging Het
Gm11939 T C 11: 99,450,138 (GRCm39) D52G probably damaging Het
Gm14403 A T 2: 177,199,054 (GRCm39) H50L possibly damaging Het
Gpam A T 19: 55,077,331 (GRCm39) D153E probably benign Het
Gzma T C 13: 113,234,794 (GRCm39) T66A probably damaging Het
Hnmt A T 2: 23,904,251 (GRCm39) W137R probably damaging Het
Hsd17b7 A T 1: 169,783,517 (GRCm39) V297D probably damaging Het
Ighv1-85 A T 12: 115,963,680 (GRCm39) S107T possibly damaging Het
Kif12 T A 4: 63,084,130 (GRCm39) Q624L possibly damaging Het
Kif1b T C 4: 149,322,939 (GRCm39) D660G probably damaging Het
Klf13 T C 7: 63,541,308 (GRCm39) probably benign Het
Klhl41 A G 2: 69,500,815 (GRCm39) Y92C probably damaging Het
Klrc2 A T 6: 129,633,420 (GRCm39) C186S probably damaging Het
Lao1 T A 4: 118,822,433 (GRCm39) probably null Het
Lmo7 A G 14: 102,166,772 (GRCm39) probably benign Het
Lyst A T 13: 13,812,081 (GRCm39) Q831L possibly damaging Het
Lzts1 A G 8: 69,591,729 (GRCm39) S140P possibly damaging Het
Man2b1 T A 8: 85,820,839 (GRCm39) I679N possibly damaging Het
Mgat5b T A 11: 116,864,226 (GRCm39) V464E probably damaging Het
Mrgprb5 G A 7: 47,817,955 (GRCm39) T260I probably benign Het
Mybpc2 T C 7: 44,156,477 (GRCm39) T825A probably benign Het
Mycbp2 T A 14: 103,524,770 (GRCm39) K597I probably damaging Het
Naalad2 G T 9: 18,246,227 (GRCm39) N568K possibly damaging Het
Neurl1a A G 19: 47,167,916 (GRCm39) N4S probably benign Het
Nfx1 T C 4: 40,984,973 (GRCm39) W366R probably null Het
Nipbl C T 15: 8,388,391 (GRCm39) V410I probably benign Het
Nlrp9a A T 7: 26,257,993 (GRCm39) H537L possibly damaging Het
Nxpe4 A G 9: 48,304,050 (GRCm39) N46D probably benign Het
Or14j10 T A 17: 37,935,323 (GRCm39) I68F probably benign Het
Or4c101 T A 2: 88,389,849 (GRCm39) M1K probably null Het
Or4f60 A T 2: 111,902,013 (GRCm39) M305K probably benign Het
Or5ae1 C A 7: 84,565,327 (GRCm39) F113L probably benign Het
Or5b95 A T 19: 12,658,336 (GRCm39) Y288F probably damaging Het
Or5p58 A T 7: 107,694,011 (GRCm39) Y255* probably null Het
Or5p60 A G 7: 107,723,858 (GRCm39) F204S probably benign Het
Or6c2 A T 10: 129,362,972 (GRCm39) N292I probably damaging Het
Or6c76b T A 10: 129,693,296 (GRCm39) V303E probably benign Het
Or8u10 T C 2: 85,915,503 (GRCm39) N206S probably damaging Het
P2ry12 A T 3: 59,125,516 (GRCm39) M53K possibly damaging Het
Pcca G A 14: 123,124,481 (GRCm39) C684Y probably damaging Het
Pdzd7 A G 19: 45,028,619 (GRCm39) S175P probably benign Het
Pgbd1 A G 13: 21,607,322 (GRCm39) C291R probably damaging Het
Plekhg5 T C 4: 152,188,797 (GRCm39) V200A probably benign Het
Pola2 A G 19: 6,011,198 (GRCm39) V42A probably benign Het
Pramel16 C T 4: 143,675,374 (GRCm39) G484D probably benign Het
Prkcd C A 14: 30,329,370 (GRCm39) K23N probably benign Het
Ptdss1 T C 13: 67,120,604 (GRCm39) F267L probably damaging Het
Rad54l C T 4: 115,956,144 (GRCm39) S561N probably benign Het
Rai14 T A 15: 10,593,137 (GRCm39) H169L probably benign Het
Rfc3 C T 5: 151,573,444 (GRCm39) V40I probably benign Het
Rpl31 C T 1: 39,409,108 (GRCm39) R41C probably benign Het
Rtl1 C T 12: 109,558,013 (GRCm39) M1275I probably benign Het
Ryr2 C A 13: 11,610,468 (GRCm39) E4119D probably damaging Het
Senp7 T C 16: 56,004,512 (GRCm39) silent Het
Sfmbt2 A T 2: 10,573,184 (GRCm39) I571F probably damaging Het
Sit1 T A 4: 43,483,562 (GRCm39) T8S probably benign Het
Slc22a30 T C 19: 8,381,980 (GRCm39) H97R possibly damaging Het
Slco1a5 A C 6: 142,183,320 (GRCm39) probably null Het
Smc6 T A 12: 11,339,995 (GRCm39) N434K probably benign Het
Snap91 G T 9: 86,672,206 (GRCm39) probably null Het
Srsf10 T C 4: 135,591,131 (GRCm39) S194P possibly damaging Het
St14 T C 9: 31,017,806 (GRCm39) M205V probably benign Het
Syndig1 A T 2: 149,741,428 (GRCm39) I5F possibly damaging Het
Tbrg1 T C 9: 37,560,709 (GRCm39) D389G probably benign Het
Tcaf2 G A 6: 42,619,707 (GRCm39) R107C possibly damaging Het
Tpmt T A 13: 47,182,435 (GRCm39) D163V probably benign Het
Trim15 T C 17: 37,177,713 (GRCm39) E94G probably damaging Het
Trit1 T C 4: 122,942,965 (GRCm39) I279T probably damaging Het
Trpm8 T A 1: 88,287,461 (GRCm39) F815I possibly damaging Het
Ttn T A 2: 76,768,867 (GRCm39) T2856S probably damaging Het
Ugdh A T 5: 65,574,204 (GRCm39) D446E probably benign Het
Unc5c C T 3: 141,383,886 (GRCm39) A88V probably damaging Het
Vmn1r43 T C 6: 89,847,354 (GRCm39) N44S probably damaging Het
Vmn2r120 T A 17: 57,831,977 (GRCm39) M271L probably benign Het
Wdr74 T A 19: 8,715,240 (GRCm39) V133E probably damaging Het
Zfp607b T C 7: 27,403,194 (GRCm39) L550P probably damaging Het
Other mutations in Dpp8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00519:Dpp8 APN 9 64,985,290 (GRCm39) missense probably damaging 1.00
IGL00576:Dpp8 APN 9 64,951,111 (GRCm39) missense probably benign 0.32
IGL01303:Dpp8 APN 9 64,962,294 (GRCm39) splice site probably benign
IGL01506:Dpp8 APN 9 64,970,699 (GRCm39) splice site probably benign
IGL01544:Dpp8 APN 9 64,962,270 (GRCm39) missense probably benign 0.05
IGL02387:Dpp8 APN 9 64,952,998 (GRCm39) missense probably damaging 1.00
IGL02567:Dpp8 APN 9 64,986,058 (GRCm39) nonsense probably null
IGL02611:Dpp8 APN 9 64,963,075 (GRCm39) missense probably benign 0.15
IGL02723:Dpp8 APN 9 64,949,549 (GRCm39) missense possibly damaging 0.91
IGL02927:Dpp8 APN 9 64,967,551 (GRCm39) missense probably benign 0.09
IGL03116:Dpp8 APN 9 64,973,749 (GRCm39) missense probably damaging 0.96
IGL03135:Dpp8 APN 9 64,960,322 (GRCm39) splice site probably null
IGL03356:Dpp8 APN 9 64,953,069 (GRCm39) missense probably benign 0.00
almaviva UTSW 9 64,983,085 (GRCm39) missense probably damaging 1.00
bartolo UTSW 9 64,986,000 (GRCm39) missense probably damaging 1.00
Cherubino UTSW 9 64,962,205 (GRCm39) missense probably benign
rosina UTSW 9 64,983,066 (GRCm39) missense possibly damaging 0.88
IGL03050:Dpp8 UTSW 9 64,962,118 (GRCm39) missense probably benign 0.00
R0498:Dpp8 UTSW 9 64,953,077 (GRCm39) splice site probably benign
R0594:Dpp8 UTSW 9 64,944,280 (GRCm39) missense probably damaging 1.00
R0675:Dpp8 UTSW 9 64,973,784 (GRCm39) splice site probably benign
R0699:Dpp8 UTSW 9 64,962,176 (GRCm39) missense probably benign 0.01
R0831:Dpp8 UTSW 9 64,985,961 (GRCm39) missense possibly damaging 0.56
R1148:Dpp8 UTSW 9 64,961,114 (GRCm39) critical splice donor site probably null
R1148:Dpp8 UTSW 9 64,961,114 (GRCm39) critical splice donor site probably null
R1512:Dpp8 UTSW 9 64,971,096 (GRCm39) splice site probably benign
R1515:Dpp8 UTSW 9 64,986,030 (GRCm39) missense probably benign 0.04
R1546:Dpp8 UTSW 9 64,970,775 (GRCm39) missense possibly damaging 0.76
R1556:Dpp8 UTSW 9 64,958,761 (GRCm39) missense probably damaging 1.00
R2027:Dpp8 UTSW 9 64,986,056 (GRCm39) missense probably damaging 1.00
R2104:Dpp8 UTSW 9 64,981,849 (GRCm39) splice site probably null
R2113:Dpp8 UTSW 9 64,971,150 (GRCm39) missense probably benign 0.00
R2656:Dpp8 UTSW 9 64,988,086 (GRCm39) missense probably damaging 1.00
R4237:Dpp8 UTSW 9 64,962,205 (GRCm39) missense probably benign
R4238:Dpp8 UTSW 9 64,962,205 (GRCm39) missense probably benign
R4239:Dpp8 UTSW 9 64,962,205 (GRCm39) missense probably benign
R4595:Dpp8 UTSW 9 64,983,085 (GRCm39) missense probably damaging 1.00
R4614:Dpp8 UTSW 9 64,973,678 (GRCm39) missense probably benign 0.00
R4946:Dpp8 UTSW 9 64,963,200 (GRCm39) missense probably benign 0.00
R5338:Dpp8 UTSW 9 64,971,206 (GRCm39) nonsense probably null
R5378:Dpp8 UTSW 9 64,985,296 (GRCm39) missense probably damaging 1.00
R5506:Dpp8 UTSW 9 64,985,391 (GRCm39) splice site probably null
R5862:Dpp8 UTSW 9 64,953,004 (GRCm39) missense probably benign 0.03
R6437:Dpp8 UTSW 9 64,981,860 (GRCm39) missense probably benign 0.01
R6783:Dpp8 UTSW 9 64,970,844 (GRCm39) missense possibly damaging 0.76
R6863:Dpp8 UTSW 9 64,942,290 (GRCm39) missense probably damaging 0.98
R7192:Dpp8 UTSW 9 64,953,068 (GRCm39) missense possibly damaging 0.70
R7461:Dpp8 UTSW 9 64,960,402 (GRCm39) missense possibly damaging 0.86
R7514:Dpp8 UTSW 9 64,986,036 (GRCm39) missense probably damaging 1.00
R7548:Dpp8 UTSW 9 64,944,517 (GRCm39) missense probably damaging 1.00
R7584:Dpp8 UTSW 9 64,986,064 (GRCm39) missense probably damaging 0.98
R7605:Dpp8 UTSW 9 64,962,240 (GRCm39) missense probably benign 0.33
R7613:Dpp8 UTSW 9 64,960,402 (GRCm39) missense possibly damaging 0.86
R7665:Dpp8 UTSW 9 64,986,000 (GRCm39) missense probably damaging 1.00
R7698:Dpp8 UTSW 9 64,949,618 (GRCm39) missense probably benign 0.00
R7844:Dpp8 UTSW 9 64,952,949 (GRCm39) missense probably damaging 0.99
R7935:Dpp8 UTSW 9 64,944,262 (GRCm39) missense possibly damaging 0.82
R8079:Dpp8 UTSW 9 64,951,017 (GRCm39) missense probably damaging 1.00
R8121:Dpp8 UTSW 9 64,985,362 (GRCm39) missense probably benign 0.10
R8315:Dpp8 UTSW 9 64,988,133 (GRCm39) makesense probably null
R8419:Dpp8 UTSW 9 64,988,037 (GRCm39) missense probably benign 0.34
R8516:Dpp8 UTSW 9 64,985,291 (GRCm39) missense probably damaging 1.00
R8524:Dpp8 UTSW 9 64,950,989 (GRCm39) missense probably damaging 1.00
R8896:Dpp8 UTSW 9 64,985,318 (GRCm39) missense possibly damaging 0.88
R8922:Dpp8 UTSW 9 64,981,793 (GRCm39) missense probably benign 0.02
R8935:Dpp8 UTSW 9 64,983,066 (GRCm39) missense possibly damaging 0.88
R9463:Dpp8 UTSW 9 64,973,700 (GRCm39) nonsense probably null
R9518:Dpp8 UTSW 9 64,981,866 (GRCm39) missense possibly damaging 0.90
R9732:Dpp8 UTSW 9 64,970,862 (GRCm39) critical splice donor site probably null
R9751:Dpp8 UTSW 9 64,960,453 (GRCm39) missense probably null 0.65
Z1177:Dpp8 UTSW 9 64,973,767 (GRCm39) missense probably damaging 1.00
Z1177:Dpp8 UTSW 9 64,971,148 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TGGATGCAGCTGTCACAATG -3'
(R):5'- CTGTCCTCCTTTAAAGGTTTAAGCAC -3'

Sequencing Primer
(F):5'- CCTTTGCGGCCCAATTTA -3'
(R):5'- GGTTTAAGCACCTGAACTTAAACATC -3'
Posted On 2016-11-08