Incidental Mutation 'R5648:Wdr93'
ID 441269
Institutional Source Beutler Lab
Gene Symbol Wdr93
Ensembl Gene ENSMUSG00000039099
Gene Name WD repeat domain 93
Synonyms EG626359
MMRRC Submission 043169-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R5648 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 79392911-79435698 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 79426974 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 638 (C638R)
Ref Sequence ENSEMBL: ENSMUSP00000037467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035622]
AlphaFold Q402B2
Predicted Effect probably benign
Transcript: ENSMUST00000035622
AA Change: C638R

PolyPhen 2 Score 0.037 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000037467
Gene: ENSMUSG00000039099
AA Change: C638R

DomainStartEndE-ValueType
low complexity region 240 251 N/A INTRINSIC
low complexity region 265 274 N/A INTRINSIC
SCOP:d1jofa_ 389 607 7e-4 SMART
Blast:WD40 413 451 2e-11 BLAST
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 T C 2: 25,326,510 (GRCm39) probably null Het
Alpk2 A G 18: 65,482,988 (GRCm39) V340A probably damaging Het
Cald1 G T 6: 34,739,267 (GRCm39) probably null Het
Col24a1 C T 3: 145,064,321 (GRCm39) T702I probably benign Het
Ddx50 T C 10: 62,452,049 (GRCm39) R725G unknown Het
Dnah9 A T 11: 65,818,581 (GRCm39) F68L probably benign Het
Dnmt3b G A 2: 153,519,118 (GRCm39) V651M probably damaging Het
Dock1 G A 7: 134,348,683 (GRCm39) C299Y probably damaging Het
Epha4 T C 1: 77,375,162 (GRCm39) I562V probably benign Het
Esco2 A T 14: 66,068,641 (GRCm39) V223D probably damaging Het
Ggt6 T C 11: 72,326,542 (GRCm39) I33T possibly damaging Het
Gm10392 A T 11: 77,408,306 (GRCm39) D104E probably benign Het
Gm9847 A G 12: 14,545,130 (GRCm39) noncoding transcript Het
Gnao1 A T 8: 94,676,070 (GRCm39) Y116F probably damaging Het
Gvin1 A T 7: 105,762,606 (GRCm39) I621K possibly damaging Het
Hyal6 T C 6: 24,734,235 (GRCm39) M56T possibly damaging Het
Hyou1 T A 9: 44,296,546 (GRCm39) D490E probably damaging Het
Igsf10 G C 3: 59,235,574 (GRCm39) Q1536E probably benign Het
Klk1b8 T C 7: 43,448,068 (GRCm39) S31P possibly damaging Het
Map3k6 A C 4: 132,970,646 (GRCm39) I178L probably benign Het
Mycbp2 T A 14: 103,528,778 (GRCm39) N427Y probably damaging Het
Ncr1 T A 7: 4,347,519 (GRCm39) I228N probably damaging Het
Nefh A T 11: 4,895,233 (GRCm39) Y319N probably damaging Het
Or4a80 A C 2: 89,582,417 (GRCm39) C252G probably damaging Het
Pakap T C 4: 57,854,848 (GRCm39) V120A probably damaging Het
Pcdhb18 G A 18: 37,623,537 (GRCm39) R289Q probably benign Het
Pkhd1 T A 1: 20,628,850 (GRCm39) Y699F probably benign Het
Plekhd1 T C 12: 80,767,362 (GRCm39) L250P probably damaging Het
Reln A G 5: 22,203,570 (GRCm39) V1228A probably benign Het
Rhobtb2 G T 14: 70,034,593 (GRCm39) R211S probably damaging Het
Rps6kb1 T C 11: 86,403,697 (GRCm39) I305V possibly damaging Het
Slc12a2 G A 18: 58,029,382 (GRCm39) G256E possibly damaging Het
Slc4a1ap A G 5: 31,708,129 (GRCm39) probably null Het
Thoc1 A G 18: 9,962,390 (GRCm39) T92A possibly damaging Het
Ticam1 TCACACA TCACA 17: 56,577,629 (GRCm39) probably null Het
Tmem117 T G 15: 94,992,653 (GRCm39) S438A possibly damaging Het
Ttll7 A G 3: 146,667,465 (GRCm39) N777S probably damaging Het
Ubd T A 17: 37,506,345 (GRCm39) V77E probably damaging Het
Ubqln3 A G 7: 103,790,117 (GRCm39) S658P probably damaging Het
Vmn1r78 G A 7: 11,886,693 (GRCm39) M101I possibly damaging Het
Zfp983 T A 17: 21,877,947 (GRCm39) V50D probably damaging Het
Zhx3 A T 2: 160,623,881 (GRCm39) H95Q probably damaging Het
Other mutations in Wdr93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00928:Wdr93 APN 7 79,425,301 (GRCm39) missense probably damaging 1.00
IGL01910:Wdr93 APN 7 79,421,321 (GRCm39) missense probably damaging 1.00
IGL01977:Wdr93 APN 7 79,402,253 (GRCm39) missense probably damaging 1.00
IGL01979:Wdr93 APN 7 79,426,400 (GRCm39) missense probably benign 0.03
IGL02191:Wdr93 APN 7 79,398,968 (GRCm39) missense probably damaging 0.98
R0008:Wdr93 UTSW 7 79,408,221 (GRCm39) missense probably damaging 1.00
R0008:Wdr93 UTSW 7 79,408,221 (GRCm39) missense probably damaging 1.00
R1136:Wdr93 UTSW 7 79,423,196 (GRCm39) missense probably damaging 1.00
R1168:Wdr93 UTSW 7 79,398,922 (GRCm39) missense probably damaging 0.99
R1586:Wdr93 UTSW 7 79,418,109 (GRCm39) missense probably damaging 0.99
R1605:Wdr93 UTSW 7 79,421,257 (GRCm39) splice site probably null
R1651:Wdr93 UTSW 7 79,399,830 (GRCm39) missense probably benign 0.00
R3078:Wdr93 UTSW 7 79,402,241 (GRCm39) missense possibly damaging 0.81
R3689:Wdr93 UTSW 7 79,421,333 (GRCm39) missense possibly damaging 0.91
R4013:Wdr93 UTSW 7 79,418,159 (GRCm39) missense possibly damaging 0.90
R4771:Wdr93 UTSW 7 79,426,511 (GRCm39) missense probably damaging 0.99
R4824:Wdr93 UTSW 7 79,399,817 (GRCm39) nonsense probably null
R4887:Wdr93 UTSW 7 79,435,522 (GRCm39) missense probably damaging 1.00
R5172:Wdr93 UTSW 7 79,402,241 (GRCm39) missense probably damaging 0.97
R5510:Wdr93 UTSW 7 79,399,779 (GRCm39) missense probably damaging 1.00
R5625:Wdr93 UTSW 7 79,420,766 (GRCm39) missense probably benign 0.00
R5950:Wdr93 UTSW 7 79,423,179 (GRCm39) missense probably damaging 0.99
R6147:Wdr93 UTSW 7 79,408,245 (GRCm39) missense probably benign
R6530:Wdr93 UTSW 7 79,405,741 (GRCm39) missense probably damaging 1.00
R7056:Wdr93 UTSW 7 79,399,088 (GRCm39) missense probably damaging 1.00
R7079:Wdr93 UTSW 7 79,399,040 (GRCm39) missense probably damaging 1.00
R7309:Wdr93 UTSW 7 79,423,103 (GRCm39) missense possibly damaging 0.86
R7397:Wdr93 UTSW 7 79,416,172 (GRCm39) missense probably null 0.01
R7426:Wdr93 UTSW 7 79,427,055 (GRCm39) critical splice donor site probably null
R7455:Wdr93 UTSW 7 79,425,267 (GRCm39) missense probably benign 0.09
R7618:Wdr93 UTSW 7 79,435,474 (GRCm39) missense probably benign 0.02
R8360:Wdr93 UTSW 7 79,398,974 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCCATACACAGAGAGCAGGC -3'
(R):5'- AGACTCATGTGGTAAAGTCCTTCAG -3'

Sequencing Primer
(F):5'- GAGAGCAGGCCCACACC -3'
(R):5'- GGTAAAGTCCTTCAGTTAGCAGC -3'
Posted On 2016-11-08