Incidental Mutation 'R5622:Or5b21'
ID 441662
Institutional Source Beutler Lab
Gene Symbol Or5b21
Ensembl Gene ENSMUSG00000046272
Gene Name olfactory receptor family 5 subfamily B member 21
Synonyms Olfr1444, GA_x6K02T2RE5P-3191201-3192160, MOR202-4
MMRRC Submission 043161-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.246) question?
Stock # R5622 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 12839141-12840100 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 12839663 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 175 (I175L)
Ref Sequence ENSEMBL: ENSMUSP00000150212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059675] [ENSMUST00000213606]
AlphaFold Q8VFX2
Predicted Effect probably benign
Transcript: ENSMUST00000059675
AA Change: I175L

PolyPhen 2 Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000062460
Gene: ENSMUSG00000046272
AA Change: I175L

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 1.6e-54 PFAM
Pfam:7tm_1 42 291 5.3e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213606
AA Change: I175L

PolyPhen 2 Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
Meta Mutation Damage Score 0.2513 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 97% (69/71)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A T 17: 24,546,642 (GRCm39) S320T probably benign Het
Alg8 T A 7: 97,036,006 (GRCm39) probably benign Het
Anp32b G A 4: 46,469,930 (GRCm39) E202K unknown Het
Apcdd1 A G 18: 63,069,973 (GRCm39) probably null Het
Apobec2 A G 17: 48,730,444 (GRCm39) V74A possibly damaging Het
Arid3c A T 4: 41,729,959 (GRCm39) C79S probably benign Het
Atp1a2 A T 1: 172,118,994 (GRCm39) probably benign Het
B2m A T 2: 121,981,471 (GRCm39) N62I probably damaging Het
Borcs5 T C 6: 134,663,086 (GRCm39) probably null Het
Ccn1 A G 3: 145,355,075 (GRCm39) L60P probably damaging Het
Cdk11b A G 4: 155,714,674 (GRCm39) K127E probably damaging Het
Cep170 T C 1: 176,563,433 (GRCm39) H726R possibly damaging Het
Col5a2 A C 1: 45,466,219 (GRCm39) S190A probably benign Het
Cryba4 T C 5: 112,398,990 (GRCm39) D5G probably damaging Het
Cyp2a5 T G 7: 26,535,299 (GRCm39) V87G probably damaging Het
Dcaf8 A G 1: 172,013,965 (GRCm39) probably benign Het
Dchs1 A G 7: 105,404,500 (GRCm39) S2681P probably benign Het
Ddx20 A G 3: 105,586,327 (GRCm39) S673P probably damaging Het
Deptor T A 15: 55,044,428 (GRCm39) I198N probably damaging Het
Ebf2 T C 14: 67,628,007 (GRCm39) I334T possibly damaging Het
F5 A G 1: 164,020,134 (GRCm39) R870G probably benign Het
Flg2 A C 3: 93,109,871 (GRCm39) H633P unknown Het
Gm11938 T A 11: 99,494,119 (GRCm39) probably null Het
Gm6370 A G 5: 146,430,708 (GRCm39) T298A probably benign Het
H60b C A 10: 22,159,441 (GRCm39) probably benign Het
Hsbp1 A G 8: 120,071,324 (GRCm39) T4A possibly damaging Het
Hsd3b3 A T 3: 98,649,524 (GRCm39) D266E possibly damaging Het
Ift172 T C 5: 31,440,426 (GRCm39) Y287C probably damaging Het
Il20rb T A 9: 100,368,371 (GRCm39) Q4L probably benign Het
Krt5 T C 15: 101,617,470 (GRCm39) D421G probably damaging Het
Lonp1 G C 17: 56,927,263 (GRCm39) A330G probably benign Het
Me3 A G 7: 89,445,871 (GRCm39) D196G probably damaging Het
Mfsd12 T A 10: 81,199,461 (GRCm39) V451E probably null Het
Mib1 A G 18: 10,794,503 (GRCm39) N663S possibly damaging Het
Mtus2 A T 5: 148,015,244 (GRCm39) N679I probably benign Het
Myt1 A G 2: 181,438,915 (GRCm39) T146A probably benign Het
Neb T A 2: 52,160,281 (GRCm39) H2244L probably damaging Het
Or51l4 T C 7: 103,404,376 (GRCm39) T139A probably damaging Het
Or5p81 C T 7: 108,267,289 (GRCm39) T222I probably benign Het
Pabpc4 A G 4: 123,185,524 (GRCm39) probably null Het
Padi1 C A 4: 140,552,266 (GRCm39) V393L probably damaging Het
Pax2 A T 19: 44,806,905 (GRCm39) D300V probably damaging Het
Pcgf2 T C 11: 97,581,078 (GRCm39) E71G probably damaging Het
Pi4kb A G 3: 94,906,172 (GRCm39) Q573R possibly damaging Het
Pitpna T A 11: 75,511,153 (GRCm39) M242K possibly damaging Het
Pkd1 A G 17: 24,793,014 (GRCm39) E1567G possibly damaging Het
Plcb2 A T 2: 118,545,210 (GRCm39) S630R probably damaging Het
Prrt2 A T 7: 126,618,937 (GRCm39) V176D probably benign Het
Prss1l A C 6: 41,373,084 (GRCm39) N119H probably damaging Het
Prss42 T C 9: 110,628,490 (GRCm39) probably null Het
Rhoq A G 17: 87,304,459 (GRCm39) R197G probably benign Het
Rin2 A T 2: 145,702,299 (GRCm39) T332S probably benign Het
Rnps1-ps C T 6: 7,982,605 (GRCm39) noncoding transcript Het
Rp1 A T 1: 4,418,060 (GRCm39) N1017K possibly damaging Het
Setbp1 T A 18: 78,900,700 (GRCm39) Y989F probably damaging Het
Slc11a1 G A 1: 74,420,065 (GRCm39) G191D probably damaging Het
Slc35f5 G A 1: 125,517,693 (GRCm39) R497Q probably damaging Het
Slf1 T C 13: 77,198,090 (GRCm39) K728R probably benign Het
Tiparp T G 3: 65,454,946 (GRCm39) S364A probably benign Het
Tph1 G A 7: 46,296,969 (GRCm39) Q409* probably null Het
Trp73 A T 4: 154,145,049 (GRCm39) I526N possibly damaging Het
Ttc9c G A 19: 8,793,332 (GRCm39) R103* probably null Het
Vmn2r75 T A 7: 85,797,702 (GRCm39) I704F probably benign Het
Wdr76 A G 2: 121,348,216 (GRCm39) R63G probably damaging Het
Zc3h3 T A 15: 75,648,928 (GRCm39) S735C probably damaging Het
Zfp383 G A 7: 29,611,615 (GRCm39) V32M probably damaging Het
Zfp810 T A 9: 22,190,392 (GRCm39) Y172F probably benign Het
Other mutations in Or5b21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01668:Or5b21 APN 19 12,839,231 (GRCm39) missense probably benign 0.00
IGL01963:Or5b21 APN 19 12,839,746 (GRCm39) missense probably benign 0.00
IGL02030:Or5b21 APN 19 12,839,799 (GRCm39) missense probably benign 0.00
IGL02178:Or5b21 APN 19 12,839,907 (GRCm39) missense possibly damaging 0.49
IGL02641:Or5b21 APN 19 12,839,566 (GRCm39) nonsense probably null
R0311:Or5b21 UTSW 19 12,839,233 (GRCm39) missense probably benign 0.01
R0543:Or5b21 UTSW 19 12,839,252 (GRCm39) missense probably benign 0.00
R0815:Or5b21 UTSW 19 12,840,008 (GRCm39) missense probably benign 0.00
R2034:Or5b21 UTSW 19 12,839,151 (GRCm39) missense possibly damaging 0.82
R2078:Or5b21 UTSW 19 12,839,751 (GRCm39) missense probably benign 0.05
R2431:Or5b21 UTSW 19 12,839,970 (GRCm39) missense probably damaging 1.00
R3032:Or5b21 UTSW 19 12,839,282 (GRCm39) missense probably benign 0.00
R3932:Or5b21 UTSW 19 12,839,994 (GRCm39) missense possibly damaging 0.95
R4498:Or5b21 UTSW 19 12,840,033 (GRCm39) missense probably damaging 1.00
R4654:Or5b21 UTSW 19 12,839,596 (GRCm39) nonsense probably null
R4708:Or5b21 UTSW 19 12,839,261 (GRCm39) missense probably benign 0.00
R4823:Or5b21 UTSW 19 12,839,180 (GRCm39) missense probably benign 0.04
R4938:Or5b21 UTSW 19 12,839,916 (GRCm39) missense probably damaging 1.00
R4980:Or5b21 UTSW 19 12,839,384 (GRCm39) missense probably benign
R5580:Or5b21 UTSW 19 12,839,168 (GRCm39) missense possibly damaging 0.59
R5671:Or5b21 UTSW 19 12,839,171 (GRCm39) missense probably benign 0.02
R6149:Or5b21 UTSW 19 12,839,723 (GRCm39) missense probably benign 0.02
R6683:Or5b21 UTSW 19 12,840,014 (GRCm39) missense probably damaging 0.98
R7389:Or5b21 UTSW 19 12,839,981 (GRCm39) missense probably benign 0.04
R7392:Or5b21 UTSW 19 12,839,951 (GRCm39) missense probably benign 0.18
R7461:Or5b21 UTSW 19 12,839,141 (GRCm39) start codon destroyed probably benign 0.00
R7613:Or5b21 UTSW 19 12,839,141 (GRCm39) start codon destroyed probably benign 0.00
R7698:Or5b21 UTSW 19 12,840,077 (GRCm39) missense possibly damaging 0.69
R7717:Or5b21 UTSW 19 12,839,159 (GRCm39) missense probably benign 0.07
R7892:Or5b21 UTSW 19 12,839,843 (GRCm39) nonsense probably null
R9151:Or5b21 UTSW 19 12,839,976 (GRCm39) missense probably damaging 1.00
R9656:Or5b21 UTSW 19 12,839,247 (GRCm39) missense probably damaging 1.00
Z1088:Or5b21 UTSW 19 12,839,648 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTATAATGGGTGTGCAGCTC -3'
(R):5'- TCGTCCCTCAGAAGACTTCATG -3'

Sequencing Primer
(F):5'- ATAATGGGTGTGCAGCTCAATTTTTC -3'
(R):5'- GTCCCTCAGAAGACTTCATGTTTTG -3'
Posted On 2016-11-08