Mutagenetix > Incidental Mutation

Incidental Mutation 'R5625:Vmn1r19'

441790

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r19

Ensembl Gene

ENSMUSG00000115799

Gene Name

vomeronasal 1 receptor 19

Synonyms

V1rc27

MMRRC Submission

043164-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R5625 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

57381449-57382375 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 57382281 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Serine at position 278 (L278S)

Ref Sequence

ENSEMBL: ENSMUSP00000087264 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089830]

AlphaFold

Q8R2C7

Predicted Effect

probably damaging
Transcript: ENSMUST00000089830
AA Change: L278S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000087264
Gene: ENSMUSG00000115799
AA Change: L278S

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	6.6e-58	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.4%
3x: 98.6%
10x: 97.1%
20x: 94.8%

Validation Efficiency

100% (61/61)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg4	T	G	9: 44,189,333 (GRCm39)	D388A	probably benign	Het
Ampd3	A	C	7: 110,401,730 (GRCm39)	E408A	probably damaging	Het
Bmp1	G	T	14: 70,723,606 (GRCm39)	N743K	probably benign	Het
Brsk1	A	G	7: 4,709,399 (GRCm39)	K398E	probably damaging	Het
Ccdc157	A	T	11: 4,101,888 (GRCm39)	M11K	probably damaging	Het
Cep295	A	C	9: 15,252,187 (GRCm39)	M394R	probably damaging	Het
Cfap44	G	T	16: 44,280,710 (GRCm39)		probably null	Het
Col13a1	C	T	10: 61,679,388 (GRCm39)	G713R	unknown	Het
Cxcr2	A	T	1: 74,197,991 (GRCm39)	K162*	probably null	Het
Cyp3a44	C	T	5: 145,716,376 (GRCm39)	D405N	possibly damaging	Het
Exo1	G	T	1: 175,721,380 (GRCm39)	D340Y	possibly damaging	Het
Farp2	T	G	1: 93,456,470 (GRCm39)	L51R	probably damaging	Het
Fat4	A	T	3: 38,943,083 (GRCm39)	I659F	possibly damaging	Het
Gbp2b	T	A	3: 142,304,806 (GRCm39)	W81R	probably damaging	Het
Gipc2	C	T	3: 151,871,541 (GRCm39)		probably benign	Het
Gm10941	G	T	10: 77,094,670 (GRCm39)		probably benign	Het
Gm1988	A	T	7: 38,823,229 (GRCm39)		noncoding transcript	Het
Hapln3	G	T	7: 78,767,006 (GRCm39)		probably null	Het
Ifi213	A	G	1: 173,396,629 (GRCm39)	S482P	possibly damaging	Het
Insc	A	G	7: 114,428,302 (GRCm39)	T92A	probably damaging	Het
Lrrn1	T	A	6: 107,544,315 (GRCm39)	C38S	probably damaging	Het
Mycbpap	T	C	11: 94,396,519 (GRCm39)	E107G	probably damaging	Het
Neb	A	T	2: 52,067,547 (GRCm39)	L5848*	probably null	Het
Nrg3	A	T	14: 38,092,950 (GRCm39)	M545K	probably damaging	Het
Nudt3	A	G	17: 27,802,202 (GRCm39)	L28P	probably damaging	Het
Or8g35	T	A	9: 39,381,099 (GRCm39)	M308L	probably benign	Het
Otop1	A	T	5: 38,460,104 (GRCm39)	Y557F	probably damaging	Het
Pcare	T	A	17: 72,058,321 (GRCm39)	D452V	probably damaging	Het
Pdgfra	G	A	5: 75,349,998 (GRCm39)		probably null	Het
Pi4kb	A	G	3: 94,891,988 (GRCm39)	M223V	probably benign	Het
Piezo1	T	C	8: 123,209,699 (GRCm39)	T2335A	probably benign	Het
Ppp6c	A	G	2: 39,087,453 (GRCm39)	V251A	probably benign	Het
Prkg1	C	T	19: 31,742,162 (GRCm39)	E21K	possibly damaging	Het
Ptpru	T	C	4: 131,530,691 (GRCm39)	E521G	probably null	Het
Rasl10b	G	T	11: 83,309,640 (GRCm39)	R199L	probably damaging	Het
Rhbdf2	G	A	11: 116,496,203 (GRCm39)	R111C	probably damaging	Het
Sec23ip	G	T	7: 128,346,707 (GRCm39)		probably benign	Het
Sptbn5	A	T	2: 119,910,273 (GRCm39)		noncoding transcript	Het
Srsf11	C	T	3: 157,728,981 (GRCm39)		probably benign	Het
Syne2	T	C	12: 76,141,886 (GRCm39)	S6141P	probably benign	Het
Szt2	A	G	4: 118,230,414 (GRCm39)	V2653A	unknown	Het
Tex46	T	C	4: 136,337,925 (GRCm39)	F39S	probably damaging	Het
Tmem50a	AACCA	AA	4: 134,625,778 (GRCm39)		probably benign	Het
Tmem62	G	T	2: 120,820,874 (GRCm39)	W180L	probably damaging	Het
Tnxb	G	A	17: 34,904,185 (GRCm39)	A1232T	probably benign	Het
Tubgcp3	T	C	8: 12,674,888 (GRCm39)	H744R	possibly damaging	Het
Uggt2	A	G	14: 119,315,136 (GRCm39)	I311T	probably damaging	Het
Usp8	C	T	2: 126,584,197 (GRCm39)	R469C	probably damaging	Het
Vmn2r129	A	T	4: 156,686,505 (GRCm39)		noncoding transcript	Het
Vmn2r59	A	T	7: 41,695,884 (GRCm39)	I176N	probably benign	Het
Wdr93	A	G	7: 79,420,766 (GRCm39)	T376A	probably benign	Het
Zfp575	G	A	7: 24,285,077 (GRCm39)	A188V	possibly damaging	Het

Other mutations in Vmn1r19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00948:Vmn1r19	APN	6	57,382,247 (GRCm39)	missense	probably benign	0.03
IGL01287:Vmn1r19	APN	6	57,382,179 (GRCm39)	missense	probably damaging	1.00
IGL01516:Vmn1r19	APN	6	57,381,857 (GRCm39)	missense	probably benign	0.03
IGL01895:Vmn1r19	APN	6	57,382,245 (GRCm39)	missense	probably benign	0.02
IGL02676:Vmn1r19	APN	6	57,382,025 (GRCm39)	missense	possibly damaging	0.94
IGL03040:Vmn1r19	APN	6	57,382,347 (GRCm39)	missense	unknown
IGL03087:Vmn1r19	APN	6	57,381,476 (GRCm39)	missense	probably benign	0.01
PIT4802001:Vmn1r19	UTSW	6	57,382,037 (GRCm39)	missense	probably damaging	1.00
R0319:Vmn1r19	UTSW	6	57,381,600 (GRCm39)	missense	possibly damaging	0.93
R1368:Vmn1r19	UTSW	6	57,381,656 (GRCm39)	missense	probably benign	0.01
R1997:Vmn1r19	UTSW	6	57,382,033 (GRCm39)	missense	probably damaging	1.00
R2920:Vmn1r19	UTSW	6	57,381,909 (GRCm39)	missense	probably benign	0.03
R3857:Vmn1r19	UTSW	6	57,382,098 (GRCm39)	missense	possibly damaging	0.68
R4090:Vmn1r19	UTSW	6	57,381,720 (GRCm39)	missense	probably damaging	1.00
R4547:Vmn1r19	UTSW	6	57,381,774 (GRCm39)	missense	possibly damaging	0.56
R4823:Vmn1r19	UTSW	6	57,382,219 (GRCm39)	nonsense	probably null
R4951:Vmn1r19	UTSW	6	57,381,927 (GRCm39)	missense	probably benign	0.36
R5077:Vmn1r19	UTSW	6	57,382,026 (GRCm39)	missense	probably benign	0.00
R5459:Vmn1r19	UTSW	6	57,381,475 (GRCm39)	nonsense	probably null
R5690:Vmn1r19	UTSW	6	57,381,780 (GRCm39)	missense	probably benign	0.10
R5761:Vmn1r19	UTSW	6	57,382,338 (GRCm39)	missense	unknown
R6124:Vmn1r19	UTSW	6	57,381,602 (GRCm39)	missense	probably benign	0.02
R6373:Vmn1r19	UTSW	6	57,382,317 (GRCm39)	missense	unknown
R6476:Vmn1r19	UTSW	6	57,381,578 (GRCm39)	missense	probably damaging	0.99
R6938:Vmn1r19	UTSW	6	57,381,992 (GRCm39)	missense	possibly damaging	0.94
R7027:Vmn1r19	UTSW	6	57,381,475 (GRCm39)	nonsense	probably null
R7359:Vmn1r19	UTSW	6	57,382,080 (GRCm39)	missense	probably damaging	0.99
R7568:Vmn1r19	UTSW	6	57,381,813 (GRCm39)	missense	possibly damaging	0.69
R7893:Vmn1r19	UTSW	6	57,381,664 (GRCm39)	missense	probably damaging	1.00
R8481:Vmn1r19	UTSW	6	57,381,932 (GRCm39)	missense	probably damaging	0.99
R8487:Vmn1r19	UTSW	6	57,382,166 (GRCm39)	missense	probably benign	0.03
R8812:Vmn1r19	UTSW	6	57,381,436 (GRCm39)	start gained	probably benign
R8907:Vmn1r19	UTSW	6	57,381,991 (GRCm39)	missense	probably benign
R8976:Vmn1r19	UTSW	6	57,381,719 (GRCm39)	missense	probably benign	0.01
R9277:Vmn1r19	UTSW	6	57,382,322 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- TCAGCTACCTGAGAGCATCC -3'
(R):5'- TATAGGACTTGGCATCAGTAATGTC -3'

Sequencing Primer
(F):5'- TACCTGAGAGCATCCCCTGAG -3'
(R):5'- CAGACCTTTGAACTTCAGGAATGC -3'

Posted On

2016-11-08