Incidental Mutation 'R5629:Robo4'
| ID |
441992 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo4
|
| Ensembl Gene |
ENSMUSG00000032125 |
| Gene Name |
roundabout guidance receptor 4 |
| Synonyms |
Magic roundabout, 1200012D01Rik |
| MMRRC Submission |
043280-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.224)
|
| Stock # |
R5629 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
9 |
| Chromosomal Location |
37313198-37325319 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 37319658 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 636
(C636Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150722
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000102895]
[ENSMUST00000115046]
[ENSMUST00000115048]
[ENSMUST00000156972]
[ENSMUST00000214185]
|
| AlphaFold |
Q8C310 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000102895
AA Change: C636Y
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000099959
Gene: ENSMUSG00000032125
AA Change: C636Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
low complexity region
|
748 |
762 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
855 |
866 |
N/A |
INTRINSIC |
|
low complexity region
|
871 |
880 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115046
AA Change: C688Y
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000110698
Gene: ENSMUSG00000032125
AA Change: C688Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
484 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
540 |
546 |
N/A |
INTRINSIC |
|
low complexity region
|
596 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
747 |
756 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
792 |
N/A |
INTRINSIC |
|
low complexity region
|
807 |
821 |
N/A |
INTRINSIC |
|
low complexity region
|
834 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
914 |
925 |
N/A |
INTRINSIC |
|
low complexity region
|
930 |
939 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115048
AA Change: C525Y
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000110700
Gene: ENSMUSG00000032125
AA Change: C525Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
37 |
N/A |
INTRINSIC |
|
IG
|
48 |
144 |
2.51e0 |
SMART |
|
IGc2
|
160 |
225 |
6.86e-11 |
SMART |
|
FN3
|
263 |
343 |
2.05e0 |
SMART |
|
FN3
|
358 |
440 |
1.27e-3 |
SMART |
|
low complexity region
|
488 |
494 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
562 |
N/A |
INTRINSIC |
|
low complexity region
|
695 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
769 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
806 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
887 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156972
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000214185
AA Change: C636Y
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215777
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a reporter/null allele display enhanced VEGF-induced endothelial migration, tube formation and vascular permeability, and show increased pathologic angiogenesis and vascular leak in models of oxygen-induced retinopathy and choroidal neovascularization. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim2 |
G |
A |
5: 36,014,507 (GRCm39) |
D189N |
probably benign |
Het |
| Adamts9 |
A |
T |
6: 92,775,114 (GRCm39) |
V1052D |
probably damaging |
Het |
| Apob |
T |
C |
12: 8,057,847 (GRCm39) |
Y2077H |
probably damaging |
Het |
| Apol7e |
A |
T |
15: 77,602,276 (GRCm39) |
K291N |
probably benign |
Het |
| Arsk |
A |
T |
13: 76,242,027 (GRCm39) |
I82N |
probably damaging |
Het |
| Art1 |
A |
G |
7: 101,756,286 (GRCm39) |
Q159R |
probably benign |
Het |
| Atp2a2 |
A |
G |
5: 122,598,159 (GRCm39) |
V733A |
probably damaging |
Het |
| Btn2a2 |
A |
T |
13: 23,666,130 (GRCm39) |
|
probably null |
Het |
| Catsper1 |
C |
T |
19: 5,386,165 (GRCm39) |
P133S |
probably benign |
Het |
| Celsr3 |
A |
G |
9: 108,726,266 (GRCm39) |
D3165G |
probably benign |
Het |
| Cldn19 |
T |
A |
4: 119,114,116 (GRCm39) |
V86E |
probably damaging |
Het |
| Ctnna1 |
T |
A |
18: 35,382,802 (GRCm39) |
D649E |
probably benign |
Het |
| Cttnbp2 |
A |
G |
6: 18,405,217 (GRCm39) |
I1094T |
probably damaging |
Het |
| Ddx24 |
T |
C |
12: 103,391,806 (GRCm39) |
|
probably benign |
Het |
| Ern2 |
T |
A |
7: 121,769,389 (GRCm39) |
H879L |
probably damaging |
Het |
| Etv4 |
T |
A |
11: 101,662,751 (GRCm39) |
H277L |
probably damaging |
Het |
| Faap100 |
G |
T |
11: 120,267,837 (GRCm39) |
A312D |
probably damaging |
Het |
| Glipr1l1 |
G |
A |
10: 111,914,308 (GRCm39) |
C223Y |
possibly damaging |
Het |
| Gna14 |
T |
C |
19: 16,414,097 (GRCm39) |
S14P |
possibly damaging |
Het |
| Hapln1 |
A |
G |
13: 89,749,634 (GRCm39) |
T60A |
probably damaging |
Het |
| Hars2 |
T |
A |
18: 36,921,719 (GRCm39) |
Y273* |
probably null |
Het |
| Ighv5-6 |
A |
T |
12: 113,589,242 (GRCm39) |
Y79* |
probably null |
Het |
| Iqgap2 |
T |
A |
13: 95,768,682 (GRCm39) |
N1406I |
probably damaging |
Het |
| Kalrn |
T |
C |
16: 33,860,304 (GRCm39) |
T215A |
possibly damaging |
Het |
| Krtap13-1 |
T |
A |
16: 88,526,047 (GRCm39) |
S90R |
probably benign |
Het |
| Mettl8 |
T |
C |
2: 70,795,913 (GRCm39) |
I372V |
probably benign |
Het |
| Mfn1 |
A |
T |
3: 32,615,659 (GRCm39) |
T341S |
possibly damaging |
Het |
| Mocos |
T |
A |
18: 24,797,142 (GRCm39) |
|
probably null |
Het |
| Muc5b |
T |
C |
7: 141,415,036 (GRCm39) |
S2661P |
possibly damaging |
Het |
| Myo15a |
C |
T |
11: 60,370,578 (GRCm39) |
P1113S |
probably benign |
Het |
| Myo5a |
A |
T |
9: 75,111,127 (GRCm39) |
I1540F |
possibly damaging |
Het |
| Myoc |
T |
C |
1: 162,476,156 (GRCm39) |
Y287H |
probably damaging |
Het |
| Napepld |
A |
G |
5: 21,880,901 (GRCm39) |
F165L |
probably benign |
Het |
| Ndufb10 |
T |
C |
17: 24,941,656 (GRCm39) |
E102G |
probably damaging |
Het |
| Nrros |
T |
A |
16: 31,963,223 (GRCm39) |
I265F |
probably damaging |
Het |
| Nrxn1 |
A |
T |
17: 90,897,460 (GRCm39) |
F891I |
possibly damaging |
Het |
| Nsfl1c |
T |
C |
2: 151,346,085 (GRCm39) |
Y169H |
probably damaging |
Het |
| Oas2 |
G |
A |
5: 120,876,516 (GRCm39) |
Q476* |
probably null |
Het |
| Or51f5 |
A |
T |
7: 102,423,847 (GRCm39) |
I39F |
possibly damaging |
Het |
| Pcnx2 |
C |
A |
8: 126,624,780 (GRCm39) |
W14L |
probably damaging |
Het |
| Pip4p1 |
T |
C |
14: 51,165,373 (GRCm39) |
H278R |
probably benign |
Het |
| Piwil2 |
C |
T |
14: 70,660,416 (GRCm39) |
V70M |
probably damaging |
Het |
| Prss23 |
A |
C |
7: 89,159,400 (GRCm39) |
V223G |
probably damaging |
Het |
| Rarres2 |
A |
T |
6: 48,547,194 (GRCm39) |
L122Q |
probably benign |
Het |
| Robo1 |
T |
C |
16: 72,780,598 (GRCm39) |
V776A |
probably benign |
Het |
| Robo3 |
G |
A |
9: 37,330,507 (GRCm39) |
Q1008* |
probably null |
Het |
| Sacm1l |
A |
G |
9: 123,395,464 (GRCm39) |
M196V |
probably benign |
Het |
| Septin7 |
T |
A |
9: 25,199,589 (GRCm39) |
Y163N |
probably damaging |
Het |
| Skint6 |
G |
A |
4: 112,870,176 (GRCm39) |
T594I |
possibly damaging |
Het |
| Slc23a1 |
T |
C |
18: 35,759,545 (GRCm39) |
H13R |
probably benign |
Het |
| Slc25a39 |
A |
C |
11: 102,295,719 (GRCm39) |
Y109* |
probably null |
Het |
| Slc8a3 |
G |
A |
12: 81,246,405 (GRCm39) |
R883C |
probably damaging |
Het |
| Spag17 |
A |
T |
3: 99,987,435 (GRCm39) |
Y1575F |
probably benign |
Het |
| Spdye4c |
T |
A |
2: 128,438,705 (GRCm39) |
I321N |
probably damaging |
Het |
| Stk32b |
G |
A |
5: 37,614,576 (GRCm39) |
P311S |
probably damaging |
Het |
| Svs3a |
T |
A |
2: 164,132,040 (GRCm39) |
S203T |
probably benign |
Het |
| Taf3 |
A |
T |
2: 9,922,989 (GRCm39) |
I45N |
probably damaging |
Het |
| Taf7 |
T |
C |
18: 37,776,555 (GRCm39) |
N4S |
probably benign |
Het |
| Tial1 |
T |
A |
7: 128,046,421 (GRCm39) |
D87V |
probably damaging |
Het |
| Tmem120a |
T |
A |
5: 135,770,904 (GRCm39) |
E78V |
probably benign |
Het |
| Tmem19 |
A |
G |
10: 115,183,165 (GRCm39) |
F137L |
probably benign |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Trim30d |
T |
C |
7: 104,137,136 (GRCm39) |
K23E |
possibly damaging |
Het |
| Ubxn7 |
C |
A |
16: 32,151,117 (GRCm39) |
H4Q |
unknown |
Het |
| Usp40 |
C |
T |
1: 87,908,731 (GRCm39) |
R590H |
probably benign |
Het |
| Vmn1r90 |
A |
G |
7: 14,296,011 (GRCm39) |
M22T |
possibly damaging |
Het |
| Vmn2r1 |
G |
A |
3: 64,012,538 (GRCm39) |
V800M |
possibly damaging |
Het |
| Vps11 |
A |
T |
9: 44,267,673 (GRCm39) |
I313N |
probably damaging |
Het |
| Zhx1 |
A |
G |
15: 57,918,207 (GRCm39) |
V13A |
probably damaging |
Het |
| Zic4 |
G |
A |
9: 91,260,805 (GRCm39) |
R20H |
probably benign |
Het |
| Zp3r |
C |
T |
1: 130,510,616 (GRCm39) |
V369M |
probably damaging |
Het |
|
| Other mutations in Robo4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Robo4
|
APN |
9 |
37,322,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Robo4
|
APN |
9 |
37,319,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00491:Robo4
|
APN |
9 |
37,317,231 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL00792:Robo4
|
APN |
9 |
37,319,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01062:Robo4
|
APN |
9 |
37,317,296 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01287:Robo4
|
APN |
9 |
37,324,336 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL02289:Robo4
|
APN |
9 |
37,319,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02486:Robo4
|
APN |
9 |
37,319,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02851:Robo4
|
APN |
9 |
37,324,678 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02898:Robo4
|
APN |
9 |
37,319,472 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02965:Robo4
|
APN |
9 |
37,321,765 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL03071:Robo4
|
APN |
9 |
37,315,580 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Robo4
|
APN |
9 |
37,315,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8562:Robo4
|
UTSW |
9 |
37,317,106 (GRCm39) |
intron |
probably benign |
|
|
PIT4305001:Robo4
|
UTSW |
9 |
37,322,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0068:Robo4
|
UTSW |
9 |
37,315,773 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0233:Robo4
|
UTSW |
9 |
37,313,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0416:Robo4
|
UTSW |
9 |
37,316,062 (GRCm39) |
splice site |
probably benign |
|
|
R1005:Robo4
|
UTSW |
9 |
37,319,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1174:Robo4
|
UTSW |
9 |
37,324,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1183:Robo4
|
UTSW |
9 |
37,319,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1254:Robo4
|
UTSW |
9 |
37,322,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1398:Robo4
|
UTSW |
9 |
37,319,372 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1505:Robo4
|
UTSW |
9 |
37,314,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Robo4
|
UTSW |
9 |
37,314,739 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1834:Robo4
|
UTSW |
9 |
37,324,355 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1899:Robo4
|
UTSW |
9 |
37,315,366 (GRCm39) |
splice site |
probably benign |
|
|
R2203:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2204:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2351:Robo4
|
UTSW |
9 |
37,322,956 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2448:Robo4
|
UTSW |
9 |
37,313,958 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R2847:Robo4
|
UTSW |
9 |
37,315,772 (GRCm39) |
nonsense |
probably null |
|
|
R2851:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2852:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R2877:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3123:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3124:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3125:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3805:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3806:Robo4
|
UTSW |
9 |
37,315,734 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3892:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R3905:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R3938:Robo4
|
UTSW |
9 |
37,313,313 (GRCm39) |
start gained |
probably benign |
|
|
R4261:Robo4
|
UTSW |
9 |
37,316,877 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4434:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4435:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4561:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4562:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R4568:Robo4
|
UTSW |
9 |
37,316,118 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4695:Robo4
|
UTSW |
9 |
37,314,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4921:Robo4
|
UTSW |
9 |
37,313,856 (GRCm39) |
missense |
probably benign |
|
|
R5000:Robo4
|
UTSW |
9 |
37,319,664 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5056:Robo4
|
UTSW |
9 |
37,316,102 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5125:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Robo4
|
UTSW |
9 |
37,319,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5279:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5285:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5347:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5348:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5361:Robo4
|
UTSW |
9 |
37,324,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5403:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5404:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5488:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5489:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5490:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5494:Robo4
|
UTSW |
9 |
37,322,786 (GRCm39) |
frame shift |
probably null |
|
|
R5736:Robo4
|
UTSW |
9 |
37,316,093 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R5796:Robo4
|
UTSW |
9 |
37,322,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5987:Robo4
|
UTSW |
9 |
37,322,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6178:Robo4
|
UTSW |
9 |
37,316,926 (GRCm39) |
nonsense |
probably null |
|
|
R6189:Robo4
|
UTSW |
9 |
37,314,829 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6365:Robo4
|
UTSW |
9 |
37,322,008 (GRCm39) |
missense |
probably benign |
0.34 |
|
R6528:Robo4
|
UTSW |
9 |
37,315,664 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6887:Robo4
|
UTSW |
9 |
37,313,363 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7196:Robo4
|
UTSW |
9 |
37,314,001 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7408:Robo4
|
UTSW |
9 |
37,322,277 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7419:Robo4
|
UTSW |
9 |
37,314,105 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7486:Robo4
|
UTSW |
9 |
37,316,870 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7707:Robo4
|
UTSW |
9 |
37,324,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7839:Robo4
|
UTSW |
9 |
37,322,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8079:Robo4
|
UTSW |
9 |
37,313,931 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8081:Robo4
|
UTSW |
9 |
37,316,936 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8280:Robo4
|
UTSW |
9 |
37,315,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8526:Robo4
|
UTSW |
9 |
37,314,801 (GRCm39) |
nonsense |
probably null |
|
|
R8547:Robo4
|
UTSW |
9 |
37,315,674 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8735:Robo4
|
UTSW |
9 |
37,319,577 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8836:Robo4
|
UTSW |
9 |
37,317,130 (GRCm39) |
missense |
unknown |
|
|
R8889:Robo4
|
UTSW |
9 |
37,314,601 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9018:Robo4
|
UTSW |
9 |
37,315,520 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9182:Robo4
|
UTSW |
9 |
37,313,206 (GRCm39) |
start gained |
probably benign |
|
|
R9375:Robo4
|
UTSW |
9 |
37,316,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9621:Robo4
|
UTSW |
9 |
37,317,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTAGTGATCTCCTGGGACCC -3'
(R):5'- CCCACTATTGTAAAGAGGAGCTGAG -3'
Sequencing Primer
(F):5'- ATCTCCTGGGACCCTCGGAG -3'
(R):5'- GAGGAGCTGAGCAATCATCCC -3'
|
| Posted On |
2016-11-08 |
Incidental Mutation