Incidental Mutation 'R5654:Ido1'
ID 442178
Institutional Source Beutler Lab
Gene Symbol Ido1
Ensembl Gene ENSMUSG00000031551
Gene Name indoleamine 2,3-dioxygenase 1
Synonyms Ido, Indo
MMRRC Submission 043300-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5654 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 25074148-25086987 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 25077819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 83 (V83M)
Ref Sequence ENSEMBL: ENSMUSP00000106295 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033956] [ENSMUST00000110667]
AlphaFold P28776
Predicted Effect probably damaging
Transcript: ENSMUST00000033956
AA Change: V174M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000033956
Gene: ENSMUSG00000031551
AA Change: V174M

DomainStartEndE-ValueType
Pfam:IDO 15 402 4.7e-124 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110667
AA Change: V83M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106295
Gene: ENSMUSG00000031551
AA Change: V83M

DomainStartEndE-ValueType
Pfam:IDO 1 313 6e-111 PFAM
Meta Mutation Damage Score 0.5374 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency 96% (69/72)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a null allele fail to induce IFN-alpha production by dendritic cells after B7 ligation, and show epididymal inflammation, teratospermia, and elevated caudal epididymal sperm counts along with higher protein and cytokine levels and reduced leukocyte count and proteasome activity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb6 T C 1: 75,151,479 (GRCm39) probably null Het
Abcc9 G A 6: 142,571,371 (GRCm39) probably benign Het
Acss2 T C 2: 155,416,575 (GRCm39) probably benign Het
Atp8b4 G A 2: 126,217,725 (GRCm39) T597I probably damaging Het
Btaf1 A T 19: 36,961,015 (GRCm39) N796I probably benign Het
Caskin2 T C 11: 115,690,905 (GRCm39) probably null Het
Cdhr2 A G 13: 54,884,349 (GRCm39) N1295D probably benign Het
Cog3 G A 14: 75,962,239 (GRCm39) T534M probably benign Het
Cpne1 A G 2: 155,919,561 (GRCm39) S303P probably damaging Het
Cs G A 10: 128,187,086 (GRCm39) G74S possibly damaging Het
Cyb5r4 G T 9: 86,929,533 (GRCm39) S229I probably damaging Het
Ddr1 C T 17: 35,997,400 (GRCm39) A531T probably benign Het
Ect2l C T 10: 18,018,810 (GRCm39) V529M probably damaging Het
Edaradd C A 13: 12,493,161 (GRCm39) R177L possibly damaging Het
Esf1 T C 2: 140,006,148 (GRCm39) D333G possibly damaging Het
Fam8a1 T A 13: 46,827,814 (GRCm39) L334H probably damaging Het
Fbxl18 A G 5: 142,871,558 (GRCm39) I559T probably damaging Het
Fcrl2 A C 3: 87,164,851 (GRCm39) V225G probably benign Het
Iffo1 T G 6: 125,130,030 (GRCm39) C419G probably damaging Het
Igfals A T 17: 25,100,439 (GRCm39) Y510F probably benign Het
Ipo9 A T 1: 135,313,210 (GRCm39) Y1006* probably null Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Jmjd1c T A 10: 67,065,785 (GRCm39) S1737T probably benign Het
Klhl32 C T 4: 24,800,805 (GRCm39) probably null Het
Klk1b11 T A 7: 43,427,810 (GRCm39) C173S probably damaging Het
Klk1b24 A T 7: 43,840,889 (GRCm39) M106L probably benign Het
Lamp1 G A 8: 13,221,388 (GRCm39) probably null Het
Mapk4 A T 18: 74,103,365 (GRCm39) V48E probably damaging Het
Marchf6 A T 15: 31,486,082 (GRCm39) D395E probably damaging Het
Mdp1 A G 14: 55,896,465 (GRCm39) F157S probably damaging Het
Mettl21e A T 1: 44,250,255 (GRCm39) F50L probably damaging Het
Mrgpra2a A G 7: 47,077,153 (GRCm39) I35T probably benign Het
Natd1 T C 11: 60,796,892 (GRCm39) Y91C probably damaging Het
Nbas T A 12: 13,633,476 (GRCm39) Y2294N probably damaging Het
Nrcam A G 12: 44,610,841 (GRCm39) T520A probably benign Het
Nrf1 A G 6: 30,117,061 (GRCm39) T324A probably benign Het
Or10a2 G A 7: 106,673,394 (GRCm39) A120T probably damaging Het
Or4k51 T A 2: 111,585,326 (GRCm39) I244N probably damaging Het
Or52a5 A C 7: 103,427,182 (GRCm39) D123E probably damaging Het
Or5m11b A G 2: 85,806,500 (GRCm39) I304M probably benign Het
Pam C T 1: 97,792,123 (GRCm39) V433I probably benign Het
Pck1 T A 2: 173,000,353 (GRCm39) Y595N probably damaging Het
Per2 C T 1: 91,373,223 (GRCm39) probably null Het
Piezo2 G C 18: 63,278,162 (GRCm39) F247L possibly damaging Het
Pkdcc A G 17: 83,523,337 (GRCm39) Y148C probably damaging Het
Plod2 A G 9: 92,475,876 (GRCm39) T320A probably benign Het
Ppip5k1 G A 2: 121,147,157 (GRCm39) R1155C probably benign Het
Ppp1r15b C T 1: 133,059,382 (GRCm39) probably benign Het
Prkn C T 17: 11,456,536 (GRCm39) A119V probably damaging Het
Ptprz1 G T 6: 22,986,133 (GRCm39) C311F probably damaging Het
Rab11fip3 A T 17: 26,235,038 (GRCm39) V44E probably damaging Het
Rpl5 T A 5: 108,051,514 (GRCm39) probably benign Het
Rttn G A 18: 89,066,556 (GRCm39) V1201I probably benign Het
Sdk1 A G 5: 141,921,853 (GRCm39) N283S probably damaging Het
Shank3 T A 15: 89,405,529 (GRCm39) N418K probably benign Het
Shmt2 T C 10: 127,353,668 (GRCm39) D499G probably benign Het
Slc25a46 A G 18: 31,716,293 (GRCm39) L403S probably damaging Het
Slc5a1 A G 5: 33,303,955 (GRCm39) T257A probably benign Het
Snrnp35 T C 5: 124,628,535 (GRCm39) V116A probably benign Het
Spag9 T A 11: 93,981,538 (GRCm39) F593I probably damaging Het
Tmem171 C A 13: 98,828,574 (GRCm39) R192L probably benign Het
Trappc3l T A 10: 33,978,703 (GRCm39) L169Q unknown Het
Ube2s T C 7: 4,811,431 (GRCm39) E148G probably damaging Het
Uspl1 T C 5: 149,146,521 (GRCm39) F424S probably damaging Het
Vmn1r2 T C 4: 3,172,261 (GRCm39) V60A probably benign Het
Wdfy4 T C 14: 32,829,575 (GRCm39) probably null Het
Zfp735 C T 11: 73,602,964 (GRCm39) S636L possibly damaging Het
Zswim9 G A 7: 12,995,094 (GRCm39) S354F probably damaging Het
Other mutations in Ido1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Ido1 APN 8 25,074,575 (GRCm39) missense possibly damaging 0.93
IGL01987:Ido1 APN 8 25,083,159 (GRCm39) missense probably benign 0.02
IGL02960:Ido1 APN 8 25,083,345 (GRCm39) splice site probably benign
R0180:Ido1 UTSW 8 25,083,156 (GRCm39) missense possibly damaging 0.87
R0652:Ido1 UTSW 8 25,075,260 (GRCm39) missense probably damaging 1.00
R1102:Ido1 UTSW 8 25,083,156 (GRCm39) missense probably damaging 1.00
R1474:Ido1 UTSW 8 25,074,462 (GRCm39) missense probably damaging 0.97
R1925:Ido1 UTSW 8 25,075,306 (GRCm39) missense possibly damaging 0.82
R2509:Ido1 UTSW 8 25,074,501 (GRCm39) nonsense probably null
R4913:Ido1 UTSW 8 25,074,533 (GRCm39) missense probably benign
R4962:Ido1 UTSW 8 25,074,565 (GRCm39) missense probably benign 0.00
R5313:Ido1 UTSW 8 25,077,794 (GRCm39) missense probably damaging 1.00
R5660:Ido1 UTSW 8 25,081,558 (GRCm39) missense probably damaging 1.00
R6144:Ido1 UTSW 8 25,075,306 (GRCm39) missense possibly damaging 0.82
R7436:Ido1 UTSW 8 25,076,932 (GRCm39) missense probably benign 0.00
R7615:Ido1 UTSW 8 25,083,204 (GRCm39) missense probably damaging 1.00
R7873:Ido1 UTSW 8 25,074,758 (GRCm39) missense probably damaging 0.98
R8490:Ido1 UTSW 8 25,086,954 (GRCm39) start codon destroyed probably null 1.00
R8896:Ido1 UTSW 8 25,077,880 (GRCm39) missense probably benign 0.00
R8917:Ido1 UTSW 8 25,081,523 (GRCm39) missense probably benign
R9361:Ido1 UTSW 8 25,079,601 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGCATGTATTGTCTCCAGTTATACG -3'
(R):5'- GGCCTTACATGCATATGATCTTTAGAC -3'

Sequencing Primer
(F):5'- GACCTGATGCTACCTTCAATCAGGG -3'
(R):5'- TGGGCATATACCACTCTGGCAC -3'
Posted On 2016-11-09