Incidental Mutation 'R5654:Zfp735'
ID 442187
Institutional Source Beutler Lab
Gene Symbol Zfp735
Ensembl Gene ENSMUSG00000060630
Gene Name zinc finger protein 735
Synonyms 1700012C15Rik
MMRRC Submission 043300-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R5654 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 73579604-73604624 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 73602964 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 636 (S636L)
Ref Sequence ENSEMBL: ENSMUSP00000079269 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080407]
AlphaFold B1ARH2
Predicted Effect possibly damaging
Transcript: ENSMUST00000080407
AA Change: S636L

PolyPhen 2 Score 0.711 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: S636L

DomainStartEndE-ValueType
KRAB 8 68 2.2e-34 SMART
ZnF_C2H2 483 505 4.38e1 SMART
ZnF_C2H2 511 533 2.67e-1 SMART
ZnF_C2H2 539 561 1.81e1 SMART
ZnF_C2H2 567 589 1.5e-4 SMART
ZnF_C2H2 595 617 4.87e-4 SMART
ZnF_C2H2 623 645 4.24e-4 SMART
ZnF_C2H2 651 673 2.27e-4 SMART
ZnF_C2H2 679 701 7.49e-5 SMART
ZnF_C2H2 707 729 4.87e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145996
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149560
Meta Mutation Damage Score 0.3932 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency 96% (69/72)
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb6 T C 1: 75,151,479 (GRCm39) probably null Het
Abcc9 G A 6: 142,571,371 (GRCm39) probably benign Het
Acss2 T C 2: 155,416,575 (GRCm39) probably benign Het
Atp8b4 G A 2: 126,217,725 (GRCm39) T597I probably damaging Het
Btaf1 A T 19: 36,961,015 (GRCm39) N796I probably benign Het
Caskin2 T C 11: 115,690,905 (GRCm39) probably null Het
Cdhr2 A G 13: 54,884,349 (GRCm39) N1295D probably benign Het
Cog3 G A 14: 75,962,239 (GRCm39) T534M probably benign Het
Cpne1 A G 2: 155,919,561 (GRCm39) S303P probably damaging Het
Cs G A 10: 128,187,086 (GRCm39) G74S possibly damaging Het
Cyb5r4 G T 9: 86,929,533 (GRCm39) S229I probably damaging Het
Ddr1 C T 17: 35,997,400 (GRCm39) A531T probably benign Het
Ect2l C T 10: 18,018,810 (GRCm39) V529M probably damaging Het
Edaradd C A 13: 12,493,161 (GRCm39) R177L possibly damaging Het
Esf1 T C 2: 140,006,148 (GRCm39) D333G possibly damaging Het
Fam8a1 T A 13: 46,827,814 (GRCm39) L334H probably damaging Het
Fbxl18 A G 5: 142,871,558 (GRCm39) I559T probably damaging Het
Fcrl2 A C 3: 87,164,851 (GRCm39) V225G probably benign Het
Ido1 C T 8: 25,077,819 (GRCm39) V83M probably damaging Het
Iffo1 T G 6: 125,130,030 (GRCm39) C419G probably damaging Het
Igfals A T 17: 25,100,439 (GRCm39) Y510F probably benign Het
Ipo9 A T 1: 135,313,210 (GRCm39) Y1006* probably null Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Jmjd1c T A 10: 67,065,785 (GRCm39) S1737T probably benign Het
Klhl32 C T 4: 24,800,805 (GRCm39) probably null Het
Klk1b11 T A 7: 43,427,810 (GRCm39) C173S probably damaging Het
Klk1b24 A T 7: 43,840,889 (GRCm39) M106L probably benign Het
Lamp1 G A 8: 13,221,388 (GRCm39) probably null Het
Mapk4 A T 18: 74,103,365 (GRCm39) V48E probably damaging Het
Marchf6 A T 15: 31,486,082 (GRCm39) D395E probably damaging Het
Mdp1 A G 14: 55,896,465 (GRCm39) F157S probably damaging Het
Mettl21e A T 1: 44,250,255 (GRCm39) F50L probably damaging Het
Mrgpra2a A G 7: 47,077,153 (GRCm39) I35T probably benign Het
Natd1 T C 11: 60,796,892 (GRCm39) Y91C probably damaging Het
Nbas T A 12: 13,633,476 (GRCm39) Y2294N probably damaging Het
Nrcam A G 12: 44,610,841 (GRCm39) T520A probably benign Het
Nrf1 A G 6: 30,117,061 (GRCm39) T324A probably benign Het
Or10a2 G A 7: 106,673,394 (GRCm39) A120T probably damaging Het
Or4k51 T A 2: 111,585,326 (GRCm39) I244N probably damaging Het
Or52a5 A C 7: 103,427,182 (GRCm39) D123E probably damaging Het
Or5m11b A G 2: 85,806,500 (GRCm39) I304M probably benign Het
Pam C T 1: 97,792,123 (GRCm39) V433I probably benign Het
Pck1 T A 2: 173,000,353 (GRCm39) Y595N probably damaging Het
Per2 C T 1: 91,373,223 (GRCm39) probably null Het
Piezo2 G C 18: 63,278,162 (GRCm39) F247L possibly damaging Het
Pkdcc A G 17: 83,523,337 (GRCm39) Y148C probably damaging Het
Plod2 A G 9: 92,475,876 (GRCm39) T320A probably benign Het
Ppip5k1 G A 2: 121,147,157 (GRCm39) R1155C probably benign Het
Ppp1r15b C T 1: 133,059,382 (GRCm39) probably benign Het
Prkn C T 17: 11,456,536 (GRCm39) A119V probably damaging Het
Ptprz1 G T 6: 22,986,133 (GRCm39) C311F probably damaging Het
Rab11fip3 A T 17: 26,235,038 (GRCm39) V44E probably damaging Het
Rpl5 T A 5: 108,051,514 (GRCm39) probably benign Het
Rttn G A 18: 89,066,556 (GRCm39) V1201I probably benign Het
Sdk1 A G 5: 141,921,853 (GRCm39) N283S probably damaging Het
Shank3 T A 15: 89,405,529 (GRCm39) N418K probably benign Het
Shmt2 T C 10: 127,353,668 (GRCm39) D499G probably benign Het
Slc25a46 A G 18: 31,716,293 (GRCm39) L403S probably damaging Het
Slc5a1 A G 5: 33,303,955 (GRCm39) T257A probably benign Het
Snrnp35 T C 5: 124,628,535 (GRCm39) V116A probably benign Het
Spag9 T A 11: 93,981,538 (GRCm39) F593I probably damaging Het
Tmem171 C A 13: 98,828,574 (GRCm39) R192L probably benign Het
Trappc3l T A 10: 33,978,703 (GRCm39) L169Q unknown Het
Ube2s T C 7: 4,811,431 (GRCm39) E148G probably damaging Het
Uspl1 T C 5: 149,146,521 (GRCm39) F424S probably damaging Het
Vmn1r2 T C 4: 3,172,261 (GRCm39) V60A probably benign Het
Wdfy4 T C 14: 32,829,575 (GRCm39) probably null Het
Zswim9 G A 7: 12,995,094 (GRCm39) S354F probably damaging Het
Other mutations in Zfp735
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00492:Zfp735 APN 11 73,602,192 (GRCm39) missense possibly damaging 0.86
IGL00798:Zfp735 APN 11 73,602,386 (GRCm39) missense possibly damaging 0.72
IGL01642:Zfp735 APN 11 73,601,305 (GRCm39) missense possibly damaging 0.73
IGL01684:Zfp735 APN 11 73,581,191 (GRCm39) missense possibly damaging 0.86
IGL02096:Zfp735 APN 11 73,602,254 (GRCm39) missense probably benign 0.01
IGL02238:Zfp735 APN 11 73,601,319 (GRCm39) missense probably benign 0.00
IGL02505:Zfp735 APN 11 73,580,626 (GRCm39) missense probably benign 0.03
IGL02740:Zfp735 APN 11 73,601,412 (GRCm39) missense possibly damaging 0.53
IGL02957:Zfp735 APN 11 73,601,755 (GRCm39) missense probably benign 0.00
bananaquit UTSW 11 73,601,412 (GRCm39) nonsense probably null
bescher UTSW 11 73,602,979 (GRCm39) missense possibly damaging 0.93
Galvanic UTSW 11 73,602,504 (GRCm39) nonsense probably null
grassquit UTSW 11 73,603,029 (GRCm39) missense possibly damaging 0.66
R0114:Zfp735 UTSW 11 73,601,488 (GRCm39) missense probably benign 0.33
R0217:Zfp735 UTSW 11 73,602,112 (GRCm39) missense possibly damaging 0.73
R0943:Zfp735 UTSW 11 73,602,909 (GRCm39) missense probably benign 0.04
R1421:Zfp735 UTSW 11 73,601,523 (GRCm39) missense probably benign
R1460:Zfp735 UTSW 11 73,603,159 (GRCm39) missense possibly damaging 0.73
R1493:Zfp735 UTSW 11 73,601,305 (GRCm39) missense possibly damaging 0.73
R1517:Zfp735 UTSW 11 73,601,470 (GRCm39) missense probably benign
R1676:Zfp735 UTSW 11 73,602,301 (GRCm39) missense possibly damaging 0.53
R1709:Zfp735 UTSW 11 73,602,589 (GRCm39) missense probably benign 0.01
R1871:Zfp735 UTSW 11 73,601,412 (GRCm39) nonsense probably null
R1931:Zfp735 UTSW 11 73,602,677 (GRCm39) missense possibly damaging 0.69
R2219:Zfp735 UTSW 11 73,601,851 (GRCm39) missense possibly damaging 0.53
R2227:Zfp735 UTSW 11 73,602,223 (GRCm39) nonsense probably null
R2227:Zfp735 UTSW 11 73,602,222 (GRCm39) missense possibly damaging 0.53
R3552:Zfp735 UTSW 11 73,602,067 (GRCm39) nonsense probably null
R3856:Zfp735 UTSW 11 73,602,282 (GRCm39) missense probably benign 0.01
R3925:Zfp735 UTSW 11 73,601,950 (GRCm39) missense probably benign 0.33
R4572:Zfp735 UTSW 11 73,580,611 (GRCm39) missense probably benign 0.02
R4585:Zfp735 UTSW 11 73,580,550 (GRCm39) missense possibly damaging 0.51
R4586:Zfp735 UTSW 11 73,580,550 (GRCm39) missense possibly damaging 0.51
R4619:Zfp735 UTSW 11 73,602,031 (GRCm39) missense probably damaging 0.98
R4687:Zfp735 UTSW 11 73,602,682 (GRCm39) missense probably damaging 0.98
R4687:Zfp735 UTSW 11 73,602,681 (GRCm39) missense probably damaging 0.98
R5435:Zfp735 UTSW 11 73,602,939 (GRCm39) missense possibly damaging 0.72
R5489:Zfp735 UTSW 11 73,601,419 (GRCm39) nonsense probably null
R5516:Zfp735 UTSW 11 73,601,640 (GRCm39) missense probably benign
R5990:Zfp735 UTSW 11 73,581,174 (GRCm39) missense possibly damaging 0.70
R6332:Zfp735 UTSW 11 73,602,504 (GRCm39) nonsense probably null
R6427:Zfp735 UTSW 11 73,581,140 (GRCm39) missense possibly damaging 0.73
R6460:Zfp735 UTSW 11 73,602,478 (GRCm39) missense probably benign 0.33
R6820:Zfp735 UTSW 11 73,579,783 (GRCm39) start codon destroyed probably null 0.01
R6831:Zfp735 UTSW 11 73,601,434 (GRCm39) missense probably damaging 1.00
R6833:Zfp735 UTSW 11 73,601,434 (GRCm39) missense probably damaging 1.00
R6834:Zfp735 UTSW 11 73,601,434 (GRCm39) missense probably damaging 1.00
R6897:Zfp735 UTSW 11 73,601,880 (GRCm39) missense probably benign 0.08
R6941:Zfp735 UTSW 11 73,581,159 (GRCm39) missense probably benign 0.33
R7335:Zfp735 UTSW 11 73,602,379 (GRCm39) missense possibly damaging 0.47
R7366:Zfp735 UTSW 11 73,602,979 (GRCm39) missense possibly damaging 0.93
R7474:Zfp735 UTSW 11 73,602,002 (GRCm39) missense possibly damaging 0.72
R7487:Zfp735 UTSW 11 73,581,154 (GRCm39) missense possibly damaging 0.53
R7583:Zfp735 UTSW 11 73,601,933 (GRCm39) missense possibly damaging 0.86
R7866:Zfp735 UTSW 11 73,601,629 (GRCm39) missense probably benign 0.00
R8005:Zfp735 UTSW 11 73,603,140 (GRCm39) nonsense probably null
R8500:Zfp735 UTSW 11 73,601,811 (GRCm39) missense possibly damaging 0.53
R8551:Zfp735 UTSW 11 73,603,122 (GRCm39) missense probably benign 0.06
R8754:Zfp735 UTSW 11 73,603,000 (GRCm39) missense possibly damaging 0.85
R8769:Zfp735 UTSW 11 73,581,127 (GRCm39) missense possibly damaging 0.53
R8794:Zfp735 UTSW 11 73,603,029 (GRCm39) missense possibly damaging 0.66
R8835:Zfp735 UTSW 11 73,601,692 (GRCm39) missense possibly damaging 0.53
R8869:Zfp735 UTSW 11 73,602,510 (GRCm39) missense possibly damaging 0.53
R8969:Zfp735 UTSW 11 73,602,699 (GRCm39) missense possibly damaging 0.83
R9072:Zfp735 UTSW 11 73,603,060 (GRCm39) missense probably benign 0.21
R9073:Zfp735 UTSW 11 73,603,060 (GRCm39) missense probably benign 0.21
R9193:Zfp735 UTSW 11 73,580,600 (GRCm39) missense possibly damaging 0.71
R9355:Zfp735 UTSW 11 73,602,362 (GRCm39) missense probably benign 0.01
R9414:Zfp735 UTSW 11 73,602,023 (GRCm39) nonsense probably null
R9456:Zfp735 UTSW 11 73,602,403 (GRCm39) missense possibly damaging 0.53
R9573:Zfp735 UTSW 11 73,602,936 (GRCm39) missense possibly damaging 0.67
R9647:Zfp735 UTSW 11 73,580,600 (GRCm39) missense probably damaging 0.98
R9710:Zfp735 UTSW 11 73,601,806 (GRCm39) missense possibly damaging 0.86
Z1176:Zfp735 UTSW 11 73,601,641 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- CAGTACTCAGCTCTTCAAAACC -3'
(R):5'- AATCATGTAAATGATTCCCCATGC -3'

Sequencing Primer
(F):5'- GGGGAATCATTTATGCAGTCATC -3'
(R):5'- AGATCTGAGCACTGTCTAAAGC -3'
Posted On 2016-11-09