Mutagenetix > Incidental Mutation

Incidental Mutation 'R5655:Or3a10'

442275

Institutional Source

Beutler Lab

Gene Symbol

Or3a10

Ensembl Gene

ENSMUSG00000047444

Gene Name

olfactory receptor family 3 subfamily A member 10

Synonyms

GA_x6K02T2P1NL-4202012-4201065, M5, Olfr139, MOR255-2

MMRRC Submission

043301-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.117) question?

Stock #

R5655 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

73935151-73936098 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to C at 73935160 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 313 (Y313*)

Ref Sequence

ENSEMBL: ENSMUSP00000148999 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050678] [ENSMUST00000206280] [ENSMUST00000214111]

AlphaFold

Q60891

Predicted Effect

probably null
Transcript: ENSMUST00000050678
AA Change: Y313*

SMART Domains

Protein: ENSMUSP00000049558
Gene: ENSMUSG00000047444
AA Change: Y313*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	34	311	1.4e-56	PFAM
Pfam:7TM_GPCR_Srsx	38	276	5.3e-6	PFAM
Pfam:7tm_1	44	293	8.1e-25	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000206280
AA Change: Y313*

Predicted Effect

probably null
Transcript: ENSMUST00000214111
AA Change: Y313*

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700016H13Rik	T	A	5: 103,796,746 (GRCm39)	I99F	probably benign	Het
Acan	G	A	7: 78,749,791 (GRCm39)	D1521N	possibly damaging	Het
Acap3	C	T	4: 155,981,076 (GRCm39)	T53I	probably benign	Het
Actr3b	G	T	5: 26,053,366 (GRCm39)	V232F	probably damaging	Het
Adgrl1	G	A	8: 84,665,230 (GRCm39)	V1311M	possibly damaging	Het
Arhgap23	T	C	11: 97,343,372 (GRCm39)		probably null	Het
Asns	A	C	6: 7,685,309 (GRCm39)	M116R	probably benign	Het
Asprv1	A	T	6: 86,605,464 (GRCm39)	E103D	probably benign	Het
Atxn2	T	C	5: 121,885,489 (GRCm39)	I232T	probably damaging	Het
B020004C17Rik	C	T	14: 57,252,689 (GRCm39)		probably benign	Het
Bckdha	A	G	7: 25,329,789 (GRCm39)	Y414H	probably damaging	Het
Bod1l	G	A	5: 41,974,387 (GRCm39)	T2309M	probably benign	Het
Cacna2d1	T	A	5: 16,507,333 (GRCm39)	F361I	probably damaging	Het
Cdc45	C	T	16: 18,626,029 (GRCm39)		probably null	Het
Cog4	A	G	8: 111,589,939 (GRCm39)	Y368C	probably damaging	Het
Cplx3	C	T	9: 57,523,258 (GRCm39)	V100M	probably damaging	Het
Cyp4a12b	C	G	4: 115,290,994 (GRCm39)	H341D	probably damaging	Het
Ddx10	A	T	9: 53,120,987 (GRCm39)		probably null	Het
Dnah12	A	T	14: 26,431,424 (GRCm39)	Y414F	probably benign	Het
Dync1h1	A	G	12: 110,595,496 (GRCm39)	K1445R	probably benign	Het
Dync2h1	A	C	9: 7,148,659 (GRCm39)	D928E	probably benign	Het
Dzip1	T	A	14: 119,124,644 (GRCm39)		probably null	Het
Fam8a1	T	A	13: 46,827,814 (GRCm39)	L334H	probably damaging	Het
Fgf14	T	C	14: 124,429,828 (GRCm39)	N36D	probably benign	Het
Fmnl3	A	T	15: 99,219,743 (GRCm39)	F668L	probably damaging	Het
Foxl2	C	T	9: 98,838,048 (GRCm39)	P112L	probably damaging	Het
Foxp2	T	G	6: 15,197,112 (GRCm39)	H51Q	probably damaging	Het
Frem3	A	T	8: 81,339,323 (GRCm39)	T539S	probably benign	Het
Ftcd	G	T	10: 76,423,937 (GRCm39)	G493C	probably damaging	Het
Gab2	A	G	7: 96,948,099 (GRCm39)	S230G	probably benign	Het
Gabra1	A	T	11: 42,073,750 (GRCm39)		probably null	Het
Gm14496	A	T	2: 181,637,975 (GRCm39)	I350L	probably benign	Het
Idh2	A	C	7: 79,747,996 (GRCm39)	C235G	probably damaging	Het
Ift140	C	T	17: 25,264,038 (GRCm39)	L514F	probably damaging	Het
Itgb4	C	T	11: 115,874,983 (GRCm39)	R447W	probably benign	Het
Lamc3	C	A	2: 31,815,729 (GRCm39)	R1142S	probably benign	Het
Lmod2	A	T	6: 24,603,853 (GRCm39)	H276L	possibly damaging	Het
Lrrc37a	T	A	11: 103,389,381 (GRCm39)	I2015L	probably benign	Het
Mcf2l	A	G	8: 13,060,444 (GRCm39)	E764G	probably damaging	Het
Mcph1	G	A	8: 18,838,326 (GRCm39)	M749I	probably benign	Het
Msh2	C	T	17: 88,026,871 (GRCm39)	A789V	possibly damaging	Het
Ndufa2	T	C	18: 36,877,519 (GRCm39)	I19V	probably benign	Het
Neurod4	T	A	10: 130,107,002 (GRCm39)	K91*	probably null	Het
Nos1	G	T	5: 118,061,322 (GRCm39)	G883C	probably damaging	Het
Npdc1	A	T	2: 25,297,692 (GRCm39)	H121L	possibly damaging	Het
Or2ak5	G	A	11: 58,611,077 (GRCm39)	H266Y	probably damaging	Het
Orc1	A	G	4: 108,450,636 (GRCm39)	I123V	probably benign	Het
P2ry13	C	T	3: 59,117,260 (GRCm39)	V173M	possibly damaging	Het
Pigk	T	A	3: 152,445,858 (GRCm39)	N156K	probably damaging	Het
Pik3ap1	A	T	19: 41,286,680 (GRCm39)	F569Y	possibly damaging	Het
Pla2g4c	T	A	7: 13,063,889 (GRCm39)		probably null	Het
Plk3	A	G	4: 116,988,677 (GRCm39)	L324P	probably damaging	Het
Pom121	A	G	5: 135,421,171 (GRCm39)	S260P	unknown	Het
Prkn	C	T	17: 11,456,536 (GRCm39)	A119V	probably damaging	Het
Prrt2	G	A	7: 126,618,574 (GRCm39)	A297V	probably damaging	Het
Prss47	A	T	13: 65,192,857 (GRCm39)	V308E	probably damaging	Het
Ptbp2	T	C	3: 119,517,806 (GRCm39)	I139V	probably benign	Het
Ptprz1	A	T	6: 22,999,772 (GRCm39)	M621L	probably benign	Het
Rab6a	G	A	7: 100,257,501 (GRCm39)		probably null	Het
Ranbp1	C	T	16: 18,059,669 (GRCm39)	D127N	probably damaging	Het
Rnpepl1	G	T	1: 92,847,032 (GRCm39)	R272L	probably damaging	Het
Slc27a2	T	C	2: 126,420,859 (GRCm39)	L314P	probably damaging	Het
Slc6a5	A	T	7: 49,606,218 (GRCm39)	M709L	probably benign	Het
Smarcc1	A	T	9: 109,986,412 (GRCm39)	S238C	probably null	Het
Snx29	C	T	16: 11,573,185 (GRCm39)	L476F	probably damaging	Het
Sorbs2	T	C	8: 46,194,618 (GRCm39)		probably null	Het
St6galnac2	T	C	11: 116,575,972 (GRCm39)	N160D	probably damaging	Het
Thsd7b	A	G	1: 129,556,671 (GRCm39)		probably null	Het
Trpc4ap	G	A	2: 155,495,547 (GRCm39)	T306I	possibly damaging	Het
Ubr5	T	G	15: 38,015,337 (GRCm39)	Y891S	probably damaging	Het
Vmn1r220	A	G	13: 23,368,298 (GRCm39)	F133L	probably benign	Het
Vmn1r56	T	A	7: 5,198,700 (GRCm39)	I306F	possibly damaging	Het
Vmn1r67	T	C	7: 10,181,315 (GRCm39)	V193A	probably benign	Het
Yipf1	T	A	4: 107,202,354 (GRCm39)	V239E	probably damaging	Het
Zfp7	G	T	15: 76,775,629 (GRCm39)	C557F	probably damaging	Het

Other mutations in Or3a10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0276:Or3a10	UTSW	11	73,935,944 (GRCm39)	missense	probably damaging	1.00
R0545:Or3a10	UTSW	11	73,935,873 (GRCm39)	missense	possibly damaging	0.90
R1560:Or3a10	UTSW	11	73,935,441 (GRCm39)	missense	probably damaging	1.00
R1570:Or3a10	UTSW	11	73,935,633 (GRCm39)	missense	possibly damaging	0.65
R1781:Or3a10	UTSW	11	73,935,786 (GRCm39)	missense	probably damaging	1.00
R2002:Or3a10	UTSW	11	73,935,865 (GRCm39)	missense	possibly damaging	0.49
R2857:Or3a10	UTSW	11	73,935,653 (GRCm39)	missense	possibly damaging	0.93
R2858:Or3a10	UTSW	11	73,935,653 (GRCm39)	missense	possibly damaging	0.93
R2859:Or3a10	UTSW	11	73,935,653 (GRCm39)	missense	possibly damaging	0.93
R3874:Or3a10	UTSW	11	73,935,525 (GRCm39)	missense	probably damaging	1.00
R5023:Or3a10	UTSW	11	73,935,881 (GRCm39)	missense	probably damaging	1.00
R5057:Or3a10	UTSW	11	73,935,881 (GRCm39)	missense	probably damaging	1.00
R5242:Or3a10	UTSW	11	73,935,848 (GRCm39)	missense	possibly damaging	0.89
R5495:Or3a10	UTSW	11	73,935,611 (GRCm39)	missense	probably damaging	1.00
R7220:Or3a10	UTSW	11	73,935,589 (GRCm39)	missense	possibly damaging	0.63
R7343:Or3a10	UTSW	11	73,935,726 (GRCm39)	missense	possibly damaging	0.68
R7793:Or3a10	UTSW	11	73,935,614 (GRCm39)	missense	possibly damaging	0.89
R8169:Or3a10	UTSW	11	73,935,707 (GRCm39)	missense	possibly damaging	0.95
R8262:Or3a10	UTSW	11	73,935,926 (GRCm39)	missense	probably damaging	1.00
R8340:Or3a10	UTSW	11	73,935,851 (GRCm39)	missense	probably damaging	0.96
R8948:Or3a10	UTSW	11	73,935,782 (GRCm39)	missense	possibly damaging	0.50
R8950:Or3a10	UTSW	11	73,935,782 (GRCm39)	missense	possibly damaging	0.50
R9046:Or3a10	UTSW	11	73,935,284 (GRCm39)	missense	probably damaging	1.00
R9202:Or3a10	UTSW	11	73,935,441 (GRCm39)	missense	probably damaging	1.00
R9575:Or3a10	UTSW	11	73,935,840 (GRCm39)	missense	probably benign	0.01
R9587:Or3a10	UTSW	11	73,935,360 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCAACGCTAAGCTATAATCTCCTC -3'
(R):5'- AGGCATTTTCCACATGCGG -3'

Sequencing Primer
(F):5'- GCTAAGCTATAATCTCCTCCAACC -3'
(R):5'- ATCTTTTATGGAACTGGCTTCTTCAG -3'

Posted On

2016-11-09