Incidental Mutation 'R5670:Zfp648'
ID 442546
Institutional Source Beutler Lab
Gene Symbol Zfp648
Ensembl Gene ENSMUSG00000066797
Gene Name zinc finger protein 648
Synonyms Gm10178, LOC207678
MMRRC Submission 043313-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R5670 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 154076933-154081435 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 154079963 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 41 (Q41K)
Ref Sequence ENSEMBL: ENSMUSP00000083370 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086195]
AlphaFold D3Z0W3
Predicted Effect probably benign
Transcript: ENSMUST00000086195
AA Change: Q41K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000083370
Gene: ENSMUSG00000066797
AA Change: Q41K

DomainStartEndE-ValueType
ZnF_C2H2 236 258 1.82e-3 SMART
ZnF_C2H2 264 286 1.28e-3 SMART
ZnF_C2H2 292 315 1.2e-3 SMART
ZnF_C2H2 321 343 1.95e-3 SMART
ZnF_C2H2 349 371 8.94e-3 SMART
ZnF_C2H2 377 399 8.34e-3 SMART
ZnF_C2H2 405 427 4.54e-4 SMART
ZnF_C2H2 433 455 4.47e-3 SMART
ZnF_C2H2 461 483 5.81e-2 SMART
ZnF_C2H2 489 511 1.2e-3 SMART
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930524J08Rik T C 5: 100,127,068 (GRCm39) probably benign Het
Ahsg T A 16: 22,716,913 (GRCm39) N158K probably benign Het
Arhgef10 T C 8: 15,004,774 (GRCm39) M430T probably benign Het
Becn2 C T 1: 175,749,179 (GRCm39) T415M probably damaging Het
Bmper T A 9: 23,384,759 (GRCm39) M588K probably damaging Het
Btla A T 16: 45,070,782 (GRCm39) D247V probably damaging Het
Cap2 T A 13: 46,684,559 (GRCm39) probably null Het
Chd2 A T 7: 73,091,465 (GRCm39) I1592K probably benign Het
Col4a4 A G 1: 82,463,300 (GRCm39) probably null Het
Copg1 C T 6: 87,889,217 (GRCm39) T853M probably damaging Het
Ddb2 C T 2: 91,042,926 (GRCm39) V353M probably damaging Het
Dip2b A G 15: 100,087,985 (GRCm39) D973G possibly damaging Het
Dscam G A 16: 96,519,364 (GRCm39) T791I probably benign Het
Dtd2 T A 12: 52,046,643 (GRCm39) L65F probably damaging Het
Fer1l6 C T 15: 58,494,331 (GRCm39) P1175S probably benign Het
Fzd6 A T 15: 38,894,510 (GRCm39) R225S probably benign Het
Glce A G 9: 61,967,793 (GRCm39) S453P probably damaging Het
Gm4787 G A 12: 81,424,805 (GRCm39) T451I probably benign Het
Igkv8-18 C T 6: 70,333,133 (GRCm39) T25I probably benign Het
Ikzf2 A G 1: 69,617,059 (GRCm39) V96A probably benign Het
Ilkap T C 1: 91,318,863 (GRCm39) T38A probably benign Het
Lpin3 A G 2: 160,739,250 (GRCm39) T353A probably benign Het
Mfsd8 A T 3: 40,776,484 (GRCm39) N389K probably benign Het
Mttp A T 3: 137,830,874 (GRCm39) V65D probably damaging Het
Ndufaf4 A T 4: 24,898,636 (GRCm39) D64V probably damaging Het
Nfe2l2 T C 2: 75,507,462 (GRCm39) T213A probably benign Het
Nkain4 A G 2: 180,584,995 (GRCm39) L73P probably damaging Het
Nwd1 T A 8: 73,419,745 (GRCm39) S977T probably damaging Het
Or1l4 T A 2: 37,092,006 (GRCm39) V251D probably benign Het
Or2y1d T G 11: 49,322,035 (GRCm39) L244R probably damaging Het
Or4b12 T C 2: 90,096,308 (GRCm39) I155M probably benign Het
Or5k1 G A 16: 58,617,424 (GRCm39) P262S possibly damaging Het
Pdgfra T C 5: 75,334,156 (GRCm39) S410P probably benign Het
Phldb1 T C 9: 44,627,078 (GRCm39) M456V probably damaging Het
Pi16 C T 17: 29,545,870 (GRCm39) T216I probably damaging Het
Plekha2 C A 8: 25,549,254 (GRCm39) A177S probably benign Het
Pramel29 A G 4: 143,936,192 (GRCm39) S23P probably benign Het
Prss16 C T 13: 22,187,221 (GRCm39) V450I possibly damaging Het
Rab3gap2 T A 1: 185,009,402 (GRCm39) L1086H probably damaging Het
Rab3gap2 C T 1: 184,954,096 (GRCm39) P56L probably benign Het
Rgs21 A G 1: 144,412,680 (GRCm39) V48A probably benign Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rnf213 A G 11: 119,325,512 (GRCm39) probably null Het
Slc4a2 G T 5: 24,639,836 (GRCm39) V506L probably damaging Het
Sptbn5 C G 2: 119,916,048 (GRCm39) probably benign Het
Steap2 C T 5: 5,723,681 (GRCm39) V400I probably benign Het
Syne2 G A 12: 75,997,733 (GRCm39) G2236D probably benign Het
Tespa1 T C 10: 130,190,624 (GRCm39) S84P probably damaging Het
Tlx2 G A 6: 83,046,807 (GRCm39) A85V possibly damaging Het
Tm4sf1 A T 3: 57,200,508 (GRCm39) F65I probably benign Het
Tmprss13 A G 9: 45,256,253 (GRCm39) I456V probably damaging Het
Tpte C T 8: 22,817,764 (GRCm39) S250F probably damaging Het
Trim24 T C 6: 37,942,536 (GRCm39) F946S probably benign Het
Vmn2r10 A T 5: 109,146,910 (GRCm39) Y459* probably null Het
Vps54 T A 11: 21,214,864 (GRCm39) I112N probably damaging Het
Vwa1 A G 4: 155,858,922 (GRCm39) L13P probably damaging Het
Other mutations in Zfp648
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Zfp648 APN 1 154,079,935 (GRCm39) missense possibly damaging 0.88
IGL01150:Zfp648 APN 1 154,081,110 (GRCm39) missense probably damaging 1.00
IGL01557:Zfp648 APN 1 154,080,426 (GRCm39) missense probably benign
IGL01757:Zfp648 APN 1 154,080,671 (GRCm39) missense probably damaging 0.98
IGL02247:Zfp648 APN 1 154,079,923 (GRCm39) missense probably benign 0.01
PIT4519001:Zfp648 UTSW 1 154,080,687 (GRCm39) missense probably damaging 0.98
R0001:Zfp648 UTSW 1 154,081,032 (GRCm39) missense probably damaging 1.00
R0256:Zfp648 UTSW 1 154,081,414 (GRCm39) missense probably benign 0.08
R0266:Zfp648 UTSW 1 154,080,632 (GRCm39) missense probably damaging 1.00
R0371:Zfp648 UTSW 1 154,080,413 (GRCm39) missense possibly damaging 0.66
R1498:Zfp648 UTSW 1 154,081,119 (GRCm39) missense probably damaging 1.00
R1562:Zfp648 UTSW 1 154,080,138 (GRCm39) missense probably benign
R1687:Zfp648 UTSW 1 154,079,988 (GRCm39) missense probably benign 0.15
R2128:Zfp648 UTSW 1 154,080,353 (GRCm39) missense probably benign
R2427:Zfp648 UTSW 1 154,080,819 (GRCm39) missense probably damaging 1.00
R2567:Zfp648 UTSW 1 154,080,695 (GRCm39) missense probably damaging 0.98
R2844:Zfp648 UTSW 1 154,080,881 (GRCm39) nonsense probably null
R3711:Zfp648 UTSW 1 154,080,304 (GRCm39) missense probably benign 0.30
R4491:Zfp648 UTSW 1 154,080,873 (GRCm39) missense probably damaging 1.00
R4693:Zfp648 UTSW 1 154,080,152 (GRCm39) missense probably benign 0.01
R5666:Zfp648 UTSW 1 154,079,963 (GRCm39) missense probably benign 0.00
R7432:Zfp648 UTSW 1 154,080,783 (GRCm39) missense possibly damaging 0.84
R8069:Zfp648 UTSW 1 154,079,862 (GRCm39) missense probably benign 0.34
R8137:Zfp648 UTSW 1 154,081,110 (GRCm39) missense probably damaging 1.00
R8282:Zfp648 UTSW 1 154,080,535 (GRCm39) missense probably benign 0.25
R9023:Zfp648 UTSW 1 154,080,914 (GRCm39) missense probably damaging 0.98
R9489:Zfp648 UTSW 1 154,080,110 (GRCm39) missense probably benign 0.17
R9520:Zfp648 UTSW 1 154,081,221 (GRCm39) missense probably benign
R9605:Zfp648 UTSW 1 154,080,110 (GRCm39) missense probably benign 0.17
Z1088:Zfp648 UTSW 1 154,080,266 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGCACACTCACTGTTGTTTG -3'
(R):5'- GAGCCTCCTGTAATTTGGGG -3'

Sequencing Primer
(F):5'- TCTGCAGGCGCTGTGAG -3'
(R):5'- GGAGTCTCGAATCTGGGTGATCC -3'
Posted On 2016-11-09