Incidental Mutation 'R5671:Olfr1388'
ID442626
Institutional Source Beutler Lab
Gene Symbol Olfr1388
Ensembl Gene ENSMUSG00000047702
Gene Nameolfactory receptor 1388
SynonymsGA_x6K02T2QP88-5991012-5990077, MOR256-28
MMRRC Submission 043314-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #R5671 (G1)
Quality Score225
Status Validated
Chromosome11
Chromosomal Location49436624-49446103 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 49444313 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 154 (V154A)
Ref Sequence ENSEMBL: ENSMUSP00000150160 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055584] [ENSMUST00000215226]
Predicted Effect probably benign
Transcript: ENSMUST00000055584
AA Change: V154A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000053834
Gene: ENSMUSG00000047702
AA Change: V154A

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.7e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 154 9.8e-7 PFAM
Pfam:7tm_1 41 289 7.6e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215226
AA Change: V154A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Meta Mutation Damage Score 0.072 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,164,546 E685* probably null Het
2700049A03Rik A T 12: 71,164,547 E685V possibly damaging Het
4930444G20Rik T A 10: 22,066,843 T413S possibly damaging Het
A530099J19Rik A G 13: 19,729,295 noncoding transcript Het
Ak2 T A 4: 129,008,247 F238I probably damaging Het
Akap8l T C 17: 32,338,292 Y115C probably damaging Het
Alms1 T A 6: 85,629,208 N2613K possibly damaging Het
Antxr1 C T 6: 87,217,273 probably null Het
Ap3b1 A T 13: 94,528,257 R901S unknown Het
Arhgap45 A G 10: 80,025,476 E491G probably damaging Het
Capn11 C T 17: 45,639,674 R293Q possibly damaging Het
Cdx1 C T 18: 61,019,899 V212I probably benign Het
Clca4b G A 3: 144,921,863 T449I probably benign Het
Clec14a T C 12: 58,267,826 I337V probably benign Het
Clip4 A C 17: 71,789,883 M1L probably damaging Het
Exoc3l4 T C 12: 111,423,417 I142T probably damaging Het
Flnb T A 14: 7,890,843 I575N probably benign Het
Gad1-ps A T 10: 99,444,533 noncoding transcript Het
Golga7 C T 8: 23,250,344 A57T probably damaging Het
Gpa33 A G 1: 166,146,791 T66A possibly damaging Het
Gpr45 A G 1: 43,033,058 Y287C probably damaging Het
H2-Eb1 C A 17: 34,314,255 Y150* probably null Het
H2-Ke6 T C 17: 34,026,461 D233G probably null Het
Ifna6 A T 4: 88,827,669 Q85L probably damaging Het
Igkv9-120 G A 6: 68,050,273 W57* probably null Het
Ivns1abp G T 1: 151,354,009 L149F probably benign Het
Kank4 A G 4: 98,765,461 probably null Het
Lama2 A T 10: 27,190,544 C1114S probably damaging Het
Lmbr1l A C 15: 98,907,608 D337E possibly damaging Het
Ly75 T C 2: 60,308,311 D1404G probably damaging Het
Muc4 A G 16: 32,753,720 T1199A probably benign Het
Nalcn A G 14: 123,295,406 I1314T probably damaging Het
Nhlrc1 A G 13: 47,013,717 F355L probably benign Het
Olfr1285 C T 2: 111,408,473 noncoding transcript Het
Olfr1444 A T 19: 12,861,807 T11S probably benign Het
Pcsk1 A G 13: 75,097,907 T135A possibly damaging Het
Ptpru T A 4: 131,820,190 Y112F possibly damaging Het
Rbbp8 A G 18: 11,742,642 S871G probably benign Het
Rhoj A T 12: 75,393,969 I135F probably damaging Het
Rnd2 C T 11: 101,468,999 L57F probably damaging Het
Ska1 G T 18: 74,196,996 D224E probably damaging Het
Slc11a2 A G 15: 100,403,288 Y295H probably damaging Het
Slc22a28 A T 19: 8,131,431 C116S probably damaging Het
Synpo T C 18: 60,595,950 D1060G probably damaging Het
Tectb T C 19: 55,192,627 S310P probably benign Het
Tmc6 A G 11: 117,775,615 S288P possibly damaging Het
Tpo A G 12: 30,119,491 S82P probably benign Het
Ttyh3 T A 5: 140,631,552 M321L probably benign Het
Usp8 A G 2: 126,742,425 D518G probably benign Het
Vmn2r11 A G 5: 109,054,906 W102R probably benign Het
Vps13a G A 19: 16,715,100 H817Y probably benign Het
Vps51 A G 19: 6,068,194 V757A probably benign Het
Washc4 T C 10: 83,570,028 S463P probably damaging Het
Zfp423 T C 8: 87,782,327 N442S probably damaging Het
Other mutations in Olfr1388
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01015:Olfr1388 APN 11 49444374 missense probably damaging 1.00
IGL01346:Olfr1388 APN 11 49444768 missense probably benign 0.00
IGL01943:Olfr1388 APN 11 49444188 nonsense probably null
IGL03343:Olfr1388 APN 11 49444243 missense probably damaging 0.97
R1530:Olfr1388 UTSW 11 49443905 missense probably benign 0.27
R1699:Olfr1388 UTSW 11 49444289 missense possibly damaging 0.88
R2059:Olfr1388 UTSW 11 49444451 missense probably damaging 0.99
R2198:Olfr1388 UTSW 11 49443959 missense probably benign 0.01
R4782:Olfr1388 UTSW 11 49443869 missense probably benign 0.00
R4885:Olfr1388 UTSW 11 49444622 missense probably damaging 0.97
R4966:Olfr1388 UTSW 11 49444118 missense possibly damaging 0.94
R5165:Olfr1388 UTSW 11 49444376 missense probably damaging 1.00
R5173:Olfr1388 UTSW 11 49443886 missense probably benign 0.12
R5667:Olfr1388 UTSW 11 49444313 missense probably benign 0.00
R5836:Olfr1388 UTSW 11 49444526 missense probably damaging 1.00
R6173:Olfr1388 UTSW 11 49444472 missense probably benign 0.01
R6801:Olfr1388 UTSW 11 49444342 missense probably benign 0.10
R6864:Olfr1388 UTSW 11 49443940 missense probably benign
R6876:Olfr1388 UTSW 11 49444241 missense probably damaging 1.00
R7386:Olfr1388 UTSW 11 49444400 missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- CTATGAAAGGTGTGTGGCTCAGC -3'
(R):5'- ACTTGACCTTCAGTACCGCC -3'

Sequencing Primer
(F):5'- GTGTGTGGCTCAGCTCCTC -3'
(R):5'- CGCCCTGGTGATATGAGCATAG -3'
Posted On2016-11-09