Incidental Mutation 'R5682:Corin'
| ID |
443097 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Corin
|
| Ensembl Gene |
ENSMUSG00000005220 |
| Gene Name |
corin, serine peptidase |
| Synonyms |
Lrp4 |
| MMRRC Submission |
043318-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.267)
|
| Stock # |
R5682 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
72457368-72661816 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 72579497 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 224
(S224P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135889
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005352]
[ENSMUST00000167460]
[ENSMUST00000175766]
[ENSMUST00000176974]
[ENSMUST00000177290]
|
| AlphaFold |
Q9Z319 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000005352
AA Change: S292P
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220
AA Change: S292P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
15 |
N/A |
INTRINSIC |
|
transmembrane domain
|
113 |
135 |
N/A |
INTRINSIC |
|
FRI
|
205 |
318 |
6.15e-11 |
SMART |
|
LDLa
|
336 |
372 |
1.31e-8 |
SMART |
|
LDLa
|
373 |
408 |
1.5e-8 |
SMART |
|
LDLa
|
409 |
447 |
5.47e-11 |
SMART |
|
LDLa
|
448 |
484 |
1.22e-8 |
SMART |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
FRI
|
522 |
643 |
2.75e-31 |
SMART |
|
LDLa
|
647 |
684 |
2.19e-10 |
SMART |
|
LDLa
|
685 |
722 |
1.76e-5 |
SMART |
|
LDLa
|
723 |
759 |
4.18e-7 |
SMART |
|
SR
|
758 |
853 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
868 |
1097 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167460
AA Change: S226P
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220
AA Change: S226P
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
342 |
1.5e-8 |
SMART |
|
LDLa
|
343 |
381 |
5.47e-11 |
SMART |
|
LDLa
|
382 |
418 |
1.22e-8 |
SMART |
|
low complexity region
|
442 |
455 |
N/A |
INTRINSIC |
|
FRI
|
456 |
577 |
2.75e-31 |
SMART |
|
LDLa
|
581 |
618 |
2.19e-10 |
SMART |
|
LDLa
|
619 |
656 |
1.76e-5 |
SMART |
|
LDLa
|
657 |
693 |
4.18e-7 |
SMART |
|
SR
|
692 |
787 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
802 |
1031 |
5.45e-76 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000175766
AA Change: S224P
PolyPhen 2
Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
AA Change: S224P
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176974
AA Change: S226P
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
AA Change: S226P
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177290
AA Change: S159P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
AA Change: S159P
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000179713
|
| Coding Region Coverage |
- 1x: 99.7%
- 3x: 99.0%
- 10x: 97.4%
- 20x: 95.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc3 |
A |
T |
11: 94,283,723 (GRCm39) |
S7T |
probably benign |
Het |
| Acot4 |
G |
A |
12: 84,085,576 (GRCm39) |
V98M |
probably damaging |
Het |
| Acsm2 |
A |
T |
7: 119,162,774 (GRCm39) |
N41I |
probably benign |
Het |
| Adamtsl3 |
A |
T |
7: 82,255,758 (GRCm39) |
N1590I |
probably damaging |
Het |
| Ank3 |
G |
A |
10: 69,729,347 (GRCm39) |
G714R |
probably damaging |
Het |
| Armh4 |
T |
C |
14: 49,989,043 (GRCm39) |
D642G |
probably damaging |
Het |
| Ash1l |
G |
A |
3: 88,914,914 (GRCm39) |
R1848Q |
probably damaging |
Het |
| Atp1a4 |
A |
T |
1: 172,081,730 (GRCm39) |
Y141N |
probably damaging |
Het |
| Atxn3 |
A |
T |
12: 101,924,406 (GRCm39) |
I1N |
probably damaging |
Het |
| Avil |
A |
C |
10: 126,849,973 (GRCm39) |
Q608P |
probably damaging |
Het |
| Axin1 |
T |
C |
17: 26,406,775 (GRCm39) |
V456A |
probably benign |
Het |
| Cacna1g |
A |
G |
11: 94,349,940 (GRCm39) |
L635P |
probably damaging |
Het |
| Card11 |
G |
A |
5: 140,888,666 (GRCm39) |
Q231* |
probably null |
Het |
| Ccdc162 |
G |
A |
10: 41,432,799 (GRCm39) |
R500* |
probably null |
Het |
| Cdh24 |
T |
C |
14: 54,874,805 (GRCm39) |
D400G |
probably damaging |
Het |
| Cep112 |
T |
C |
11: 108,361,138 (GRCm39) |
L164P |
probably damaging |
Het |
| Csgalnact2 |
T |
C |
6: 118,097,953 (GRCm39) |
Y371C |
probably damaging |
Het |
| Cspg4 |
A |
T |
9: 56,793,480 (GRCm39) |
E405V |
probably benign |
Het |
| Ctnna3 |
T |
A |
10: 64,709,085 (GRCm39) |
M708K |
probably damaging |
Het |
| Cyp7a1 |
T |
A |
4: 6,268,429 (GRCm39) |
Y432F |
probably benign |
Het |
| Dcaf11 |
T |
A |
14: 55,800,883 (GRCm39) |
V113E |
probably damaging |
Het |
| Dhx29 |
T |
C |
13: 113,067,383 (GRCm39) |
I88T |
probably damaging |
Het |
| Dnhd1 |
G |
A |
7: 105,352,416 (GRCm39) |
R2523Q |
probably damaging |
Het |
| Elmo2 |
A |
G |
2: 165,139,330 (GRCm39) |
F406L |
probably damaging |
Het |
| Eps15l1 |
G |
A |
8: 73,125,592 (GRCm39) |
Q648* |
probably null |
Het |
| Fam171a1 |
G |
A |
2: 3,227,126 (GRCm39) |
R753Q |
probably damaging |
Het |
| Figla |
T |
A |
6: 85,995,604 (GRCm39) |
V86E |
probably damaging |
Het |
| Galnt7 |
C |
A |
8: 58,036,967 (GRCm39) |
E141* |
probably null |
Het |
| Garnl3 |
A |
G |
2: 32,944,185 (GRCm39) |
Y125H |
probably damaging |
Het |
| Gnb5 |
A |
G |
9: 75,234,523 (GRCm39) |
D74G |
probably damaging |
Het |
| Grk1 |
A |
T |
8: 13,464,351 (GRCm39) |
I408F |
possibly damaging |
Het |
| Has1 |
A |
T |
17: 18,064,425 (GRCm39) |
W405R |
possibly damaging |
Het |
| Hdac5 |
A |
G |
11: 102,104,749 (GRCm39) |
|
probably benign |
Het |
| Helq |
T |
A |
5: 100,933,170 (GRCm39) |
M555L |
probably benign |
Het |
| Hipk2 |
T |
C |
6: 38,714,408 (GRCm39) |
N556S |
possibly damaging |
Het |
| Htr7 |
C |
A |
19: 35,947,271 (GRCm39) |
A248S |
probably damaging |
Het |
| Ing3 |
T |
C |
6: 21,968,949 (GRCm39) |
S144P |
probably damaging |
Het |
| Itgb1 |
G |
A |
8: 129,453,549 (GRCm39) |
|
probably null |
Het |
| Kcnh4 |
A |
T |
11: 100,640,628 (GRCm39) |
M466K |
possibly damaging |
Het |
| Krit1 |
T |
A |
5: 3,880,737 (GRCm39) |
N565K |
probably damaging |
Het |
| Limk1 |
A |
C |
5: 134,694,059 (GRCm39) |
|
probably null |
Het |
| Lrif1 |
T |
C |
3: 106,639,884 (GRCm39) |
I323T |
possibly damaging |
Het |
| Macf1 |
T |
C |
4: 123,328,552 (GRCm39) |
E1811G |
probably damaging |
Het |
| Mctp2 |
A |
C |
7: 71,895,207 (GRCm39) |
|
probably null |
Het |
| Mmp21 |
A |
G |
7: 133,276,358 (GRCm39) |
I495T |
probably benign |
Het |
| Mpz |
A |
T |
1: 170,986,463 (GRCm39) |
T126S |
possibly damaging |
Het |
| Napsa |
A |
G |
7: 44,234,768 (GRCm39) |
Y301C |
possibly damaging |
Het |
| Ncbp1 |
T |
A |
4: 46,170,474 (GRCm39) |
|
probably benign |
Het |
| Nup160 |
A |
G |
2: 90,510,155 (GRCm39) |
E47G |
probably benign |
Het |
| Or8b56 |
A |
G |
9: 38,739,424 (GRCm39) |
I146V |
probably benign |
Het |
| Pcdha11 |
A |
G |
18: 37,144,502 (GRCm39) |
K198E |
probably damaging |
Het |
| Pcdha3 |
A |
G |
18: 37,081,040 (GRCm39) |
D594G |
probably damaging |
Het |
| Pdcd5 |
G |
A |
7: 35,346,613 (GRCm39) |
|
probably benign |
Het |
| Pdhx |
A |
T |
2: 102,865,685 (GRCm39) |
S166T |
probably benign |
Het |
| Pigc |
A |
G |
1: 161,798,516 (GRCm39) |
Y166C |
probably damaging |
Het |
| Prkch |
C |
T |
12: 73,744,724 (GRCm39) |
H246Y |
probably damaging |
Het |
| Ptk2 |
A |
T |
15: 73,134,413 (GRCm39) |
L562* |
probably null |
Het |
| Rab3ip |
C |
T |
10: 116,743,008 (GRCm39) |
W439* |
probably null |
Het |
| Rasef |
T |
A |
4: 73,659,208 (GRCm39) |
R435* |
probably null |
Het |
| Rnf103 |
C |
T |
6: 71,485,708 (GRCm39) |
|
probably benign |
Het |
| Rtel1 |
T |
C |
2: 180,991,765 (GRCm39) |
F388L |
probably benign |
Het |
| Sds |
A |
C |
5: 120,621,784 (GRCm39) |
S309R |
possibly damaging |
Het |
| Sgip1 |
T |
A |
4: 102,824,847 (GRCm39) |
D736E |
possibly damaging |
Het |
| Sgms2 |
A |
G |
3: 131,118,611 (GRCm39) |
Y291H |
probably damaging |
Het |
| Sgsm3 |
A |
G |
15: 80,895,661 (GRCm39) |
|
probably null |
Het |
| Siglec1 |
T |
A |
2: 130,925,930 (GRCm39) |
I259F |
probably damaging |
Het |
| Sik2 |
G |
A |
9: 50,828,382 (GRCm39) |
P220L |
probably damaging |
Het |
| Slc29a3 |
A |
G |
10: 60,551,991 (GRCm39) |
V351A |
probably benign |
Het |
| Slc36a3 |
A |
G |
11: 55,016,489 (GRCm39) |
S369P |
probably benign |
Het |
| Srgap1 |
A |
T |
10: 121,640,919 (GRCm39) |
M649K |
probably damaging |
Het |
| Thnsl1 |
A |
G |
2: 21,216,879 (GRCm39) |
E211G |
possibly damaging |
Het |
| Tmprss9 |
A |
G |
10: 80,733,207 (GRCm39) |
|
probably null |
Het |
| Tpgs1 |
G |
A |
10: 79,511,421 (GRCm39) |
V188M |
probably damaging |
Het |
| Vmn1r201 |
G |
T |
13: 22,659,355 (GRCm39) |
V190F |
probably damaging |
Het |
| Vmn1r64 |
A |
T |
7: 5,886,622 (GRCm39) |
L307Q |
possibly damaging |
Het |
| Wbp11 |
T |
C |
6: 136,791,252 (GRCm39) |
|
probably benign |
Het |
| Wdr35 |
A |
G |
12: 9,031,125 (GRCm39) |
Y134C |
probably damaging |
Het |
| Zan |
G |
T |
5: 137,412,521 (GRCm39) |
C3263* |
probably null |
Het |
| Zc3h12c |
G |
T |
9: 52,037,876 (GRCm39) |
D301E |
probably damaging |
Het |
| Zfp365 |
A |
C |
10: 67,745,637 (GRCm39) |
L47R |
probably damaging |
Het |
| Zmym6 |
C |
T |
4: 126,998,200 (GRCm39) |
P412L |
probably damaging |
Het |
|
| Other mutations in Corin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Corin
|
APN |
5 |
72,462,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01114:Corin
|
APN |
5 |
72,462,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01351:Corin
|
APN |
5 |
72,496,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Corin
|
APN |
5 |
72,611,830 (GRCm39) |
nonsense |
probably null |
|
|
IGL01785:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01786:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Corin
|
APN |
5 |
72,511,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02097:Corin
|
APN |
5 |
72,529,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02629:Corin
|
APN |
5 |
72,490,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Corin
|
APN |
5 |
72,511,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Corin
|
APN |
5 |
72,518,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03150:Corin
|
APN |
5 |
72,460,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03183:Corin
|
APN |
5 |
72,458,929 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03185:Corin
|
APN |
5 |
72,490,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03408:Corin
|
APN |
5 |
72,500,304 (GRCm39) |
missense |
probably benign |
0.40 |
|
alpaca
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0078:Corin
|
UTSW |
5 |
72,611,816 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0724:Corin
|
UTSW |
5 |
72,490,138 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Corin
|
UTSW |
5 |
72,458,993 (GRCm39) |
nonsense |
probably null |
|
|
R1301:Corin
|
UTSW |
5 |
72,462,276 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1520:Corin
|
UTSW |
5 |
72,488,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Corin
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1912:Corin
|
UTSW |
5 |
72,515,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2059:Corin
|
UTSW |
5 |
72,473,394 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2173:Corin
|
UTSW |
5 |
72,661,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2242:Corin
|
UTSW |
5 |
72,490,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2373:Corin
|
UTSW |
5 |
72,496,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2850:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3683:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3684:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Corin
|
UTSW |
5 |
72,592,641 (GRCm39) |
missense |
probably benign |
0.38 |
|
R3847:Corin
|
UTSW |
5 |
72,579,508 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3926:Corin
|
UTSW |
5 |
72,529,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Corin
|
UTSW |
5 |
72,497,222 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3945:Corin
|
UTSW |
5 |
72,515,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Corin
|
UTSW |
5 |
72,661,226 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4224:Corin
|
UTSW |
5 |
72,500,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4473:Corin
|
UTSW |
5 |
72,496,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4586:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Corin
|
UTSW |
5 |
72,460,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4926:Corin
|
UTSW |
5 |
72,529,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Corin
|
UTSW |
5 |
72,511,194 (GRCm39) |
intron |
probably benign |
|
|
R5138:Corin
|
UTSW |
5 |
72,496,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5262:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5268:Corin
|
UTSW |
5 |
72,500,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5302:Corin
|
UTSW |
5 |
72,473,441 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5307:Corin
|
UTSW |
5 |
72,514,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5324:Corin
|
UTSW |
5 |
72,592,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5352:Corin
|
UTSW |
5 |
72,462,376 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5373:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5374:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Corin
|
UTSW |
5 |
72,515,827 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5502:Corin
|
UTSW |
5 |
72,473,449 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Corin
|
UTSW |
5 |
72,462,357 (GRCm39) |
nonsense |
probably null |
|
|
R5818:Corin
|
UTSW |
5 |
72,592,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Corin
|
UTSW |
5 |
72,473,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6115:Corin
|
UTSW |
5 |
72,518,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6181:Corin
|
UTSW |
5 |
72,529,439 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6317:Corin
|
UTSW |
5 |
72,496,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7053:Corin
|
UTSW |
5 |
72,458,870 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7242:Corin
|
UTSW |
5 |
72,462,398 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7452:Corin
|
UTSW |
5 |
72,592,590 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7783:Corin
|
UTSW |
5 |
72,458,967 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7903:Corin
|
UTSW |
5 |
72,458,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7956:Corin
|
UTSW |
5 |
72,579,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8007:Corin
|
UTSW |
5 |
72,473,446 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8125:Corin
|
UTSW |
5 |
72,515,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8215:Corin
|
UTSW |
5 |
72,462,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Corin
|
UTSW |
5 |
72,514,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Corin
|
UTSW |
5 |
72,462,274 (GRCm39) |
missense |
probably benign |
|
|
R8505:Corin
|
UTSW |
5 |
72,592,750 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8746:Corin
|
UTSW |
5 |
72,592,695 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8887:Corin
|
UTSW |
5 |
72,486,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9484:Corin
|
UTSW |
5 |
72,497,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Corin
|
UTSW |
5 |
72,592,597 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Corin
|
UTSW |
5 |
72,611,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGGTGGTATCACGGAATAC -3'
(R):5'- GTGGCTGAAACTATTGTAGGACC -3'
Sequencing Primer
(F):5'- TCACGGAATACAAACTTTAAAAGGG -3'
(R):5'- CAGAAGTTTAAGTTGCTGACAGTGC -3'
|
| Posted On |
2016-11-09 |
Incidental Mutation